Amino acid dipepetide frequency for Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.484AlaAla: 11.484 ± 0.15	1.313AlaCys: 1.313 ± 0.04	5.234AlaAsp: 5.234 ± 0.072	6.733AlaGlu: 6.733 ± 0.106	3.722AlaPhe: 3.722 ± 0.067	9.066AlaGly: 9.066 ± 0.098	1.682AlaHis: 1.682 ± 0.037	5.522AlaIle: 5.522 ± 0.078	4.152AlaLys: 4.152 ± 0.068	9.852AlaLeu: 9.852 ± 0.116	2.603AlaMet: 2.603 ± 0.052	2.592AlaAsn: 2.592 ± 0.06	4.075AlaPro: 4.075 ± 0.072	2.607AlaGln: 2.607 ± 0.052	6.313AlaArg: 6.313 ± 0.093	4.941AlaSer: 4.941 ± 0.072	5.413AlaThr: 5.413 ± 0.119	7.909AlaVal: 7.909 ± 0.087	0.963AlaTrp: 0.963 ± 0.03	2.241AlaTyr: 2.241 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.132CysAla: 1.132 ± 0.029	0.219CysCys: 0.219 ± 0.014	0.677CysAsp: 0.677 ± 0.033	0.549CysGlu: 0.549 ± 0.021	0.482CysPhe: 0.482 ± 0.022	1.356CysGly: 1.356 ± 0.04	0.828CysHis: 0.828 ± 0.079	0.608CysIle: 0.608 ± 0.024	0.392CysLys: 0.392 ± 0.022	1.012CysLeu: 1.012 ± 0.028	0.267CysMet: 0.267 ± 0.016	0.385CysAsn: 0.385 ± 0.02	0.695CysPro: 0.695 ± 0.031	0.305CysGln: 0.305 ± 0.016	0.888CysArg: 0.888 ± 0.027	0.777CysSer: 0.777 ± 0.026	0.662CysThr: 0.662 ± 0.025	0.749CysVal: 0.749 ± 0.03	0.128CysTrp: 0.128 ± 0.011	0.361CysTyr: 0.361 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.751AspAla: 4.751 ± 0.074	0.662AspCys: 0.662 ± 0.028	2.749AspAsp: 2.749 ± 0.054	3.744AspGlu: 3.744 ± 0.061	2.302AspPhe: 2.302 ± 0.046	4.394AspGly: 4.394 ± 0.068	1.038AspHis: 1.038 ± 0.032	3.326AspIle: 3.326 ± 0.055	2.144AspLys: 2.144 ± 0.05	5.454AspLeu: 5.454 ± 0.079	1.213AspMet: 1.213 ± 0.03	1.595AspAsn: 1.595 ± 0.039	2.783AspPro: 2.783 ± 0.054	1.407AspGln: 1.407 ± 0.036	3.654AspArg: 3.654 ± 0.06	2.449AspSer: 2.449 ± 0.053	2.665AspThr: 2.665 ± 0.055	3.713AspVal: 3.713 ± 0.052	0.58AspTrp: 0.58 ± 0.024	1.78AspTyr: 1.78 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.363GluAla: 6.363 ± 0.083	0.616GluCys: 0.616 ± 0.023	2.574GluAsp: 2.574 ± 0.048	5.392GluGlu: 5.392 ± 0.083	2.336GluPhe: 2.336 ± 0.041	5.072GluGly: 5.072 ± 0.071	1.299GluHis: 1.299 ± 0.036	4.279GluIle: 4.279 ± 0.075	4.065GluLys: 4.065 ± 0.072	6.846GluLeu: 6.846 ± 0.1	1.92GluMet: 1.92 ± 0.047	2.072GluAsn: 2.072 ± 0.039	2.491GluPro: 2.491 ± 0.043	2.363GluGln: 2.363 ± 0.051	5.324GluArg: 5.324 ± 0.085	3.065GluSer: 3.065 ± 0.056	3.499GluThr: 3.499 ± 0.06	4.707GluVal: 4.707 ± 0.068	0.645GluTrp: 0.645 ± 0.027	1.654GluTyr: 1.654 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.759PheAla: 3.759 ± 0.07	0.57PheCys: 0.57 ± 0.022	2.358PheAsp: 2.358 ± 0.044	2.073PheGlu: 2.073 ± 0.038	1.852PhePhe: 1.852 ± 0.05	3.463PheGly: 3.463 ± 0.063	0.835PheHis: 0.835 ± 0.029	2.19PheIle: 2.19 ± 0.046	1.432PheLys: 1.432 ± 0.04	4.141PheLeu: 4.141 ± 0.067	0.922PheMet: 0.922 ± 0.03	1.293PheAsn: 1.293 ± 0.036	1.914PhePro: 1.914 ± 0.043	1.033PheGln: 1.033 ± 0.03	2.65PheArg: 2.65 ± 0.055	2.776PheSer: 2.776 ± 0.047	2.471PheThr: 2.471 ± 0.058	2.843PheVal: 2.843 ± 0.056	0.495PheTrp: 0.495 ± 0.023	1.189PheTyr: 1.189 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.463GlyAla: 7.463 ± 0.091	1.302GlyCys: 1.302 ± 0.038	4.253GlyAsp: 4.253 ± 0.063	5.693GlyGlu: 5.693 ± 0.084	3.491GlyPhe: 3.491 ± 0.057	7.183GlyGly: 7.183 ± 0.106	1.687GlyHis: 1.687 ± 0.038	5.8GlyIle: 5.8 ± 0.074	5.011GlyLys: 5.011 ± 0.081	7.39GlyLeu: 7.39 ± 0.093	2.388GlyMet: 2.388 ± 0.046	2.772GlyAsn: 2.772 ± 0.061	2.455GlyPro: 2.455 ± 0.051	2.167GlyGln: 2.167 ± 0.038	5.186GlyArg: 5.186 ± 0.075	4.642GlySer: 4.642 ± 0.077	5.273GlyThr: 5.273 ± 0.108	6.286GlyVal: 6.286 ± 0.087	1.001GlyTrp: 1.001 ± 0.031	2.708GlyTyr: 2.708 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.677HisAla: 1.677 ± 0.042	0.337HisCys: 0.337 ± 0.017	1.234HisAsp: 1.234 ± 0.038	1.175HisGlu: 1.175 ± 0.032	0.866HisPhe: 0.866 ± 0.03	1.919HisGly: 1.919 ± 0.044	0.568HisHis: 0.568 ± 0.023	1.034HisIle: 1.034 ± 0.029	0.713HisLys: 0.713 ± 0.028	2.203HisLeu: 2.203 ± 0.044	0.438HisMet: 0.438 ± 0.017	0.709HisAsn: 0.709 ± 0.027	1.384HisPro: 1.384 ± 0.036	0.605HisGln: 0.605 ± 0.026	1.371HisArg: 1.371 ± 0.034	1.003HisSer: 1.003 ± 0.034	0.983HisThr: 0.983 ± 0.028	1.32HisVal: 1.32 ± 0.033	0.233HisTrp: 0.233 ± 0.016	0.639HisTyr: 0.639 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.861IleAla: 5.861 ± 0.076	0.669IleCys: 0.669 ± 0.024	3.439IleAsp: 3.439 ± 0.053	3.573IleGlu: 3.573 ± 0.061	2.207IlePhe: 2.207 ± 0.044	4.608IleGly: 4.608 ± 0.066	1.226IleHis: 1.226 ± 0.027	3.462IleIle: 3.462 ± 0.064	2.338IleLys: 2.338 ± 0.053	5.563IleLeu: 5.563 ± 0.08	1.281IleMet: 1.281 ± 0.035	1.886IleAsn: 1.886 ± 0.043	3.17IlePro: 3.17 ± 0.048	1.465IleGln: 1.465 ± 0.037	3.699IleArg: 3.699 ± 0.055	3.305IleSer: 3.305 ± 0.059	3.468IleThr: 3.468 ± 0.057	4.426IleVal: 4.426 ± 0.075	0.484IleTrp: 0.484 ± 0.022	1.478IleTyr: 1.478 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.443LysAla: 4.443 ± 0.083	0.47LysCys: 0.47 ± 0.026	2.295LysAsp: 2.295 ± 0.049	3.619LysGlu: 3.619 ± 0.07	1.297LysPhe: 1.297 ± 0.034	4.283LysGly: 4.283 ± 0.066	0.834LysHis: 0.834 ± 0.031	2.762LysIle: 2.762 ± 0.061	3.125LysLys: 3.125 ± 0.065	4.118LysLeu: 4.118 ± 0.063	1.222LysMet: 1.222 ± 0.033	1.637LysAsn: 1.637 ± 0.042	2.147LysPro: 2.147 ± 0.037	1.432LysGln: 1.432 ± 0.041	2.993LysArg: 2.993 ± 0.056	2.379LysSer: 2.379 ± 0.048	2.507LysThr: 2.507 ± 0.053	3.582LysVal: 3.582 ± 0.061	0.404LysTrp: 0.404 ± 0.017	1.227LysTyr: 1.227 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.343LeuAla: 11.343 ± 0.141	1.181LeuCys: 1.181 ± 0.035	5.432LeuAsp: 5.432 ± 0.075	6.34LeuGlu: 6.34 ± 0.084	4.203LeuPhe: 4.203 ± 0.074	7.47LeuGly: 7.47 ± 0.085	1.942LeuHis: 1.942 ± 0.04	4.793LeuIle: 4.793 ± 0.074	4.954LeuLys: 4.954 ± 0.073	10.253LeuLeu: 10.253 ± 0.14	2.327LeuMet: 2.327 ± 0.051	3.067LeuAsn: 3.067 ± 0.051	5.051LeuPro: 5.051 ± 0.075	2.757LeuGln: 2.757 ± 0.054	6.504LeuArg: 6.504 ± 0.1	6.109LeuSer: 6.109 ± 0.077	5.458LeuThr: 5.458 ± 0.085	7.406LeuVal: 7.406 ± 0.097	0.91LeuTrp: 0.91 ± 0.032	2.485LeuTyr: 2.485 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.903MetAla: 2.903 ± 0.054	0.186MetCys: 0.186 ± 0.014	1.226MetAsp: 1.226 ± 0.032	1.756MetGlu: 1.756 ± 0.045	0.679MetPhe: 0.679 ± 0.024	2.126MetGly: 2.126 ± 0.05	0.429MetHis: 0.429 ± 0.021	1.232MetIle: 1.232 ± 0.031	1.652MetLys: 1.652 ± 0.036	2.212MetLeu: 2.212 ± 0.05	0.58MetMet: 0.58 ± 0.024	0.942MetAsn: 0.942 ± 0.026	1.176MetPro: 1.176 ± 0.031	0.641MetGln: 0.641 ± 0.023	1.41MetArg: 1.41 ± 0.039	1.281MetSer: 1.281 ± 0.034	1.548MetThr: 1.548 ± 0.039	1.945MetVal: 1.945 ± 0.049	0.141MetTrp: 0.141 ± 0.011	0.408MetTyr: 0.408 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.841AsnAla: 2.841 ± 0.055	0.45AsnCys: 0.45 ± 0.023	1.593AsnAsp: 1.593 ± 0.041	1.525AsnGlu: 1.525 ± 0.044	1.176AsnPhe: 1.176 ± 0.035	2.783AsnGly: 2.783 ± 0.071	0.65AsnHis: 0.65 ± 0.022	1.892AsnIle: 1.892 ± 0.046	1.19AsnLys: 1.19 ± 0.034	3.398AsnLeu: 3.398 ± 0.057	0.674AsnMet: 0.674 ± 0.027	1.033AsnAsn: 1.033 ± 0.04	2.156AsnPro: 2.156 ± 0.045	0.838AsnGln: 0.838 ± 0.029	2.32AsnArg: 2.32 ± 0.044	1.639AsnSer: 1.639 ± 0.045	1.551AsnThr: 1.551 ± 0.051	2.213AsnVal: 2.213 ± 0.053	0.362AsnTrp: 0.362 ± 0.016	0.968AsnTyr: 0.968 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.968ProAla: 4.968 ± 0.08	0.464ProCys: 0.464 ± 