Amino acid dipepetide frequency for Corynebacterium sp. 1959

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.322AlaAla: 14.322 ± 0.198	0.862AlaCys: 0.862 ± 0.032	6.479AlaAsp: 6.479 ± 0.113	7.788AlaGlu: 7.788 ± 0.132	3.733AlaPhe: 3.733 ± 0.075	9.455AlaGly: 9.455 ± 0.118	2.172AlaHis: 2.172 ± 0.061	5.803AlaIle: 5.803 ± 0.092	4.235AlaLys: 4.235 ± 0.077	11.858AlaLeu: 11.858 ± 0.14	2.955AlaMet: 2.955 ± 0.065	2.792AlaAsn: 2.792 ± 0.067	5.173AlaPro: 5.173 ± 0.1	4.207AlaGln: 4.207 ± 0.087	6.498AlaArg: 6.498 ± 0.116	6.016AlaSer: 6.016 ± 0.093	6.862AlaThr: 6.862 ± 0.105	9.369AlaVal: 9.369 ± 0.116	1.444AlaTrp: 1.444 ± 0.045	2.217AlaTyr: 2.217 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.912CysAla: 0.912 ± 0.035	0.092CysCys: 0.092 ± 0.012	0.458CysAsp: 0.458 ± 0.025	0.444CysGlu: 0.444 ± 0.024	0.267CysPhe: 0.267 ± 0.018	0.815CysGly: 0.815 ± 0.037	0.157CysHis: 0.157 ± 0.013	0.37CysIle: 0.37 ± 0.025	0.161CysLys: 0.161 ± 0.014	0.629CysLeu: 0.629 ± 0.029	0.161CysMet: 0.161 ± 0.015	0.201CysAsn: 0.201 ± 0.015	0.45CysPro: 0.45 ± 0.027	0.209CysGln: 0.209 ± 0.016	0.38CysArg: 0.38 ± 0.023	0.515CysSer: 0.515 ± 0.028	0.537CysThr: 0.537 ± 0.03	0.598CysVal: 0.598 ± 0.026	0.078CysTrp: 0.078 ± 0.01	0.145CysTyr: 0.145 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.396AspAla: 6.396 ± 0.102	0.416AspCys: 0.416 ± 0.024	3.115AspAsp: 3.115 ± 0.077	3.856AspGlu: 3.856 ± 0.078	2.186AspPhe: 2.186 ± 0.057	4.789AspGly: 4.789 ± 0.09	1.195AspHis: 1.195 ± 0.039	3.284AspIle: 3.284 ± 0.065	2.057AspLys: 2.057 ± 0.06	5.626AspLeu: 5.626 ± 0.078	1.307AspMet: 1.307 ± 0.035	1.576AspAsn: 1.576 ± 0.053	3.594AspPro: 3.594 ± 0.078	1.797AspGln: 1.797 ± 0.048	3.288AspArg: 3.288 ± 0.062	3.043AspSer: 3.043 ± 0.071	2.922AspThr: 2.922 ± 0.064	4.703AspVal: 4.703 ± 0.081	0.766AspTrp: 0.766 ± 0.037	1.428AspTyr: 1.428 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.786GluAla: 6.786 ± 0.124	0.409GluCys: 0.409 ± 0.021	3.375GluAsp: 3.375 ± 0.078	4.07GluGlu: 4.07 ± 0.098	2.344GluPhe: 2.344 ± 0.059	4.328GluGly: 4.328 ± 0.085	1.53GluHis: 1.53 ± 0.049	3.523GluIle: 3.523 ± 0.079	2.82GluLys: 2.82 ± 0.066	7.335GluLeu: 7.335 ± 0.121	1.434GluMet: 1.434 ± 0.044	1.905GluAsn: 1.905 ± 0.054	2.824GluPro: 2.824 ± 0.065	2.643GluGln: 2.643 ± 0.06	3.994GluArg: 3.994 ± 0.079	3.163GluSer: 3.163 ± 0.059	3.19GluThr: 3.19 ± 0.061	4.952GluVal: 4.952 ± 0.09	0.864GluTrp: 0.864 ± 0.033	1.368GluTyr: 1.368 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	4.1PheAla: 4.1 ± 0.086	0.288PheCys: 0.288 ± 0.022	2.421PheAsp: 2.421 ± 0.057	2.202PheGlu: 2.202 ± 0.061	1.339PhePhe: 1.339 ± 0.051	3.683PheGly: 3.683 ± 0.08	0.754PheHis: 0.754 ± 0.035	1.734PheIle: 1.734 ± 0.052	0.987PheLys: 0.987 ± 0.038	3.221PheLeu: 3.221 ± 0.073	0.717PheMet: 0.717 ± 0.031	1.064PheAsn: 1.064 ± 0.042	1.566PhePro: 1.566 ± 0.044	0.986PheGln: 0.986 ± 0.041	1.686PheArg: 1.686 ± 0.048	2.218PheSer: 2.218 ± 0.063	2.244PheThr: 2.244 ± 0.06	2.801PheVal: 2.801 ± 0.057	0.448PheTrp: 0.448 ± 0.026	0.833PheTyr: 0.833 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.459GlyAla: 8.459 ± 0.131	0.712GlyCys: 0.712 ± 0.03	4.273GlyAsp: 4.273 ± 0.079	4.989GlyGlu: 4.989 ± 0.084	3.317GlyPhe: 3.317 ± 0.062	6.455GlyGly: 6.455 ± 0.127	1.852GlyHis: 1.852 ± 0.056	4.967GlyIle: 4.967 ± 0.086	3.4GlyLys: 3.4 ± 0.071	8.287GlyLeu: 8.287 ± 0.115	2.343GlyMet: 2.343 ± 0.06	2.247GlyAsn: 2.247 ± 0.058	3.244GlyPro: 3.244 ± 0.064	2.866GlyGln: 2.866 ± 0.069	4.735GlyArg: 4.735 ± 0.082	4.885GlySer: 4.885 ± 0.081	5.09GlyThr: 5.09 ± 0.09	6.852GlyVal: 6.852 ± 0.101	1.391GlyTrp: 1.391 ± 0.045	2.143GlyTyr: 2.143 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.102HisAla: 2.102 ± 0.055	0.196HisCys: 0.196 ± 0.015	1.264HisAsp: 1.264 ± 0.04	1.183HisGlu: 1.183 ± 0.041	0.727HisPhe: 0.727 ± 0.029	1.851HisGly: 1.851 ± 0.047	0.541HisHis: 0.541 ± 0.032	1.097HisIle: 1.097 ± 0.042	0.533HisLys: 0.533 ± 0.028	1.998HisLeu: 1.998 ± 0.051	0.463HisMet: 0.463 ± 0.026	0.603HisAsn: 0.603 ± 0.031	1.386HisPro: 1.386 ± 0.052	0.7HisGln: 0.7 ± 0.033	1.378HisArg: 1.378 ± 0.046	1.165HisSer: 1.165 ± 0.042	1.185HisThr: 1.185 ± 0.042	1.59HisVal: 1.59 ± 0.041	0.29HisTrp: 0.29 ± 0.019	0.52HisTyr: 0.52 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.827IleAla: 6.827 ± 0.101	0.421IleCys: 0.421 ± 0.025	3.886IleAsp: 3.886 ± 0.073	3.305IleGlu: 3.305 ± 0.069	1.682IlePhe: 1.682 ± 0.051	4.765IleGly: 4.765 ± 0.087	1.006IleHis: 1.006 ± 0.039	2.728IleIle: 2.728 ± 0.071	1.723IleLys: 1.723 ± 0.056	4.402IleLeu: 4.402 ± 0.077	1.108IleMet: 1.108 ± 0.039	1.609IleAsn: 1.609 ± 0.053	2.854IlePro: 2.854 ± 0.064	1.377IleGln: 1.377 ± 0.047	2.8IleArg: 2.8 ± 0.063	3.282IleSer: 3.282 ± 0.071	3.301IleThr: 3.301 ± 0.068	4.584IleVal: 4.584 ± 0.089	0.521IleTrp: 0.521 ± 0.03	1.125IleTyr: 1.125 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.865LysAla: 3.865 ± 0.081	0.186LysCys: 0.186 ± 0.015	2.104LysAsp: 2.104 ± 0.053	2.161LysGlu: 2.161 ± 0.053	1.127LysPhe: 1.127 ± 0.046	2.556LysGly: 2.556 ± 0.061	0.769LysHis: 0.769 ± 0.03	1.83LysIle: 1.83 ± 0.049	1.764LysLys: 1.764 ± 0.058	3.45LysLeu: 3.45 ± 0.061	0.94LysMet: 0.94 ± 0.04	1.223LysAsn: 1.223 ± 0.045	1.898LysPro: 1.898 ± 0.053	1.403LysGln: 1.403 ± 0.043	2.198LysArg: 2.198 ± 0.051	1.95LysSer: 1.95 ± 0.05	2.029LysThr: 2.029 ± 0.058	2.887LysVal: 2.887 ± 0.061	0.469LysTrp: 0.469 ± 0.026	0.862LysTyr: 0.862 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	12.313LeuAla: 12.313 ± 0.149	0.773LeuCys: 0.773 ± 0.037	5.796LeuAsp: 5.796 ± 0.098	5.575LeuGlu: 5.575 ± 0.106	3.147LeuPhe: 3.147 ± 0.081	8.672LeuGly: 8.672 ± 0.144	1.877LeuHis: 1.877 ± 0.055	5.497LeuIle: 5.497 ± 0.085	3.326LeuLys: 3.326 ± 0.066	9.429LeuLeu: 9.429 ± 0.146	2.254LeuMet: 2.254 ± 0.058	2.527LeuAsn: 2.527 ± 0.064	5.222LeuPro: 5.222 ± 0.093	2.921LeuGln: 2.921 ± 0.068	6.103LeuArg: 6.103 ± 0.097	6.138LeuSer: 6.138 ± 0.1	6.179LeuThr: 6.179 ± 0.093	8.215LeuVal: 8.215 ± 0.109	1.215LeuTrp: 1.215 ± 0.042	1.806LeuTyr: 1.806 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.716MetAla: 2.716 ± 0.067	0.176MetCys: 0.176 ± 0.017	1.173MetAsp: 1.173 ± 0.039	1.127MetGlu: 1.127 ± 0.036	0.817MetPhe: 0.817 ± 0.034	1.9MetGly: 1.9 ± 0.053	0.49MetHis: 0.49 ± 0.026	1.337MetIle: 1.337 ± 0.047	0.956MetLys: 0.956 ± 0.035	2.373MetLeu: 2.373 ± 0.065	0.581MetMet: 0.581 ± 0.029	0.829MetAsn: 0.829 ± 0.032	1.269MetPro: 1.269 ± 0.044	0.781MetGln: 0.781 ± 0.029	1.41MetArg: 1.41 ± 0.043	1.768MetSer: 1.768 ± 0.05	1.772MetThr: 1.772 ± 0.043	1.811MetVal: 1.811 ± 0.045	0.373MetTrp: 0.373 ± 0.021	0.436MetTyr: 0.436 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.917AsnAla: 2.917 ± 0.071	0.229AsnCys: 0.229 ± 0.017	1.406AsnAsp: 1.406 ± 0.043	1.718AsnGlu: 1.718 ± 0.049	1.029AsnPhe: 1.029 ± 0.044	2.194AsnGly: 2.194 ± 0.058	0.557AsnHis: 0.557 ± 0.027	1.382AsnIle: 1.382 ± 0.047	1.007AsnLys: 1.007 ± 0.036	2.687AsnLeu: 2.687 ± 0.059	0.641AsnMet: 0.641 ± 0.028	0.883AsnAsn: 0.883 ± 0.039	2.036AsnPro: 2.036 ± 0.057	0.882AsnGln: 0.882 ± 0.039	1.549AsnArg: 1.549 ± 0.052	1.786AsnSer: 1.786 ± 0.052	1.552AsnThr: 1.552 ± 0.045	2.205AsnVal: 2.205 ± 0.057	0.467AsnTrp: 0.467 ± 0.026	0.754AsnTyr: 0.754 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.872ProAla: 5.872 ± 0.099	0.286ProCys: 