Amino acid dipepetide frequency for Bifidobacterium tsurumiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.556AlaAla: 11.556 ± 0.236
0.966AlaCys: 0.966 ± 0.042
6.484AlaAsp: 6.484 ± 0.13
5.648AlaGlu: 5.648 ± 0.11
3.476AlaPhe: 3.476 ± 0.091
7.815AlaGly: 7.815 ± 0.128
2.298AlaHis: 2.298 ± 0.068
5.944AlaIle: 5.944 ± 0.093
4.254AlaLys: 4.254 ± 0.104
10.051AlaLeu: 10.051 ± 0.17
3.161AlaMet: 3.161 ± 0.082
3.55AlaAsn: 3.55 ± 0.091
3.492AlaPro: 3.492 ± 0.08
5.515AlaGln: 5.515 ± 0.118
5.27AlaArg: 5.27 ± 0.098
7.016AlaSer: 7.016 ± 0.128
5.603AlaThr: 5.603 ± 0.11
8.265AlaVal: 8.265 ± 0.133
1.435AlaTrp: 1.435 ± 0.045
2.78AlaTyr: 2.78 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.017CysAla: 1.017 ± 0.042
0.114CysCys: 0.114 ± 0.015
0.515CysAsp: 0.515 ± 0.034
0.525CysGlu: 0.525 ± 0.032
0.333CysPhe: 0.333 ± 0.023
0.933CysGly: 0.933 ± 0.044
0.222CysHis: 0.222 ± 0.02
0.514CysIle: 0.514 ± 0.029
0.27CysLys: 0.27 ± 0.023
0.731CysLeu: 0.731 ± 0.041
0.253CysMet: 0.253 ± 0.021
0.24CysAsn: 0.24 ± 0.018
0.422CysPro: 0.422 ± 0.028
0.212CysGln: 0.212 ± 0.018
0.466CysArg: 0.466 ± 0.027
0.598CysSer: 0.598 ± 0.031
0.495CysThr: 0.495 ± 0.029
0.716CysVal: 0.716 ± 0.036
0.104CysTrp: 0.104 ± 0.014
0.2CysTyr: 0.2 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
7.25AspAla: 7.25 ± 0.13
0.492AspCys: 0.492 ± 0.027
4.339AspAsp: 4.339 ± 0.116
4.954AspGlu: 4.954 ± 0.103
2.261AspPhe: 2.261 ± 0.068
5.631AspGly: 5.631 ± 0.132
1.236AspHis: 1.236 ± 0.044
3.757AspIle: 3.757 ± 0.102
2.271AspLys: 2.271 ± 0.072
4.919AspLeu: 4.919 ± 0.095
1.763AspMet: 1.763 ± 0.056
2.029AspAsn: 2.029 ± 0.068
3.156AspPro: 3.156 ± 0.087
2.041AspGln: 2.041 ± 0.061
3.151AspArg: 3.151 ± 0.086
3.989AspSer: 3.989 ± 0.09
3.39AspThr: 3.39 ± 0.09
4.871AspVal: 4.871 ± 0.098
1.001AspTrp: 1.001 ± 0.048
1.721AspTyr: 1.721 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
6.12GluAla: 6.12 ± 0.122
0.436GluCys: 0.436 ± 0.028
3.738GluAsp: 3.738 ± 0.093
3.96GluGlu: 3.96 ± 0.094
1.851GluPhe: 1.851 ± 0.059
4.115GluGly: 4.115 ± 0.087
1.824GluHis: 1.824 ± 0.062
2.883GluIle: 2.883 ± 0.076
1.915GluLys: 1.915 ± 0.066
5.379GluLeu: 5.379 ± 0.116
1.518GluMet: 1.518 ± 0.057
2.006GluAsn: 2.006 ± 0.06
2.343GluPro: 2.343 ± 0.067
3.237GluGln: 3.237 ± 0.081
4.263GluArg: 4.263 ± 0.108
3.963GluSer: 3.963 ± 0.085
2.881GluThr: 2.881 ± 0.073
4.162GluVal: 4.162 ± 0.092
0.754GluTrp: 0.754 ± 0.042
1.801GluTyr: 1.801 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.837PheAla: 3.837 ± 0.094
0.34PheCys: 0.34 ± 0.023
2.553PheAsp: 2.553 ± 0.06
1.846PheGlu: 1.846 ± 0.061
1.292PhePhe: 1.292 ± 0.056
3.163PheGly: 3.163 ± 0.08
0.734PheHis: 0.734 ± 0.032
2.0PheIle: 2.0 ± 0.062
1.092PheLys: 1.092 ± 0.05
2.686PheLeu: 2.686 ± 0.074
0.8PheMet: 0.8 ± 0.034
1.388PheAsn: 1.388 ± 0.049
1.38PhePro: 1.38 ± 0.051
1.027PheGln: 1.027 ± 0.04
1.554PheArg: 1.554 ± 0.061
2.416PheSer: 2.416 ± 0.072
2.192PheThr: 2.192 ± 0.065
2.618PheVal: 2.618 ± 0.073
0.475PheTrp: 0.475 ± 0.034
0.847PheTyr: 0.847 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
6.945GlyAla: 6.945 ± 0.122
0.726GlyCys: 0.726 ± 0.037
4.51GlyAsp: 4.51 ± 0.101
4.553GlyGlu: 4.553 ± 0.107
3.103GlyPhe: 3.103 ± 0.071
5.529GlyGly: 5.529 ± 0.123
1.668GlyHis: 1.668 ± 0.057
5.192GlyIle: 5.192 ± 0.108
3.786GlyLys: 3.786 ± 0.081
6.932GlyLeu: 6.932 ± 0.113
2.275GlyMet: 2.275 ± 0.066
2.971GlyAsn: 2.971 ± 0.076
2.275GlyPro: 2.275 ± 0.068
2.742GlyGln: 2.742 ± 0.072
4.057GlyArg: 4.057 ± 0.095
5.762GlySer: 5.762 ± 0.108
4.823GlyThr: 4.823 ± 0.113
6.204GlyVal: 6.204 ± 0.117
1.14GlyTrp: 1.14 ± 0.051
2.608GlyTyr: 2.608 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.237HisAla: 2.237 ± 0.069
0.21HisCys: 0.21 ± 0.018
1.637HisAsp: 1.637 ± 0.051
1.37HisGlu: 1.37 ± 0.049
0.654HisPhe: 0.654 ± 0.035
1.915HisGly: 1.915 ± 0.06
0.595HisHis: 0.595 ± 0.03
1.532HisIle: 1.532 ± 0.054
0.653HisLys: 0.653 ± 0.032
1.617HisLeu: 1.617 ± 0.051
0.729HisMet: 0.729 ± 0.037
0.852HisAsn: 0.852 ± 0.036
1.206HisPro: 1.206 ± 0.045
0.699HisGln: 0.699 ± 0.031
1.397HisArg: 1.397 ± 0.057
1.312HisSer: 1.312 ± 0.048
1.243HisThr: 1.243 ± 0.05
1.7HisVal: 1.7 ± 0.056
0.364HisTrp: 0.364 ± 0.026
0.62HisTyr: 0.62 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
7.006IleAla: 7.006 ± 0.107
0.596IleCys: 0.596 ± 0.03
4.061IleAsp: 4.061 ± 0.084
3.509IleGlu: 3.509 ± 0.084
1.75IlePhe: 1.75 ± 0.06
4.824IleGly: 4.824 ± 0.111
1.102IleHis: 1.102 ± 0.046
3.194IleIle: 3.194 ± 0.099
1.63IleLys: 1.63 ± 0.061
4.047IleLeu: 4.047 ± 0.093
1.32IleMet: 1.32 ± 0.051
2.029IleAsn: 2.029 ± 0.057
2.99IlePro: 2.99 ± 0.087
1.635IleGln: 1.635 ± 0.055
3.055IleArg: 3.055 ± 0.082
3.744IleSer: 3.744 ± 0.091
3.534IleThr: 3.534 ± 0.08
4.975IleVal: 4.975 ± 0.102
0.693IleTrp: 0.693 ± 0.038
1.14IleTyr: 1.14 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.372LysAla: 4.372 ± 0.106
0.177LysCys: 0.177 ± 0.018
2.425LysAsp: 2.425 ± 0.076
2.198LysGlu: 2.198 ± 0.08
0.876LysPhe: 0.876 ± 0.042
2.551LysGly: 2.551 ± 0.064
0.89LysHis: 0.89 ± 0.037
1.634LysIle: 1.634 ± 0.061
1.481LysLys: 1.481 ± 0.068
2.995LysLeu: 2.995 ± 0.078
0.772LysMet: 0.772 ± 0.035
1.4LysAsn: 1.4 ± 0.061
1.975LysPro: 1.975 ± 0.063
1.725LysGln: 1.725 ± 0.059
2.45LysArg: 2.45 ± 0.07
2.366LysSer: 2.366 ± 0.062
2.286LysThr: 2.286 ± 0.063
2.775LysVal: 2.775 ± 0.075
0.394LysTrp: 0.394 ± 0.025
1.044LysTyr: 1.044 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
9.163LeuAla: 9.163 ± 0.143
0.934LeuCys: 0.934 ± 0.044
5.876LeuAsp: 5.876 ± 0.109
4.713LeuGlu: 4.713 ± 0.103
3.017LeuPhe: 3.017 ± 0.086
6.887LeuGly: 6.887 ± 0.126
2.005LeuHis: 2.005 ± 0.064
4.763LeuIle: 4.763 ± 0.099
3.229LeuLys: 3.229 ± 0.087
7.482LeuLeu: 7.482 ± 0.141
2.256LeuMet: 2.256 ± 0.067
3.184LeuAsn: 3.184 ± 0.07
4.278LeuPro: 4.278 ± 0.082
3.146LeuGln: 3.146 ± 0.07
5.106LeuArg: 5.106 ± 0.089
6.231LeuSer: 6.231 ± 0.097
4.982LeuThr: 4.982 ± 0.086
6.383LeuVal: 6.383 ± 0.111
0.977LeuTrp: 0.977 ± 0.046
1.907LeuTyr: 1.907 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
2.715MetAla: 2.715 ± 0.069
0.253MetCys: 0.253 ± 0.019
1.532MetAsp: 1.532 ± 0.053
1.249MetGlu: 1.249 ± 0.051
0.83MetPhe: 0.83 ± 0.038
1.874MetGly: 1.874 ± 0.06
0.658MetHis: 0.658 ± 0.033
1.287MetIle: 1.287 ± 0.05
1.009MetLys: 1.009 ± 0.04
2.533MetLeu: 2.533 ± 0.074
0.699MetMet: 0.699 ± 0.036
1.117MetAsn: 1.117 ± 0.045
1.481MetPro: 1.481 ± 0.054
1.016MetGln: 1.016 ± 0.05
1.721MetArg: 1.721 ± 0.059
2.006MetSer: 2.006 ± 0.064
1.778MetThr: 1.778 ± 0.058
2.058MetVal: 2.058 ± 0.066
0.341MetTrp: 0.341 ± 0.026
0.578MetTyr: 0.578 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.236AsnAla: 4.236 ± 0.123
0.224AsnCys: 0.224 ± 0.021
2.182AsnAsp: 2.182 ± 0.062
2.049AsnGlu: 2.049 ± 0.058
0.989AsnPhe: 0.989 ± 0.045
3.292AsnGly: 3.292 ± 0.082
0.659AsnHis: 0.659 ± 0.037
2.074AsnIle: 2.074 ± 0.056
1.315AsnLys: 1.315 ± 0.055
2.755AsnLeu: 2.755 ± 0.064
0.928AsnMet: 0.928 ± 0.04
1.445AsnAsn: 1.445 ± 0.059
2.28AsnPro: 2.28 ± 0.059
1.228AsnGln: 1.228 ± 0.05
1.98AsnArg: 1.98 ± 0.065
2.122AsnSer: 2.122 ± 0.075
2.364AsnThr: 2.364 ± 0.071
2.523AsnVal: 2.523 ± 0.067
0.477AsnTrp: 0.477 ± 0.029
0.953AsnTyr: 0.953 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
3.945ProAla: 3.945 ± 0.076
0.316ProCys: 0.316 ± 0.025
3.088ProAsp: 3.088 ± 0.093
3.362ProGlu: 3.362 ± 0.091
1.59ProPhe: 1.59 ± 0.054
3.108ProGly: 3.108 ± 0.068
1.002ProHis: 1.002 ± 0.039
2.309ProIle: 2.309 ± 0.072
1.546ProLys: 1.546 ± 0.052
3.521ProLeu: 3.521 ± 0.08
1.087ProMet: 1.087 ± 0.042
1.521ProAsn: 1.521 ± 0.056
1.1ProPro: 1.1 ± 0.048
2.145ProGln: 2.145 ± 0.068
2.126ProArg: 2.126 ± 0.065
3.133ProSer: 3.133 ± 0.07
2.553ProThr: 2.553 ± 0.078
3.733ProVal: 3.733 ± 0.089
0.678ProTrp: 0.678 ± 0.034
1.276ProTyr: 1.276 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
4.65GlnAla: 4.65 ± 0.117
0.33GlnCys: 0.33 ± 0.022
2.126GlnAsp: 2.126 ± 0.059
2.394GlnGlu: 2.394 ± 0.064
1.301GlnPhe: 1.301 ± 0.041
3.053GlnGly: 3.053 ± 0.085
1.024GlnHis: 1.024 ± 0.044
2.058GlnIle: 2.058 ± 0.063
1.158GlnLys: 1.158 ± 0.053
3.617GlnLeu: 3.617 ± 0.076
1.075GlnMet: 1.075 ± 0.043
1.252GlnAsn: 1.252 ± 0.051
1.703GlnPro: 1.703 ± 0.071
2.281GlnGln: 2.281 ± 0.09
2.628GlnArg: 2.628 ± 0.079
2.883GlnSer: 2.883 ± 0.072
2.102GlnThr: 2.102 ± 0.062
2.745GlnVal: 2.745 ± 0.069
0.746GlnTrp: 0.746 ± 0.029
1.34GlnTyr: 1.34 ± 0.055
0.002GlnXaa: 0.002 ± 0.002
Arg
4.584ArgAla: 4.584 ± 0.103
0.492ArgCys: 0.492 ± 0.036
3.257ArgAsp: 3.257 ± 0.085
3.552ArgGlu: 3.552 ± 0.087
2.208ArgPhe: 2.208 ± 0.061
3.585ArgGly: 3.585 ± 0.096
1.499ArgHis: 1.499 ± 0.054
3.756ArgIle: 3.756 ± 0.089
2.5ArgLys: 2.5 ± 0.07
5.05ArgLeu: 5.05 ± 0.113
1.798ArgMet: 1.798 ± 0.058
2.207ArgAsn: 2.207 ± 0.069
2.207ArgPro: 2.207 ± 0.068
2.265ArgGln: 2.265 ± 0.07
4.155ArgArg: 4.155 ± 0.142
3.676ArgSer: 3.676 ± 0.085
2.896ArgThr: 2.896 ± 0.068
4.069ArgVal: 4.069 ± 0.09
0.863ArgTrp: 0.863 ± 0.038
1.839ArgTyr: 1.839 ± 0.061
0.0ArgXaa: 0.0 ± 0.0
Ser
6.822SerAla: 6.822 ± 0.128
0.575SerCys: 0.575 ± 0.034
4.472SerAsp: 4.472 ± 0.108
3.663SerGlu: 3.663 ± 0.088
2.268SerPhe: 2.268 ± 0.07
5.876SerGly: 5.876 ± 0.121
1.518SerHis: 1.518 ± 0.055
3.935SerIle: 3.935 ± 0.086
2.46SerLys: 2.46 ± 0.069
6.002SerLeu: 6.002 ± 0.108
1.892SerMet: 1.892 ± 0.059
2.475SerAsn: 2.475 ± 0.072
2.568SerPro: 2.568 ± 0.067
2.992SerGln: 2.992 ± 0.082
3.661SerArg: 3.661 ± 0.088
5.295SerSer: 5.295 ± 0.153
4.246SerThr: 4.246 ± 0.097
5.143SerVal: 5.143 ± 0.105
0.946SerTrp: 0.946 ± 0.042
1.809SerTyr: 1.809 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
6.034ThrAla: 6.034 ± 0.139
0.422ThrCys: 0.422 ± 0.027
3.612ThrAsp: 3.612 ± 0.086
2.757ThrGlu: 2.757 ± 0.082
1.933ThrPhe: 1.933 ± 0.073
4.8ThrGly: 4.8 ± 0.103
1.128ThrHis: 1.128 ± 0.043
3.398ThrIle: 3.398 ± 0.092
2.039ThrLys: 2.039 ± 0.062
5.326ThrLeu: 5.326 ± 0.103
1.42ThrMet: 1.42 ± 0.043
2.029ThrAsn: 2.029 ± 0.063
2.969ThrPro: 2.969 ± 0.069
2.165ThrGln: 2.165 ± 0.063
2.662ThrArg: 2.662 ± 0.072
3.767ThrSer: 3.767 ± 0.093
3.633ThrThr: 3.633 ± 0.094
5.437ThrVal: 5.437 ± 0.127
0.82ThrTrp: 0.82 ± 0.037
1.65ThrTyr: 1.65 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
7.861ValAla: 7.861 ± 0.136
0.795ValCys: 0.795 ± 0.041
5.179ValAsp: 5.179 ± 0.101
4.611ValGlu: 4.611 ± 0.106
2.884ValPhe: 2.884 ± 0.071
5.318ValGly: 5.318 ± 0.095
1.617ValHis: 1.617 ± 0.052
4.573ValIle: 4.573 ± 0.105
2.798ValLys: 2.798 ± 0.065
7.266ValLeu: 7.266 ± 0.126
1.973ValMet: 1.973 ± 0.056
2.878ValAsn: 2.878 ± 0.064
3.564ValPro: 3.564 ± 0.077
2.702ValGln: 2.702 ± 0.062
4.197ValArg: 4.197 ± 0.094
5.618ValSer: 5.618 ± 0.102
4.791ValThr: 4.791 ± 0.111
6.534ValVal: 6.534 ± 0.127
0.986ValTrp: 0.986 ± 0.042
1.778ValTyr: 1.778 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.128TrpAla: 1.128 ± 0.045
0.195TrpCys: 0.195 ± 0.019
0.8TrpAsp: 0.8 ± 0.041
0.606TrpGlu: 0.606 ± 0.034
0.557TrpPhe: 0.557 ± 0.033
0.954TrpGly: 0.954 ± 0.042
0.388TrpHis: 0.388 ± 0.029
0.737TrpIle: 0.737 ± 0.038
0.582TrpLys: 0.582 ± 0.031
1.418TrpLeu: 1.418 ± 0.049
0.442TrpMet: 0.442 ± 0.028
0.636TrpAsn: 0.636 ± 0.035
0.545TrpPro: 0.545 ± 0.033
0.702TrpGln: 0.702 ± 0.03
0.871TrpArg: 0.871 ± 0.04
0.973TrpSer: 0.973 ± 0.041
0.775TrpThr: 0.775 ± 0.037
0.862TrpVal: 0.862 ± 0.043
0.278TrpTrp: 0.278 ± 0.022
0.456TrpTyr: 0.456 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.101TyrAla: 3.101 ± 0.075
0.287TyrCys: 0.287 ± 0.023
1.837TyrAsp: 1.837 ± 0.06
1.629TyrGlu: 1.629 ± 0.052
1.064TyrPhe: 1.064 ± 0.044
2.575TyrGly: 2.575 ± 0.073
0.475TyrHis: 0.475 ± 0.029
1.296TyrIle: 1.296 ± 0.041
0.799TyrLys: 0.799 ± 0.037
2.194TyrLeu: 2.194 ± 0.067
0.573TyrMet: 0.573 ± 0.034
0.865TyrAsn: 0.865 ± 0.038
1.204TyrPro: 1.204 ± 0.046
0.991TyrGln: 0.991 ± 0.041
1.688TyrArg: 1.688 ± 0.059
1.748TyrSer: 1.748 ± 0.067
1.436TyrThr: 1.436 ± 0.066
2.15TyrVal: 2.15 ± 0.06
0.434TyrTrp: 0.434 ± 0.025
0.769TyrTyr: 0.769 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1629 proteins (603598 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski