Amino acid dipepetide frequency for Grapevine vein clearing virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.275AlaAla: 5.275 ± 4.075
0.44AlaCys: 0.44 ± 0.22
3.956AlaAsp: 3.956 ± 0.895
6.154AlaGlu: 6.154 ± 2.913
2.637AlaPhe: 2.637 ± 1.32
2.637AlaGly: 2.637 ± 1.32
1.319AlaHis: 1.319 ± 0.66
5.275AlaIle: 5.275 ± 1.829
4.396AlaLys: 4.396 ± 0.963
3.077AlaLeu: 3.077 ± 0.691
1.319AlaMet: 1.319 ± 0.66
1.758AlaAsn: 1.758 ± 0.847
3.077AlaPro: 3.077 ± 1.581
6.154AlaGln: 6.154 ± 0.432
3.956AlaArg: 3.956 ± 1.571
3.956AlaSer: 3.956 ± 1.98
3.956AlaThr: 3.956 ± 3.15
4.835AlaVal: 4.835 ± 0.773
0.879AlaTrp: 0.879 ± 0.44
3.516AlaTyr: 3.516 ± 0.768
0.0AlaXaa: 0.0 ± 0.0
Cys
1.319CysAla: 1.319 ± 0.66
0.879CysCys: 0.879 ± 0.44
0.44CysAsp: 0.44 ± 0.22
0.0CysGlu: 0.0 ± 0.0
0.44CysPhe: 0.44 ± 0.22
0.879CysGly: 0.879 ± 0.44
0.879CysHis: 0.879 ± 1.167
0.44CysIle: 0.44 ± 0.22
3.077CysLys: 3.077 ± 1.54
0.44CysLeu: 0.44 ± 0.22
0.44CysMet: 0.44 ± 0.22
0.44CysAsn: 0.44 ± 0.22
0.879CysPro: 0.879 ± 0.44
1.319CysGln: 1.319 ± 0.66
0.0CysArg: 0.0 ± 0.0
1.319CysSer: 1.319 ± 0.66
1.319CysThr: 1.319 ± 0.66
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.879CysTyr: 0.879 ± 1.167
0.0CysXaa: 0.0 ± 0.0
Asp
2.198AspAla: 2.198 ± 1.1
0.879AspCys: 0.879 ± 0.44
3.516AspAsp: 3.516 ± 1.76
2.198AspGlu: 2.198 ± 1.244
3.077AspPhe: 3.077 ± 1.54
1.758AspGly: 1.758 ± 0.88
0.0AspHis: 0.0 ± 0.0
2.637AspIle: 2.637 ± 1.32
2.637AspLys: 2.637 ± 1.32
7.473AspLeu: 7.473 ± 3.259
2.198AspMet: 2.198 ± 1.27
1.758AspAsn: 1.758 ± 2.223
3.077AspPro: 3.077 ± 1.54
3.077AspGln: 3.077 ± 1.54
3.077AspArg: 3.077 ± 2.923
3.516AspSer: 3.516 ± 1.76
2.637AspThr: 2.637 ± 1.16
2.637AspVal: 2.637 ± 1.32
0.879AspTrp: 0.879 ± 0.44
1.758AspTyr: 1.758 ± 0.88
0.0AspXaa: 0.0 ± 0.0
Glu
5.275GluAla: 5.275 ± 1.829
1.319GluCys: 1.319 ± 0.66
3.077GluAsp: 3.077 ± 1.54
8.352GluGlu: 8.352 ± 2.125
0.879GluPhe: 0.879 ± 1.653
7.033GluGly: 7.033 ± 2.156
2.637GluHis: 2.637 ± 1.32
4.835GluIle: 4.835 ± 6.609
4.396GluLys: 4.396 ± 0.963
7.033GluLeu: 7.033 ± 0.964
1.319GluMet: 1.319 ± 0.66
2.198GluAsn: 2.198 ± 1.1
3.077GluPro: 3.077 ± 1.581
3.516GluGln: 3.516 ± 1.371
7.033GluArg: 7.033 ± 4.044
5.275GluSer: 5.275 ± 5.481
3.516GluThr: 3.516 ± 0.768
2.198GluVal: 2.198 ± 1.1
0.879GluTrp: 0.879 ± 0.44
2.637GluTyr: 2.637 ± 1.793
0.0GluXaa: 0.0 ± 0.0
Phe
0.879PheAla: 0.879 ± 1.167
0.879PheCys: 0.879 ± 0.44
2.637PheAsp: 2.637 ± 1.32
3.956PheGlu: 3.956 ± 1.164
0.0PhePhe: 0.0 ± 0.0
1.319PheGly: 1.319 ± 1.497
0.44PheHis: 0.44 ± 0.22
2.198PheIle: 2.198 ± 1.1
2.198PheLys: 2.198 ± 1.1
1.758PheLeu: 1.758 ± 0.88
0.0PheMet: 0.0 ± 0.0
1.758PheAsn: 1.758 ± 0.88
1.758PhePro: 1.758 ± 2.333
2.198PheGln: 2.198 ± 1.1
2.198PheArg: 2.198 ± 1.244
2.637PheSer: 2.637 ± 1.16
0.44PheThr: 0.44 ± 0.22
1.319PheVal: 1.319 ± 2.439
0.0PheTrp: 0.0 ± 0.0
1.758PheTyr: 1.758 ± 0.88
0.0PheXaa: 0.0 ± 0.0
Gly
2.637GlyAla: 2.637 ± 1.32
1.319GlyCys: 1.319 ± 0.66
2.637GlyAsp: 2.637 ± 0.678
3.516GlyGlu: 3.516 ± 1.76
2.198GlyPhe: 2.198 ± 1.244
3.956GlyGly: 3.956 ± 1.98
0.879GlyHis: 0.879 ± 0.44
5.275GlyIle: 5.275 ± 2.64
4.835GlyLys: 4.835 ± 0.773
5.275GlyLeu: 5.275 ± 1.472
2.637GlyMet: 2.637 ± 1.32
0.879GlyAsn: 0.879 ± 0.44
1.758GlyPro: 1.758 ± 0.88
3.077GlyGln: 3.077 ± 1.113
2.637GlyArg: 2.637 ± 1.32
2.637GlySer: 2.637 ± 1.32
4.835GlyThr: 4.835 ± 2.395
3.077GlyVal: 3.077 ± 1.54
1.758GlyTrp: 1.758 ± 0.88
2.198GlyTyr: 2.198 ± 0.735
0.0GlyXaa: 0.0 ± 0.0
His
1.319HisAla: 1.319 ± 0.995
0.0HisCys: 0.0 ± 0.0
1.319HisAsp: 1.319 ± 0.66
1.758HisGlu: 1.758 ± 1.358
0.879HisPhe: 0.879 ± 2.704
2.637HisGly: 2.637 ± 0.678
0.44HisHis: 0.44 ± 0.22
2.637HisIle: 2.637 ± 1.32
0.879HisLys: 0.879 ± 0.44
2.198HisLeu: 2.198 ± 1.244
0.0HisMet: 0.0 ± 0.0
1.319HisAsn: 1.319 ± 0.995
0.879HisPro: 0.879 ± 0.44
1.319HisGln: 1.319 ± 0.995
0.879HisArg: 0.879 ± 0.44
0.879HisSer: 0.879 ± 0.44
0.44HisThr: 0.44 ± 0.22
2.198HisVal: 2.198 ± 1.1
0.44HisTrp: 0.44 ± 0.22
1.758HisTyr: 1.758 ± 0.88
0.0HisXaa: 0.0 ± 0.0
Ile
4.396IleAla: 4.396 ± 1.227
1.758IleCys: 1.758 ± 0.88
3.516IleAsp: 3.516 ± 1.76
4.835IleGlu: 4.835 ± 4.146
1.758IlePhe: 1.758 ± 0.88
1.758IleGly: 1.758 ± 0.88
1.319IleHis: 1.319 ± 1.497
5.275IleIle: 5.275 ± 1.472
6.154IleLys: 6.154 ± 4.438
2.198IleLeu: 2.198 ± 1.1
0.0IleMet: 0.0 ± 0.0
3.956IleAsn: 3.956 ± 1.98
5.714IlePro: 5.714 ± 1.351
5.714IleGln: 5.714 ± 2.421
4.396IleArg: 4.396 ± 1.052
4.835IleSer: 4.835 ± 0.773
5.275IleThr: 5.275 ± 0.603
2.198IleVal: 2.198 ± 1.1
0.0IleTrp: 0.0 ± 0.0
1.319IleTyr: 1.319 ± 0.995
0.0IleXaa: 0.0 ± 0.0
Lys
3.516LysAla: 3.516 ± 3.344
1.319LysCys: 1.319 ± 0.66
3.516LysAsp: 3.516 ± 1.371
5.275LysGlu: 5.275 ± 4.595
2.198LysPhe: 2.198 ± 2.008
7.473LysGly: 7.473 ± 4.504
2.637LysHis: 2.637 ± 0.678
3.077LysIle: 3.077 ± 1.54
4.835LysLys: 4.835 ± 2.42
4.396LysLeu: 4.396 ± 2.2
2.637LysMet: 2.637 ± 0.893
2.637LysAsn: 2.637 ± 1.16
5.275LysPro: 5.275 ± 1.829
1.758LysGln: 1.758 ± 0.88
0.879LysArg: 0.879 ± 0.44
4.396LysSer: 4.396 ± 2.2
4.835LysThr: 4.835 ± 1.397
3.516LysVal: 3.516 ± 0.768
0.44LysTrp: 0.44 ± 0.22
1.319LysTyr: 1.319 ± 0.66
0.0LysXaa: 0.0 ± 0.0
Leu
7.033LeuAla: 7.033 ± 2.232
2.198LeuCys: 2.198 ± 1.1
3.077LeuAsp: 3.077 ± 1.54
7.912LeuGlu: 7.912 ± 2.297
0.879LeuPhe: 0.879 ± 0.44
3.956LeuGly: 3.956 ± 1.98
1.758LeuHis: 1.758 ± 0.847
3.516LeuIle: 3.516 ± 2.717
6.154LeuLys: 6.154 ± 2.913
5.714LeuLeu: 5.714 ± 3.123
2.198LeuMet: 2.198 ± 1.1
3.956LeuAsn: 3.956 ± 1.164
4.396LeuPro: 4.396 ± 0.963
5.275LeuGln: 5.275 ± 1.418
6.154LeuArg: 6.154 ± 2.913
4.835LeuSer: 4.835 ± 1.229
3.077LeuThr: 3.077 ± 4.401
6.593LeuVal: 6.593 ± 1.178
0.0LeuTrp: 0.0 ± 0.0
3.077LeuTyr: 3.077 ± 0.691
0.0LeuXaa: 0.0 ± 0.0
Met
2.198MetAla: 2.198 ± 1.1
0.0MetCys: 0.0 ± 0.0
0.44MetAsp: 0.44 ± 0.22
2.198MetGlu: 2.198 ± 1.1
0.0MetPhe: 0.0 ± 0.0
0.44MetGly: 0.44 ± 0.22
0.0MetHis: 0.0 ± 0.0
1.319MetIle: 1.319 ± 0.66
1.758MetLys: 1.758 ± 0.88
2.637MetLeu: 2.637 ± 1.32
0.879MetMet: 0.879 ± 0.44
0.879MetAsn: 0.879 ± 0.44
2.198MetPro: 2.198 ± 1.1
0.879MetGln: 0.879 ± 1.167
0.0MetArg: 0.0 ± 0.0
1.758MetSer: 1.758 ± 1.358
2.198MetThr: 2.198 ± 1.1
1.319MetVal: 1.319 ± 0.66
0.44MetTrp: 0.44 ± 0.22
0.44MetTyr: 0.44 ± 0.22
0.0MetXaa: 0.0 ± 0.0
Asn
2.637AsnAla: 2.637 ± 1.16
0.44AsnCys: 0.44 ± 0.22
2.637AsnAsp: 2.637 ± 1.16
0.879AsnGlu: 0.879 ± 0.44
3.516AsnPhe: 3.516 ± 1.11
0.44AsnGly: 0.44 ± 0.22
0.879AsnHis: 0.879 ± 0.44
1.319AsnIle: 1.319 ± 1.497
0.879AsnLys: 0.879 ± 0.44
4.396AsnLeu: 4.396 ± 2.2
0.44AsnMet: 0.44 ± 0.22
0.879AsnAsn: 0.879 ± 1.653
0.879AsnPro: 0.879 ± 0.44
3.516AsnGln: 3.516 ± 4.667
1.319AsnArg: 1.319 ± 0.66
2.637AsnSer: 2.637 ± 1.32
3.516AsnThr: 3.516 ± 1.371
1.758AsnVal: 1.758 ± 2.223
0.44AsnTrp: 0.44 ± 0.22
1.758AsnTyr: 1.758 ± 0.88
0.0AsnXaa: 0.0 ± 0.0
Pro
2.637ProAla: 2.637 ± 0.678
0.44ProCys: 0.44 ± 1.352
3.956ProAsp: 3.956 ± 1.149
4.835ProGlu: 4.835 ± 2.679
1.319ProPhe: 1.319 ± 0.66
4.835ProGly: 4.835 ± 2.42
2.198ProHis: 2.198 ± 1.244
2.637ProIle: 2.637 ± 0.678
3.956ProLys: 3.956 ± 1.164
3.077ProLeu: 3.077 ± 1.835
0.44ProMet: 0.44 ± 0.22
1.758ProAsn: 1.758 ± 1.358
7.033ProPro: 7.033 ± 3.519
2.198ProGln: 2.198 ± 0.735
2.637ProArg: 2.637 ± 0.678
3.516ProSer: 3.516 ± 0.768
3.077ProThr: 3.077 ± 1.54
2.637ProVal: 2.637 ± 1.16
1.319ProTrp: 1.319 ± 0.66
1.758ProTyr: 1.758 ± 0.88
0.0ProXaa: 0.0 ± 0.0
Gln
6.154GlnAla: 6.154 ± 1.817
1.319GlnCys: 1.319 ± 0.995
3.956GlnAsp: 3.956 ± 1.98
4.396GlnGlu: 4.396 ± 1.052
2.198GlnPhe: 2.198 ± 0.735
2.637GlnGly: 2.637 ± 1.32
3.077GlnHis: 3.077 ± 0.691
3.516GlnIle: 3.516 ± 3.344
0.879GlnLys: 0.879 ± 0.44
7.033GlnLeu: 7.033 ± 2.5
0.0GlnMet: 0.0 ± 0.0
2.198GlnAsn: 2.198 ± 1.244
2.198GlnPro: 2.198 ± 1.244
3.516GlnGln: 3.516 ± 1.694
2.637GlnArg: 2.637 ± 1.16
3.956GlnSer: 3.956 ± 2.485
2.637GlnThr: 2.637 ± 1.16
4.835GlnVal: 4.835 ± 2.047
0.0GlnTrp: 0.0 ± 0.0
1.319GlnTyr: 1.319 ± 0.66
0.0GlnXaa: 0.0 ± 0.0
Arg
4.396ArgAla: 4.396 ± 2.96
0.44ArgCys: 0.44 ± 0.22
1.758ArgAsp: 1.758 ± 0.847
3.956ArgGlu: 3.956 ± 2.986
1.758ArgPhe: 1.758 ± 0.88
2.637ArgGly: 2.637 ± 1.32
0.44ArgHis: 0.44 ± 0.22
4.396ArgIle: 4.396 ± 2.266
3.516ArgLys: 3.516 ± 0.768
3.077ArgLeu: 3.077 ± 0.691
3.956ArgMet: 3.956 ± 1.233
2.637ArgAsn: 2.637 ± 0.678
3.516ArgPro: 3.516 ± 1.76
4.396ArgGln: 4.396 ± 1.227
5.714ArgArg: 5.714 ± 2.86
3.956ArgSer: 3.956 ± 0.895
3.077ArgThr: 3.077 ± 1.835
4.396ArgVal: 4.396 ± 1.227
1.319ArgTrp: 1.319 ± 0.66
2.637ArgTyr: 2.637 ± 1.991
0.0ArgXaa: 0.0 ± 0.0
Ser
4.396SerAla: 4.396 ± 1.47
0.0SerCys: 0.0 ± 0.0
3.956SerAsp: 3.956 ± 1.149
3.077SerGlu: 3.077 ± 1.835
1.758SerPhe: 1.758 ± 0.88
4.396SerGly: 4.396 ± 2.2
2.198SerHis: 2.198 ± 1.1
6.154SerIle: 6.154 ± 1.381
4.396SerLys: 4.396 ± 2.2
7.473SerLeu: 7.473 ± 0.804
0.879SerMet: 0.879 ± 0.44
1.319SerAsn: 1.319 ± 0.66
3.077SerPro: 3.077 ± 1.54
1.319SerGln: 1.319 ± 0.66
6.154SerArg: 6.154 ± 1.817
4.835SerSer: 4.835 ± 1.397
4.835SerThr: 4.835 ± 2.775
2.198SerVal: 2.198 ± 0.735
2.198SerTrp: 2.198 ± 0.735
1.319SerTyr: 1.319 ± 0.66
0.0SerXaa: 0.0 ± 0.0
Thr
6.154ThrAla: 6.154 ± 4.451
1.319ThrCys: 1.319 ± 0.66
1.319ThrAsp: 1.319 ± 0.995
4.835ThrGlu: 4.835 ± 1.397
2.637ThrPhe: 2.637 ± 1.793
5.275ThrGly: 5.275 ± 2.64
0.879ThrHis: 0.879 ± 0.44
3.956ThrIle: 3.956 ± 1.98
3.516ThrLys: 3.516 ± 3.344
7.033ThrLeu: 7.033 ± 8.681
0.0ThrMet: 0.0 ± 0.0
1.319ThrAsn: 1.319 ± 1.497
1.758ThrPro: 1.758 ± 0.847
1.758ThrGln: 1.758 ± 1.358
3.077ThrArg: 3.077 ± 1.54
3.956ThrSer: 3.956 ± 1.98
6.154ThrThr: 6.154 ± 3.08
3.077ThrVal: 3.077 ± 0.691
2.198ThrTrp: 2.198 ± 1.244
1.319ThrTyr: 1.319 ± 0.995
0.0ThrXaa: 0.0 ± 0.0
Val
1.758ValAla: 1.758 ± 0.847
0.44ValCys: 0.44 ± 0.22
2.637ValAsp: 2.637 ± 1.32
4.396ValGlu: 4.396 ± 0.963
1.319ValPhe: 1.319 ± 0.66
1.758ValGly: 1.758 ± 1.358
0.44ValHis: 0.44 ± 1.352
4.396ValIle: 4.396 ± 1.052
3.956ValLys: 3.956 ± 2.595
3.077ValLeu: 3.077 ± 0.691
2.198ValMet: 2.198 ± 1.1
1.758ValAsn: 1.758 ± 0.847
2.637ValPro: 2.637 ± 0.678
5.275ValGln: 5.275 ± 1.829
5.275ValArg: 5.275 ± 1.418
3.956ValSer: 3.956 ± 1.98
3.516ValThr: 3.516 ± 1.11
2.198ValVal: 2.198 ± 1.244
0.879ValTrp: 0.879 ± 1.653
1.319ValTyr: 1.319 ± 0.66
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.879TrpAsp: 0.879 ± 0.44
1.319TrpGlu: 1.319 ± 0.995
0.0TrpPhe: 0.0 ± 0.0
0.879TrpGly: 0.879 ± 0.44
0.44TrpHis: 0.44 ± 0.22
0.879TrpIle: 0.879 ± 0.44
1.758TrpLys: 1.758 ± 1.358
1.319TrpLeu: 1.319 ± 0.66
0.0TrpMet: 0.0 ± 0.0
0.879TrpAsn: 0.879 ± 0.44
0.0TrpPro: 0.0 ± 0.0
0.44TrpGln: 0.44 ± 1.823
1.319TrpArg: 1.319 ± 0.66
1.758TrpSer: 1.758 ± 0.88
0.44TrpThr: 0.44 ± 0.22
1.319TrpVal: 1.319 ± 0.66
0.0TrpTrp: 0.0 ± 0.0
0.44TrpTyr: 0.44 ± 0.22
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.396TyrAla: 4.396 ± 2.2
0.0TyrCys: 0.0 ± 0.0
2.198TyrAsp: 2.198 ± 2.158
2.637TyrGlu: 2.637 ± 0.678
0.879TyrPhe: 0.879 ± 0.44
1.319TyrGly: 1.319 ± 0.66
1.319TyrHis: 1.319 ± 0.995
2.637TyrIle: 2.637 ± 1.32
1.758TyrLys: 1.758 ± 1.358
3.077TyrLeu: 3.077 ± 0.691
0.0TyrMet: 0.0 ± 0.0
0.879TyrAsn: 0.879 ± 0.44
3.077TyrPro: 3.077 ± 0.691
1.758TyrGln: 1.758 ± 0.88
2.637TyrArg: 2.637 ± 0.678
1.319TyrSer: 1.319 ± 0.66
1.758TyrThr: 1.758 ± 2.333
0.879TyrVal: 0.879 ± 0.44
0.0TyrTrp: 0.0 ± 0.0
0.879TyrTyr: 0.879 ± 0.44
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski