Amino acid dipepetide frequency for Firmicutes bacterium CAG:884

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.783AlaAla: 1.783 ± 0.089
0.564AlaCys: 0.564 ± 0.044
2.017AlaAsp: 2.017 ± 0.068
2.275AlaGlu: 2.275 ± 0.091
2.066AlaPhe: 2.066 ± 0.076
2.352AlaGly: 2.352 ± 0.089
0.674AlaHis: 0.674 ± 0.044
4.234AlaIle: 4.234 ± 0.126
3.838AlaLys: 3.838 ± 0.105
4.529AlaLeu: 4.529 ± 0.124
0.996AlaMet: 0.996 ± 0.052
2.87AlaAsn: 2.87 ± 0.098
0.985AlaPro: 0.985 ± 0.059
0.856AlaGln: 0.856 ± 0.049
1.794AlaArg: 1.794 ± 0.08
3.392AlaSer: 3.392 ± 0.105
2.226AlaThr: 2.226 ± 0.087
2.446AlaVal: 2.446 ± 0.097
0.223AlaTrp: 0.223 ± 0.025
2.174AlaTyr: 2.174 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.614CysAla: 0.614 ± 0.039
0.116CysCys: 0.116 ± 0.016
0.737CysAsp: 0.737 ± 0.064
0.677CysGlu: 0.677 ± 0.045
0.468CysPhe: 0.468 ± 0.04
0.836CysGly: 0.836 ± 0.052
0.182CysHis: 0.182 ± 0.022
0.996CysIle: 0.996 ± 0.056
1.054CysLys: 1.054 ± 0.061
0.963CysLeu: 0.963 ± 0.056
0.234CysMet: 0.234 ± 0.023
0.801CysAsn: 0.801 ± 0.05
0.41CysPro: 0.41 ± 0.035
0.198CysGln: 0.198 ± 0.025
0.272CysArg: 0.272 ± 0.026
1.101CysSer: 1.101 ± 0.098
0.693CysThr: 0.693 ± 0.046
0.567CysVal: 0.567 ± 0.041
0.083CysTrp: 0.083 ± 0.015
0.526CysTyr: 0.526 ± 0.044
0.0CysXaa: 0.0 ± 0.0
Asp
2.586AspAla: 2.586 ± 0.088
0.644AspCys: 0.644 ± 0.047
3.511AspAsp: 3.511 ± 0.114
5.084AspGlu: 5.084 ± 0.143
2.966AspPhe: 2.966 ± 0.1
3.164AspGly: 3.164 ± 0.137
0.539AspHis: 0.539 ± 0.039
6.155AspIle: 6.155 ± 0.144
5.83AspLys: 5.83 ± 0.119
5.497AspLeu: 5.497 ± 0.133
1.45AspMet: 1.45 ± 0.063
4.298AspAsn: 4.298 ± 0.142
1.189AspPro: 1.189 ± 0.051
0.699AspGln: 0.699 ± 0.039
1.596AspArg: 1.596 ± 0.079
3.225AspSer: 3.225 ± 0.105
2.875AspThr: 2.875 ± 0.104
3.643AspVal: 3.643 ± 0.104
0.289AspTrp: 0.289 ± 0.03
3.635AspTyr: 3.635 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
3.247GluAla: 3.247 ± 0.113
0.762GluCys: 0.762 ± 0.049
3.505GluAsp: 3.505 ± 0.113
6.98GluGlu: 6.98 ± 0.191
2.509GluPhe: 2.509 ± 0.081
3.148GluGly: 3.148 ± 0.109
0.836GluHis: 0.836 ± 0.044
7.371GluIle: 7.371 ± 0.147
7.927GluLys: 7.927 ± 0.174
7.412GluLeu: 7.412 ± 0.164
2.036GluMet: 2.036 ± 0.075
6.251GluAsn: 6.251 ± 0.155
1.403GluPro: 1.403 ± 0.067
1.557GluGln: 1.557 ± 0.066
2.369GluArg: 2.369 ± 0.094
3.277GluSer: 3.277 ± 0.089
3.582GluThr: 3.582 ± 0.106
4.339GluVal: 4.339 ± 0.127
0.418GluTrp: 0.418 ± 0.035
4.254GluTyr: 4.254 ± 0.144
0.0GluXaa: 0.0 ± 0.0
Phe
1.799PheAla: 1.799 ± 0.065
0.537PheCys: 0.537 ± 0.036
3.021PheAsp: 3.021 ± 0.093
2.771PheGlu: 2.771 ± 0.095
1.725PhePhe: 1.725 ± 0.087
2.685PheGly: 2.685 ± 0.107
0.404PheHis: 0.404 ± 0.037
4.556PheIle: 4.556 ± 0.118
4.022PheLys: 4.022 ± 0.1
3.621PheLeu: 3.621 ± 0.133
1.018PheMet: 1.018 ± 0.056
3.574PheAsn: 3.574 ± 0.14
1.09PhePro: 1.09 ± 0.055
0.647PheGln: 0.647 ± 0.044
1.158PheArg: 1.158 ± 0.062
2.641PheSer: 2.641 ± 0.103
2.182PheThr: 2.182 ± 0.082
2.762PheVal: 2.762 ± 0.087
0.292PheTrp: 0.292 ± 0.029
2.215PheTyr: 2.215 ± 0.083
0.0PheXaa: 0.0 ± 0.0
Gly
2.644GlyAla: 2.644 ± 0.113
0.748GlyCys: 0.748 ± 0.058
2.666GlyAsp: 2.666 ± 0.093
3.247GlyGlu: 3.247 ± 0.103
2.471GlyPhe: 2.471 ± 0.081
3.062GlyGly: 3.062 ± 0.203
0.966GlyHis: 0.966 ± 0.054
5.566GlyIle: 5.566 ± 0.132
5.137GlyLys: 5.137 ± 0.119
4.71GlyLeu: 4.71 ± 0.129
1.329GlyMet: 1.329 ± 0.056
3.695GlyAsn: 3.695 ± 0.142
1.101GlyPro: 1.101 ± 0.11
0.902GlyGln: 0.902 ± 0.053
1.744GlyArg: 1.744 ± 0.081
3.445GlySer: 3.445 ± 0.125
3.318GlyThr: 3.318 ± 0.15
3.189GlyVal: 3.189 ± 0.116
0.303GlyTrp: 0.303 ± 0.034
3.315GlyTyr: 3.315 ± 0.094
0.0GlyXaa: 0.0 ± 0.0
His
0.487HisAla: 0.487 ± 0.036
0.102HisCys: 0.102 ± 0.018
0.509HisAsp: 0.509 ± 0.044
0.66HisGlu: 0.66 ± 0.041
0.6HisPhe: 0.6 ± 0.041
0.647HisGly: 0.647 ± 0.053
0.228HisHis: 0.228 ± 0.022
1.277HisIle: 1.277 ± 0.069
1.103HisLys: 1.103 ± 0.058
1.211HisLeu: 1.211 ± 0.061
0.325HisMet: 0.325 ± 0.032
0.985HisAsn: 0.985 ± 0.056
0.492HisPro: 0.492 ± 0.043
0.305HisGln: 0.305 ± 0.031
0.402HisArg: 0.402 ± 0.033
0.743HisSer: 0.743 ± 0.048
0.721HisThr: 0.721 ± 0.046
0.44HisVal: 0.44 ± 0.041
0.058HisTrp: 0.058 ± 0.014
0.699HisTyr: 0.699 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
4.149IleAla: 4.149 ± 0.128
1.266IleCys: 1.266 ± 0.068
7.104IleAsp: 7.104 ± 0.168
7.269IleGlu: 7.269 ± 0.175
4.24IlePhe: 4.24 ± 0.142
5.208IleGly: 5.208 ± 0.142
1.021IleHis: 1.021 ± 0.051
11.159IleIle: 11.159 ± 0.295
10.917IleLys: 10.917 ± 0.219
8.837IleLeu: 8.837 ± 0.198
2.275IleMet: 2.275 ± 0.092
8.312IleAsn: 8.312 ± 0.183
2.672IlePro: 2.672 ± 0.089
1.318IleGln: 1.318 ± 0.063
2.985IleArg: 2.985 ± 0.103
6.38IleSer: 6.38 ± 0.174
5.406IleThr: 5.406 ± 0.144
6.6IleVal: 6.6 ± 0.138
0.465IleTrp: 0.465 ± 0.035
5.214IleTyr: 5.214 ± 0.132
0.003IleXaa: 0.003 ± 0.003
Lys
4.006LysAla: 4.006 ± 0.121
1.183LysCys: 1.183 ± 0.069
6.124LysAsp: 6.124 ± 0.139
10.359LysGlu: 10.359 ± 0.209
2.867LysPhe: 2.867 ± 0.105
4.523LysGly: 4.523 ± 0.118
1.065LysHis: 1.065 ± 0.061
10.218LysIle: 10.218 ± 0.203
11.058LysLys: 11.058 ± 0.249
8.028LysLeu: 8.028 ± 0.15
2.875LysMet: 2.875 ± 0.104
8.452LysAsn: 8.452 ± 0.177
2.165LysPro: 2.165 ± 0.078
2.317LysGln: 2.317 ± 0.097
3.403LysArg: 3.403 ± 0.096
4.749LysSer: 4.749 ± 0.125
5.178LysThr: 5.178 ± 0.115
6.413LysVal: 6.413 ± 0.145
0.534LysTrp: 0.534 ± 0.039
6.386LysTyr: 6.386 ± 0.171
0.0LysXaa: 0.0 ± 0.0
Leu
3.965LeuAla: 3.965 ± 0.118
1.015LeuCys: 1.015 ± 0.058
5.695LeuAsp: 5.695 ± 0.124
6.702LeuGlu: 6.702 ± 0.16
4.267LeuPhe: 4.267 ± 0.141
4.719LeuGly: 4.719 ± 0.136
0.93LeuHis: 0.93 ± 0.051
8.65LeuIle: 8.65 ± 0.208
9.652LeuLys: 9.652 ± 0.203
8.009LeuLeu: 8.009 ± 0.207
1.893LeuMet: 1.893 ± 0.07
6.76LeuAsn: 6.76 ± 0.137
2.495LeuPro: 2.495 ± 0.092
1.477LeuGln: 1.477 ± 0.063
2.639LeuArg: 2.639 ± 0.097
6.268LeuSer: 6.268 ± 0.147
4.848LeuThr: 4.848 ± 0.136
5.349LeuVal: 5.349 ± 0.136
0.462LeuTrp: 0.462 ± 0.044
4.276LeuTyr: 4.276 ± 0.113
0.0LeuXaa: 0.0 ± 0.0
Met
1.142MetAla: 1.142 ± 0.052
0.212MetCys: 0.212 ± 0.022
1.266MetAsp: 1.266 ± 0.054
1.725MetGlu: 1.725 ± 0.067
1.491MetPhe: 1.491 ± 0.109
1.244MetGly: 1.244 ± 0.056
0.338MetHis: 0.338 ± 0.034
2.102MetIle: 2.102 ± 0.074
2.685MetLys: 2.685 ± 0.077
2.058MetLeu: 2.058 ± 0.082
0.586MetMet: 0.586 ± 0.046
1.923MetAsn: 1.923 ± 0.08
0.801MetPro: 0.801 ± 0.048
0.682MetGln: 0.682 ± 0.043
0.729MetArg: 0.729 ± 0.045
1.332MetSer: 1.332 ± 0.073
1.114MetThr: 1.114 ± 0.053
1.345MetVal: 1.345 ± 0.061
0.107MetTrp: 0.107 ± 0.019
1.092MetTyr: 1.092 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
3.15AsnAla: 3.15 ± 0.089
0.801AsnCys: 0.801 ± 0.08
4.884AsnAsp: 4.884 ± 0.129
5.907AsnGlu: 5.907 ± 0.16
2.837AsnPhe: 2.837 ± 0.082
4.421AsnGly: 4.421 ± 0.139
0.93AsnHis: 0.93 ± 0.054
9.267AsnIle: 9.267 ± 0.197
8.419AsnLys: 8.419 ± 0.184
6.438AsnLeu: 6.438 ± 0.146
1.912AsnMet: 1.912 ± 0.098
6.848AsnAsn: 6.848 ± 0.187
1.953AsnPro: 1.953 ± 0.084
1.667AsnGln: 1.667 ± 0.076
2.124AsnArg: 2.124 ± 0.087
3.91AsnSer: 3.91 ± 0.108
3.824AsnThr: 3.824 ± 0.143
4.856AsnVal: 4.856 ± 0.138
0.399AsnTrp: 0.399 ± 0.039
4.886AsnTyr: 4.886 ± 0.113
0.003AsnXaa: 0.003 ± 0.003
Pro
0.858ProAla: 0.858 ± 0.047
0.237ProCys: 0.237 ± 0.027
1.323ProAsp: 1.323 ± 0.068
1.753ProGlu: 1.753 ± 0.079
1.365ProPhe: 1.365 ± 0.076
1.351ProGly: 1.351 ± 0.062
0.396ProHis: 0.396 ± 0.034
2.358ProIle: 2.358 ± 0.086
2.165ProLys: 2.165 ± 0.074
2.088ProLeu: 2.088 ± 0.074
0.454ProMet: 0.454 ± 0.04
1.918ProAsn: 1.918 ± 0.075
0.366ProPro: 0.366 ± 0.031
0.476ProGln: 0.476 ± 0.035
0.704ProArg: 0.704 ± 0.054
1.832ProSer: 1.832 ± 0.075
1.315ProThr: 1.315 ± 0.095
1.612ProVal: 1.612 ± 0.074
0.19ProTrp: 0.19 ± 0.022
1.491ProTyr: 1.491 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
0.858GlnAla: 0.858 ± 0.049
0.107GlnCys: 0.107 ± 0.018
0.889GlnAsp: 0.889 ± 0.054
1.222GlnGlu: 1.222 ± 0.061
0.696GlnPhe: 0.696 ± 0.045
1.001GlnGly: 1.001 ± 0.056
0.138GlnHis: 0.138 ± 0.02
2.22GlnIle: 2.22 ± 0.08
2.201GlnLys: 2.201 ± 0.083
1.521GlnLeu: 1.521 ± 0.078
0.619GlnMet: 0.619 ± 0.04
1.725GlnAsn: 1.725 ± 0.07
0.289GlnPro: 0.289 ± 0.034
0.259GlnGln: 0.259 ± 0.028
0.68GlnArg: 0.68 ± 0.044
0.974GlnSer: 0.974 ± 0.053
1.12GlnThr: 1.12 ± 0.057
1.106GlnVal: 1.106 ± 0.057
0.091GlnTrp: 0.091 ± 0.019
0.693GlnTyr: 0.693 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
1.345ArgAla: 1.345 ± 0.07
0.47ArgCys: 0.47 ± 0.033
1.662ArgAsp: 1.662 ± 0.073
2.399ArgGlu: 2.399 ± 0.086
1.4ArgPhe: 1.4 ± 0.073
1.607ArgGly: 1.607 ± 0.072
0.404ArgHis: 0.404 ± 0.035
3.024ArgIle: 3.024 ± 0.103
3.134ArgLys: 3.134 ± 0.097
2.749ArgLeu: 2.749 ± 0.1
1.007ArgMet: 1.007 ± 0.057
2.278ArgAsn: 2.278 ± 0.081
0.798ArgPro: 0.798 ± 0.053
0.677ArgGln: 0.677 ± 0.046
1.191ArgArg: 1.191 ± 0.063
1.654ArgSer: 1.654 ± 0.069
1.648ArgThr: 1.648 ± 0.076
1.89ArgVal: 1.89 ± 0.085
0.184ArgTrp: 0.184 ± 0.021
1.53ArgTyr: 1.53 ± 0.079
0.0ArgXaa: 0.0 ± 0.0
Ser
2.465SerAla: 2.465 ± 0.086
0.715SerCys: 0.715 ± 0.051
3.043SerAsp: 3.043 ± 0.112
2.999SerGlu: 2.999 ± 0.098
3.12SerPhe: 3.12 ± 0.118
3.621SerGly: 3.621 ± 0.157
0.724SerHis: 0.724 ± 0.048
6.325SerIle: 6.325 ± 0.14
6.21SerLys: 6.21 ± 0.143
6.188SerLeu: 6.188 ± 0.168
1.359SerMet: 1.359 ± 0.071
5.084SerAsn: 5.084 ± 0.181
1.2SerPro: 1.2 ± 0.058
1.023SerGln: 1.023 ± 0.051
1.907SerArg: 1.907 ± 0.076
4.867SerSer: 4.867 ± 0.182
3.175SerThr: 3.175 ± 0.124
3.428SerVal: 3.428 ± 0.097
0.333SerTrp: 0.333 ± 0.031
3.469SerTyr: 3.469 ± 0.113
0.0SerXaa: 0.0 ± 0.0
Thr
1.912ThrAla: 1.912 ± 0.088
0.586ThrCys: 0.586 ± 0.05
2.996ThrAsp: 2.996 ± 0.114
2.963ThrGlu: 2.963 ± 0.098
2.424ThrPhe: 2.424 ± 0.087
3.194ThrGly: 3.194 ± 0.149
0.707ThrHis: 0.707 ± 0.042
5.748ThrIle: 5.748 ± 0.136
4.903ThrLys: 4.903 ± 0.12
5.079ThrLeu: 5.079 ± 0.131
0.966ThrMet: 0.966 ± 0.051
4.32ThrAsn: 4.32 ± 0.134
1.607ThrPro: 1.607 ± 0.068
0.916ThrGln: 0.916 ± 0.043
1.61ThrArg: 1.61 ± 0.069
3.893ThrSer: 3.893 ± 0.179
2.914ThrThr: 2.914 ± 0.12
2.729ThrVal: 2.729 ± 0.094
0.281ThrTrp: 0.281 ± 0.027
2.705ThrTyr: 2.705 ± 0.108
0.0ThrXaa: 0.0 ± 0.0
Val
2.674ValAla: 2.674 ± 0.096
0.836ValCys: 0.836 ± 0.046
3.786ValAsp: 3.786 ± 0.108
3.67ValGlu: 3.67 ± 0.127
2.556ValPhe: 2.556 ± 0.092
3.541ValGly: 3.541 ± 0.101
0.702ValHis: 0.702 ± 0.046
5.753ValIle: 5.753 ± 0.14
5.786ValLys: 5.786 ± 0.128
5.536ValLeu: 5.536 ± 0.141
1.323ValMet: 1.323 ± 0.065
4.245ValAsn: 4.245 ± 0.136
1.827ValPro: 1.827 ± 0.074
1.156ValGln: 1.156 ± 0.051
1.821ValArg: 1.821 ± 0.079
4.072ValSer: 4.072 ± 0.113
3.461ValThr: 3.461 ± 0.128
4.033ValVal: 4.033 ± 0.111
0.311ValTrp: 0.311 ± 0.032
2.883ValTyr: 2.883 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.201TrpAla: 0.201 ± 0.025
0.085TrpCys: 0.085 ± 0.013
0.325TrpAsp: 0.325 ± 0.026
0.272TrpGlu: 0.272 ± 0.024
0.278TrpPhe: 0.278 ± 0.033
0.283TrpGly: 0.283 ± 0.029
0.08TrpHis: 0.08 ± 0.016
0.492TrpIle: 0.492 ± 0.041
0.404TrpLys: 0.404 ± 0.039
0.49TrpLeu: 0.49 ± 0.035
0.171TrpMet: 0.171 ± 0.022
0.443TrpAsn: 0.443 ± 0.038
0.154TrpPro: 0.154 ± 0.023
0.127TrpGln: 0.127 ± 0.021
0.182TrpArg: 0.182 ± 0.022
0.396TrpSer: 0.396 ± 0.038
0.237TrpThr: 0.237 ± 0.031
0.256TrpVal: 0.256 ± 0.027
0.063TrpTrp: 0.063 ± 0.015
0.404TrpTyr: 0.404 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.407TyrAla: 2.407 ± 0.08
0.539TyrCys: 0.539 ± 0.045
3.811TyrAsp: 3.811 ± 0.111
4.245TyrGlu: 4.245 ± 0.131
2.374TyrPhe: 2.374 ± 0.085
2.949TyrGly: 2.949 ± 0.126
0.729TyrHis: 0.729 ± 0.042
5.329TyrIle: 5.329 ± 0.152
5.459TyrLys: 5.459 ± 0.133
5.106TyrLeu: 5.106 ± 0.134
1.142TyrMet: 1.142 ± 0.048
4.655TyrAsn: 4.655 ± 0.118
1.257TyrPro: 1.257 ± 0.061
1.15TyrGln: 1.15 ± 0.056
1.742TyrArg: 1.742 ± 0.071
3.109TyrSer: 3.109 ± 0.095
2.614TyrThr: 2.614 ± 0.092
2.969TyrVal: 2.969 ± 0.099
0.259TyrTrp: 0.259 ± 0.029
3.065TyrTyr: 3.065 ± 0.123
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.003XaaGlu: 0.003 ± 0.003
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.003XaaMet: 0.003 ± 0.003
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.011XaaXaa: 0.011 ± 0.007
Statistics based on 1232 proteins (363460 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski