Amino acid dipepetide frequency for Streptococcus phage P3684

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.236AlaAla: 3.236 ± 1.066
0.185AlaCys: 0.185 ± 0.143
4.253AlaAsp: 4.253 ± 0.623
3.329AlaGlu: 3.329 ± 0.451
2.497AlaPhe: 2.497 ± 0.63
4.531AlaGly: 4.531 ± 0.926
1.202AlaHis: 1.202 ± 0.349
5.178AlaIle: 5.178 ± 0.755
6.75AlaLys: 6.75 ± 0.909
6.195AlaLeu: 6.195 ± 0.748
1.664AlaMet: 1.664 ± 0.397
4.253AlaAsn: 4.253 ± 1.005
1.572AlaPro: 1.572 ± 0.386
2.681AlaGln: 2.681 ± 0.556
2.404AlaArg: 2.404 ± 0.446
4.438AlaSer: 4.438 ± 0.638
4.623AlaThr: 4.623 ± 0.773
3.514AlaVal: 3.514 ± 0.671
1.017AlaTrp: 1.017 ± 0.221
2.312AlaTyr: 2.312 ± 0.493
0.0AlaXaa: 0.0 ± 0.0
Cys
0.092CysAla: 0.092 ± 0.078
0.0CysCys: 0.0 ± 0.0
0.647CysAsp: 0.647 ± 0.321
0.185CysGlu: 0.185 ± 0.126
0.185CysPhe: 0.185 ± 0.206
0.185CysGly: 0.185 ± 0.143
0.092CysHis: 0.092 ± 0.098
0.092CysIle: 0.092 ± 0.083
0.37CysLys: 0.37 ± 0.208
0.37CysLeu: 0.37 ± 0.215
0.092CysMet: 0.092 ± 0.103
0.37CysAsn: 0.37 ± 0.191
0.277CysPro: 0.277 ± 0.168
0.185CysGln: 0.185 ± 0.147
0.277CysArg: 0.277 ± 0.235
0.277CysSer: 0.277 ± 0.179
0.277CysThr: 0.277 ± 0.185
0.185CysVal: 0.185 ± 0.098
0.185CysTrp: 0.185 ± 0.132
0.185CysTyr: 0.185 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
3.329AspAla: 3.329 ± 0.609
0.277AspCys: 0.277 ± 0.175
4.623AspAsp: 4.623 ± 0.528
4.346AspGlu: 4.346 ± 0.78
3.329AspPhe: 3.329 ± 0.592
6.195AspGly: 6.195 ± 1.05
1.202AspHis: 1.202 ± 0.294
4.901AspIle: 4.901 ± 0.63
4.438AspLys: 4.438 ± 0.611
4.161AspLeu: 4.161 ± 0.67
2.034AspMet: 2.034 ± 0.444
3.699AspAsn: 3.699 ± 0.758
2.127AspPro: 2.127 ± 0.519
1.849AspGln: 1.849 ± 0.338
2.681AspArg: 2.681 ± 0.457
3.421AspSer: 3.421 ± 0.502
4.901AspThr: 4.901 ± 0.627
3.883AspVal: 3.883 ± 0.81
0.925AspTrp: 0.925 ± 0.254
3.051AspTyr: 3.051 ± 0.598
0.0AspXaa: 0.0 ± 0.0
Glu
3.883GluAla: 3.883 ± 0.611
0.277GluCys: 0.277 ± 0.133
3.606GluAsp: 3.606 ± 0.663
3.421GluGlu: 3.421 ± 0.736
2.404GluPhe: 2.404 ± 0.496
3.051GluGly: 3.051 ± 0.406
1.294GluHis: 1.294 ± 0.344
5.918GluIle: 5.918 ± 0.834
3.514GluLys: 3.514 ± 0.892
6.657GluLeu: 6.657 ± 0.999
1.942GluMet: 1.942 ± 0.401
4.716GluAsn: 4.716 ± 0.752
2.034GluPro: 2.034 ± 0.65
2.774GluGln: 2.774 ± 0.461
3.236GluArg: 3.236 ± 0.656
3.144GluSer: 3.144 ± 0.492
3.514GluThr: 3.514 ± 0.471
4.438GluVal: 4.438 ± 0.698
1.017GluTrp: 1.017 ± 0.278
2.959GluTyr: 2.959 ± 0.782
0.0GluXaa: 0.0 ± 0.0
Phe
3.236PheAla: 3.236 ± 0.486
0.185PheCys: 0.185 ± 0.127
3.329PheAsp: 3.329 ± 0.568
1.572PheGlu: 1.572 ± 0.435
1.757PhePhe: 1.757 ± 0.398
3.144PheGly: 3.144 ± 0.535
0.277PheHis: 0.277 ± 0.144
2.127PheIle: 2.127 ± 0.506
3.514PheLys: 3.514 ± 0.628
2.959PheLeu: 2.959 ± 0.516
0.647PheMet: 0.647 ± 0.304
3.699PheAsn: 3.699 ± 0.751
0.37PhePro: 0.37 ± 0.171
1.387PheGln: 1.387 ± 0.336
1.479PheArg: 1.479 ± 0.3
3.051PheSer: 3.051 ± 0.573
2.034PheThr: 2.034 ± 0.642
3.144PheVal: 3.144 ± 0.591
0.37PheTrp: 0.37 ± 0.162
1.849PheTyr: 1.849 ± 0.346
0.0PheXaa: 0.0 ± 0.0
Gly
3.976GlyAla: 3.976 ± 0.94
0.185GlyCys: 0.185 ± 0.133
4.623GlyAsp: 4.623 ± 0.688
3.329GlyGlu: 3.329 ± 0.519
3.144GlyPhe: 3.144 ± 0.525
4.346GlyGly: 4.346 ± 1.032
0.832GlyHis: 0.832 ± 0.251
5.363GlyIle: 5.363 ± 0.711
6.472GlyLys: 6.472 ± 0.942
6.75GlyLeu: 6.75 ± 0.826
1.664GlyMet: 1.664 ± 0.438
3.791GlyAsn: 3.791 ± 0.801
1.757GlyPro: 1.757 ± 0.545
2.959GlyGln: 2.959 ± 0.678
2.866GlyArg: 2.866 ± 0.484
4.808GlySer: 4.808 ± 0.936
4.438GlyThr: 4.438 ± 0.593
3.051GlyVal: 3.051 ± 0.584
1.664GlyTrp: 1.664 ± 0.364
3.051GlyTyr: 3.051 ± 0.446
0.0GlyXaa: 0.0 ± 0.0
His
0.277HisAla: 0.277 ± 0.159
0.0HisCys: 0.0 ± 0.0
0.925HisAsp: 0.925 ± 0.285
0.832HisGlu: 0.832 ± 0.265
0.74HisPhe: 0.74 ± 0.204
0.832HisGly: 0.832 ± 0.287
0.462HisHis: 0.462 ± 0.177
1.11HisIle: 1.11 ± 0.318
0.925HisLys: 0.925 ± 0.289
0.832HisLeu: 0.832 ± 0.269
0.555HisMet: 0.555 ± 0.25
0.832HisAsn: 0.832 ± 0.346
0.74HisPro: 0.74 ± 0.24
0.647HisGln: 0.647 ± 0.295
0.555HisArg: 0.555 ± 0.22
0.925HisSer: 0.925 ± 0.247
0.462HisThr: 0.462 ± 0.157
1.572HisVal: 1.572 ± 0.269
0.185HisTrp: 0.185 ± 0.146
0.925HisTyr: 0.925 ± 0.344
0.0HisXaa: 0.0 ± 0.0
Ile
5.27IleAla: 5.27 ± 0.764
0.37IleCys: 0.37 ± 0.204
5.64IleAsp: 5.64 ± 0.668
4.623IleGlu: 4.623 ± 0.688
1.294IlePhe: 1.294 ± 0.355
4.438IleGly: 4.438 ± 0.646
0.74IleHis: 0.74 ± 0.214
3.329IleIle: 3.329 ± 0.509
6.38IleLys: 6.38 ± 0.688
4.346IleLeu: 4.346 ± 0.944
2.034IleMet: 2.034 ± 0.452
3.699IleAsn: 3.699 ± 0.525
3.421IlePro: 3.421 ± 0.478
3.051IleGln: 3.051 ± 0.413
3.144IleArg: 3.144 ± 0.594
4.346IleSer: 4.346 ± 0.677
4.253IleThr: 4.253 ± 0.517
3.329IleVal: 3.329 ± 0.633
1.202IleTrp: 1.202 ± 0.233
2.681IleTyr: 2.681 ± 0.546
0.0IleXaa: 0.0 ± 0.0
Lys
5.455LysAla: 5.455 ± 0.599
0.277LysCys: 0.277 ± 0.177
4.438LysAsp: 4.438 ± 0.664
7.397LysGlu: 7.397 ± 0.839
3.514LysPhe: 3.514 ± 0.795
5.733LysGly: 5.733 ± 0.658
1.11LysHis: 1.11 ± 0.409
4.623LysIle: 4.623 ± 0.583
6.842LysLys: 6.842 ± 1.149
6.75LysLeu: 6.75 ± 0.902
1.387LysMet: 1.387 ± 0.383
5.363LysAsn: 5.363 ± 0.688
2.774LysPro: 2.774 ± 0.449
3.883LysGln: 3.883 ± 0.631
3.421LysArg: 3.421 ± 0.561
4.253LysSer: 4.253 ± 0.685
5.733LysThr: 5.733 ± 0.907
4.346LysVal: 4.346 ± 0.652
0.832LysTrp: 0.832 ± 0.266
3.051LysTyr: 3.051 ± 0.505
0.0LysXaa: 0.0 ± 0.0
Leu
7.027LeuAla: 7.027 ± 0.775
0.555LeuCys: 0.555 ± 0.263
5.733LeuAsp: 5.733 ± 0.731
6.01LeuGlu: 6.01 ± 0.889
2.774LeuPhe: 2.774 ± 0.382
5.27LeuGly: 5.27 ± 0.966
0.925LeuHis: 0.925 ± 0.3
4.716LeuIle: 4.716 ± 0.686
6.935LeuLys: 6.935 ± 0.74
5.733LeuLeu: 5.733 ± 0.766
2.497LeuMet: 2.497 ± 0.429
5.548LeuAsn: 5.548 ± 0.693
3.329LeuPro: 3.329 ± 0.409
2.681LeuGln: 2.681 ± 0.567
3.514LeuArg: 3.514 ± 0.811
5.086LeuSer: 5.086 ± 0.835
6.565LeuThr: 6.565 ± 1.121
3.976LeuVal: 3.976 ± 0.632
0.925LeuTrp: 0.925 ± 0.327
1.664LeuTyr: 1.664 ± 0.367
0.0LeuXaa: 0.0 ± 0.0
Met
2.312MetAla: 2.312 ± 0.485
0.0MetCys: 0.0 ± 0.0
0.555MetAsp: 0.555 ± 0.196
1.664MetGlu: 1.664 ± 0.512
1.294MetPhe: 1.294 ± 0.244
0.832MetGly: 0.832 ± 0.244
0.277MetHis: 0.277 ± 0.186
1.387MetIle: 1.387 ± 0.377
2.589MetLys: 2.589 ± 0.485
1.942MetLeu: 1.942 ± 0.318
0.555MetMet: 0.555 ± 0.258
1.11MetAsn: 1.11 ± 0.284
1.11MetPro: 1.11 ± 0.271
0.74MetGln: 0.74 ± 0.168
1.017MetArg: 1.017 ± 0.28
1.757MetSer: 1.757 ± 0.404
1.387MetThr: 1.387 ± 0.359
2.034MetVal: 2.034 ± 0.405
0.185MetTrp: 0.185 ± 0.119
0.74MetTyr: 0.74 ± 0.286
0.0MetXaa: 0.0 ± 0.0
Asn
5.363AsnAla: 5.363 ± 0.973
0.277AsnCys: 0.277 ± 0.166
3.606AsnAsp: 3.606 ± 0.485
3.791AsnGlu: 3.791 ± 0.769
2.219AsnPhe: 2.219 ± 0.481
7.212AsnGly: 7.212 ± 1.361
1.387AsnHis: 1.387 ± 0.321
3.699AsnIle: 3.699 ± 0.614
3.883AsnLys: 3.883 ± 0.534
5.363AsnLeu: 5.363 ± 0.584
0.925AsnMet: 0.925 ± 0.257
4.346AsnAsn: 4.346 ± 0.754
3.051AsnPro: 3.051 ± 0.666
2.866AsnGln: 2.866 ± 0.437
2.497AsnArg: 2.497 ± 0.599
3.421AsnSer: 3.421 ± 0.706
3.421AsnThr: 3.421 ± 0.553
3.514AsnVal: 3.514 ± 0.422
1.387AsnTrp: 1.387 ± 0.321
2.127AsnTyr: 2.127 ± 0.43
0.0AsnXaa: 0.0 ± 0.0
Pro
1.572ProAla: 1.572 ± 0.339
0.0ProCys: 0.0 ± 0.0
1.757ProAsp: 1.757 ± 0.45
2.681ProGlu: 2.681 ± 0.513
1.294ProPhe: 1.294 ± 0.299
1.294ProGly: 1.294 ± 0.39
0.277ProHis: 0.277 ± 0.13
1.479ProIle: 1.479 ± 0.317
3.606ProLys: 3.606 ± 0.539
2.404ProLeu: 2.404 ± 0.552
0.277ProMet: 0.277 ± 0.177
3.051ProAsn: 3.051 ± 0.526
0.832ProPro: 0.832 ± 0.383
1.572ProGln: 1.572 ± 0.31
1.11ProArg: 1.11 ± 0.34
2.404ProSer: 2.404 ± 0.344
3.144ProThr: 3.144 ± 0.534
1.757ProVal: 1.757 ± 0.491
0.37ProTrp: 0.37 ± 0.163
0.832ProTyr: 0.832 ± 0.321
0.0ProXaa: 0.0 ± 0.0
Gln
3.329GlnAla: 3.329 ± 0.567
0.277GlnCys: 0.277 ± 0.158
2.312GlnAsp: 2.312 ± 0.447
3.329GlnGlu: 3.329 ± 0.683
1.572GlnPhe: 1.572 ± 0.373
3.791GlnGly: 3.791 ± 0.831
0.462GlnHis: 0.462 ± 0.163
2.681GlnIle: 2.681 ± 0.62
2.959GlnLys: 2.959 ± 0.42
3.144GlnLeu: 3.144 ± 0.462
0.925GlnMet: 0.925 ± 0.276
2.219GlnAsn: 2.219 ± 0.379
0.647GlnPro: 0.647 ± 0.214
2.774GlnGln: 2.774 ± 0.52
1.757GlnArg: 1.757 ± 0.331
2.774GlnSer: 2.774 ± 0.548
2.774GlnThr: 2.774 ± 0.471
1.757GlnVal: 1.757 ± 0.396
1.017GlnTrp: 1.017 ± 0.411
2.127GlnTyr: 2.127 ± 0.334
0.0GlnXaa: 0.0 ± 0.0
Arg
2.497ArgAla: 2.497 ± 0.487
0.092ArgCys: 0.092 ± 0.103
2.127ArgAsp: 2.127 ± 0.485
2.404ArgGlu: 2.404 ± 0.45
1.664ArgPhe: 1.664 ± 0.417
2.589ArgGly: 2.589 ± 0.465
0.925ArgHis: 0.925 ± 0.298
3.421ArgIle: 3.421 ± 0.66
3.329ArgLys: 3.329 ± 0.631
3.883ArgLeu: 3.883 ± 0.793
1.202ArgMet: 1.202 ± 0.356
2.959ArgAsn: 2.959 ± 0.399
1.11ArgPro: 1.11 ± 0.277
1.849ArgGln: 1.849 ± 0.326
1.202ArgArg: 1.202 ± 0.39
1.479ArgSer: 1.479 ± 0.315
2.497ArgThr: 2.497 ± 0.653
2.681ArgVal: 2.681 ± 0.404
1.202ArgTrp: 1.202 ± 0.309
2.034ArgTyr: 2.034 ± 0.5
0.0ArgXaa: 0.0 ± 0.0
Ser
2.681SerAla: 2.681 ± 0.481
0.647SerCys: 0.647 ± 0.287
4.438SerAsp: 4.438 ± 0.509
3.976SerGlu: 3.976 ± 0.497
2.774SerPhe: 2.774 ± 0.413
4.068SerGly: 4.068 ± 0.557
0.277SerHis: 0.277 ± 0.137
5.178SerIle: 5.178 ± 0.505
4.901SerLys: 4.901 ± 0.714
3.883SerLeu: 3.883 ± 0.492
1.849SerMet: 1.849 ± 0.34
4.531SerAsn: 4.531 ± 0.609
1.942SerPro: 1.942 ± 0.459
2.589SerGln: 2.589 ± 0.546
2.497SerArg: 2.497 ± 0.644
4.623SerSer: 4.623 ± 1.273
4.346SerThr: 4.346 ± 0.677
4.901SerVal: 4.901 ± 0.768
0.647SerTrp: 0.647 ± 0.254
1.757SerTyr: 1.757 ± 0.383
0.0SerXaa: 0.0 ± 0.0
Thr
4.808ThrAla: 4.808 ± 0.734
0.277ThrCys: 0.277 ± 0.139
4.068ThrAsp: 4.068 ± 0.755
3.699ThrGlu: 3.699 ± 0.513
2.959ThrPhe: 2.959 ± 0.601
4.068ThrGly: 4.068 ± 0.607
1.11ThrHis: 1.11 ± 0.269
5.178ThrIle: 5.178 ± 0.961
5.178ThrLys: 5.178 ± 0.71
6.935ThrLeu: 6.935 ± 0.861
1.11ThrMet: 1.11 ± 0.301
4.068ThrAsn: 4.068 ± 0.729
1.572ThrPro: 1.572 ± 0.478
2.866ThrGln: 2.866 ± 0.647
1.942ThrArg: 1.942 ± 0.353
4.068ThrSer: 4.068 ± 0.657
3.236ThrThr: 3.236 ± 0.609
4.346ThrVal: 4.346 ± 0.448
1.11ThrTrp: 1.11 ± 0.298
3.699ThrTyr: 3.699 ± 0.653
0.0ThrXaa: 0.0 ± 0.0
Val
3.883ValAla: 3.883 ± 0.825
0.185ValCys: 0.185 ± 0.089
5.363ValAsp: 5.363 ± 0.549
3.421ValGlu: 3.421 ± 0.613
1.849ValPhe: 1.849 ± 0.374
4.716ValGly: 4.716 ± 0.503
0.555ValHis: 0.555 ± 0.21
4.161ValIle: 4.161 ± 0.674
4.993ValLys: 4.993 ± 0.617
3.976ValLeu: 3.976 ± 0.701
1.11ValMet: 1.11 ± 0.239
3.514ValAsn: 3.514 ± 0.688
1.849ValPro: 1.849 ± 0.358
2.127ValGln: 2.127 ± 0.46
2.034ValArg: 2.034 ± 0.539
4.716ValSer: 4.716 ± 0.665
5.363ValThr: 5.363 ± 0.69
3.699ValVal: 3.699 ± 0.639
0.832ValTrp: 0.832 ± 0.268
1.664ValTyr: 1.664 ± 0.382
0.0ValXaa: 0.0 ± 0.0
Trp
0.555TrpAla: 0.555 ± 0.21
0.092TrpCys: 0.092 ± 0.098
1.11TrpAsp: 1.11 ± 0.38
0.925TrpGlu: 0.925 ± 0.254
0.74TrpPhe: 0.74 ± 0.242
0.647TrpGly: 0.647 ± 0.311
0.277TrpHis: 0.277 ± 0.163
0.925TrpIle: 0.925 ± 0.298
1.017TrpLys: 1.017 ± 0.432
1.479TrpLeu: 1.479 ± 0.422
0.092TrpMet: 0.092 ± 0.097
1.294TrpAsn: 1.294 ± 0.451
0.092TrpPro: 0.092 ± 0.093
0.647TrpGln: 0.647 ± 0.237
0.925TrpArg: 0.925 ± 0.272
1.664TrpSer: 1.664 ± 0.536
1.479TrpThr: 1.479 ± 0.621
1.202TrpVal: 1.202 ± 0.257
0.277TrpTrp: 0.277 ± 0.179
0.185TrpTyr: 0.185 ± 0.113
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.051TyrAla: 3.051 ± 0.623
0.37TyrCys: 0.37 ± 0.265
2.219TyrAsp: 2.219 ± 0.423
2.866TyrGlu: 2.866 ± 0.518
2.127TyrPhe: 2.127 ± 0.481
2.127TyrGly: 2.127 ± 0.608
0.647TyrHis: 0.647 ± 0.213
2.127TyrIle: 2.127 ± 0.458
2.681TyrLys: 2.681 ± 0.476
3.699TyrLeu: 3.699 ± 0.408
0.832TyrMet: 0.832 ± 0.277
1.294TyrAsn: 1.294 ± 0.321
1.11TyrPro: 1.11 ± 0.333
2.497TyrGln: 2.497 ± 0.356
2.589TyrArg: 2.589 ± 0.647
1.849TyrSer: 1.849 ± 0.541
1.849TyrThr: 1.849 ± 0.435
2.681TyrVal: 2.681 ± 0.571
0.277TyrTrp: 0.277 ± 0.153
2.034TyrTyr: 2.034 ± 0.642
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 44 proteins (10816 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski