Amino acid dipepetide frequency for Danionella translucida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.358AlaAla: 5.358 ± 0.027	1.221AlaCys: 1.221 ± 0.011	3.035AlaAsp: 3.035 ± 0.014	4.588AlaGlu: 4.588 ± 0.03	2.317AlaPhe: 2.317 ± 0.013	3.993AlaGly: 3.993 ± 0.024	1.51AlaHis: 1.51 ± 0.008	2.65AlaIle: 2.65 ± 0.015	3.197AlaLys: 3.197 ± 0.024	6.699AlaLeu: 6.699 ± 0.029	1.465AlaMet: 1.465 ± 0.009	2.106AlaAsn: 2.106 ± 0.011	3.508AlaPro: 3.508 ± 0.021	2.973AlaGln: 2.973 ± 0.017	3.085AlaArg: 3.085 ± 0.015	5.621AlaSer: 5.621 ± 0.02	3.176AlaThr: 3.176 ± 0.015	4.69AlaVal: 4.69 ± 0.018	0.618AlaTrp: 0.618 ± 0.006	1.339AlaTyr: 1.339 ± 0.01	0.0AlaXaa: 0.0 ± 0.0
Cys	1.24CysAla: 1.24 ± 0.011	0.637CysCys: 0.637 ± 0.007	1.116CysAsp: 1.116 ± 0.013	1.351CysGlu: 1.351 ± 0.014	0.917CysPhe: 0.917 ± 0.008	1.474CysGly: 1.474 ± 0.015	0.618CysHis: 0.618 ± 0.007	0.959CysIle: 0.959 ± 0.01	1.147CysLys: 1.147 ± 0.01	2.18CysLeu: 2.18 ± 0.015	0.462CysMet: 0.462 ± 0.005	0.818CysAsn: 0.818 ± 0.01	1.245CysPro: 1.245 ± 0.014	1.045CysGln: 1.045 ± 0.012	1.277CysArg: 1.277 ± 0.009	2.312CysSer: 2.312 ± 0.018	1.182CysThr: 1.182 ± 0.012	1.608CysVal: 1.608 ± 0.013	0.284CysTrp: 0.284 ± 0.004	0.553CysTyr: 0.553 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	3.091AspAla: 3.091 ± 0.017	1.132AspCys: 1.132 ± 0.012	2.994AspAsp: 2.994 ± 0.021	3.975AspGlu: 3.975 ± 0.023	2.094AspPhe: 2.094 ± 0.013	3.659AspGly: 3.659 ± 0.021	1.169AspHis: 1.169 ± 0.008	2.589AspIle: 2.589 ± 0.016	2.498AspLys: 2.498 ± 0.018	5.185AspLeu: 5.185 ± 0.023	1.161AspMet: 1.161 ± 0.009	1.756AspAsn: 1.756 ± 0.014	2.829AspPro: 2.829 ± 0.015	2.046AspGln: 2.046 ± 0.01	2.564AspArg: 2.564 ± 0.015	4.597AspSer: 4.597 ± 0.021	2.504AspThr: 2.504 ± 0.013	3.39AspVal: 3.39 ± 0.018	0.662AspTrp: 0.662 ± 0.007	1.426AspTyr: 1.426 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.752GluAla: 4.752 ± 0.029	1.334GluCys: 1.334 ± 0.015	4.597GluAsp: 4.597 ± 0.021	7.942GluGlu: 7.942 ± 0.059	2.061GluPhe: 2.061 ± 0.012	3.983GluGly: 3.983 ± 0.017	1.596GluHis: 1.596 ± 0.009	3.177GluIle: 3.177 ± 0.016	5.004GluLys: 5.004 ± 0.032	6.511GluLeu: 6.511 ± 0.035	1.917GluMet: 1.917 ± 0.013	2.991GluAsn: 2.991 ± 0.015	2.959GluPro: 2.959 ± 0.019	3.303GluGln: 3.303 ± 0.023	4.647GluArg: 4.647 ± 0.026	5.046GluSer: 5.046 ± 0.024	3.728GluThr: 3.728 ± 0.018	4.285GluVal: 4.285 ± 0.021	0.677GluTrp: 0.677 ± 0.007	