0.022	2.898ProAsp: 2.898 ± 0.056	3.645ProGlu: 3.645 ± 0.061	2.114ProPhe: 2.114 ± 0.045	3.961ProGly: 3.961 ± 0.061	1.008ProHis: 1.008 ± 0.03	2.018ProIle: 2.018 ± 0.04	1.824ProLys: 1.824 ± 0.043	4.895ProLeu: 4.895 ± 0.075	0.992ProMet: 0.992 ± 0.03	1.239ProAsn: 1.239 ± 0.036	2.412ProPro: 2.412 ± 0.059	1.404ProGln: 1.404 ± 0.038	2.514ProArg: 2.514 ± 0.049	2.449ProSer: 2.449 ± 0.051	2.29ProThr: 2.29 ± 0.059	4.178ProVal: 4.178 ± 0.057	0.59ProTrp: 0.59 ± 0.026	1.335ProTyr: 1.335 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.815GlnAla: 2.815 ± 0.053	0.353GlnCys: 0.353 ± 0.02	1.154GlnAsp: 1.154 ± 0.033	2.093GlnGlu: 2.093 ± 0.043	1.053GlnPhe: 1.053 ± 0.032	2.367GlnGly: 2.367 ± 0.042	0.513GlnHis: 0.513 ± 0.022	1.707GlnIle: 1.707 ± 0.042	1.525GlnLys: 1.525 ± 0.041	2.697GlnLeu: 2.697 ± 0.05	0.802GlnMet: 0.802 ± 0.024	0.892GlnAsn: 0.892 ± 0.026	1.167GlnPro: 1.167 ± 0.035	1.103GlnGln: 1.103 ± 0.035	1.945GlnArg: 1.945 ± 0.042	1.443GlnSer: 1.443 ± 0.042	1.463GlnThr: 1.463 ± 0.047	2.318GlnVal: 2.318 ± 0.041	0.328GlnTrp: 0.328 ± 0.014	0.719GlnTyr: 0.719 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.926ArgAla: 4.926 ± 0.075	0.753ArgCys: 0.753 ± 0.033	3.574ArgAsp: 3.574 ± 0.059	5.67ArgGlu: 5.67 ± 0.089	2.965ArgPhe: 2.965 ± 0.049	4.747ArgGly: 4.747 ± 0.079	1.492ArgHis: 1.492 ± 0.043	4.326ArgIle: 4.326 ± 0.065	3.163ArgLys: 3.163 ± 0.05	7.216ArgLeu: 7.216 ± 0.098	1.84ArgMet: 1.84 ± 0.044	2.109ArgAsn: 2.109 ± 0.042	2.538ArgPro: 2.538 ± 0.045	2.389ArgGln: 2.389 ± 0.05	4.767ArgArg: 4.767 ± 0.096	3.242ArgSer: 3.242 ± 0.065	3.103ArgThr: 3.103 ± 0.051	4.527ArgVal: 4.527 ± 0.067	0.726ArgTrp: 0.726 ± 0.026	2.055ArgTyr: 2.055 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.032SerAla: 5.032 ± 0.077	0.83SerCys: 0.83 ± 0.029	2.733SerAsp: 2.733 ± 0.057	2.764SerGlu: 2.764 ± 0.053	2.671SerPhe: 2.671 ± 0.053	5.022SerGly: 5.022 ± 0.078	1.159SerHis: 1.159 ± 0.037	3.024SerIle: 3.024 ± 0.057	1.866SerLys: 1.866 ± 0.034	6.029SerLeu: 6.029 ± 0.079	1.197SerMet: 1.197 ± 0.031	1.517SerAsn: 1.517 ± 0.045	2.896SerPro: 2.896 ± 0.054	1.472SerGln: 1.472 ± 0.034	3.704SerArg: 3.704 ± 0.057	3.285SerSer: 3.285 ± 0.067	2.784SerThr: 2.784 ± 0.067	4.002SerVal: 4.002 ± 0.067	0.638SerTrp: 0.638 ± 0.024	1.69SerTyr: 1.69 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.632ThrAla: 5.632 ± 0.114	0.652ThrCys: 0.652 ± 0.03	2.772ThrAsp: 2.772 ± 0.056	2.962ThrGlu: 2.962 ± 0.054	2.331ThrPhe: 2.331 ± 0.049	5.453ThrGly: 5.453 ± 0.09	0.953ThrHis: 0.953 ± 0.027	3.441ThrIle: 3.441 ± 0.059	1.999ThrLys: 1.999 ± 0.045	5.647ThrLeu: 5.647 ± 0.076	1.261ThrMet: 1.261 ± 0.036	1.571ThrAsn: 1.571 ± 0.05	3.268ThrPro: 3.268 ± 0.072	1.189ThrGln: 1.189 ± 0.034	2.864ThrArg: 2.864 ± 0.055	2.978ThrSer: 2.978 ± 0.075	3.174ThrThr: 3.174 ± 0.095	5.123ThrVal: 5.123 ± 0.087	0.582ThrTrp: 0.582 ± 0.029	1.427ThrTyr: 1.427 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	8.05ValAla: 8.05 ± 0.085	0.902ValCys: 0.902 ± 0.028	4.012ValAsp: 4.012 ± 0.062	5.14ValGlu: 5.14 ± 0.076	2.805ValPhe: 2.805 ± 0.052	5.535ValGly: 5.535 ± 0.076	1.362ValHis: 1.362 ± 0.033	4.532ValIle: 4.532 ± 0.069	3.751ValLys: 3.751 ± 0.054	6.787ValLeu: 6.787 ± 0.085	1.812ValMet: 1.812 ± 0.044	2.62ValAsn: 2.62 ± 0.056	3.602ValPro: 3.602 ± 0.067	1.911ValGln: 1.911 ± 0.045	4.953ValArg: 4.953 ± 0.073	4.436ValSer: 4.436 ± 0.069	5.006ValThr: 5.006 ± 0.094	6.298ValVal: 6.298 ± 0.08	0.729ValTrp: 0.729 ± 0.027	1.775ValTyr: 1.775 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.706TrpAla: 0.706 ± 0.024	0.136TrpCys: 0.136 ± 0.01	0.577TrpAsp: 0.577 ± 0.024	0.669TrpGlu: 0.669 ± 0.024	0.466TrpPhe: 0.466 ± 0.023	0.911TrpGly: 0.911 ± 0.03	0.272TrpHis: 0.272 ± 0.013	0.491TrpIle: 0.491 ± 0.021	0.521TrpLys: 0.521 ± 0.021	1.181TrpLeu: 1.181 ± 0.036	0.251TrpMet: 0.251 ± 0.014	0.396TrpAsn: 0.396 ± 0.02	0.42TrpPro: 0.42 ± 0.021	0.422TrpGln: 0.422 ± 0.022	0.743TrpArg: 0.743 ± 0.028	0.601TrpSer: 0.601 ± 0.023	0.457TrpThr: 0.457 ± 0.023	0.676TrpVal: 0.676 ± 0.027	0.162TrpTrp: 0.162 ± 0.012	0.334TrpTyr: 0.334 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.269TyrAla: 2.269 ± 0.049	0.405TyrCys: 0.405 ± 0.018	1.621TyrAsp: 1.621 ± 0.044	1.465TyrGlu: 1.465 ± 0.034	1.242TyrPhe: 1.242 ± 0.033	2.433TyrGly: 2.433 ± 0.055	0.63TyrHis: 0.63 ± 0.023	1.169TyrIle: 1.169 ± 0.032	0.956TyrLys: 0.956 ± 0.033	3.091TyrLeu: 3.091 ± 0.056	0.482TyrMet: 0.482 ± 0.021	0.926TyrAsn: 0.926 ± 0.032	1.397TyrPro: 1.397 ± 0.036	0.947TyrGln: 0.947 ± 0.03	2.327TyrArg: 2.327 ± 0.052	1.516TyrSer: 1.516 ± 0.044	1.504TyrThr: 1.504 ± 0.051	1.797TyrVal: 1.797 ± 0.039	0.293TyrTrp: 0.293 ± 0.016	0.957TyrTyr: 0.957 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3502 proteins (1188476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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