Amino acid dipepetide frequency for Marinifilum breve

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.946AlaAla: 3.946 ± 0.063	0.749AlaCys: 0.749 ± 0.022	3.561AlaAsp: 3.561 ± 0.063	4.251AlaGlu: 4.251 ± 0.069	3.066AlaPhe: 3.066 ± 0.043	4.067AlaGly: 4.067 ± 0.069	1.06AlaHis: 1.06 ± 0.027	4.908AlaIle: 4.908 ± 0.061	4.923AlaLys: 4.923 ± 0.058	5.666AlaLeu: 5.666 ± 0.074	1.637AlaMet: 1.637 ± 0.038	3.473AlaAsn: 3.473 ± 0.057	1.733AlaPro: 1.733 ± 0.041	2.218AlaGln: 2.218 ± 0.037	2.052AlaArg: 2.052 ± 0.042	3.968AlaSer: 3.968 ± 0.064	2.956AlaThr: 2.956 ± 0.054	3.748AlaVal: 3.748 ± 0.055	0.624AlaTrp: 0.624 ± 0.021	2.528AlaTyr: 2.528 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.525CysAla: 0.525 ± 0.019	0.138CysCys: 0.138 ± 0.01	0.535CysAsp: 0.535 ± 0.018	0.641CysGlu: 0.641 ± 0.023	0.507CysPhe: 0.507 ± 0.019	0.733CysGly: 0.733 ± 0.022	0.236CysHis: 0.236 ± 0.017	0.727CysIle: 0.727 ± 0.021	0.733CysLys: 0.733 ± 0.02	0.817CysLeu: 0.817 ± 0.025	0.226CysMet: 0.226 ± 0.011	0.527CysAsn: 0.527 ± 0.019	0.415CysPro: 0.415 ± 0.018	0.27CysGln: 0.27 ± 0.012	0.347CysArg: 0.347 ± 0.014	0.686CysSer: 0.686 ± 0.023	0.48CysThr: 0.48 ± 0.018	0.541CysVal: 0.541 ± 0.02	0.098CysTrp: 0.098 ± 0.008	0.381CysTyr: 0.381 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.411AspAla: 3.411 ± 0.054	0.496AspCys: 0.496 ± 0.016	3.0AspAsp: 3.0 ± 0.054	4.145AspGlu: 4.145 ± 0.049	3.495AspPhe: 3.495 ± 0.044	3.641AspGly: 3.641 ± 0.06	1.027AspHis: 1.027 ± 0.027	4.344AspIle: 4.344 ± 0.058	4.32AspLys: 4.32 ± 0.047	5.621AspLeu: 5.621 ± 0.058	1.298AspMet: 1.298 ± 0.033	2.963AspAsn: 2.963 ± 0.054	1.898AspPro: 1.898 ± 0.031	1.95AspGln: 1.95 ± 0.036	2.095AspArg: 2.095 ± 0.037	3.27AspSer: 3.27 ± 0.05	2.41AspThr: 2.41 ± 0.043	3.563AspVal: 3.563 ± 0.059	0.772AspTrp: 0.772 ± 0.024	2.812AspTyr: 2.812 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.177GluAla: 4.177 ± 0.056	0.534GluCys: 0.534 ± 0.02	3.665GluAsp: 3.665 ± 0.052	5.811GluGlu: 5.811 ± 0.088	3.487GluPhe: 3.487 ± 0.047	3.915GluGly: 3.915 ± 0.056	1.151GluHis: 1.151 ± 0.026	5.924GluIle: 5.924 ± 0.074	6.523GluLys: 6.523 ± 0.072	7.191GluLeu: 7.191 ± 0.071	2.043GluMet: 2.043 ± 0.036	4.823GluAsn: 4.823 ± 0.063	1.498GluPro: 1.498 ± 0.033	2.35GluGln: 2.35 ± 0.038	2.557GluArg: 2.557 ± 0.044	4.019GluSer: 4.019 ± 0.05	3.145GluThr: 3.145 ± 0.045	4.455GluVal: 4.455 ± 0.063	0.737GluTrp: 0.737 ± 0.021	2.931GluTyr: 2.931 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.108PheAla: 3.108 ± 0.048	0.548PheCys: 0.548 ± 0.018	3.219PheAsp: 3.219 ± 0.043	3.423PheGlu: 3.423 ± 0.046	2.423PhePhe: 2.423 ± 0.051	3.302PheGly: 3.302 ± 0.053	0.869PheHis: 0.869 ± 0.025	3.616PheIle: 3.616 ± 0.059	3.599PheLys: 3.599 ± 0.049	4.403PheLeu: 4.403 ± 0.068	1.189PheMet: 1.189 ± 0.03	2.906PheAsn: 2.906 ± 0.043	1.618PhePro: 1.618 ± 0.036	1.539PheGln: 1.539 ± 0.034	1.826PheArg: 1.826 ± 0.036	3.85PheSer: 3.85 ± 0.056	2.901PheThr: 2.901 ± 0.049	3.188PheVal: 3.188 ± 0.047	0.568PheTrp: 0.568 ± 0.021	2.12PheTyr: 2.12 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	3.826GlyAla: 3.826 ± 0.057	0.662GlyCys: 0.662 ± 0.023	3.384GlyAsp: 3.384 ± 0.053	4.115GlyGlu: 4.115 ± 0.05	3.437GlyPhe: 3.437 ± 0.054	4.321GlyGly: 4.321 ± 0.071	1.083GlyHis: 1.083 ± 0.028	5.378GlyIle: 5.378 ± 0.058	5.533GlyLys: 5.533 ± 0.064	5.555GlyLeu: 5.555 ± 0.069	1.802GlyMet: 1.802 ± 0.036	3.707GlyAsn: 3.707 ± 0.061	1.255GlyPro: 1.255 ± 0.027	1.687GlyGln: 1.687 ± 0.032	2.191GlyArg: 2.191 ± 0.043	4.003GlySer: 4.003 ± 0.061	3.55GlyThr: 3.55 ± 0.064	4.444GlyVal: 4.444 ± 0.062	0.777GlyTrp: 0.777 ± 0.022	2.789GlyTyr: 2.789 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.015HisAla: 1.015 ± 0.026	0.227HisCys: 0.227 ± 0.014	0.896HisAsp: 0.896 ± 0.026	1.127HisGlu: 1.127 ± 0.029	1.109HisPhe: 1.109 ± 0.029	1.085HisGly: 1.085 ± 0.029	0.452HisHis: 0.452 ± 0.019	1.34HisIle: 1.34 ± 0.031	1.296HisLys: 1.296 ± 0.03	1.857HisLeu: 1.857 ± 0.042	0.411HisMet: 0.411 ± 0.014	0.906HisAsn: 0.906 ± 0.027	0.93HisPro: 0.93 ± 0.028	0.613HisGln: 0.613 ± 0.02	0.721HisArg: 0.721 ± 0.027	1.22HisSer: 1.22 ± 0.029	0.895HisThr: 0.895 ± 0.023	0.985HisVal: 0.985 ± 0.027	0.237HisTrp: 0.237 ± 0.015	0.856HisTyr: 0.856 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.127IleAla: 5.127 ± 0.068	0.776IleCys: 0.776 ± 0.024	4.837IleAsp: 4.837 ± 0.061	5.608IleGlu: 5.608 ± 0.07	3.346IlePhe: 3.346 ± 0.05	5.02IleGly: 5.02 ± 0.07	1.504IleHis: 1.504 ± 0.032	5.35IleIle: 5.35 ± 0.069	5.714IleLys: 5.714 ± 0.066	7.036IleLeu: 7.036 ± 0.079	1.441IleMet: 1.441 ± 0.031	4.512IleAsn: 4.512 ± 0.059	3.143IlePro: 3.143 ± 0.043	2.689IleGln: 2.689 ± 0.044	3.015IleArg: 3.015 ± 0.043	5.788IleSer: 5.788 ± 0.076	4.079IleThr: 4.079 ± 0.059	4.703IleVal: 4.703 ± 0.061	0.755IleTrp: 0.755 ± 0.028	2.776IleTyr: 2.776 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.096LysAla: 5.096 ± 0.069	0.543LysCys: 0.543 ± 0.022	4.711LysAsp: 4.711 ± 0.064	6.998LysGlu: 6.998 ± 0.079	3.104LysPhe: 3.104 ± 0.042	4.787LysGly: 4.787 ± 0.058	1.505LysHis: 1.505 ± 0.031	6.064LysIle: 6.064 ± 0.068	6.837LysLys: 6.837 ± 0.092	7.286LysLeu: 7.286 ± 0.068	2.208LysMet: 2.208 ± 0.041	5.059LysAsn: 5.059 ± 0.058	2.253LysPro: 2.253 ± 0.043	2.868LysGln: 2.868 ± 0.048	3.114LysArg: 3.114 ± 0.047	4.944LysSer: 4.944 ± 0.064	3.937LysThr: 3.937 ± 0.05	5.019LysVal: 5.019 ± 0.059	0.881LysTrp: 0.881 ± 0.024	3.491LysTyr: 3.491 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.713LeuAla: 5.713 ± 0.07	0.826LeuCys: 0.826 ± 0.022	4.883LeuAsp: 4.883 ± 0.056	6.162LeuGlu: 6.162 ± 0.073	4.792LeuPhe: 4.792 ± 0.077	5.586LeuGly: 5.586 ± 0.072	1.607LeuHis: 1.607 ± 0.037	7.141LeuIle: 7.141 ± 0.101	7.933LeuLys: 7.933 ± 0.08	8.936LeuLeu: 8.936 ± 0.101	2.231LeuMet: 2.231 ± 0.04	5.87LeuAsn: 5.87 ± 0.072	3.445LeuPro: 3.445 ± 0.049	3.225LeuGln: 3.225 ± 0.053	3.406LeuArg: 3.406 ± 0.056	7.146LeuSer: 7.146 ± 0.078	4.508LeuThr: 4.508 ± 0.061	5.293LeuVal: 5.293 ± 0.059	0.858LeuTrp: 0.858 ± 0.026	3.253LeuTyr: 3.253 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.723MetAla: 1.723 ± 0.036	0.183MetCys: 0.183 ± 0.012	1.442MetAsp: 1.442 ± 0.03	1.625MetGlu: 1.625 ± 0.029	0.926MetPhe: 0.926 ± 0.025	1.681MetGly: 1.681 ± 0.034	0.447MetHis: 0.447 ± 0.016	1.816MetIle: 1.816 ± 0.038	2.36MetLys: 2.36 ± 0.042	2.109MetLeu: 2.109 ± 0.039	0.594MetMet: 0.594 ± 0.021	1.687MetAsn: 1.687 ± 0.035	0.929MetPro: 0.929 ± 0.024	0.846MetGln: 0.846 ± 0.026	0.948MetArg: 0.948 ± 0.021	1.445MetSer: 1.445 ± 0.032	1.064MetThr: 1.064 ± 0.026	1.524MetVal: 1.524 ± 0.031	0.198MetTrp: 0.198 ± 0.012	0.781MetTyr: 0.781 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.509AsnAla: 3.509 ± 0.052	0.606AsnCys: 0.606 ± 0.022	3.056AsnAsp: 3.056 ± 0.053	3.866AsnGlu: 3.866 ± 0.052	2.875AsnPhe: 2.875 ± 0.047	4.072AsnGly: 4.072 ± 0.062	1.202AsnHis: 1.202 ± 0.028	4.543AsnIle: 4.543 ± 0.057	4.547AsnLys: 4.547 ± 0.061	5.621AsnLeu: 5.621 ± 0.075	1.386AsnMet: 1.386 ± 0.03	3.376AsnAsn: 3.376 ± 0.054	2.584AsnPro: 2.584 ± 0.043	2.395AsnGln: 2.395 ± 0.041	2.277AsnArg: 2.277 ± 0.04	3.99AsnSer: 3.99 ± 0.061	3.1AsnThr: 3.1 ± 0.056	3.466AsnVal: 3.466 ± 0.048	0.84AsnTrp: 0.84 ± 0.021	2.859AsnTyr: 2.859 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.907ProAla: 1.907 ± 0.04	0.271ProCys: 0.271 ± 0.014	2.144ProAsp: 2.144 ± 0.039	2.918ProGlu: 2.918 ± 0.048	1.702ProPhe: 1.702 ± 0.033	1.983ProGly: 1.983 ± 0.044	0.591ProHis: 0.591 ± 0.021	2.431ProIle: 2.431 ± 0.038	2.501ProLys: 2.501 ± 0.047	2.714ProLeu: 2.714 ± 0.039	0.759ProMet: 0.759 ± 0.022	2.074ProAsn: 2.074 ± 0.034	0.714ProPro: 0.714 ± 0.023	1.052ProGln: 1.052 ± 0.026	0.962ProArg: 0.962 ± 0.025	1.967ProSer: 1.967 ± 0.035	1.671ProThr: 1.671 ± 0.033	2.442ProVal: 2.442 ± 0.05	0.328ProTrp: 0.328 ± 0.014	1.326ProTyr: 1.326 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	2.114GlnAla: 2.114 ± 0.042	0.225GlnCys: 0.225 ± 0.011	1.662GlnAsp: 1.662 ± 0.038	2.544GlnGlu: 2.544 ± 0.048	1.724GlnPhe: 1.724 ± 0.035	1.662GlnGly: 1.662 ± 0.033	0.56GlnHis: 0.56 ± 0.021	2.75GlnIle: 2.75 ± 0.043	3.071GlnLys: 3.071 ± 0.047	3.45GlnLeu: 3.45 ± 0.048	0.934GlnMet: 0.934 ± 0.024	2.161GlnAsn: 2.161 ± 0.038	0.927GlnPro: 0.927 ± 0.032	1.212GlnGln: 1.212 ± 0.032	1.227GlnArg: 1.227 ± 0.033	1.994GlnSer: 1.994 ± 0.032	1.686GlnThr: 1.686 ± 0.036	2.021GlnVal: 2.021 ± 0.033	0.347GlnTrp: 0.347 ± 0.016	1.402GlnTyr: 1.402 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.0ArgAla: 2.0 ± 0.036	0.282ArgCys: 0.282 ± 0.013	1.877ArgAsp: 1.877 ± 0.037	2.56ArgGlu: 2.56 ± 0.053	2.005ArgPhe: 2.005 ± 0.035	2.009ArgGly: 2.009 ± 0.039	0.625ArgHis: 0.625 ± 0.019	3.225ArgIle: 3.225 ± 0.049	3.38ArgLys: 3.38 ± 0.057	3.445ArgLeu: 3.445 ± 0.046	1.101ArgMet: 1.101 ± 0.029	2.31ArgAsn: 2.31 ± 0.043	1.045ArgPro: 1.045 ± 0.028	1.075ArgGln: 1.075 ± 0.029	1.517ArgArg: 1.517 ± 0.038	2.152ArgSer: 2.152 ± 0.04	1.846ArgThr: 1.846 ± 0.033	2.251ArgVal: 2.251 ± 0.037	0.411ArgTrp: 0.411 ± 0.015	1.699ArgTyr: 1.699 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.8SerAla: 3.8 ± 0.052	0.75SerCys: 0.75 ± 0.026	3.741SerAsp: 3.741 ± 0.05	4.339SerGlu: 4.339 ± 0.059	3.841SerPhe: 3.841 ± 0.052	4.714SerGly: 4.714 ± 0.074	1.174SerHis: 1.174 ± 0.028	5.424SerIle: 5.424 ± 0.074	5.053SerLys: 5.053 ± 0.056	6.185SerLeu: 6.185 ± 0.061	1.505SerMet: 1.505 ± 0.032	3.927SerAsn: 3.927 ± 0.053	2.04SerPro: 2.04 ± 0.037	2.015SerGln: 2.015 ± 0.036	2.307SerArg: 2.307 ± 0.039	4.542SerSer: 4.542 ± 0.075	3.24SerThr: 3.24 ± 0.047	4.314SerVal: 4.314 ± 0.049	0.788SerTrp: 0.788 ± 0.023	2.926SerTyr: 2.926 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	3.233ThrAla: 3.233 ± 0.057	0.482ThrCys: 0.482 ± 0.019	3.025ThrAsp: 3.025 ± 0.056	3.172ThrGlu: 3.172 ± 0.043	2.295ThrPhe: 2.295 ± 0.047	3.745ThrGly: 3.745 ± 0.059	0.952ThrHis: 0.952 ± 0.026	4.075ThrIle: 4.075 ± 0.062	3.467ThrLys: 3.467 ± 0.053	4.343ThrLeu: 4.343 ± 0.061	0.906ThrMet: 0.906 ± 0.023	2.908ThrAsn: 2.908 ± 0.055	2.109ThrPro: 2.109 ± 0.033	1.584ThrGln: 1.584 ± 0.036	1.665ThrArg: 1.665 ± 0.036	3.351ThrSer: 3.351 ± 0.056	2.736ThrThr: 2.736 ± 0.059	3.198ThrVal: 3.198 ± 0.06	0.528ThrTrp: 0.528 ± 0.019	2.176ThrTyr: 2.176 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	3.874ValAla: 3.874 ± 0.059	0.679ValCys: 0.679 ± 0.022	3.893ValAsp: 3.893 ± 0.051	4.364ValGlu: 4.364 ± 0.057	3.159ValPhe: 3.159 ± 0.047	3.85ValGly: 3.85 ± 0.055	0.982ValHis: 0.982 ± 0.024	4.691ValIle: 4.691 ± 0.057	4.84ValLys: 4.84 ± 0.058	5.71ValLeu: 5.71 ± 0.072	1.441ValMet: 1.441 ± 0.03	3.73ValAsn: 3.73 ± 0.052	2.133ValPro: 2.133 ± 0.041	1.821ValGln: 1.821 ± 0.034	2.298ValArg: 2.298 ± 0.039	4.421ValSer: 4.421 ± 0.066	2.864ValThr: 2.864 ± 0.064	4.2ValVal: 4.2 ± 0.059	0.65ValTrp: 0.65 ± 0.021	2.488ValTyr: 2.488 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.619TrpAla: 0.619 ± 0.021	0.123TrpCys: 0.123 ± 0.009	0.664TrpAsp: 0.664 ± 0.023	0.788TrpGlu: 0.788 ± 0.024	0.528TrpPhe: 0.528 ± 0.015	0.743TrpGly: 0.743 ± 0.022	0.218TrpHis: 0.218 ± 0.012	0.866TrpIle: 0.866 ± 0.027	0.904TrpLys: 0.904 ± 0.025	0.939TrpLeu: 0.939 ± 0.028	0.351TrpMet: 0.351 ± 0.015	0.727TrpAsn: 0.727 ± 0.023	0.233TrpPro: 0.233 ± 0.015	0.416TrpGln: 0.416 ± 0.019	0.434TrpArg: 0.434 ± 0.018	0.701TrpSer: 0.701 ± 0.023	0.563TrpThr: 0.563 ± 0.019	0.66TrpVal: 0.66 ± 0.018	0.141TrpTrp: 0.141 ± 0.01	0.47TrpTyr: 0.47 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.41TyrAla: 2.41 ± 0.041	0.461TyrCys: 0.461 ± 0.019	2.334TyrAsp: 2.334 ± 0.041	2.478TyrGlu: 2.478 ± 0.038	2.395TyrPhe: 2.395 ± 0.042	2.582TyrGly: 2.582 ± 0.047	0.934TyrHis: 0.934 ± 0.024	2.606TyrIle: 2.606 ± 0.046	3.169TyrLys: 3.169 ± 0.043	3.929TyrLeu: 3.929 ± 0.055	0.864TyrMet: 0.864 ± 0.024	2.524TyrAsn: 2.524 ± 0.045	1.557TyrPro: 1.557 ± 0.031	1.844TyrGln: 1.844 ± 0.035	1.857TyrArg: 1.857 ± 0.037	3.17TyrSer: 3.17 ± 0.047	2.323TyrThr: 2.323 ± 0.046	2.074TyrVal: 2.074 ± 0.037	0.553TyrTrp: 0.553 ± 0.022	1.945TyrTyr: 1.945 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4572 proteins (1604438 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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