0.286 ± 0.018	3.017ProAsp: 3.017 ± 0.056	4.333ProGlu: 4.333 ± 0.081	1.647ProPhe: 1.647 ± 0.04	4.327ProGly: 4.327 ± 0.088	1.074ProHis: 1.074 ± 0.039	2.396ProIle: 2.396 ± 0.058	1.777ProLys: 1.777 ± 0.058	4.548ProLeu: 4.548 ± 0.095	1.199ProMet: 1.199 ± 0.041	1.522ProAsn: 1.522 ± 0.044	1.724ProPro: 1.724 ± 0.064	1.647ProGln: 1.647 ± 0.05	2.605ProArg: 2.605 ± 0.061	2.725ProSer: 2.725 ± 0.055	3.208ProThr: 3.208 ± 0.077	4.547ProVal: 4.547 ± 0.1	0.753ProTrp: 0.753 ± 0.034	1.086ProTyr: 1.086 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.761GlnAla: 3.761 ± 0.086	0.204GlnCys: 0.204 ± 0.013	1.578GlnAsp: 1.578 ± 0.05	2.006GlnGlu: 2.006 ± 0.059	1.191GlnPhe: 1.191 ± 0.036	2.366GlnGly: 2.366 ± 0.062	0.808GlnHis: 0.808 ± 0.035	1.79GlnIle: 1.79 ± 0.05	1.128GlnLys: 1.128 ± 0.037	3.928GlnLeu: 3.928 ± 0.09	0.825GlnMet: 0.825 ± 0.031	0.841GlnAsn: 0.841 ± 0.031	1.772GlnPro: 1.772 ± 0.048	1.498GlnGln: 1.498 ± 0.051	2.537GlnArg: 2.537 ± 0.062	1.623GlnSer: 1.623 ± 0.042	1.509GlnThr: 1.509 ± 0.049	2.733GlnVal: 2.733 ± 0.065	0.617GlnTrp: 0.617 ± 0.027	0.711GlnTyr: 0.711 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.034ArgAla: 6.034 ± 0.088	0.374ArgCys: 0.374 ± 0.023	3.442ArgAsp: 3.442 ± 0.062	4.027ArgGlu: 4.027 ± 0.075	2.075ArgPhe: 2.075 ± 0.055	4.327ArgGly: 4.327 ± 0.088	1.21ArgHis: 1.21 ± 0.043	3.408ArgIle: 3.408 ± 0.064	2.246ArgLys: 2.246 ± 0.059	5.505ArgLeu: 5.505 ± 0.105	1.653ArgMet: 1.653 ± 0.042	1.628ArgAsn: 1.628 ± 0.053	2.795ArgPro: 2.795 ± 0.069	2.043ArgGln: 2.043 ± 0.048	4.489ArgArg: 4.489 ± 0.094	3.416ArgSer: 3.416 ± 0.064	3.498ArgThr: 3.498 ± 0.067	4.503ArgVal: 4.503 ± 0.087	0.892ArgTrp: 0.892 ± 0.036	1.449ArgTyr: 1.449 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.444SerAla: 6.444 ± 0.101	0.45SerCys: 0.45 ± 0.025	3.136SerAsp: 3.136 ± 0.07	3.5SerGlu: 3.5 ± 0.069	2.194SerPhe: 2.194 ± 0.06	5.441SerGly: 5.441 ± 0.089	1.247SerHis: 1.247 ± 0.042	2.892SerIle: 2.892 ± 0.061	1.896SerLys: 1.896 ± 0.049	5.663SerLeu: 5.663 ± 0.098	1.566SerMet: 1.566 ± 0.048	1.601SerAsn: 1.601 ± 0.046	2.876SerPro: 2.876 ± 0.058	1.927SerGln: 1.927 ± 0.053	3.316SerArg: 3.316 ± 0.084	3.541SerSer: 3.541 ± 0.083	3.624SerThr: 3.624 ± 0.078	4.594SerVal: 4.594 ± 0.081	0.952SerTrp: 0.952 ± 0.038	1.391SerTyr: 1.391 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.638ThrAla: 6.638 ± 0.107	0.445ThrCys: 0.445 ± 0.024	3.292ThrAsp: 3.292 ± 0.073	3.387ThrGlu: 3.387 ± 0.07	2.159ThrPhe: 2.159 ± 0.058	5.173ThrGly: 5.173 ± 0.083	1.164ThrHis: 1.164 ± 0.037	3.195ThrIle: 3.195 ± 0.071	2.047ThrLys: 2.047 ± 0.055	5.728ThrLeu: 5.728 ± 0.097	1.344ThrMet: 1.344 ± 0.046	1.534ThrAsn: 1.534 ± 0.04	3.774ThrPro: 3.774 ± 0.116	1.724ThrGln: 1.724 ± 0.052	3.046ThrArg: 3.046 ± 0.066	3.635ThrSer: 3.635 ± 0.076	3.952ThrThr: 3.952 ± 0.147	5.258ThrVal: 5.258 ± 0.097	0.918ThrTrp: 0.918 ± 0.034	1.403ThrTyr: 1.403 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	9.987ValAla: 9.987 ± 0.135	0.708ValCys: 0.708 ± 0.028	5.079ValAsp: 5.079 ± 0.082	5.106ValGlu: 5.106 ± 0.089	2.785ValPhe: 2.785 ± 0.069	6.398ValGly: 6.398 ± 0.106	1.627ValHis: 1.627 ± 0.05	4.432ValIle: 4.432 ± 0.081	2.577ValLys: 2.577 ± 0.053	8.158ValLeu: 8.158 ± 0.135	1.842ValMet: 1.842 ± 0.053	2.205ValAsn: 2.205 ± 0.061	4.041ValPro: 4.041 ± 0.072	2.284ValGln: 2.284 ± 0.058	4.611ValArg: 4.611 ± 0.07	5.202ValSer: 5.202 ± 0.081	5.269ValThr: 5.269 ± 0.092	7.448ValVal: 7.448 ± 0.116	1.045ValTrp: 1.045 ± 0.035	1.566ValTyr: 1.566 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.514TrpAla: 1.514 ± 0.047	0.126TrpCys: 0.126 ± 0.014	0.732TrpAsp: 0.732 ± 0.026	0.765TrpGlu: 0.765 ± 0.033	0.584TrpPhe: 0.584 ± 0.027	0.993TrpGly: 0.993 ± 0.036	0.315TrpHis: 0.315 ± 0.024	0.749TrpIle: 0.749 ± 0.032	0.465TrpLys: 0.465 ± 0.029	1.735TrpLeu: 1.735 ± 0.062	0.363TrpMet: 0.363 ± 0.022	0.425TrpAsn: 0.425 ± 0.026	0.62TrpPro: 0.62 ± 0.031	0.625TrpGln: 0.625 ± 0.025	0.887TrpArg: 0.887 ± 0.036	0.844TrpSer: 0.844 ± 0.039	0.744TrpThr: 0.744 ± 0.035	1.07TrpVal: 1.07 ± 0.042	0.367TrpTrp: 0.367 ± 0.024	0.317TrpTyr: 0.317 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.273TyrAla: 2.273 ± 0.058	0.224TyrCys: 0.224 ± 0.017	1.322TyrAsp: 1.322 ± 0.044	1.312TyrGlu: 1.312 ± 0.038	0.941TyrPhe: 0.941 ± 0.037	2.019TyrGly: 2.019 ± 0.055	0.429TyrHis: 0.429 ± 0.023	0.894TyrIle: 0.894 ± 0.037	0.565TyrLys: 0.565 ± 0.03	2.427TyrLeu: 2.427 ± 0.057	0.395TyrMet: 0.395 ± 0.022	0.669TyrAsn: 0.669 ± 0.032	1.174TyrPro: 1.174 ± 0.036	0.906TyrGln: 0.906 ± 0.03	1.505TyrArg: 1.505 ± 0.048	1.336TyrSer: 1.336 ± 0.037	1.148TyrThr: 1.148 ± 0.041	1.652TyrVal: 1.652 ± 0.047	0.371TyrTrp: 0.371 ± 0.023	0.491TyrTyr: 0.491 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2392 proteins (759665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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