Amino acid dipepetide frequency for Methanocaldococcus fervens tailed virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.881AlaAla: 2.881 ± 1.212
0.533AlaCys: 0.533 ± 0.192
3.201AlaAsp: 3.201 ± 0.542
4.588AlaGlu: 4.588 ± 0.763
2.134AlaPhe: 2.134 ± 0.59
2.24AlaGly: 2.24 ± 0.481
0.747AlaHis: 0.747 ± 0.261
6.615AlaIle: 6.615 ± 0.859
4.481AlaLys: 4.481 ± 0.705
5.655AlaLeu: 5.655 ± 0.847
1.174AlaMet: 1.174 ± 0.336
2.454AlaAsn: 2.454 ± 0.407
1.174AlaPro: 1.174 ± 0.319
1.387AlaGln: 1.387 ± 0.551
2.027AlaArg: 2.027 ± 0.438
3.521AlaSer: 3.521 ± 0.829
2.774AlaThr: 2.774 ± 0.639
4.801AlaVal: 4.801 ± 0.559
0.32AlaTrp: 0.32 ± 0.148
2.347AlaTyr: 2.347 ± 0.612
0.0AlaXaa: 0.0 ± 0.0
Cys
0.64CysAla: 0.64 ± 0.257
0.213CysCys: 0.213 ± 0.139
0.747CysAsp: 0.747 ± 0.283
0.747CysGlu: 0.747 ± 0.287
0.213CysPhe: 0.213 ± 0.172
0.213CysGly: 0.213 ± 0.148
0.32CysHis: 0.32 ± 0.161
0.747CysIle: 0.747 ± 0.262
0.427CysLys: 0.427 ± 0.209
0.64CysLeu: 0.64 ± 0.269
0.107CysMet: 0.107 ± 0.156
0.64CysAsn: 0.64 ± 0.236
0.32CysPro: 0.32 ± 0.237
0.107CysGln: 0.107 ± 0.086
0.747CysArg: 0.747 ± 0.237
0.64CysSer: 0.64 ± 0.229
0.213CysThr: 0.213 ± 0.149
0.747CysVal: 0.747 ± 0.246
0.213CysTrp: 0.213 ± 0.14
0.747CysTyr: 0.747 ± 0.331
0.0CysXaa: 0.0 ± 0.0
Asp
3.201AspAla: 3.201 ± 0.534
0.427AspCys: 0.427 ± 0.194
4.268AspAsp: 4.268 ± 0.582
4.801AspGlu: 4.801 ± 0.611
2.347AspPhe: 2.347 ± 0.548
3.948AspGly: 3.948 ± 0.541
0.32AspHis: 0.32 ± 0.149
5.441AspIle: 5.441 ± 0.669
6.081AspLys: 6.081 ± 0.791
6.295AspLeu: 6.295 ± 0.795
1.28AspMet: 1.28 ± 0.389
3.307AspAsn: 3.307 ± 0.483
1.707AspPro: 1.707 ± 0.476
0.96AspGln: 0.96 ± 0.304
1.707AspArg: 1.707 ± 0.417
2.774AspSer: 2.774 ± 0.554
2.561AspThr: 2.561 ± 0.491
3.627AspVal: 3.627 ± 0.536
0.96AspTrp: 0.96 ± 0.308
4.694AspTyr: 4.694 ± 0.592
0.0AspXaa: 0.0 ± 0.0
Glu
5.121GluAla: 5.121 ± 0.802
0.854GluCys: 0.854 ± 0.381
3.307GluAsp: 3.307 ± 0.539
6.508GluGlu: 6.508 ± 0.969
3.948GluPhe: 3.948 ± 0.544
4.588GluGly: 4.588 ± 0.642
1.067GluHis: 1.067 ± 0.203
10.669GluIle: 10.669 ± 1.099
8.108GluLys: 8.108 ± 0.932
9.922GluLeu: 9.922 ± 1.129
1.387GluMet: 1.387 ± 0.351
5.121GluAsn: 5.121 ± 0.679
1.067GluPro: 1.067 ± 0.4
2.027GluGln: 2.027 ± 0.374
2.881GluArg: 2.881 ± 0.736
3.201GluSer: 3.201 ± 0.617
2.987GluThr: 2.987 ± 0.53
5.334GluVal: 5.334 ± 0.878
0.96GluTrp: 0.96 ± 0.254
3.521GluTyr: 3.521 ± 0.746
0.0GluXaa: 0.0 ± 0.0
Phe
1.92PheAla: 1.92 ± 0.411
0.107PheCys: 0.107 ± 0.116
3.521PheAsp: 3.521 ± 0.492
2.24PheGlu: 2.24 ± 0.425
1.387PhePhe: 1.387 ± 0.395
3.521PheGly: 3.521 ± 0.535
0.427PheHis: 0.427 ± 0.187
3.201PheIle: 3.201 ± 0.625
4.161PheLys: 4.161 ± 0.874
2.454PheLeu: 2.454 ± 0.508
0.747PheMet: 0.747 ± 0.229
2.347PheAsn: 2.347 ± 0.376
1.067PhePro: 1.067 ± 0.274
0.854PheGln: 0.854 ± 0.299
1.387PheArg: 1.387 ± 0.352
2.134PheSer: 2.134 ± 0.431
2.24PheThr: 2.24 ± 0.565
2.134PheVal: 2.134 ± 0.5
0.213PheTrp: 0.213 ± 0.171
1.6PheTyr: 1.6 ± 0.448
0.0PheXaa: 0.0 ± 0.0
Gly
3.094GlyAla: 3.094 ± 0.822
0.747GlyCys: 0.747 ± 0.257
3.734GlyAsp: 3.734 ± 0.522
2.881GlyGlu: 2.881 ± 0.491
1.92GlyPhe: 1.92 ± 0.472
2.347GlyGly: 2.347 ± 0.46
1.067GlyHis: 1.067 ± 0.237
4.054GlyIle: 4.054 ± 0.684
6.721GlyLys: 6.721 ± 0.935
5.441GlyLeu: 5.441 ± 1.078
1.707GlyMet: 1.707 ± 0.365
2.667GlyAsn: 2.667 ± 0.435
0.747GlyPro: 0.747 ± 0.259
1.6GlyGln: 1.6 ± 0.37
3.094GlyArg: 3.094 ± 0.711
2.774GlySer: 2.774 ± 0.452
2.454GlyThr: 2.454 ± 0.523
3.734GlyVal: 3.734 ± 0.657
0.533GlyTrp: 0.533 ± 0.195
2.24GlyTyr: 2.24 ± 0.454
0.0GlyXaa: 0.0 ± 0.0
His
0.32HisAla: 0.32 ± 0.155
0.107HisCys: 0.107 ± 0.115
0.533HisAsp: 0.533 ± 0.192
1.494HisGlu: 1.494 ± 0.425
1.067HisPhe: 1.067 ± 0.364
0.96HisGly: 0.96 ± 0.304
0.32HisHis: 0.32 ± 0.171
1.174HisIle: 1.174 ± 0.4
1.067HisLys: 1.067 ± 0.319
0.854HisLeu: 0.854 ± 0.282
0.32HisMet: 0.32 ± 0.168
0.213HisAsn: 0.213 ± 0.124
0.32HisPro: 0.32 ± 0.168
0.427HisGln: 0.427 ± 0.192
0.747HisArg: 0.747 ± 0.26
1.067HisSer: 1.067 ± 0.266
0.96HisThr: 0.96 ± 0.223
0.64HisVal: 0.64 ± 0.288
0.213HisTrp: 0.213 ± 0.117
0.854HisTyr: 0.854 ± 0.268
0.0HisXaa: 0.0 ± 0.0
Ile
3.841IleAla: 3.841 ± 0.605
0.64IleCys: 0.64 ± 0.241
7.255IleAsp: 7.255 ± 1.018
10.669IleGlu: 10.669 ± 0.93
2.454IlePhe: 2.454 ± 0.452
2.667IleGly: 2.667 ± 0.487
1.6IleHis: 1.6 ± 0.346
7.468IleIle: 7.468 ± 0.884
9.282IleLys: 9.282 ± 1.145
9.389IleLeu: 9.389 ± 1.116
2.24IleMet: 2.24 ± 0.494
5.548IleAsn: 5.548 ± 0.714
3.521IlePro: 3.521 ± 0.639
3.094IleGln: 3.094 ± 0.546
3.948IleArg: 3.948 ± 0.473
5.228IleSer: 5.228 ± 0.62
5.655IleThr: 5.655 ± 0.857
6.188IleVal: 6.188 ± 0.88
1.494IleTrp: 1.494 ± 0.392
2.774IleTyr: 2.774 ± 0.439
0.0IleXaa: 0.0 ± 0.0
Lys
4.481LysAla: 4.481 ± 0.812
0.854LysCys: 0.854 ± 0.316
5.868LysAsp: 5.868 ± 0.71
11.949LysGlu: 11.949 ± 1.33
2.454LysPhe: 2.454 ± 0.522
5.548LysGly: 5.548 ± 0.873
1.6LysHis: 1.6 ± 0.363
11.202LysIle: 11.202 ± 1.193
10.135LysLys: 10.135 ± 1.281
8.322LysLeu: 8.322 ± 1.181
2.454LysMet: 2.454 ± 0.481
4.694LysAsn: 4.694 ± 0.644
2.881LysPro: 2.881 ± 0.506
4.268LysGln: 4.268 ± 0.537
4.268LysArg: 4.268 ± 0.745
5.228LysSer: 5.228 ± 0.62
5.334LysThr: 5.334 ± 0.805
6.935LysVal: 6.935 ± 0.903
0.32LysTrp: 0.32 ± 0.155
3.094LysTyr: 3.094 ± 0.529
0.0LysXaa: 0.0 ± 0.0
Leu
6.295LeuAla: 6.295 ± 1.257
1.067LeuCys: 1.067 ± 0.38
5.228LeuAsp: 5.228 ± 0.79
7.362LeuGlu: 7.362 ± 1.006
3.094LeuPhe: 3.094 ± 0.814
4.801LeuGly: 4.801 ± 1.025
1.174LeuHis: 1.174 ± 0.288
6.401LeuIle: 6.401 ± 0.831
13.016LeuLys: 13.016 ± 1.687
7.788LeuLeu: 7.788 ± 1.478
2.027LeuMet: 2.027 ± 0.452
4.268LeuAsn: 4.268 ± 0.572
3.841LeuPro: 3.841 ± 0.787
2.454LeuGln: 2.454 ± 0.593
3.521LeuArg: 3.521 ± 0.58
5.548LeuSer: 5.548 ± 0.839
4.588LeuThr: 4.588 ± 0.81
4.908LeuVal: 4.908 ± 0.815
0.64LeuTrp: 0.64 ± 0.194
4.588LeuTyr: 4.588 ± 0.914
0.0LeuXaa: 0.0 ± 0.0
Met
2.454MetAla: 2.454 ± 0.418
0.0MetCys: 0.0 ± 0.0
1.28MetAsp: 1.28 ± 0.374
1.494MetGlu: 1.494 ± 0.341
0.747MetPhe: 0.747 ± 0.336
1.6MetGly: 1.6 ± 0.364
0.0MetHis: 0.0 ± 0.0
1.387MetIle: 1.387 ± 0.372
2.667MetLys: 2.667 ± 0.627
1.28MetLeu: 1.28 ± 0.34
0.427MetMet: 0.427 ± 0.198
1.174MetAsn: 1.174 ± 0.3
1.174MetPro: 1.174 ± 0.266
0.854MetGln: 0.854 ± 0.323
1.174MetArg: 1.174 ± 0.408
1.28MetSer: 1.28 ± 0.377
0.96MetThr: 0.96 ± 0.312
1.494MetVal: 1.494 ± 0.357
0.32MetTrp: 0.32 ± 0.161
0.747MetTyr: 0.747 ± 0.262
0.0MetXaa: 0.0 ± 0.0
Asn
3.307AsnAla: 3.307 ± 0.615
0.427AsnCys: 0.427 ± 0.185
2.027AsnAsp: 2.027 ± 0.455
3.734AsnGlu: 3.734 ± 0.517
1.92AsnPhe: 1.92 ± 0.329
4.268AsnGly: 4.268 ± 0.67
1.28AsnHis: 1.28 ± 0.385
5.228AsnIle: 5.228 ± 0.896
4.588AsnLys: 4.588 ± 0.591
4.161AsnLeu: 4.161 ± 0.542
2.027AsnMet: 2.027 ± 0.381
1.387AsnAsn: 1.387 ± 0.321
3.307AsnPro: 3.307 ± 0.508
1.067AsnGln: 1.067 ± 0.304
1.28AsnArg: 1.28 ± 0.31
3.521AsnSer: 3.521 ± 0.9
3.948AsnThr: 3.948 ± 0.847
2.881AsnVal: 2.881 ± 0.397
1.067AsnTrp: 1.067 ± 0.301
3.307AsnTyr: 3.307 ± 0.674
0.0AsnXaa: 0.0 ± 0.0
Pro
1.92ProAla: 1.92 ± 0.518
0.0ProCys: 0.0 ± 0.0
1.814ProAsp: 1.814 ± 0.352
2.667ProGlu: 2.667 ± 0.643
0.64ProPhe: 0.64 ± 0.258
0.32ProGly: 0.32 ± 0.307
0.747ProHis: 0.747 ± 0.286
3.627ProIle: 3.627 ± 0.698
4.054ProLys: 4.054 ± 0.651
2.881ProLeu: 2.881 ± 0.483
0.427ProMet: 0.427 ± 0.206
2.24ProAsn: 2.24 ± 0.378
1.494ProPro: 1.494 ± 0.376
0.747ProGln: 0.747 ± 0.232
0.747ProArg: 0.747 ± 0.301
1.494ProSer: 1.494 ± 0.412
2.134ProThr: 2.134 ± 0.454
2.027ProVal: 2.027 ± 0.547
0.107ProTrp: 0.107 ± 0.116
0.96ProTyr: 0.96 ± 0.348
0.0ProXaa: 0.0 ± 0.0
Gln
2.454GlnAla: 2.454 ± 0.423
0.213GlnCys: 0.213 ± 0.124
0.747GlnAsp: 0.747 ± 0.263
1.494GlnGlu: 1.494 ± 0.381
1.28GlnPhe: 1.28 ± 0.29
0.854GlnGly: 0.854 ± 0.28
0.533GlnHis: 0.533 ± 0.228
3.627GlnIle: 3.627 ± 0.675
2.667GlnLys: 2.667 ± 0.585
4.374GlnLeu: 4.374 ± 0.703
0.32GlnMet: 0.32 ± 0.139
1.387GlnAsn: 1.387 ± 0.313
1.067GlnPro: 1.067 ± 0.469
2.027GlnGln: 2.027 ± 0.538
1.28GlnArg: 1.28 ± 0.407
1.387GlnSer: 1.387 ± 0.42
1.174GlnThr: 1.174 ± 0.491
1.28GlnVal: 1.28 ± 0.33
0.213GlnTrp: 0.213 ± 0.117
1.707GlnTyr: 1.707 ± 0.39
0.0GlnXaa: 0.0 ± 0.0
Arg
2.134ArgAla: 2.134 ± 0.577
0.747ArgCys: 0.747 ± 0.275
1.6ArgAsp: 1.6 ± 0.399
2.881ArgGlu: 2.881 ± 0.466
1.814ArgPhe: 1.814 ± 0.387
2.881ArgGly: 2.881 ± 0.485
0.213ArgHis: 0.213 ± 0.132
3.521ArgIle: 3.521 ± 0.679
5.121ArgLys: 5.121 ± 0.828
2.774ArgLeu: 2.774 ± 0.582
1.067ArgMet: 1.067 ± 0.29
2.027ArgAsn: 2.027 ± 0.371
0.427ArgPro: 0.427 ± 0.172
1.387ArgGln: 1.387 ± 0.345
1.494ArgArg: 1.494 ± 0.43
1.067ArgSer: 1.067 ± 0.3
1.814ArgThr: 1.814 ± 0.475
3.414ArgVal: 3.414 ± 0.432
0.747ArgTrp: 0.747 ± 0.269
0.96ArgTyr: 0.96 ± 0.252
0.0ArgXaa: 0.0 ± 0.0
Ser
2.454SerAla: 2.454 ± 0.418
0.427SerCys: 0.427 ± 0.223
3.521SerAsp: 3.521 ± 0.588
4.481SerGlu: 4.481 ± 0.721
2.774SerPhe: 2.774 ± 0.53
3.627SerGly: 3.627 ± 0.467
0.64SerHis: 0.64 ± 0.282
4.801SerIle: 4.801 ± 0.577
5.014SerLys: 5.014 ± 0.667
3.948SerLeu: 3.948 ± 0.654
1.174SerMet: 1.174 ± 0.321
4.374SerAsn: 4.374 ± 1.28
1.707SerPro: 1.707 ± 0.316
2.454SerGln: 2.454 ± 0.379
2.134SerArg: 2.134 ± 0.486
2.454SerSer: 2.454 ± 0.437
1.92SerThr: 1.92 ± 0.365
3.201SerVal: 3.201 ± 0.393
0.107SerTrp: 0.107 ± 0.112
2.027SerTyr: 2.027 ± 0.413
0.0SerXaa: 0.0 ± 0.0
Thr
3.201ThrAla: 3.201 ± 0.509
0.427ThrCys: 0.427 ± 0.208
2.347ThrAsp: 2.347 ± 0.44
3.307ThrGlu: 3.307 ± 0.476
2.561ThrPhe: 2.561 ± 0.529
2.24ThrGly: 2.24 ± 0.359
0.32ThrHis: 0.32 ± 0.166
5.228ThrIle: 5.228 ± 0.909
3.948ThrLys: 3.948 ± 0.611
5.334ThrLeu: 5.334 ± 1.049
0.96ThrMet: 0.96 ± 0.285
3.627ThrAsn: 3.627 ± 0.989
2.24ThrPro: 2.24 ± 0.832
1.174ThrGln: 1.174 ± 0.399
1.174ThrArg: 1.174 ± 0.302
2.987ThrSer: 2.987 ± 0.675
2.667ThrThr: 2.667 ± 1.118
3.841ThrVal: 3.841 ± 0.837
0.427ThrTrp: 0.427 ± 0.235
2.027ThrTyr: 2.027 ± 0.571
0.0ThrXaa: 0.0 ± 0.0
Val
3.521ValAla: 3.521 ± 0.522
0.854ValCys: 0.854 ± 0.321
5.441ValAsp: 5.441 ± 0.679
5.868ValGlu: 5.868 ± 0.72
2.454ValPhe: 2.454 ± 0.477
3.521ValGly: 3.521 ± 0.62
0.747ValHis: 0.747 ± 0.271
6.721ValIle: 6.721 ± 0.873
6.721ValLys: 6.721 ± 0.953
5.228ValLeu: 5.228 ± 0.615
1.28ValMet: 1.28 ± 0.481
3.307ValAsn: 3.307 ± 0.539
2.027ValPro: 2.027 ± 0.475
1.067ValGln: 1.067 ± 0.301
2.667ValArg: 2.667 ± 0.497
3.414ValSer: 3.414 ± 0.634
2.454ValThr: 2.454 ± 0.566
3.841ValVal: 3.841 ± 0.691
0.64ValTrp: 0.64 ± 0.259
2.667ValTyr: 2.667 ± 0.786
0.0ValXaa: 0.0 ± 0.0
Trp
0.427TrpAla: 0.427 ± 0.203
0.107TrpCys: 0.107 ± 0.086
1.174TrpAsp: 1.174 ± 0.303
0.32TrpGlu: 0.32 ± 0.147
0.32TrpPhe: 0.32 ± 0.231
0.533TrpGly: 0.533 ± 0.24
0.0TrpHis: 0.0 ± 0.0
0.96TrpIle: 0.96 ± 0.296
0.533TrpLys: 0.533 ± 0.18
0.854TrpLeu: 0.854 ± 0.314
0.533TrpMet: 0.533 ± 0.22
1.067TrpAsn: 1.067 ± 0.246
0.107TrpPro: 0.107 ± 0.097
0.64TrpGln: 0.64 ± 0.188
0.32TrpArg: 0.32 ± 0.196
0.64TrpSer: 0.64 ± 0.312
0.747TrpThr: 0.747 ± 0.245
0.213TrpVal: 0.213 ± 0.139
0.533TrpTrp: 0.533 ± 0.281
0.32TrpTyr: 0.32 ± 0.174
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.387TyrAla: 1.387 ± 0.373
0.747TyrCys: 0.747 ± 0.254
3.094TyrAsp: 3.094 ± 0.669
3.094TyrGlu: 3.094 ± 0.525
2.134TyrPhe: 2.134 ± 0.428
2.881TyrGly: 2.881 ± 0.489
0.533TyrHis: 0.533 ± 0.176
2.881TyrIle: 2.881 ± 0.693
3.094TyrLys: 3.094 ± 0.567
5.014TyrLeu: 5.014 ± 0.786
0.747TyrMet: 0.747 ± 0.292
2.881TyrAsn: 2.881 ± 0.896
0.854TyrPro: 0.854 ± 0.287
1.494TyrGln: 1.494 ± 0.473
1.494TyrArg: 1.494 ± 0.447
2.881TyrSer: 2.881 ± 0.713
2.454TyrThr: 2.454 ± 0.53
3.201TyrVal: 3.201 ± 0.635
0.32TyrTrp: 0.32 ± 0.174
2.24TyrTyr: 2.24 ± 0.527
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (9374 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski