Amino acid dipepetide frequency for Peaton virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.264AlaAla: 2.264 ± 1.145
2.264AlaCys: 2.264 ± 0.829
2.767AlaAsp: 2.767 ± 0.387
3.774AlaGlu: 3.774 ± 2.504
1.761AlaPhe: 1.761 ± 1.269
1.509AlaGly: 1.509 ± 0.733
0.755AlaHis: 0.755 ± 0.474
3.774AlaIle: 3.774 ± 1.13
5.283AlaLys: 5.283 ± 2.156
5.283AlaLeu: 5.283 ± 0.722
1.761AlaMet: 1.761 ± 0.427
2.013AlaAsn: 2.013 ± 1.286
1.258AlaPro: 1.258 ± 0.569
2.767AlaGln: 2.767 ± 1.904
0.503AlaArg: 0.503 ± 0.744
3.019AlaSer: 3.019 ± 1.497
3.27AlaThr: 3.27 ± 0.638
1.006AlaVal: 1.006 ± 1.472
0.503AlaTrp: 0.503 ± 0.161
1.006AlaTyr: 1.006 ± 0.346
0.0AlaXaa: 0.0 ± 0.0
Cys
2.013CysAla: 2.013 ± 0.952
0.0CysCys: 0.0 ± 0.0
1.258CysAsp: 1.258 ± 0.516
1.006CysGlu: 1.006 ± 0.927
1.006CysPhe: 1.006 ± 0.592
2.013CysGly: 2.013 ± 1.183
0.503CysHis: 0.503 ± 0.161
2.013CysIle: 2.013 ± 0.881
1.761CysLys: 1.761 ± 1.062
3.774CysLeu: 3.774 ± 2.139
1.006CysMet: 1.006 ± 0.322
2.264CysAsn: 2.264 ± 0.655
1.006CysPro: 1.006 ± 0.322
1.006CysGln: 1.006 ± 0.843
1.258CysArg: 1.258 ± 0.516
2.516CysSer: 2.516 ± 0.643
1.761CysThr: 1.761 ± 1.062
0.755CysVal: 0.755 ± 0.695
0.0CysTrp: 0.0 ± 0.0
2.264CysTyr: 2.264 ± 0.655
0.0CysXaa: 0.0 ± 0.0
Asp
2.516AspAla: 2.516 ± 0.932
1.006AspCys: 1.006 ± 0.346
2.767AspAsp: 2.767 ± 1.134
3.522AspGlu: 3.522 ± 1.0
2.767AspPhe: 2.767 ± 1.421
1.509AspGly: 1.509 ± 0.617
1.006AspHis: 1.006 ± 0.322
7.799AspIle: 7.799 ± 1.486
3.019AspLys: 3.019 ± 0.877
5.535AspLeu: 5.535 ± 1.359
2.264AspMet: 2.264 ± 0.812
3.27AspAsn: 3.27 ± 0.97
2.264AspPro: 2.264 ± 1.108
2.264AspGln: 2.264 ± 0.495
2.767AspArg: 2.767 ± 0.902
2.264AspSer: 2.264 ± 1.108
2.516AspThr: 2.516 ± 1.073
2.013AspVal: 2.013 ± 1.232
0.0AspTrp: 0.0 ± 0.0
2.767AspTyr: 2.767 ± 0.902
0.0AspXaa: 0.0 ± 0.0
Glu
1.761GluAla: 1.761 ± 0.427
1.258GluCys: 1.258 ± 0.351
2.767GluAsp: 2.767 ± 0.812
5.283GluGlu: 5.283 ± 1.473
5.031GluPhe: 5.031 ± 1.363
1.761GluGly: 1.761 ± 0.484
1.006GluHis: 1.006 ± 0.322
7.044GluIle: 7.044 ± 2.231
6.038GluLys: 6.038 ± 0.932
5.535GluLeu: 5.535 ± 1.646
2.264GluMet: 2.264 ± 0.495
2.264GluAsn: 2.264 ± 0.655
2.516GluPro: 2.516 ± 0.774
2.767GluGln: 2.767 ± 0.471
2.264GluArg: 2.264 ± 1.421
4.025GluSer: 4.025 ± 0.764
2.013GluThr: 2.013 ± 0.909
2.516GluVal: 2.516 ± 1.287
0.755GluTrp: 0.755 ± 0.366
2.767GluTyr: 2.767 ± 0.988
0.0GluXaa: 0.0 ± 0.0
Phe
1.509PheAla: 1.509 ± 0.577
1.258PheCys: 1.258 ± 0.492
2.013PheAsp: 2.013 ± 0.434
2.767PheGlu: 2.767 ± 1.062
2.264PhePhe: 2.264 ± 1.1
2.264PheGly: 2.264 ± 1.285
0.503PheHis: 0.503 ± 0.316
3.774PheIle: 3.774 ± 1.052
4.025PheLys: 4.025 ± 1.5
4.528PheLeu: 4.528 ± 2.459
1.006PheMet: 1.006 ± 0.624
4.025PheAsn: 4.025 ± 1.117
1.509PhePro: 1.509 ± 1.396
1.006PheGln: 1.006 ± 0.603
1.761PheArg: 1.761 ± 0.558
3.019PheSer: 3.019 ± 0.503
2.516PheThr: 2.516 ± 0.31
3.019PheVal: 3.019 ± 0.966
0.755PheTrp: 0.755 ± 0.219
2.516PheTyr: 2.516 ± 0.611
0.0PheXaa: 0.0 ± 0.0
Gly
1.258GlyAla: 1.258 ± 1.439
1.761GlyCys: 1.761 ± 0.741
2.767GlyAsp: 2.767 ± 0.902
2.516GlyGlu: 2.516 ± 0.774
2.264GlyPhe: 2.264 ± 1.239
2.013GlyGly: 2.013 ± 0.593
1.006GlyHis: 1.006 ± 0.592
4.78GlyIle: 4.78 ± 2.216
2.264GlyLys: 2.264 ± 0.829
5.031GlyLeu: 5.031 ± 0.841
1.761GlyMet: 1.761 ± 1.311
2.264GlyAsn: 2.264 ± 0.658
1.509GlyPro: 1.509 ± 0.748
1.761GlyGln: 1.761 ± 0.626
1.006GlyArg: 1.006 ± 0.631
2.516GlySer: 2.516 ± 0.805
2.516GlyThr: 2.516 ± 1.661
0.503GlyVal: 0.503 ± 0.316
0.503GlyTrp: 0.503 ± 0.161
1.258GlyTyr: 1.258 ± 1.401
0.0GlyXaa: 0.0 ± 0.0
His
1.006HisAla: 1.006 ± 0.322
0.503HisCys: 0.503 ± 0.463
1.258HisAsp: 1.258 ± 0.492
1.258HisGlu: 1.258 ± 0.516
1.258HisPhe: 1.258 ± 0.569
1.006HisGly: 1.006 ± 0.346
1.258HisHis: 1.258 ± 0.351
2.013HisIle: 2.013 ± 1.183
1.761HisLys: 1.761 ± 0.956
2.264HisLeu: 2.264 ± 1.64
1.006HisMet: 1.006 ± 0.304
2.013HisAsn: 2.013 ± 0.69
0.755HisPro: 0.755 ± 0.366
0.0HisGln: 0.0 ± 0.0
1.006HisArg: 1.006 ± 1.472
2.013HisSer: 2.013 ± 0.562
1.761HisThr: 1.761 ± 0.5
1.761HisVal: 1.761 ± 0.5
0.252HisTrp: 0.252 ± 1.012
0.503HisTyr: 0.503 ± 0.161
0.0HisXaa: 0.0 ± 0.0
Ile
4.025IleAla: 4.025 ± 1.08
2.516IleCys: 2.516 ± 1.322
4.78IleAsp: 4.78 ± 1.741
7.044IleGlu: 7.044 ± 1.999
2.516IlePhe: 2.516 ± 1.175
3.27IleGly: 3.27 ± 0.911
2.264IleHis: 2.264 ± 0.655
6.038IleIle: 6.038 ± 2.375
8.553IleLys: 8.553 ± 0.97
11.321IleLeu: 11.321 ± 1.747
2.264IleMet: 2.264 ± 0.705
3.774IleAsn: 3.774 ± 0.339
2.264IlePro: 2.264 ± 0.625
3.522IleGln: 3.522 ± 1.327
5.535IleArg: 5.535 ± 0.841
7.296IleSer: 7.296 ± 1.788
5.283IleThr: 5.283 ± 0.932
3.522IleVal: 3.522 ± 0.259
0.755IleTrp: 0.755 ± 0.474
2.767IleTyr: 2.767 ± 0.902
0.0IleXaa: 0.0 ± 0.0
Lys
3.522LysAla: 3.522 ± 0.455
3.27LysCys: 3.27 ± 2.003
3.019LysAsp: 3.019 ± 0.347
5.786LysGlu: 5.786 ± 1.653
3.522LysPhe: 3.522 ± 0.455
3.27LysGly: 3.27 ± 0.984
1.258LysHis: 1.258 ± 0.492
7.044LysIle: 7.044 ± 0.518
6.792LysLys: 6.792 ± 1.499
6.289LysLeu: 6.289 ± 1.053
3.019LysMet: 3.019 ± 0.503
5.786LysAsn: 5.786 ± 1.653
2.516LysPro: 2.516 ± 0.701
2.767LysGln: 2.767 ± 0.812
3.019LysArg: 3.019 ± 1.286
5.031LysSer: 5.031 ± 1.125
5.535LysThr: 5.535 ± 0.468
3.522LysVal: 3.522 ± 0.435
1.258LysTrp: 1.258 ± 0.769
3.27LysTyr: 3.27 ± 0.542
0.0LysXaa: 0.0 ± 0.0
Leu
6.038LeuAla: 6.038 ± 2.762
3.522LeuCys: 3.522 ± 1.256
5.535LeuAsp: 5.535 ± 2.842
5.786LeuGlu: 5.786 ± 0.369
4.025LeuPhe: 4.025 ± 1.125
2.264LeuGly: 2.264 ± 0.758
2.516LeuHis: 2.516 ± 2.164
7.296LeuIle: 7.296 ± 2.717
7.799LeuLys: 7.799 ± 1.354
5.786LeuLeu: 5.786 ± 1.211
2.516LeuMet: 2.516 ± 0.983
8.05LeuAsn: 8.05 ± 1.447
3.522LeuPro: 3.522 ± 0.689
3.522LeuGln: 3.522 ± 1.127
4.025LeuArg: 4.025 ± 0.723
6.541LeuSer: 6.541 ± 1.637
7.547LeuThr: 7.547 ± 2.27
4.78LeuVal: 4.78 ± 1.321
0.503LeuTrp: 0.503 ± 0.161
4.025LeuTyr: 4.025 ± 1.904
0.0LeuXaa: 0.0 ± 0.0
Met
1.258MetAla: 1.258 ± 0.564
0.252MetCys: 0.252 ± 0.158
2.013MetAsp: 2.013 ± 1.037
1.509MetGlu: 1.509 ± 0.577
1.006MetPhe: 1.006 ± 1.52
1.509MetGly: 1.509 ± 0.983
0.755MetHis: 0.755 ± 0.674
1.509MetIle: 1.509 ± 0.438
2.516MetLys: 2.516 ± 0.983
1.509MetLeu: 1.509 ± 0.643
0.252MetMet: 0.252 ± 0.158
1.509MetAsn: 1.509 ± 0.438
1.258MetPro: 1.258 ± 0.769
1.258MetGln: 1.258 ± 0.351
2.013MetArg: 2.013 ± 0.372
3.019MetSer: 3.019 ± 0.848
2.516MetThr: 2.516 ± 0.593
1.509MetVal: 1.509 ± 0.577
0.503MetTrp: 0.503 ± 0.956
0.755MetTyr: 0.755 ± 0.674
0.0MetXaa: 0.0 ± 0.0
Asn
1.761AsnAla: 1.761 ± 0.741
2.013AsnCys: 2.013 ± 0.644
5.031AsnAsp: 5.031 ± 1.547
1.258AsnGlu: 1.258 ± 0.351
1.761AsnPhe: 1.761 ± 1.269
2.767AsnGly: 2.767 ± 1.318
1.006AsnHis: 1.006 ± 0.603
6.792AsnIle: 6.792 ± 1.317
3.019AsnLys: 3.019 ± 1.039
5.031AsnLeu: 5.031 ± 0.57
2.767AsnMet: 2.767 ± 0.633
3.27AsnAsn: 3.27 ± 0.984
2.264AsnPro: 2.264 ± 1.145
3.774AsnGln: 3.774 ± 2.492
2.013AsnArg: 2.013 ± 0.693
3.27AsnSer: 3.27 ± 0.991
4.277AsnThr: 4.277 ± 0.976
3.019AsnVal: 3.019 ± 0.966
1.006AsnTrp: 1.006 ± 0.346
3.522AsnTyr: 3.522 ± 1.327
0.0AsnXaa: 0.0 ± 0.0
Pro
2.013ProAla: 2.013 ± 0.708
0.755ProCys: 0.755 ± 0.219
2.013ProAsp: 2.013 ± 0.434
3.27ProGlu: 3.27 ± 0.326
2.013ProPhe: 2.013 ± 0.562
2.013ProGly: 2.013 ± 0.708
0.755ProHis: 0.755 ± 0.695
3.019ProIle: 3.019 ± 0.877
2.013ProLys: 2.013 ± 1.183
1.509ProLeu: 1.509 ± 2.305
0.252ProMet: 0.252 ± 0.158
1.509ProAsn: 1.509 ± 0.748
1.006ProPro: 1.006 ± 0.346
1.006ProGln: 1.006 ± 1.489
1.509ProArg: 1.509 ± 0.748
2.767ProSer: 2.767 ± 2.188
1.258ProThr: 1.258 ± 0.516
2.516ProVal: 2.516 ± 0.322
0.503ProTrp: 0.503 ± 0.316
1.258ProTyr: 1.258 ± 0.351
0.0ProXaa: 0.0 ± 0.0
Gln
1.761GlnAla: 1.761 ± 0.558
1.761GlnCys: 1.761 ± 1.062
2.264GlnAsp: 2.264 ± 0.45
1.509GlnGlu: 1.509 ± 0.643
1.761GlnPhe: 1.761 ± 1.307
1.761GlnGly: 1.761 ± 0.672
0.252GlnHis: 0.252 ± 0.232
4.025GlnIle: 4.025 ± 1.085
3.27GlnLys: 3.27 ± 1.194
3.27GlnLeu: 3.27 ± 1.098
0.252GlnMet: 0.252 ± 0.158
3.522GlnAsn: 3.522 ± 1.116
0.755GlnPro: 0.755 ± 0.809
1.258GlnGln: 1.258 ± 0.823
2.264GlnArg: 2.264 ± 1.488
1.006GlnSer: 1.006 ± 0.322
3.019GlnThr: 3.019 ± 0.564
2.013GlnVal: 2.013 ± 0.868
0.755GlnTrp: 0.755 ± 0.719
1.761GlnTyr: 1.761 ± 0.484
0.0GlnXaa: 0.0 ± 0.0
Arg
2.264ArgAla: 2.264 ± 0.495
1.509ArgCys: 1.509 ± 0.733
2.264ArgAsp: 2.264 ± 0.942
2.516ArgGlu: 2.516 ± 1.264
2.264ArgPhe: 2.264 ± 1.421
1.006ArgGly: 1.006 ± 0.592
1.761ArgHis: 1.761 ± 0.702
4.025ArgIle: 4.025 ± 2.207
3.27ArgLys: 3.27 ± 0.984
4.78ArgLeu: 4.78 ± 0.582
0.0ArgMet: 0.0 ± 0.0
2.013ArgAsn: 2.013 ± 0.434
0.755ArgPro: 0.755 ± 0.908
1.761ArgGln: 1.761 ± 0.427
1.761ArgArg: 1.761 ± 3.872
4.528ArgSer: 4.528 ± 0.845
1.258ArgThr: 1.258 ± 0.564
1.761ArgVal: 1.761 ± 1.269
0.252ArgTrp: 0.252 ± 1.012
2.767ArgTyr: 2.767 ± 0.234
0.0ArgXaa: 0.0 ± 0.0
Ser
3.019SerAla: 3.019 ± 1.466
1.761SerCys: 1.761 ± 0.956
4.277SerAsp: 4.277 ± 1.331
2.767SerGlu: 2.767 ± 0.988
2.264SerPhe: 2.264 ± 0.658
2.264SerGly: 2.264 ± 2.087
2.013SerHis: 2.013 ± 0.644
9.057SerIle: 9.057 ± 1.758
6.289SerLys: 6.289 ± 1.827
7.799SerLeu: 7.799 ± 1.169
2.013SerMet: 2.013 ± 0.952
3.27SerAsn: 3.27 ± 0.586
2.767SerPro: 2.767 ± 0.712
2.013SerGln: 2.013 ± 0.881
4.277SerArg: 4.277 ± 1.275
6.038SerSer: 6.038 ± 2.993
4.528SerThr: 4.528 ± 0.687
4.528SerVal: 4.528 ± 0.694
0.503SerTrp: 0.503 ± 0.771
1.509SerTyr: 1.509 ± 0.483
0.0SerXaa: 0.0 ± 0.0
Thr
3.774ThrAla: 3.774 ± 3.244
2.013ThrCys: 2.013 ± 0.644
1.761ThrAsp: 1.761 ± 0.5
3.019ThrGlu: 3.019 ± 0.236
4.025ThrPhe: 4.025 ± 2.413
3.522ThrGly: 3.522 ± 1.913
2.264ThrHis: 2.264 ± 1.099
4.277ThrIle: 4.277 ± 0.709
4.78ThrLys: 4.78 ± 1.348
6.038ThrLeu: 6.038 ± 1.975
1.006ThrMet: 1.006 ± 0.603
3.27ThrAsn: 3.27 ± 0.263
1.258ThrPro: 1.258 ± 0.492
2.516ThrGln: 2.516 ± 1.154
0.755ThrArg: 0.755 ± 0.908
7.044ThrSer: 7.044 ± 2.231
1.761ThrThr: 1.761 ± 0.956
1.761ThrVal: 1.761 ± 0.427
1.258ThrTrp: 1.258 ± 0.564
2.767ThrTyr: 2.767 ± 0.902
0.0ThrXaa: 0.0 ± 0.0
Val
2.767ValAla: 2.767 ± 1.985
1.006ValCys: 1.006 ± 0.322
3.522ValAsp: 3.522 ± 0.435
2.264ValGlu: 2.264 ± 0.829
1.509ValPhe: 1.509 ± 0.838
1.761ValGly: 1.761 ± 1.269
1.258ValHis: 1.258 ± 0.516
1.761ValIle: 1.761 ± 0.93
3.522ValLys: 3.522 ± 1.46
6.038ValLeu: 6.038 ± 2.395
1.509ValMet: 1.509 ± 0.577
2.264ValAsn: 2.264 ± 1.285
2.013ValPro: 2.013 ± 1.232
1.258ValGln: 1.258 ± 0.516
2.516ValArg: 2.516 ± 1.971
3.27ValSer: 3.27 ± 0.991
1.761ValThr: 1.761 ± 0.558
2.516ValVal: 2.516 ± 0.805
0.252ValTrp: 0.252 ± 0.158
3.522ValTyr: 3.522 ± 1.913
0.0ValXaa: 0.0 ± 0.0
Trp
0.503TrpAla: 0.503 ± 0.744
0.252TrpCys: 0.252 ± 1.012
0.252TrpAsp: 0.252 ± 0.158
0.252TrpGlu: 0.252 ± 0.158
1.006TrpPhe: 1.006 ± 0.322
0.755TrpGly: 0.755 ± 0.695
0.503TrpHis: 0.503 ± 0.994
1.006TrpIle: 1.006 ± 0.631
0.0TrpLys: 0.0 ± 0.0
1.509TrpLeu: 1.509 ± 0.748
0.252TrpMet: 0.252 ± 0.801
0.755TrpAsn: 0.755 ± 0.474
0.0TrpPro: 0.0 ± 0.0
0.503TrpGln: 0.503 ± 0.316
0.252TrpArg: 0.252 ± 0.232
1.509TrpSer: 1.509 ± 0.643
0.252TrpThr: 0.252 ± 0.801
1.006TrpVal: 1.006 ± 0.727
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.509TyrAla: 1.509 ± 0.483
0.503TyrCys: 0.503 ± 0.463
1.509TyrAsp: 1.509 ± 0.483
4.528TyrGlu: 4.528 ± 1.315
2.013TyrPhe: 2.013 ± 0.693
3.019TyrGly: 3.019 ± 0.992
2.013TyrHis: 2.013 ± 0.562
2.516TyrIle: 2.516 ± 0.805
3.522TyrLys: 3.522 ± 1.116
2.767TyrLeu: 2.767 ± 1.135
1.006TyrMet: 1.006 ± 0.631
2.516TyrAsn: 2.516 ± 0.983
1.761TyrPro: 1.761 ± 0.741
1.509TyrGln: 1.509 ± 0.438
2.013TyrArg: 2.013 ± 0.644
2.264TyrSer: 2.264 ± 1.099
3.522TyrThr: 3.522 ± 0.781
2.264TyrVal: 2.264 ± 1.452
0.252TyrTrp: 0.252 ± 0.158
1.006TyrTyr: 1.006 ± 0.592
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski