Amino acid dipepetide frequency for Phytomonas sp. isolate EM1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.964AlaAla: 7.964 ± 0.074	1.405AlaCys: 1.405 ± 0.021	3.364AlaAsp: 3.364 ± 0.03	5.061AlaGlu: 5.061 ± 0.051	2.97AlaPhe: 2.97 ± 0.033	4.145AlaGly: 4.145 ± 0.042	1.953AlaHis: 1.953 ± 0.026	3.532AlaIle: 3.532 ± 0.037	3.615AlaLys: 3.615 ± 0.044	8.269AlaLeu: 8.269 ± 0.058	2.02AlaMet: 2.02 ± 0.027	2.659AlaAsn: 2.659 ± 0.03	3.857AlaPro: 3.857 ± 0.045	2.878AlaGln: 2.878 ± 0.038	4.996AlaArg: 4.996 ± 0.047	6.935AlaSer: 6.935 ± 0.055	4.439AlaThr: 4.439 ± 0.042	5.365AlaVal: 5.365 ± 0.041	0.823AlaTrp: 0.823 ± 0.017	1.908AlaTyr: 1.908 ± 0.025	0.003AlaXaa: 0.003 ± 0.001
Cys	1.496CysAla: 1.496 ± 0.021	0.498CysCys: 0.498 ± 0.013	0.98CysAsp: 0.98 ± 0.017	1.15CysGlu: 1.15 ± 0.02	0.901CysPhe: 0.901 ± 0.018	1.482CysGly: 1.482 ± 0.027	0.468CysHis: 0.468 ± 0.014	1.036CysIle: 1.036 ± 0.021	0.718CysLys: 0.718 ± 0.015	1.785CysLeu: 1.785 ± 0.025	0.462CysMet: 0.462 ± 0.012	0.676CysAsn: 0.676 ± 0.016	0.891CysPro: 0.891 ± 0.019	0.552CysGln: 0.552 ± 0.012	1.21CysArg: 1.21 ± 0.02	1.587CysSer: 1.587 ± 0.025	1.02CysThr: 1.02 ± 0.021	1.555CysVal: 1.555 ± 0.028	0.203CysTrp: 0.203 ± 0.008	0.551CysTyr: 0.551 ± 0.018	0.001CysXaa: 0.001 ± 0.0
Asp	4.698AspAla: 4.698 ± 0.04	0.81AspCys: 0.81 ± 0.016	3.245AspAsp: 3.245 ± 0.044	3.895AspGlu: 3.895 ± 0.043	2.026AspPhe: 2.026 ± 0.03	3.472AspGly: 3.472 ± 0.038	1.151AspHis: 1.151 ± 0.022	2.531AspIle: 2.531 ± 0.033	2.019AspLys: 2.019 ± 0.027	4.642AspLeu: 4.642 ± 0.045	1.117AspMet: 1.117 ± 0.019	1.782AspAsn: 1.782 ± 0.025	2.897AspPro: 2.897 ± 0.034	1.388AspGln: 1.388 ± 0.024	2.792AspArg: 2.792 ± 0.031	3.922AspSer: 3.922 ± 0.038	2.657AspThr: 2.657 ± 0.029	3.715AspVal: 3.715 ± 0.035	0.516AspTrp: 0.516 ± 0.015	1.339AspTyr: 1.339 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.994GluAla: 5.994 ± 0.055	1.078GluCys: 1.078 ± 0.019	3.807GluAsp: 3.807 ± 0.037	6.336GluGlu: 6.336 ± 0.069	1.957GluPhe: 1.957 ± 0.027	4.662GluGly: 4.662 ± 0.047	1.519GluHis: 1.519 ± 0.022	2.931GluIle: 2.931 ± 0.03	4.009GluLys: 4.009 ± 0.047	6.398GluLeu: 6.398 ± 0.063	1.731GluMet: 1.731 ± 0.023	2.684GluAsn: 2.684 ± 0.027	2.293GluPro: 2.293 ± 0.028	2.383GluGln: 2.383 ± 0.034	4.745GluArg: 4.745 ± 0.051	4.609GluSer: 4.609 ± 0.038	3.177GluThr: 3.177 ± 0.035	4.685GluVal: 4.685 ± 0.039	0.758GluTrp: 0.758 ± 0.016	1.624GluTyr: 1.624 ± 0.023	0.001GluXaa: 0.001 ± 0.0
