Amino acid dipepetide frequency for Hyphomicrobium sulfonivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.097AlaAla: 18.097 ± 0.21	1.073AlaCys: 1.073 ± 0.035	7.312AlaAsp: 7.312 ± 0.091	7.845AlaGlu: 7.845 ± 0.115	4.24AlaPhe: 4.24 ± 0.067	10.206AlaGly: 10.206 ± 0.118	2.357AlaHis: 2.357 ± 0.05	6.489AlaIle: 6.489 ± 0.082	4.512AlaLys: 4.512 ± 0.091	12.831AlaLeu: 12.831 ± 0.151	3.317AlaMet: 3.317 ± 0.059	3.444AlaAsn: 3.444 ± 0.063	6.255AlaPro: 6.255 ± 0.11	4.367AlaGln: 4.367 ± 0.076	8.613AlaArg: 8.613 ± 0.116	7.349AlaSer: 7.349 ± 0.109	6.221AlaThr: 6.221 ± 0.079	8.709AlaVal: 8.709 ± 0.105	1.372AlaTrp: 1.372 ± 0.039	2.593AlaTyr: 2.593 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.065CysAla: 1.065 ± 0.031	0.173CysCys: 0.173 ± 0.014	0.496CysAsp: 0.496 ± 0.024	0.439CysGlu: 0.439 ± 0.021	0.313CysPhe: 0.313 ± 0.019	0.88CysGly: 0.88 ± 0.035	0.22CysHis: 0.22 ± 0.016	0.417CysIle: 0.417 ± 0.019	0.235CysLys: 0.235 ± 0.015	0.74CysLeu: 0.74 ± 0.029	0.189CysMet: 0.189 ± 0.014	0.252CysAsn: 0.252 ± 0.015	0.447CysPro: 0.447 ± 0.022	0.227CysGln: 0.227 ± 0.015	0.618CysArg: 0.618 ± 0.03	0.505CysSer: 0.505 ± 0.023	0.422CysThr: 0.422 ± 0.021	0.651CysVal: 0.651 ± 0.029	0.107CysTrp: 0.107 ± 0.012	0.217CysTyr: 0.217 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.432AspAla: 7.432 ± 0.104	0.516AspCys: 0.516 ± 0.024	3.464AspAsp: 3.464 ± 0.069	3.603AspGlu: 3.603 ± 0.076	1.949AspPhe: 1.949 ± 0.048	5.36AspGly: 5.36 ± 0.087	1.141AspHis: 1.141 ± 0.034	3.029AspIle: 3.029 ± 0.052	1.868AspLys: 1.868 ± 0.054	5.412AspLeu: 5.412 ± 0.077	1.259AspMet: 1.259 ± 0.037	1.473AspAsn: 1.473 ± 0.035	2.972AspPro: 2.972 ± 0.059	1.68AspGln: 1.68 ± 0.048	4.021AspArg: 4.021 ± 0.07	2.217AspSer: 2.217 ± 0.05	2.745AspThr: 2.745 ± 0.056	4.439AspVal: 4.439 ± 0.07	0.886AspTrp: 0.886 ± 0.028	1.482AspTyr: 1.482 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.473GluAla: 7.473 ± 0.1	0.396GluCys: 0.396 ± 0.026	2.559GluAsp: 2.559 ± 0.053	3.045GluGlu: 3.045 ± 0.06	1.801GluPhe: 1.801 ± 0.041	3.989GluGly: 3.989 ± 0.071	1.275GluHis: 1.275 ± 0.034	3.414GluIle: 3.414 ± 0.06	2.376GluLys: 2.376 ± 0.053	5.739GluLeu: 5.739 ± 0.081	1.489GluMet: 1.489 ± 0.04	1.67GluAsn: 1.67 ± 0.039	2.724GluPro: 2.724 ± 0.058	2.424GluGln: 2.424 ± 0.051	5.117GluArg: 5.117 ± 0.083	2.264GluSer: 2.264 ± 0.042	3.298GluThr: 3.298 ± 0.057	3.979GluVal: 3.979 ± 0.064	0.72GluTrp: 0.72 ± 0.023	1.056GluTyr: 1.056 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.64PheAla: 4.64 ± 0.075	0.344PheCys: 0.344 ± 0.018	2.517PheAsp: 2.517 ± 0.05	2.082PheGlu: 2.082 ± 0.049	1.32PhePhe: 1.32 ± 0.046	3.412PheGly: 3.412 ± 0.063	0.703PheHis: 0.703 ± 0.026	1.728PheIle: 1.728 ± 0.048	1.195PheLys: 1.195 ± 0.037	3.002PheLeu: 3.002 ± 0.067	0.786PheMet: 0.786 ± 0.026	1.27PheAsn: 1.27 ± 0.039	1.536PhePro: 1.536 ± 0.035	0.878PheGln: 0.878 ± 0.028	2.166PheArg: 2.166 ± 0.042	2.316PheSer: 2.316 ± 0.051	2.02PheThr: 2.02 ± 0.045	2.634PheVal: 2.634 ± 0.055	0.569PheTrp: 0.569 ± 0.025	0.924PheTyr: 0.924 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.575GlyAla: 9.575 ± 0.106	0.841GlyCys: 0.841 ± 0.03	4.522GlyAsp: 4.522 ± 0.077	4.632GlyGlu: 4.632 ± 0.077	3.453GlyPhe: 3.453 ± 0.059	7.549GlyGly: 7.549 ± 0.164	1.793GlyHis: 1.793 ± 0.049	4.318GlyIle: 4.318 ± 0.075	3.359GlyLys: 3.359 ± 0.069	7.909GlyLeu: 7.909 ± 0.083	2.12GlyMet: 2.12 ± 0.05	2.473GlyAsn: 2.473 ± 0.073	3.328GlyPro: 3.328 ± 0.049	2.75GlyGln: 2.75 ± 0.052	5.759GlyArg: 5.759 ± 0.078	4.903GlySer: 4.903 ± 0.077	4.58GlyThr: 4.58 ± 0.092	6.209GlyVal: 6.209 ± 0.086	1.277GlyTrp: 1.277 ± 0.033	2.311GlyTyr: 2.311 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.379HisAla: 2.379 ± 0.047	0.216HisCys: 0.216 ± 0.014	1.201HisAsp: 1.201 ± 0.038	1.025HisGlu: 1.025 ± 0.04	0.845HisPhe: 0.845 ± 0.031	1.838HisGly: 1.838 ± 0.041	0.551HisHis: 0.551 ± 0.025	1.045HisIle: 1.045 ± 0.03	0.548HisLys: 0.548 ± 0.023	1.851HisLeu: 1.851 ± 0.045	0.513HisMet: 0.513 ± 0.022	0.552HisAsn: 0.552 ± 0.022	1.231HisPro: 1.231 ± 0.033	0.587HisGln: 0.587 ± 0.024	1.451HisArg: 1.451 ± 0.042	1.006HisSer: 1.006 ± 0.034	0.989HisThr: 0.989 ± 0.036	1.49HisVal: 1.49 ± 0.043	0.313HisTrp: 0.313 ± 0.017	0.564HisTyr: 0.564 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.652IleAla: 7.652 ± 0.096	0.481IleCys: 0.481 ± 0.021	3.733IleAsp: 3.733 ± 0.061	3.677IleGlu: 3.677 ± 0.067	1.619IlePhe: 1.619 ± 0.047	4.933IleGly: 4.933 ± 0.071	0.792IleHis: 0.792 ± 0.025	2.44IleIle: 2.44 ± 0.051	1.704IleLys: 1.704 ± 0.042	3.88IleLeu: 3.88 ± 0.072	0.952IleMet: 0.952 ± 0.029	1.698IleAsn: 1.698 ± 0.043	2.219IlePro: 2.219 ± 0.045	1.071IleGln: 1.071 ± 0.03	2.852IleArg: 2.852 ± 0.052	2.993IleSer: 2.993 ± 0.057	2.868IleThr: 2.868 ± 0.054	4.38IleVal: 4.38 ± 0.078	0.587IleTrp: 0.587 ± 0.022	1.179IleTyr: 1.179 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.421LysAla: 4.421 ± 0.078	0.241LysCys: 0.241 ± 0.018	1.8LysAsp: 1.8 ± 0.044	1.685LysGlu: 1.685 ± 0.047	1.07LysPhe: 1.07 ± 0.031	2.705LysGly: 2.705 ± 0.056	0.72LysHis: 0.72 ± 0.027	1.787LysIle: 1.787 ± 0.05	1.539LysLys: 1.539 ± 0.051	3.712LysLeu: 3.712 ± 0.072	0.76LysMet: 0.76 ± 0.027	0.977LysAsn: 0.977 ± 0.037	2.375LysPro: 2.375 ± 0.059	1.216LysGln: 1.216 ± 0.037	2.778LysArg: 2.778 ± 0.057	2.129LysSer: 2.129 ± 0.057	1.962LysThr: 1.962 ± 0.044	2.488LysVal: 2.488 ± 0.061	0.411LysTrp: 0.411 ± 0.02	0.675LysTyr: 0.675 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.867LeuAla: 12.867 ± 0.129	0.803LeuCys: 0.803 ± 0.026	5.461LeuAsp: 5.461 ± 0.083	5.369LeuGlu: 5.369 ± 0.089	3.358LeuPhe: 3.358 ± 0.07	7.56LeuGly: 7.56 ± 0.107	1.796LeuHis: 1.796 ± 0.04	4.953LeuIle: 4.953 ± 0.078	3.909LeuLys: 3.909 ± 0.06	9.028LeuLeu: 9.028 ± 0.139	2.291LeuMet: 2.291 ± 0.053	2.737LeuAsn: 2.737 ± 0.052	5.182LeuPro: 5.182 ± 0.064	2.972LeuGln: 2.972 ± 0.057	6.535LeuArg: 6.535 ± 0.096	6.141LeuSer: 6.141 ± 0.087	5.39LeuThr: 5.39 ± 0.078	6.604LeuVal: 6.604 ± 0.087	1.105LeuTrp: 1.105 ± 0.035	2.011LeuTyr: 2.011 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.005MetAla: 3.005 ± 0.065	0.175MetCys: 0.175 ± 0.013	1.061MetAsp: 1.061 ± 0.027	1.054MetGlu: 1.054 ± 0.036	0.766MetPhe: 0.766 ± 0.032	1.699MetGly: 1.699 ± 0.047	0.527MetHis: 0.527 ± 0.023	1.131MetIle: 1.131 ± 0.033	0.897MetLys: 0.897 ± 0.031	2.596MetLeu: 2.596 ± 0.059	0.546MetMet: 0.546 ± 0.023	0.697MetAsn: 0.697 ± 0.027	1.516MetPro: 1.516 ± 0.041	1.001MetGln: 1.001 ± 0.033	2.004MetArg: 2.004 ± 0.046	1.534MetSer: 1.534 ± 0.039	1.599MetThr: 1.599 ± 0.039	1.472MetVal: 1.472 ± 0.039	0.248MetTrp: 0.248 ± 0.018	0.327MetTyr: 0.327 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.812AsnAla: 3.812 ± 0.074	0.286AsnCys: 0.286 ± 0.022	1.583AsnAsp: 1.583 ± 0.039	1.432AsnGlu: 1.432 ± 0.046	0.999AsnPhe: 0.999 ± 0.034	2.763AsnGly: 2.763 ± 0.069	0.515AsnHis: 0.515 ± 0.021	1.548AsnIle: 1.548 ± 0.042	0.792AsnLys: 0.792 ± 0.032	2.577AsnLeu: 2.577 ± 0.054	0.65AsnMet: 0.65 ± 0.024	0.805AsnAsn: 0.805 ± 0.036	1.879AsnPro: 1.879 ± 0.045	0.742AsnGln: 0.742 ± 0.029	1.964AsnArg: 1.964 ± 0.043	1.494AsnSer: 1.494 ± 0.043	1.486AsnThr: 1.486 ± 0.04	2.295AsnVal: 2.295 ± 0.06	0.471AsnTrp: 0.471 ± 0.026	0.739AsnTyr: 0.739 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.291ProAla: 6.291 ± 0.096	0.331ProCys: 0.331 ± 0.018	3.46ProAsp: 3.46 ± 0.06	3.615ProGlu: 3.615 ± 0.053	1.926ProPhe: 1.926 ± 0.049	4.33ProGly: 4.33 ± 0.068	1.105ProHis: 1.105 ± 0.036	2.405ProIle: 2.405 ± 0.048	1.82ProLys: 1.82 ± 0.041	4.644ProLeu: 4.644 ± 0.076	1.157ProMet: 1.157 ± 0.036	1.474ProAsn: 1.474 ± 0.042	2.957ProPro: 2.957 ± 0.087	1.922ProGln: 1.922 ± 0.055	3.004ProArg: 3.004 ± 0.061	3.138ProSer: 3.138 ± 0.055	2.645ProThr: 2.645 ± 0.051	3.998ProVal: 3.998 ± 0.062	0.646ProTrp: 0.646 ± 0.026	1.219ProTyr: 1.219 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.935GlnAla: 3.935 ± 0.064	0.223GlnCys: 0.223 ± 0.015	1.458GlnAsp: 1.458 ± 0.037	1.449GlnGlu: 1.449 ± 0.039	1.151GlnPhe: 1.151 ± 0.033	2.212GlnGly: 2.212 ± 0.054	0.807GlnHis: 0.807 ± 0.03	1.866GlnIle: 1.866 ± 0.04	1.177GlnLys: 1.177 ± 0.034	3.148GlnLeu: 3.148 ± 0.057	0.863GlnMet: 0.863 ± 0.032	0.981GlnAsn: 0.981 ± 0.031	2.077GlnPro: 2.077 ± 0.052	1.658GlnGln: 1.658 ± 0.061	2.908GlnArg: 2.908 ± 0.059	2.043GlnSer: 2.043 ± 0.037	1.716GlnThr: 1.716 ± 0.038	2.155GlnVal: 2.155 ± 0.041	0.411GlnTrp: 0.411 ± 0.02	0.678GlnTyr: 0.678 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.959ArgAla: 7.959 ± 0.112	0.571ArgCys: 0.571 ± 0.025	3.799ArgAsp: 3.799 ± 0.067	4.054ArgGlu: 4.054 ± 0.066	2.836ArgPhe: 2.836 ± 0.054	4.726ArgGly: 4.726 ± 0.08	1.578ArgHis: 1.578 ± 0.042	4.108ArgIle: 4.108 ± 0.057	2.519ArgLys: 2.519 ± 0.063	7.332ArgLeu: 7.332 ± 0.108	1.89ArgMet: 1.89 ± 0.042	2.193ArgAsn: 2.193 ± 0.047	3.421ArgPro: 3.421 ± 0.055	2.52ArgGln: 2.52 ± 0.05	5.501ArgArg: 5.501 ± 0.089	3.962ArgSer: 3.962 ± 0.07	3.566ArgThr: 3.566 ± 0.057	4.818ArgVal: 4.818 ± 0.073	0.949ArgTrp: 0.949 ± 0.032	1.875ArgTyr: 1.875 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.066SerAla: 7.066 ± 0.097	0.45SerCys: 0.45 ± 0.024	3.241SerAsp: 3.241 ± 0.068	3.061SerGlu: 3.061 ± 0.06	2.192SerPhe: 2.192 ± 0.047	5.864SerGly: 5.864 ± 0.089	1.106SerHis: 1.106 ± 0.032	2.923SerIle: 2.923 ± 0.057	1.842SerLys: 1.842 ± 0.046	5.082SerLeu: 5.082 ± 0.075	1.344SerMet: 1.344 ± 0.035	1.614SerAsn: 1.614 ± 0.046	2.948SerPro: 2.948 ± 0.056	1.838SerGln: 1.838 ± 0.049	3.582SerArg: 3.582 ± 0.064	3.448SerSer: 3.448 ± 0.079	3.0SerThr: 3.0 ± 0.057	4.232SerVal: 4.232 ± 0.07	0.727SerTrp: 0.727 ± 0.026	1.421SerTyr: 1.421 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.568ThrAla: 6.568 ± 0.071	0.469ThrCys: 0.469 ± 0.024	2.914ThrAsp: 2.914 ± 0.055	2.584ThrGlu: 2.584 ± 0.054	2.072ThrPhe: 2.072 ± 0.042	5.046ThrGly: 5.046 ± 0.087	1.055ThrHis: 1.055 ± 0.031	2.673ThrIle: 2.673 ± 0.058	1.612ThrLys: 1.612 ± 0.039	5.506ThrLeu: 5.506 ± 0.071	1.134ThrMet: 1.134 ± 0.035	1.425ThrAsn: 1.425 ± 0.042	3.394ThrPro: 3.394 ± 0.058	1.6ThrGln: 1.6 ± 0.041	3.254ThrArg: 3.254 ± 0.056	3.03ThrSer: 3.03 ± 0.063	2.852ThrThr: 2.852 ± 0.054	4.344ThrVal: 4.344 ± 0.081	0.633ThrTrp: 0.633 ± 0.026	1.247ThrTyr: 1.247 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	9.185ValAla: 9.185 ± 0.108	0.658ValCys: 0.658 ± 0.024	4.197ValAsp: 4.197 ± 0.066	4.419ValGlu: 4.419 ± 0.076	2.71ValPhe: 2.71 ± 0.059	5.544ValGly: 5.544 ± 0.086	1.405ValHis: 1.405 ± 0.038	3.808ValIle: 3.808 ± 0.069	2.416ValLys: 2.416 ± 0.06	7.246ValLeu: 7.246 ± 0.088	1.777ValMet: 1.777 ± 0.047	1.953ValAsn: 1.953 ± 0.046	3.936ValPro: 3.936 ± 0.064	2.124ValGln: 2.124 ± 0.052	5.079ValArg: 5.079 ± 0.074	4.376ValSer: 4.376 ± 0.065	4.247ValThr: 4.247 ± 0.074	5.718ValVal: 5.718 ± 0.09	0.888ValTrp: 0.888 ± 0.032	1.499ValTyr: 1.499 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.036	0.128TrpCys: 0.128 ± 0.012	0.62TrpAsp: 0.62 ± 0.025	0.554TrpGlu: 0.554 ± 0.027	0.493TrpPhe: 0.493 ± 0.022	0.928TrpGly: 0.928 ± 0.034	0.314TrpHis: 0.314 ± 0.02	0.62TrpIle: 0.62 ± 0.023	0.459TrpLys: 0.459 ± 0.022	1.665TrpLeu: 1.665 ± 0.048	0.353TrpMet: 0.353 ± 0.017	0.456TrpAsn: 0.456 ± 0.025	0.643TrpPro: 0.643 ± 0.03	0.595TrpGln: 0.595 ± 0.024	1.174TrpArg: 1.174 ± 0.033	0.836TrpSer: 0.836 ± 0.026	0.673TrpThr: 0.673 ± 0.028	0.767TrpVal: 0.767 ± 0.026	0.201TrpTrp: 0.201 ± 0.014	0.279TrpTyr: 0.279 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.631TyrAla: 2.631 ± 0.053	0.236TyrCys: 0.236 ± 0.015	1.548TyrAsp: 1.548 ± 0.041	1.186TyrGlu: 1.186 ± 0.035	0.929TyrPhe: 0.929 ± 0.031	2.118TyrGly: 2.118 ± 0.048	0.435TyrHis: 0.435 ± 0.018	1.009TyrIle: 1.009 ± 0.036	0.675TyrLys: 0.675 ± 0.03	2.17TyrLeu: 2.17 ± 0.047	0.466TyrMet: 0.466 ± 0.021	0.687TyrAsn: 0.687 ± 0.024	1.046TyrPro: 1.046 ± 0.035	0.748TyrGln: 0.748 ± 0.029	1.796TyrArg: 1.796 ± 0.049	1.297TyrSer: 1.297 ± 0.041	1.132TyrThr: 1.132 ± 0.034	1.804TyrVal: 1.804 ± 0.042	0.386TyrTrp: 0.386 ± 0.022	0.644TyrTyr: 0.644 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3495 proteins (1023349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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