Amino acid dipepetide frequency for Butyrivibrio sp. CAG:318

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.911AlaAla: 7.911 ± 0.149	1.14AlaCys: 1.14 ± 0.035	5.57AlaAsp: 5.57 ± 0.1	4.75AlaGlu: 4.75 ± 0.103	2.872AlaPhe: 2.872 ± 0.063	6.882AlaGly: 6.882 ± 0.116	1.209AlaHis: 1.209 ± 0.05	5.455AlaIle: 5.455 ± 0.106	4.516AlaLys: 4.516 ± 0.083	6.479AlaLeu: 6.479 ± 0.117	2.4AlaMet: 2.4 ± 0.067	2.546AlaAsn: 2.546 ± 0.063	1.947AlaPro: 1.947 ± 0.056	2.019AlaGln: 2.019 ± 0.052	3.104AlaArg: 3.104 ± 0.07	4.491AlaSer: 4.491 ± 0.083	3.268AlaThr: 3.268 ± 0.086	6.731AlaVal: 6.731 ± 0.118	0.477AlaTrp: 0.477 ± 0.026	2.939AlaTyr: 2.939 ± 0.07	0.001AlaXaa: 0.001 ± 0.002
Cys	1.144CysAla: 1.144 ± 0.044	0.252CysCys: 0.252 ± 0.022	1.111CysAsp: 1.111 ± 0.042	0.91CysGlu: 0.91 ± 0.043	0.546CysPhe: 0.546 ± 0.027	1.438CysGly: 1.438 ± 0.048	0.335CysHis: 0.335 ± 0.021	1.256CysIle: 1.256 ± 0.043	0.822CysLys: 0.822 ± 0.038	0.925CysLeu: 0.925 ± 0.037	0.476CysMet: 0.476 ± 0.024	0.715CysAsn: 0.715 ± 0.032	0.543CysPro: 0.543 ± 0.032	0.261CysGln: 0.261 ± 0.02	0.698CysArg: 0.698 ± 0.032	0.92CysSer: 0.92 ± 0.031	0.733CysThr: 0.733 ± 0.036	1.065CysVal: 1.065 ± 0.039	0.103CysTrp: 0.103 ± 0.012	0.546CysTyr: 0.546 ± 0.027	0.003CysXaa: 0.003 ± 0.002
Asp	4.79AspAla: 4.79 ± 0.085	0.885AspCys: 0.885 ± 0.033	4.572AspAsp: 4.572 ± 0.106	5.569AspGlu: 5.569 ± 0.106	2.799AspPhe: 2.799 ± 0.066	5.355AspGly: 5.355 ± 0.108	0.717AspHis: 0.717 ± 0.037	5.954AspIle: 5.954 ± 0.116	5.136AspLys: 5.136 ± 0.092	3.842AspLeu: 3.842 ± 0.076	2.308AspMet: 2.308 ± 0.055	3.798AspAsn: 3.798 ± 0.082	1.513AspPro: 1.513 ± 0.05	0.786AspGln: 0.786 ± 0.034	2.77AspArg: 2.77 ± 0.077	3.709AspSer: 3.709 ± 0.077	3.662AspThr: 3.662 ± 0.086	4.647AspVal: 4.647 ± 0.083	0.52AspTrp: 0.52 ± 0.03	3.331AspTyr: 3.331 ± 0.078	0.001AspXaa: 0.001 ± 0.001
Glu	4.909GluAla: 4.909 ± 0.088	0.992GluCys: 0.992 ± 0.036	4.171GluAsp: 4.171 ± 0.085	5.324GluGlu: 5.324 ± 0.102	2.582GluPhe: 2.582 ± 0.065	3.672GluGly: 3.672 ± 0.079	1.418GluHis: 1.418 ± 0.052	5.46GluIle: 5.46 ± 0.095	4.992GluLys: 4.992 ± 0.094	6.445GluLeu: 6.445 ± 0.106	1.99GluMet: 1.99 ± 0.047	3.811GluAsn: 3.811 ± 0.072	1.854GluPro: 1.854 ± 0.058	2.138GluGln: 2.138 ± 0.058	2.985GluArg: 2.985 ± 0.08	3.461GluSer: 3.461 ± 0.08	3.461GluThr: 3.461 ± 0.081	3.966GluVal: 3.966 ± 0.081	0.625GluTrp: 0.625 ± 0.032	3.556GluTyr: 3.556 ± 0.079	0.0GluXaa: 0.0 ± 0.0
Phe	3.128PheAla: 3.128 ± 0.076	0.667PheCys: 0.667 ± 0.031	2.856PheAsp: 2.856 ± 0.062	2.46PheGlu: 2.46 ± 0.07	1.622PhePhe: 1.622 ± 0.058	3.057PheGly: 3.057 ± 0.082	0.566PheHis: 0.566 ± 0.03	3.21PheIle: 3.21 ± 0.067	2.359PheLys: 2.359 ± 0.062	2.78PheLeu: 2.78 ± 0.078	1.309PheMet: 1.309 ± 0.048	1.811PheAsn: 1.811 ± 0.049	1.167PhePro: 1.167 ± 0.035	0.72PheGln: 0.72 ± 0.031	1.61PheArg: 1.61 ± 0.056	2.3PheSer: 2.3 ± 0.067	2.459PheThr: 2.459 ± 0.059	2.756PheVal: 2.756 ± 0.072	0.343PheTrp: 0.343 ± 0.023	1.703PheTyr: 1.703 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	5.045GlyAla: 5.045 ± 0.104	1.343GlyCys: 1.343 ± 0.048	3.966GlyAsp: 3.966 ± 0.085	4.227GlyGlu: 4.227 ± 0.074	3.062GlyPhe: 3.062 ± 0.071	4.777GlyGly: 4.777 ± 0.124	1.351GlyHis: 1.351 ± 0.046	6.757GlyIle: 6.757 ± 0.098	4.823GlyLys: 4.823 ± 0.101	5.725GlyLeu: 5.725 ± 0.096	2.684GlyMet: 2.684 ± 0.062	3.553GlyAsn: 3.553 ± 0.085	1.32GlyPro: 1.32 ± 0.042	1.775GlyGln: 1.775 ± 0.055	3.613GlyArg: 3.613 ± 0.078	4.209GlySer: 4.209 ± 0.076	4.344GlyThr: 4.344 ± 0.092	5.038GlyVal: 5.038 ± 0.096	0.631GlyTrp: 0.631 ± 0.033	3.614GlyTyr: 3.614 ± 0.083	0.001GlyXaa: 0.001 ± 0.001
His	0.963HisAla: 0.963 ± 0.038	0.268HisCys: 0.268 ± 0.019	1.039HisAsp: 1.039 ± 0.04	0.925HisGlu: 0.925 ± 0.042	0.734HisPhe: 0.734 ± 0.034	1.226HisGly: 1.226 ± 0.046	0.353HisHis: 0.353 ± 0.035	1.564HisIle: 1.564 ± 0.045	1.105HisLys: 1.105 ± 0.039	1.157HisLeu: 1.157 ± 0.042	0.525HisMet: 0.525 ± 0.029	0.982HisAsn: 0.982 ± 0.037	0.761HisPro: 0.761 ± 0.037	0.33HisGln: 0.33 ± 0.025	0.743HisArg: 0.743 ± 0.03	0.975HisSer: 0.975 ± 0.037	0.928HisThr: 0.928 ± 0.036	0.961HisVal: 0.961 ± 0.034	0.148HisTrp: 0.148 ± 0.014	0.723HisTyr: 0.723 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.372IleAla: 6.372 ± 0.108	1.404IleCys: 1.404 ± 0.048	5.381IleAsp: 5.381 ± 0.096	5.324IleGlu: 5.324 ± 0.094	3.1IlePhe: 3.1 ± 0.078	5.445IleGly: 5.445 ± 0.093	1.193IleHis: 1.193 ± 0.044	7.186IleIle: 7.186 ± 0.122	5.42IleLys: 5.42 ± 0.079	6.35IleLeu: 6.35 ± 0.104	2.503IleMet: 2.503 ± 0.064	4.25IleAsn: 4.25 ± 0.085	3.137IlePro: 3.137 ± 0.058	1.772IleGln: 1.772 ± 0.057	3.716IleArg: 3.716 ± 0.081	5.589IleSer: 5.589 ± 0.102	4.906IleThr: 4.906 ± 0.101	5.638IleVal: 5.638 ± 0.095	0.612IleTrp: 0.612 ± 0.03	3.346IleTyr: 3.346 ± 0.079	0.001IleXaa: 0.001 ± 0.001
Lys	5.567LysAla: 5.567 ± 0.096	0.789LysCys: 0.789 ± 0.036	4.488LysAsp: 4.488 ± 0.088	5.646LysGlu: 5.646 ± 0.103	2.055LysPhe: 2.055 ± 0.06	4.115LysGly: 4.115 ± 0.083	1.081LysHis: 1.081 ± 0.038	5.022LysIle: 5.022 ± 0.095	5.004LysLys: 5.004 ± 0.104	5.322LysLeu: 5.322 ± 0.085	2.032LysMet: 2.032 ± 0.054	3.454LysAsn: 3.454 ± 0.078	2.113LysPro: 2.113 ± 0.057	1.895LysGln: 1.895 ± 0.059	2.71LysArg: 2.71 ± 0.064	3.802LysSer: 3.802 ± 0.077	3.491LysThr: 3.491 ± 0.072	4.386LysVal: 4.386 ± 0.088	0.578LysTrp: 0.578 ± 0.03	3.338LysTyr: 3.338 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	6.148LeuAla: 6.148 ± 0.09	1.295LeuCys: 1.295 ± 0.038	5.166LeuAsp: 5.166 ± 0.104	4.885LeuGlu: 4.885 ± 0.096	3.176LeuPhe: 3.176 ± 0.078	5.355LeuGly: 5.355 ± 0.096	1.316LeuHis: 1.316 ± 0.044	6.2LeuIle: 6.2 ± 0.12	5.795LeuLys: 5.795 ± 0.114	6.4LeuLeu: 6.4 ± 0.103	2.609LeuMet: 2.609 ± 0.064	3.891LeuAsn: 3.891 ± 0.069	2.767LeuPro: 2.767 ± 0.066	1.742LeuGln: 1.742 ± 0.052	3.253LeuArg: 3.253 ± 0.071	5.342LeuSer: 5.342 ± 0.099	4.443LeuThr: 4.443 ± 0.081	5.2LeuVal: 5.2 ± 0.086	0.618LeuTrp: 0.618 ± 0.029	3.213LeuTyr: 3.213 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.558MetAla: 2.558 ± 0.074	0.439MetCys: 0.439 ± 0.022	2.03MetAsp: 2.03 ± 0.049	2.175MetGlu: 2.175 ± 0.058	1.085MetPhe: 1.085 ± 0.038	2.063MetGly: 2.063 ± 0.066	0.536MetHis: 0.536 ± 0.03	2.482MetIle: 2.482 ± 0.058	2.426MetLys: 2.426 ± 0.065	2.736MetLeu: 2.736 ± 0.065	0.928MetMet: 0.928 ± 0.032	1.702MetAsn: 1.702 ± 0.043	1.22MetPro: 1.22 ± 0.037	0.925MetGln: 0.925 ± 0.035	1.362MetArg: 1.362 ± 0.049	2.036MetSer: 2.036 ± 0.053	1.792MetThr: 1.792 ± 0.054	2.065MetVal: 2.065 ± 0.059	0.229MetTrp: 0.229 ± 0.019	1.138MetTyr: 1.138 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	3.516AsnAla: 3.516 ± 0.076	0.657AsnCys: 0.657 ± 0.031	2.959AsnAsp: 2.959 ± 0.068	2.989AsnGlu: 2.989 ± 0.068	1.606AsnPhe: 1.606 ± 0.047	3.994AsnGly: 3.994 ± 0.088	0.75AsnHis: 0.75 ± 0.036	4.621AsnIle: 4.621 ± 0.079	3.256AsnLys: 3.256 ± 0.076	3.768AsnLeu: 3.768 ± 0.074	1.738AsnMet: 1.738 ± 0.053	2.83AsnAsn: 2.83 ± 0.077	2.073AsnPro: 2.073 ± 0.054	0.968AsnGln: 0.968 ± 0.037	2.042AsnArg: 2.042 ± 0.061	2.839AsnSer: 2.839 ± 0.058	2.761AsnThr: 2.761 ± 0.072	3.56AsnVal: 3.56 ± 0.078	0.374AsnTrp: 0.374 ± 0.022	2.225AsnTyr: 2.225 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.499ProAla: 2.499 ± 0.064	0.426ProCys: 0.426 ± 0.023	2.822ProAsp: 2.822 ± 0.07	2.857ProGlu: 2.857 ± 0.067	1.31ProPhe: 1.31 ± 0.046	2.308ProGly: 2.308 ± 0.058	0.518ProHis: 0.518 ± 0.029	1.743ProIle: 1.743 ± 0.052	1.68ProLys: 1.68 ± 0.052	2.228ProLeu: 2.228 ± 0.055	0.783ProMet: 0.783 ± 0.032	1.054ProAsn: 1.054 ± 0.038	0.618ProPro: 0.618 ± 0.027	0.931ProGln: 0.931 ± 0.04	0.912ProArg: 0.912 ± 0.037	1.742ProSer: 1.742 ± 0.058	1.407ProThr: 1.407 ± 0.047	3.083ProVal: 3.083 ± 0.072	0.274ProTrp: 0.274 ± 0.02	1.482ProTyr: 1.482 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.937GlnAla: 1.937 ± 0.055	0.325GlnCys: 0.325 ± 0.02	1.206GlnAsp: 1.206 ± 0.042	1.409GlnGlu: 1.409 ± 0.048	0.935GlnPhe: 0.935 ± 0.039	1.418GlnGly: 1.418 ± 0.05	0.331GlnHis: 0.331 ± 0.021	2.254GlnIle: 2.254 ± 0.059	1.818GlnLys: 1.818 ± 0.049	1.905GlnLeu: 1.905 ± 0.056	0.945GlnMet: 0.945 ± 0.035	1.372GlnAsn: 1.372 ± 0.043	0.682GlnPro: 0.682 ± 0.037	0.741GlnGln: 0.741 ± 0.04	1.048GlnArg: 1.048 ± 0.044	1.385GlnSer: 1.385 ± 0.048	1.454GlnThr: 1.454 ± 0.048	1.461GlnVal: 1.461 ± 0.047	0.176GlnTrp: 0.176 ± 0.016	1.2GlnTyr: 1.2 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.694ArgAla: 2.694 ± 0.066	0.53ArgCys: 0.53 ± 0.029	2.473ArgAsp: 2.473 ± 0.064	3.177ArgGlu: 3.177 ± 0.074	1.764ArgPhe: 1.764 ± 0.049	2.284ArgGly: 2.284 ± 0.061	0.862ArgHis: 0.862 ± 0.036	3.99ArgIle: 3.99 ± 0.066	3.52ArgLys: 3.52 ± 0.068	3.702ArgLeu: 3.702 ± 0.07	1.561ArgMet: 1.561 ± 0.042	2.416ArgAsn: 2.416 ± 0.065	1.292ArgPro: 1.292 ± 0.051	1.412ArgGln: 1.412 ± 0.05	2.141ArgArg: 2.141 ± 0.063	2.063ArgSer: 2.063 ± 0.053	2.284ArgThr: 2.284 ± 0.061	2.541ArgVal: 2.541 ± 0.065	0.292ArgTrp: 0.292 ± 0.022	2.063ArgTyr: 2.063 ± 0.056	0.001ArgXaa: 0.001 ± 0.002
Ser	4.479SerAla: 4.479 ± 0.092	0.784SerCys: 0.784 ± 0.035	4.413SerAsp: 4.413 ± 0.085	3.999SerGlu: 3.999 ± 0.077	2.333SerPhe: 2.333 ± 0.059	5.392SerGly: 5.392 ± 0.096	1.058SerHis: 1.058 ± 0.041	4.571SerIle: 4.571 ± 0.087	3.351SerLys: 3.351 ± 0.081	4.789SerLeu: 4.789 ± 0.092	1.851SerMet: 1.851 ± 0.058	2.604SerAsn: 2.604 ± 0.062	1.599SerPro: 1.599 ± 0.05	1.599SerGln: 1.599 ± 0.051	2.759SerArg: 2.759 ± 0.061	3.834SerSer: 3.834 ± 0.106	2.945SerThr: 2.945 ± 0.063	4.611SerVal: 4.611 ± 0.083	0.462SerTrp: 0.462 ± 0.027	2.816SerTyr: 2.816 ± 0.076	0.0SerXaa: 0.0 ± 0.0
Thr	4.544ThrAla: 4.544 ± 0.092	0.652ThrCys: 0.652 ± 0.032	3.971ThrAsp: 3.971 ± 0.089	3.669ThrGlu: 3.669 ± 0.085	2.129ThrPhe: 2.129 ± 0.055	5.114ThrGly: 5.114 ± 0.081	0.877ThrHis: 0.877 ± 0.038	4.318ThrIle: 4.318 ± 0.09	2.797ThrLys: 2.797 ± 0.063	4.417ThrLeu: 4.417 ± 0.076	1.348ThrMet: 1.348 ± 0.044	2.088ThrAsn: 2.088 ± 0.053	2.065ThrPro: 2.065 ± 0.053	1.353ThrGln: 1.353 ± 0.043	2.043ThrArg: 2.043 ± 0.056	3.223ThrSer: 3.223 ± 0.079	2.932ThrThr: 2.932 ± 0.084	4.71ThrVal: 4.71 ± 0.127	0.401ThrTrp: 0.401 ± 0.026	2.338ThrTyr: 2.338 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	5.028ValAla: 5.028 ± 0.105	1.212ValCys: 1.212 ± 0.036	4.357ValAsp: 4.357 ± 0.083	3.908ValGlu: 3.908 ± 0.075	2.981ValPhe: 2.981 ± 0.065	4.152ValGly: 4.152 ± 0.087	1.081ValHis: 1.081 ± 0.039	6.379ValIle: 6.379 ± 0.103	4.817ValLys: 4.817 ± 0.082	5.831ValLeu: 5.831 ± 0.083	2.307ValMet: 2.307 ± 0.063	3.538ValAsn: 3.538 ± 0.071	2.437ValPro: 2.437 ± 0.068	1.45ValGln: 1.45 ± 0.051	3.141ValArg: 3.141 ± 0.074	4.971ValSer: 4.971 ± 0.08	4.685ValThr: 4.685 ± 0.104	4.946ValVal: 4.946 ± 0.107	0.548ValTrp: 0.548 ± 0.031	3.137ValTyr: 3.137 ± 0.073	0.0ValXaa: 0.0 ± 0.0
Trp	0.446TrpAla: 0.446 ± 0.028	0.12TrpCys: 0.12 ± 0.013	0.533TrpAsp: 0.533 ± 0.032	0.457TrpGlu: 0.457 ± 0.025	0.393TrpPhe: 0.393 ± 0.025	0.553TrpGly: 0.553 ± 0.033	0.161TrpHis: 0.161 ± 0.016	0.592TrpIle: 0.592 ± 0.029	0.569TrpLys: 0.569 ± 0.032	0.724TrpLeu: 0.724 ± 0.035	0.26TrpMet: 0.26 ± 0.018	0.49TrpAsn: 0.49 ± 0.029	0.205TrpPro: 0.205 ± 0.021	0.272TrpGln: 0.272 ± 0.018	0.311TrpArg: 0.311 ± 0.019	0.46TrpSer: 0.46 ± 0.032	0.374TrpThr: 0.374 ± 0.024	0.43TrpVal: 0.43 ± 0.027	0.086TrpTrp: 0.086 ± 0.013	0.377TrpTyr: 0.377 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.028TyrAla: 3.028 ± 0.061	0.625TyrCys: 0.625 ± 0.029	3.579TyrAsp: 3.579 ± 0.093	3.15TyrGlu: 3.15 ± 0.074	1.799TyrPhe: 1.799 ± 0.051	3.257TyrGly: 3.257 ± 0.076	0.697TyrHis: 0.697 ± 0.031	3.63TyrIle: 3.63 ± 0.074	2.68TyrLys: 2.68 ± 0.064	3.288TyrLeu: 3.288 ± 0.069	1.368TyrMet: 1.368 ± 0.05	2.621TyrAsn: 2.621 ± 0.063	1.362TyrPro: 1.362 ± 0.04	0.916TyrGln: 0.916 ± 0.037	2.1TyrArg: 2.1 ± 0.06	2.895TyrSer: 2.895 ± 0.075	2.662TyrThr: 2.662 ± 0.061	3.114TyrVal: 3.114 ± 0.072	0.315TyrTrp: 0.315 ± 0.023	2.247TyrTyr: 2.247 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.007

Statistics based on 2127 proteins (697473 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---