1.473GluTyr: 1.473 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	1.869PheAla: 1.869 ± 0.011	0.925PheCys: 0.925 ± 0.007	1.739PheAsp: 1.739 ± 0.012	2.014PheGlu: 2.014 ± 0.011	1.56PhePhe: 1.56 ± 0.013	2.203PheGly: 2.203 ± 0.014	1.029PheHis: 1.029 ± 0.008	1.933PheIle: 1.933 ± 0.013	1.81PheLys: 1.81 ± 0.011	3.881PheLeu: 3.881 ± 0.021	0.791PheMet: 0.791 ± 0.007	1.51PheAsn: 1.51 ± 0.01	1.904PhePro: 1.904 ± 0.011	1.708PheGln: 1.708 ± 0.011	1.924PheArg: 1.924 ± 0.012	3.683PheSer: 3.683 ± 0.017	2.266PheThr: 2.266 ± 0.015	2.133PheVal: 2.133 ± 0.012	0.489PheTrp: 0.489 ± 0.006	1.138PheTyr: 1.138 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	3.862GlyAla: 3.862 ± 0.024	1.243GlyCys: 1.243 ± 0.011	3.171GlyAsp: 3.171 ± 0.018	4.001GlyGlu: 4.001 ± 0.026	2.582GlyPhe: 2.582 ± 0.018	4.407GlyGly: 4.407 ± 0.034	1.577GlyHis: 1.577 ± 0.011	2.637GlyIle: 2.637 ± 0.015	3.481GlyLys: 3.481 ± 0.019	5.381GlyLeu: 5.381 ± 0.026	1.425GlyMet: 1.425 ± 0.011	2.462GlyAsn: 2.462 ± 0.016	3.115GlyPro: 3.115 ± 0.044	2.589GlyGln: 2.589 ± 0.015	3.441GlyArg: 3.441 ± 0.019	5.824GlySer: 5.824 ± 0.029	3.295GlyThr: 3.295 ± 0.018	3.808GlyVal: 3.808 ± 0.02	0.73GlyTrp: 0.73 ± 0.008	1.676GlyTyr: 1.676 ± 0.016	0.0GlyXaa: 0.0 ± 0.0
His	1.337HisAla: 1.337 ± 0.01	0.742HisCys: 0.742 ± 0.007	0.951HisAsp: 0.951 ± 0.007	1.335HisGlu: 1.335 ± 0.01	1.099HisPhe: 1.099 ± 0.008	1.525HisGly: 1.525 ± 0.011	1.0HisHis: 1.0 ± 0.011	1.253HisIle: 1.253 ± 0.01	1.273HisLys: 1.273 ± 0.009	2.708HisLeu: 2.708 ± 0.014	0.622HisMet: 0.622 ± 0.006	0.98HisAsn: 0.98 ± 0.009	1.597HisPro: 1.597 ± 0.013	1.3HisGln: 1.3 ± 0.009	1.627HisArg: 1.627 ± 0.011	2.54HisSer: 2.54 ± 0.012	1.544HisThr: 1.544 ± 0.01	1.447HisVal: 1.447 ± 0.01	0.348HisTrp: 0.348 ± 0.004	0.792HisTyr: 0.792 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.501IleAla: 2.501 ± 0.014	1.094IleCys: 1.094 ± 0.008	2.179IleAsp: 2.179 ± 0.013	2.604IleGlu: 2.604 ± 0.015	1.781IlePhe: 1.781 ± 0.012	2.298IleGly: 2.298 ± 0.015	1.284IleHis: 1.284 ± 0.009	2.39IleIle: 2.39 ± 0.017	2.58IleLys: 2.58 ± 0.016	4.268IleLeu: 4.268 ± 0.018	1.057IleMet: 1.057 ± 0.008	1.974IleAsn: 1.974 ± 0.014	2.595IlePro: 2.595 ± 0.014	2.323IleGln: 2.323 ± 0.013	2.526IleArg: 2.526 ± 0.013	4.232IleSer: 4.232 ± 0.018	2.846IleThr: 2.846 ± 0.016	2.508IleVal: 2.508 ± 0.013	0.482IleTrp: 0.482 ± 0.005	1.294IleTyr: 1.294 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.7LysAla: 3.7 ± 0.024	1.063LysCys: 1.063 ± 0.011	3.227LysAsp: 3.227 ± 0.022	4.782LysGlu: 4.782 ± 0.03	1.541LysPhe: 1.541 ± 0.012	3.148LysGly: 3.148 ± 0.021	1.489LysHis: 1.489 ± 0.011	2.562LysIle: 2.562 ± 0.014	4.46LysLys: 4.46 ± 0.036	5.067LysLeu: 5.067 ± 0.025	1.458LysMet: 1.458 ± 0.01	2.365LysAsn: 2.365 ± 0.013	3.033LysPro: 3.033 ± 0.018	2.66LysGln: 2.66 ± 0.018	3.49LysArg: 3.49 ± 0.021	4.17LysSer: 4.17 ± 0.017	3.201LysThr: 3.201 ± 0.016	3.352LysVal: 3.352 ± 0.018	0.542LysTrp: 0.542 ± 0.006	1.382LysTyr: 1.382 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	5.794LeuAla: 5.794 ± 0.024	2.297LeuCys: 2.297 ± 0.015	4.852LeuAsp: 4.852 ± 0.022	7.065LeuGlu: 7.065 ± 0.045	3.453LeuPhe: 3.453 ± 0.019	5.001LeuGly: 5.001 ± 0.021	2.748LeuHis: 2.748 ± 0.015	3.935LeuIle: 3.935 ± 0.019	5.888LeuLys: 5.888 ± 0.028	10.288LeuLeu: 10.288 ± 0.049	2.211LeuMet: 2.211 ± 0.012	3.878LeuAsn: 3.878 ± 0.018	5.279LeuPro: 5.279 ± 0.024	5.75LeuGln: 5.75 ± 0.033	5.726LeuArg: 5.726 ± 0.025	8.786LeuSer: 8.786 ± 0.031	5.075LeuThr: 5.075 ± 0.019	5.484LeuVal: 5.484 ± 0.024	1.043LeuTrp: 1.043 ± 0.009	2.436LeuTyr: 2.436 ± 0.014	0.0LeuXaa: 0.0 ± 0.0
Met	1.782MetAla: 1.782 ± 0.011	0.471MetCys: 0.471 ± 0.005	1.413MetAsp: 1.413 ± 0.008	2.077MetGlu: 2.077 ± 0.015	0.862MetPhe: 0.862 ± 0.008	1.366MetGly: 1.366 ± 0.01	0.512MetHis: 0.512 ± 0.005	0.911MetIle: 0.911 ± 0.008	1.497MetLys: 1.497 ± 0.011	2.099MetLeu: 2.099 ± 0.013	0.715MetMet: 0.715 ± 0.007	0.961MetAsn: 0.961 ± 0.009	1.113MetPro: 1.113 ± 0.009	0.993MetGln: 0.993 ± 0.007	1.207MetArg: 1.207 ± 0.009	1.939MetSer: 1.939 ± 0.01	1.189MetThr: 1.189 ± 0.009	1.489MetVal: 1.489 ± 0.009	0.242MetTrp: 0.242 ± 0.003	0.572MetTyr: 0.572 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.241AsnAla: 2.241 ± 0.013	0.842AsnCys: 0.842 ± 0.01	1.703AsnAsp: 1.703 ± 0.013	2.27AsnGlu: 2.27 ± 0.014	1.396AsnPhe: 1.396 ± 0.01	2.761AsnGly: 2.761 ± 0.02	1.021AsnHis: 1.021 ± 0.008	2.21AsnIle: 2.21 ± 0.013	2.226AsnLys: 2.226 ± 0.012	3.718AsnLeu: 3.718 ± 0.016	1.009AsnMet: 1.009 ± 0.008	1.742AsnAsn: 1.742 ± 0.014	2.334AsnPro: 2.334 ± 0.014	1.858AsnGln: 1.858 ± 0.013	2.025AsnArg: 2.025 ± 0.012	3.391AsnSer: 3.391 ± 0.014	2.336AsnThr: 2.336 ± 0.014	2.297AsnVal: 2.297 ± 0.013	0.439AsnTrp: 0.439 ± 0.005	1.056AsnTyr: 1.056 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	3.83ProAla: 3.83 ± 0.02	1.101ProCys: 1.101 ± 0.012	2.772ProAsp: 2.772 ± 0.016	4.012ProGlu: 4.012 ± 0.018	1.815ProPhe: 1.815 ± 0.01	4.092ProGly: 4.092 ± 0.048	1.436ProHis: 1.436 ± 0.01	1.987ProIle: 1.987 ± 0.012	2.636ProLys: 2.636 ± 0.018	5.018ProLeu: 5.018 ± 0.022	1.036ProMet: 1.036 ± 0.008	1.949ProAsn: 1.949 ± 0.014	5.158ProPro: 5.158 ± 0.047	2.646ProGln: 2.646 ± 0.022	2.742ProArg: 2.742 ± 0.018	5.733ProSer: 5.733 ± 0.033	2.871ProThr: 2.871 ± 0.021	3.845ProVal: 3.845 ± 0.02	0.523ProTrp: 0.523 ± 0.007	1.26ProTyr: 1.26 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	3.069GlnAla: 3.069 ± 0.018	1.021GlnCys: 1.021 ± 0.011	2.331GlnAsp: 2.331 ± 0.013	3.714GlnGlu: 3.714 ± 0.023	1.401GlnPhe: 1.401 ± 0.01	2.619GlnGly: 2.619 ± 0.02	1.356GlnHis: 1.356 ± 0.01	2.136GlnIle: 2.136 ± 0.012	2.794GlnLys: 2.794 ± 0.019	4.499GlnLeu: 4.499 ± 0.028	1.226GlnMet: 1.226 ± 0.009	1.966GlnAsn: 1.966 ± 0.01	2.415GlnPro: 2.415 ± 0.018	3.125GlnGln: 3.125 ± 0.029	3.18GlnArg: 3.18 ± 0.019	3.86GlnSer: 3.86 ± 0.019	2.806GlnThr: 2.806 ± 0.016	2.677GlnVal: 2.677 ± 0.013	0.541GlnTrp: 0.541 ± 0.005	1.143GlnTyr: 1.143 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.561ArgAla: 3.561 ± 0.017	1.283ArgCys: 1.283 ± 0.013	2.917ArgAsp: 2.917 ± 0.014	4.17ArgGlu: 4.17 ± 0.025	2.012ArgPhe: 2.012 ± 0.012	3.502ArgGly: 3.502 ± 0.024	1.468ArgHis: 1.468 ± 0.01	2.457ArgIle: 2.457 ± 0.012	3.638ArgLys: 3.638 ± 0.02	5.297ArgLeu: 5.297 ± 0.023	1.33ArgMet: 1.33 ± 0.009	2.204ArgAsn: 2.204 ± 0.013	2.706ArgPro: 2.706 ± 0.015	2.543ArgGln: 2.543 ± 0.016	4.362ArgArg: 4.362 ± 0.024	4.958ArgSer: 4.958 ± 0.023	2.865ArgThr: 2.865 ± 0.014	3.436ArgVal: 3.436 ± 0.017	0.672ArgTrp: 0.672 ± 0.006	1.392ArgTyr: 1.392 ± 0.01	0.0ArgXaa: 0.0 ± 0.0
Ser	5.711SerAla: 5.711 ± 0.023	2.066SerCys: 2.066 ± 0.02	4.505SerAsp: 4.505 ± 0.022	5.75SerGlu: 5.75 ± 0.022	3.414SerPhe: 3.414 ± 0.016	5.798SerGly: 5.798 ± 0.026	2.218SerHis: 2.218 ± 0.013	3.797SerIle: 3.797 ± 0.019	4.243SerLys: 4.243 ± 0.017	8.854SerLeu: 8.854 ± 0.033	1.888SerMet: 1.888 ± 0.011	3.138SerAsn: 3.138 ± 0.017	5.982SerPro: 5.982 ± 0.041	4.064SerGln: 4.064 ± 0.019	4.943SerArg: 4.943 ± 0.021	11.341SerSer: 11.341 ± 0.055	5.187SerThr: 5.187 ± 0.035	5.865SerVal: 5.865 ± 0.024	1.037SerTrp: 1.037 ± 0.008	2.051SerTyr: 2.051 ± 0.011	0.0SerXaa: 0.0 ± 0.0
Thr	3.775ThrAla: 3.775 ± 0.016	1.301ThrCys: 1.301 ± 0.018	2.86ThrAsp: 2.86 ± 0.016	3.883ThrGlu: 3.883 ± 0.022	2.018ThrPhe: 2.018 ± 0.013	3.596ThrGly: 3.596 ± 0.021	1.444ThrHis: 1.444 ± 0.01	2.468ThrIle: 2.468 ± 0.015	2.567ThrLys: 2.567 ± 0.015	5.503ThrLeu: 5.503 ± 0.02	1.174ThrMet: 1.174 ± 0.009	1.98ThrAsn: 1.98 ± 0.015	3.648ThrPro: 3.648 ± 0.026	2.456ThrGln: 2.456 ± 0.015	2.52ThrArg: 2.52 ± 0.012	4.984ThrSer: 4.984 ± 0.032	3.238ThrThr: 3.238 ± 0.038	3.966ThrVal: 3.966 ± 0.022	0.603ThrTrp: 0.603 ± 0.007	1.299ThrTyr: 1.299 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	3.785ValAla: 3.785 ± 0.017	1.743ValCys: 1.743 ± 0.013	3.103ValAsp: 3.103 ± 0.015	4.195ValGlu: 4.195 ± 0.019	2.613ValPhe: 2.613 ± 0.016	3.169ValGly: 3.169 ± 0.018	1.573ValHis: 1.573 ± 0.009	2.897ValIle: 2.897 ± 0.016	3.627ValLys: 3.627 ± 0.018	6.351ValLeu: 6.351 ± 0.025	1.505ValMet: 1.505 ± 0.009	2.489ValAsn: 2.489 ± 0.015	3.433ValPro: 3.433 ± 0.021	2.889ValGln: 2.889 ± 0.016	3.175ValArg: 3.175 ± 0.015	5.603ValSer: 5.603 ± 0.023	3.771ValThr: 3.771 ± 0.021	4.124ValVal: 4.124 ± 0.028	0.747ValTrp: 0.747 ± 0.007	1.701ValTyr: 1.701 ± 0.012	0.0ValXaa: 0.0 ± 0.0
Trp	0.622TrpAla: 0.622 ± 0.006	0.255TrpCys: 0.255 ± 0.004	0.605TrpAsp: 0.605 ± 0.006	0.709TrpGlu: 0.709 ± 0.007	0.473TrpPhe: 0.473 ± 0.005	0.583TrpGly: 0.583 ± 0.007	0.274TrpHis: 0.274 ± 0.004	0.572TrpIle: 0.572 ± 0.006	0.721TrpLys: 0.721 ± 0.006	1.105TrpLeu: 1.105 ± 0.009	0.349TrpMet: 0.349 ± 0.006	0.491TrpAsn: 0.491 ± 0.005	0.426TrpPro: 0.426 ± 0.005	0.459TrpGln: 0.459 ± 0.005	0.769TrpArg: 0.769 ± 0.007	0.987TrpSer: 0.987 ± 0.009	0.678TrpThr: 0.678 ± 0.007	0.655TrpVal: 0.655 ± 0.006	0.179TrpTrp: 0.179 ± 0.003	0.304TrpTyr: 0.304 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.268TyrAla: 1.268 ± 0.009	0.652TyrCys: 0.652 ± 0.005	1.247TyrAsp: 1.247 ± 0.011	1.544TyrGlu: 1.544 ± 0.011	1.103TyrPhe: 1.103 ± 0.008	1.53TyrGly: 1.53 ± 0.012	0.703TyrHis: 0.703 ± 0.007	1.295TyrIle: 1.295 ± 0.01	1.406TyrLys: 1.406 ± 0.021	2.379TyrLeu: 2.379 ± 0.014	0.609TyrMet: 0.609 ± 0.006	1.114TyrAsn: 1.114 ± 0.008	1.181TyrPro: 1.181 ± 0.01	1.148TyrGln: 1.148 ± 0.008	1.544TyrArg: 1.544 ± 0.012	2.247TyrSer: 2.247 ± 0.013	1.525TyrThr: 1.525 ± 0.012	1.436TyrVal: 1.436 ± 0.011	0.357TyrTrp: 0.357 ± 0.006	0.857TyrTyr: 0.857 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 32815 proteins (20250203 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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