Phe	2.62PheAla: 2.62 ± 0.032	0.848PheCys: 0.848 ± 0.017	1.984PheAsp: 1.984 ± 0.027	2.104PheGlu: 2.104 ± 0.027	2.053PhePhe: 2.053 ± 0.034	2.078PheGly: 2.078 ± 0.031	1.163PheHis: 1.163 ± 0.021	1.962PheIle: 1.962 ± 0.03	1.432PheLys: 1.432 ± 0.024	4.096PheLeu: 4.096 ± 0.045	0.903PheMet: 0.903 ± 0.018	1.493PheAsn: 1.493 ± 0.024	2.121PhePro: 2.121 ± 0.023	1.321PheGln: 1.321 ± 0.022	2.211PheArg: 2.211 ± 0.029	3.615PheSer: 3.615 ± 0.039	2.165PheThr: 2.165 ± 0.03	2.618PheVal: 2.618 ± 0.032	0.417PheTrp: 0.417 ± 0.012	1.22PheTyr: 1.22 ± 0.023	0.001PheXaa: 0.001 ± 0.001
Gly	4.528GlyAla: 4.528 ± 0.048	1.223GlyCys: 1.223 ± 0.021	3.311GlyAsp: 3.311 ± 0.037	4.165GlyGlu: 4.165 ± 0.051	2.287GlyPhe: 2.287 ± 0.032	5.637GlyGly: 5.637 ± 0.071	1.275GlyHis: 1.275 ± 0.021	2.934GlyIle: 2.934 ± 0.035	3.195GlyLys: 3.195 ± 0.036	4.965GlyLeu: 4.965 ± 0.046	1.47GlyMet: 1.47 ± 0.023	2.507GlyAsn: 2.507 ± 0.032	2.198GlyPro: 2.198 ± 0.03	1.562GlyGln: 1.562 ± 0.023	3.774GlyArg: 3.774 ± 0.049	5.123GlySer: 5.123 ± 0.052	3.063GlyThr: 3.063 ± 0.037	4.593GlyVal: 4.593 ± 0.049	0.683GlyTrp: 0.683 ± 0.015	1.595GlyTyr: 1.595 ± 0.021	0.005GlyXaa: 0.005 ± 0.001
His	2.122HisAla: 2.122 ± 0.025	0.561HisCys: 0.561 ± 0.015	1.276HisAsp: 1.276 ± 0.022	1.607HisGlu: 1.607 ± 0.02	1.101HisPhe: 1.101 ± 0.02	1.58HisGly: 1.58 ± 0.022	1.032HisHis: 1.032 ± 0.022	1.301HisIle: 1.301 ± 0.02	0.985HisLys: 0.985 ± 0.017	2.682HisLeu: 2.682 ± 0.034	0.539HisMet: 0.539 ± 0.013	0.992HisAsn: 0.992 ± 0.018	1.77HisPro: 1.77 ± 0.025	1.079HisGln: 1.079 ± 0.02	1.918HisArg: 1.918 ± 0.026	2.161HisSer: 2.161 ± 0.028	1.524HisThr: 1.524 ± 0.024	1.698HisVal: 1.698 ± 0.022	0.291HisTrp: 0.291 ± 0.01	0.819HisTyr: 0.819 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.631IleAla: 3.631 ± 0.032	0.898IleCys: 0.898 ± 0.019	2.482IleAsp: 2.482 ± 0.026	2.984IleGlu: 2.984 ± 0.033	1.957IlePhe: 1.957 ± 0.026	2.416IleGly: 2.416 ± 0.034	1.32IleHis: 1.32 ± 0.023	2.171IleIle: 2.171 ± 0.032	2.123IleLys: 2.123 ± 0.029	4.53IleLeu: 4.53 ± 0.042	0.985IleMet: 0.985 ± 0.018	1.773IleAsn: 1.773 ± 0.029	2.826IlePro: 2.826 ± 0.035	1.9IleGln: 1.9 ± 0.03	2.887IleArg: 2.887 ± 0.033	3.919IleSer: 3.919 ± 0.04	2.59IleThr: 2.59 ± 0.03	2.957IleVal: 2.957 ± 0.035	0.416IleTrp: 0.416 ± 0.013	1.235IleTyr: 1.235 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	3.578LysAla: 3.578 ± 0.042	0.749LysCys: 0.749 ± 0.018	2.605LysAsp: 2.605 ± 0.036	3.867LysGlu: 3.867 ± 0.043	1.28LysPhe: 1.28 ± 0.02	3.108LysGly: 3.108 ± 0.036	1.243LysHis: 1.243 ± 0.022	2.085LysIle: 2.085 ± 0.029	3.212LysLys: 3.212 ± 0.05	4.233LysLeu: 4.233 ± 0.046	1.177LysMet: 1.177 ± 0.021	1.992LysAsn: 1.992 ± 0.027	2.169LysPro: 2.169 ± 0.03	1.899LysGln: 1.899 ± 0.031	3.542LysArg: 3.542 ± 0.041	3.424LysSer: 3.424 ± 0.037	2.455LysThr: 2.455 ± 0.032	2.866LysVal: 2.866 ± 0.036	0.458LysTrp: 0.458 ± 0.012	1.279LysTyr: 1.279 ± 0.022	0.001LysXaa: 0.001 ± 0.0
Leu	6.949LeuAla: 6.949 ± 0.047	2.17LeuCys: 2.17 ± 0.029	4.818LeuAsp: 4.818 ± 0.044	6.36LeuGlu: 6.36 ± 0.065	3.894LeuPhe: 3.894 ± 0.044	4.757LeuGly: 4.757 ± 0.041	3.06LeuHis: 3.06 ± 0.03	4.013LeuIle: 4.013 ± 0.042	4.742LeuLys: 4.742 ± 0.045	10.577LeuLeu: 10.577 ± 0.084	2.219LeuMet: 2.219 ± 0.029	3.758LeuAsn: 3.758 ± 0.035	5.704LeuPro: 5.704 ± 0.046	4.591LeuGln: 4.591 ± 0.05	7.51LeuArg: 7.51 ± 0.059	8.679LeuSer: 8.679 ± 0.06	4.913LeuThr: 4.913 ± 0.04	5.671LeuVal: 5.671 ± 0.052	1.137LeuTrp: 1.137 ± 0.02	2.64LeuTyr: 2.64 ± 0.032	0.001LeuXaa: 0.001 ± 0.001
Met	1.665MetAla: 1.665 ± 0.023	0.452MetCys: 0.452 ± 0.012	1.276MetAsp: 1.276 ± 0.023	1.745MetGlu: 1.745 ± 0.024	0.748MetPhe: 0.748 ± 0.016	1.322MetGly: 1.322 ± 0.019	0.641MetHis: 0.641 ± 0.014	0.987MetIle: 0.987 ± 0.02	1.185MetLys: 1.185 ± 0.019	2.339MetLeu: 2.339 ± 0.028	0.62MetMet: 0.62 ± 0.017	1.025MetAsn: 1.025 ± 0.018	1.236MetPro: 1.236 ± 0.022	1.1MetGln: 1.1 ± 0.019	1.776MetArg: 1.776 ± 0.024	1.828MetSer: 1.828 ± 0.025	1.173MetThr: 1.173 ± 0.021	1.364MetVal: 1.364 ± 0.021	0.274MetTrp: 0.274 ± 0.011	0.563MetTyr: 0.563 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.246AsnAla: 3.246 ± 0.031	0.659AsnCys: 0.659 ± 0.017	2.087AsnAsp: 2.087 ± 0.026	2.561AsnGlu: 2.561 ± 0.031	1.502AsnPhe: 1.502 ± 0.024	2.418AsnGly: 2.418 ± 0.034	1.012AsnHis: 1.012 ± 0.02	2.02AsnIle: 2.02 ± 0.029	1.687AsnLys: 1.687 ± 0.023	3.332AsnLeu: 3.332 ± 0.036	0.856AsnMet: 0.856 ± 0.018	1.58AsnAsn: 1.58 ± 0.025	2.38AsnPro: 2.38 ± 0.031	1.258AsnGln: 1.258 ± 0.021	2.259AsnArg: 2.259 ± 0.028	3.234AsnSer: 3.234 ± 0.038	2.329AsnThr: 2.329 ± 0.027	2.445AsnVal: 2.445 ± 0.025	0.344AsnTrp: 0.344 ± 0.011	1.094AsnTyr: 1.094 ± 0.019	0.001AsnXaa: 0.001 ± 0.0
Pro	3.602ProAla: 3.602 ± 0.034	0.925ProCys: 0.925 ± 0.02	2.257ProAsp: 2.257 ± 0.029	3.0ProGlu: 3.0 ± 0.035	2.28ProPhe: 2.28 ± 0.029	2.537ProGly: 2.537 ± 0.037	1.641ProHis: 1.641 ± 0.024	2.342ProIle: 2.342 ± 0.029	2.196ProLys: 2.196 ± 0.03	5.481ProLeu: 5.481 ± 0.053	1.05ProMet: 1.05 ± 0.019	2.078ProAsn: 2.078 ± 0.026	4.479ProPro: 4.479 ± 0.062	2.11ProGln: 2.11 ± 0.027	3.25ProArg: 3.25 ± 0.041	5.701ProSer: 5.701 ± 0.061	3.28ProThr: 3.28 ± 0.038	3.002ProVal: 3.002 ± 0.035	0.53ProTrp: 0.53 ± 0.014	1.385ProTyr: 1.385 ± 0.02	0.004ProXaa: 0.004 ± 0.001
Gln	2.637GlnAla: 2.637 ± 0.033	0.708GlnCys: 0.708 ± 0.017	1.631GlnAsp: 1.631 ± 0.026	2.629GlnGlu: 2.629 ± 0.031	1.099GlnPhe: 1.099 ± 0.018	2.03GlnGly: 2.03 ± 0.028	1.237GlnHis: 1.237 ± 0.022	1.638GlnIle: 1.638 ± 0.026	2.097GlnLys: 2.097 ± 0.029	4.14GlnLeu: 4.14 ± 0.049	0.914GlnMet: 0.914 ± 0.016	1.456GlnAsn: 1.456 ± 0.023	1.827GlnPro: 1.827 ± 0.026	2.266GlnGln: 2.266 ± 0.044	3.342GlnArg: 3.342 ± 0.037	2.683GlnSer: 2.683 ± 0.037	1.999GlnThr: 1.999 ± 0.027	2.058GlnVal: 2.058 ± 0.026	0.462GlnTrp: 0.462 ± 0.011	1.031GlnTyr: 1.031 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.994ArgAla: 4.994 ± 0.055	1.459ArgCys: 1.459 ± 0.023	3.25ArgAsp: 3.25 ± 0.028	4.806ArgGlu: 4.806 ± 0.051	2.469ArgPhe: 2.469 ± 0.032	4.245ArgGly: 4.245 ± 0.052	1.864ArgHis: 1.864 ± 0.026	3.174ArgIle: 3.174 ± 0.033	3.273ArgLys: 3.273 ± 0.037	6.602ArgLeu: 6.602 ± 0.049	1.612ArgMet: 1.612 ± 0.022	2.431ArgAsn: 2.431 ± 0.029	2.912ArgPro: 2.912 ± 0.028	2.866ArgGln: 2.866 ± 0.036	5.898ArgArg: 5.898 ± 0.056	5.0ArgSer: 5.0 ± 0.042	3.109ArgThr: 3.109 ± 0.033	4.428ArgVal: 4.428 ± 0.043	0.91ArgTrp: 0.91 ± 0.018	2.008ArgTyr: 2.008 ± 0.027	0.004ArgXaa: 0.004 ± 0.001
Ser	6.186SerAla: 6.186 ± 0.047	1.622SerCys: 1.622 ± 0.026	4.074SerAsp: 4.074 ± 0.039	4.892SerGlu: 4.892 ± 0.036	3.543SerPhe: 3.543 ± 0.036	5.063SerGly: 5.063 ± 0.047	2.2SerHis: 2.2 ± 0.025	4.079SerIle: 4.079 ± 0.043	3.859SerLys: 3.859 ± 0.035	8.181SerLeu: 8.181 ± 0.055	1.963SerMet: 1.963 ± 0.024	3.417SerAsn: 3.417 ± 0.037	5.057SerPro: 5.057 ± 0.054	2.909SerGln: 2.909 ± 0.034	5.09SerArg: 5.09 ± 0.046	9.646SerSer: 9.646 ± 0.094	5.376SerThr: 5.376 ± 0.049	5.14SerVal: 5.14 ± 0.042	0.792SerTrp: 0.792 ± 0.018	2.051SerTyr: 2.051 ± 0.031	0.002SerXaa: 0.002 ± 0.001
Thr	4.322ThrAla: 4.322 ± 0.042	0.91ThrCys: 0.91 ± 0.019	2.455ThrAsp: 2.455 ± 0.027	3.177ThrGlu: 3.177 ± 0.031	2.068ThrPhe: 2.068 ± 0.03	2.993ThrGly: 2.993 ± 0.034	1.468ThrHis: 1.468 ± 0.022	2.543ThrIle: 2.543 ± 0.032	2.431ThrLys: 2.431 ± 0.028	5.422ThrLeu: 5.422 ± 0.051	1.183ThrMet: 1.183 ± 0.018	2.086ThrAsn: 2.086 ± 0.029	3.651ThrPro: 3.651 ± 0.038	2.038ThrGln: 2.038 ± 0.026	3.152ThrArg: 3.152 ± 0.037	4.996ThrSer: 4.996 ± 0.053	3.739ThrThr: 3.739 ± 0.041	3.336ThrVal: 3.336 ± 0.039	0.502ThrTrp: 0.502 ± 0.012	1.324ThrTyr: 1.324 ± 0.022	0.002ThrXaa: 0.002 ± 0.001
Val	5.198ValAla: 5.198 ± 0.043	1.41ValCys: 1.41 ± 0.026	3.673ValAsp: 3.673 ± 0.035	4.761ValGlu: 4.761 ± 0.04	2.651ValPhe: 2.651 ± 0.036	3.842ValGly: 3.842 ± 0.04	1.688ValHis: 1.688 ± 0.023	2.817ValIle: 2.817 ± 0.034	2.825ValLys: 2.825 ± 0.03	6.754ValLeu: 6.754 ± 0.057	1.557ValMet: 1.557 ± 0.022	2.357ValAsn: 2.357 ± 0.03	3.218ValPro: 3.218 ± 0.035	2.39ValGln: 2.39 ± 0.033	4.203ValArg: 4.203 ± 0.041	5.357ValSer: 5.357 ± 0.047	2.786ValThr: 2.786 ± 0.032	5.164ValVal: 5.164 ± 0.041	0.773ValTrp: 0.773 ± 0.016	1.805ValTyr: 1.805 ± 0.027	0.002ValXaa: 0.002 ± 0.001
Trp	0.695TrpAla: 0.695 ± 0.016	0.277TrpCys: 0.277 ± 0.009	0.578TrpAsp: 0.578 ± 0.014	0.687TrpGlu: 0.687 ± 0.018	0.394TrpPhe: 0.394 ± 0.011	0.665TrpGly: 0.665 ± 0.017	0.254TrpHis: 0.254 ± 0.01	0.533TrpIle: 0.533 ± 0.014	0.577TrpLys: 0.577 ± 0.015	1.039TrpLeu: 1.039 ± 0.02	0.335TrpMet: 0.335 ± 0.01	0.478TrpAsn: 0.478 ± 0.012	0.349TrpPro: 0.349 ± 0.011	0.405TrpGln: 0.405 ± 0.011	0.954TrpArg: 0.954 ± 0.023	0.821TrpSer: 0.821 ± 0.019	0.491TrpThr: 0.491 ± 0.013	0.72TrpVal: 0.72 ± 0.017	0.195TrpTrp: 0.195 ± 0.008	0.334TrpTyr: 0.334 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.035TyrAla: 2.035 ± 0.029	0.56TyrCys: 0.56 ± 0.013	1.46TyrAsp: 1.46 ± 0.026	1.593TyrGlu: 1.593 ± 0.023	1.242TyrPhe: 1.242 ± 0.023	1.643TyrGly: 1.643 ± 0.024	0.846TyrHis: 0.846 ± 0.018	1.371TyrIle: 1.371 ± 0.021	1.042TyrLys: 1.042 ± 0.022	2.69TyrLeu: 2.69 ± 0.034	0.608TyrMet: 0.608 ± 0.014	1.079TyrAsn: 1.079 ± 0.018	1.294TyrPro: 1.294 ± 0.021	0.987TyrGln: 0.987 ± 0.018	1.804TyrArg: 1.804 ± 0.024	1.897TyrSer: 1.897 ± 0.026	1.512TyrThr: 1.512 ± 0.023	1.849TyrVal: 1.849 ± 0.025	0.296TyrTrp: 0.296 ± 0.011	1.017TyrTyr: 1.017 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	5.921XaaXaa: 5.921 ± 1.225

Statistics based on 6361 proteins (3125077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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