Amino acid dipepetide frequency for Brevibacillus borstelensis AK1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.111AlaAla: 9.111 ± 0.117	0.808AlaCys: 0.808 ± 0.027	4.484AlaAsp: 4.484 ± 0.066	6.436AlaGlu: 6.436 ± 0.073	3.558AlaPhe: 3.558 ± 0.056	7.22AlaGly: 7.22 ± 0.082	1.568AlaHis: 1.568 ± 0.029	5.737AlaIle: 5.737 ± 0.071	4.917AlaLys: 4.917 ± 0.064	8.749AlaLeu: 8.749 ± 0.091	2.462AlaMet: 2.462 ± 0.046	2.655AlaAsn: 2.655 ± 0.046	2.867AlaPro: 2.867 ± 0.044	2.906AlaGln: 2.906 ± 0.04	4.181AlaArg: 4.181 ± 0.05	5.0AlaSer: 5.0 ± 0.064	3.895AlaThr: 3.895 ± 0.056	7.13AlaVal: 7.13 ± 0.08	0.875AlaTrp: 0.875 ± 0.027	2.691AlaTyr: 2.691 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.524CysAla: 0.524 ± 0.018	0.095CysCys: 0.095 ± 0.009	0.403CysAsp: 0.403 ± 0.016	0.456CysGlu: 0.456 ± 0.018	0.355CysPhe: 0.355 ± 0.013	0.775CysGly: 0.775 ± 0.026	0.202CysHis: 0.202 ± 0.012	0.466CysIle: 0.466 ± 0.017	0.37CysLys: 0.37 ± 0.016	0.852CysLeu: 0.852 ± 0.024	0.217CysMet: 0.217 ± 0.012	0.236CysAsn: 0.236 ± 0.015	0.385CysPro: 0.385 ± 0.018	0.261CysGln: 0.261 ± 0.014	0.456CysArg: 0.456 ± 0.017	0.508CysSer: 0.508 ± 0.019	0.393CysThr: 0.393 ± 0.016	0.481CysVal: 0.481 ± 0.019	0.101CysTrp: 0.101 ± 0.009	0.266CysTyr: 0.266 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.793AspAla: 3.793 ± 0.051	0.37AspCys: 0.37 ± 0.016	2.322AspAsp: 2.322 ± 0.049	3.977AspGlu: 3.977 ± 0.058	2.066AspPhe: 2.066 ± 0.039	3.641AspGly: 3.641 ± 0.061	1.045AspHis: 1.045 ± 0.028	3.184AspIle: 3.184 ± 0.053	2.769AspLys: 2.769 ± 0.052	4.732AspLeu: 4.732 ± 0.061	1.299AspMet: 1.299 ± 0.028	1.434AspAsn: 1.434 ± 0.034	2.374AspPro: 2.374 ± 0.039	2.019AspGln: 2.019 ± 0.035	2.921AspArg: 2.921 ± 0.05	2.434AspSer: 2.434 ± 0.044	2.312AspThr: 2.312 ± 0.04	3.865AspVal: 3.865 ± 0.049	0.763AspTrp: 0.763 ± 0.024	1.685AspTyr: 1.685 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.711GluAla: 6.711 ± 0.073	0.416GluCys: 0.416 ± 0.018	3.079GluAsp: 3.079 ± 0.047	6.311GluGlu: 6.311 ± 0.083	1.941GluPhe: 1.941 ± 0.038	4.462GluGly: 4.462 ± 0.064	1.432GluHis: 1.432 ± 0.029	4.443GluIle: 4.443 ± 0.063	5.182GluLys: 5.182 ± 0.067	7.192GluLeu: 7.192 ± 0.078	2.309GluMet: 2.309 ± 0.041	2.457GluAsn: 2.457 ± 0.045	2.375GluPro: 2.375 ± 0.045	3.84GluGln: 3.84 ± 0.058	4.692GluArg: 4.692 ± 0.067	3.338GluSer: 3.338 ± 0.047	3.666GluThr: 3.666 ± 0.051	4.901GluVal: 4.901 ± 0.057	1.005GluTrp: 1.005 ± 0.028	1.996GluTyr: 1.996 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.63PheAla: 3.63 ± 0.06	0.38PheCys: 0.38 ± 0.016	2.105PheAsp: 2.105 ± 0.04	2.215PheGlu: 2.215 ± 0.041	2.096PhePhe: 2.096 ± 0.038	3.258PheGly: 3.258 ± 0.05	0.933PheHis: 0.933 ± 0.025	2.458PheIle: 2.458 ± 0.043	1.346PheLys: 1.346 ± 0.036	4.497PheLeu: 4.497 ± 0.066	0.929PheMet: 0.929 ± 0.029	1.104PheAsn: 1.104 ± 0.028	1.783PhePro: 1.783 ± 0.04	1.567PheGln: 1.567 ± 0.029	2.063PheArg: 2.063 ± 0.041	2.865PheSer: 2.865 ± 0.047	2.351PheThr: 2.351 ± 0.039	3.12PheVal: 3.12 ± 0.052	0.512PheTrp: 0.512 ± 0.02	1.348PheTyr: 1.348 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	5.669GlyAla: 5.669 ± 0.075	0.763GlyCys: 0.763 ± 0.024	3.304GlyAsp: 3.304 ± 0.051	5.025GlyGlu: 5.025 ± 0.061	3.241GlyPhe: 3.241 ± 0.048	5.403GlyGly: 5.403 ± 0.074	1.542GlyHis: 1.542 ± 0.036	5.579GlyIle: 5.579 ± 0.082	5.052GlyLys: 5.052 ± 0.064	7.259GlyLeu: 7.259 ± 0.088	2.461GlyMet: 2.461 ± 0.038	2.456GlyAsn: 2.456 ± 0.042	2.085GlyPro: 2.085 ± 0.048	2.819GlyGln: 2.819 ± 0.046	3.661GlyArg: 3.661 ± 0.058	4.332GlySer: 4.332 ± 0.055	4.474GlyThr: 4.474 ± 0.055	5.704GlyVal: 5.704 ± 0.074	1.0GlyTrp: 1.0 ± 0.027	2.824GlyTyr: 2.824 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.647HisAla: 1.647 ± 0.034	0.199HisCys: 0.199 ± 0.012	1.06HisAsp: 1.06 ± 0.027	1.319HisGlu: 1.319 ± 0.036	1.037HisPhe: 1.037 ± 0.028	1.488HisGly: 1.488 ± 0.031	0.585HisHis: 0.585 ± 0.024	1.271HisIle: 1.271 ± 0.027	0.822HisLys: 0.822 ± 0.022	2.239HisLeu: 2.239 ± 0.045	0.55HisMet: 0.55 ± 0.02	0.598HisAsn: 0.598 ± 0.021	1.301HisPro: 1.301 ± 0.033	0.84HisGln: 0.84 ± 0.025	1.18HisArg: 1.18 ± 0.029	1.151HisSer: 1.151 ± 0.029	1.029HisThr: 1.029 ± 0.025	1.632HisVal: 1.632 ± 0.031	0.275HisTrp: 0.275 ± 0.013	0.755HisTyr: 0.755 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.121IleAla: 6.121 ± 0.072	0.661IleCys: 0.661 ± 0.023	3.435IleAsp: 3.435 ± 0.054	4.098IleGlu: 4.098 ± 0.055	2.243IlePhe: 2.243 ± 0.045	5.496IleGly: 5.496 ± 0.078	1.383IleHis: 1.383 ± 0.03	3.477IleIle: 3.477 ± 0.064	2.782IleLys: 2.782 ± 0.053	5.957IleLeu: 5.957 ± 0.075	1.493IleMet: 1.493 ± 0.03	2.0IleAsn: 2.0 ± 0.035	3.227IlePro: 3.227 ± 0.049	2.278IleGln: 2.278 ± 0.042	3.81IleArg: 3.81 ± 0.049	3.994IleSer: 3.994 ± 0.053	3.367IleThr: 3.367 ± 0.044	5.183IleVal: 5.183 ± 0.059	0.651IleTrp: 0.651 ± 0.023	1.762IleTyr: 1.762 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.69LysAla: 4.69 ± 0.065	0.246LysCys: 0.246 ± 0.013	2.576LysAsp: 2.576 ± 0.049	4.806LysGlu: 4.806 ± 0.054	1.195LysPhe: 1.195 ± 0.029	4.003LysGly: 4.003 ± 0.048	1.118LysHis: 1.118 ± 0.027	2.964LysIle: 2.964 ± 0.051	3.81LysLys: 3.81 ± 0.057	5.2LysLeu: 5.2 ± 0.059	1.654LysMet: 1.654 ± 0.034	1.995LysAsn: 1.995 ± 0.037	2.325LysPro: 2.325 ± 0.047	2.864LysGln: 2.864 ± 0.049	3.55LysArg: 3.55 ± 0.047	2.694LysSer: 2.694 ± 0.041	3.058LysThr: 3.058 ± 0.048	3.811LysVal: 3.811 ± 0.056	0.809LysTrp: 0.809 ± 0.022	1.515LysTyr: 1.515 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.653LeuAla: 9.653 ± 0.107	0.823LeuCys: 0.823 ± 0.025	5.06LeuAsp: 5.06 ± 0.061	6.702LeuGlu: 6.702 ± 0.071	4.796LeuPhe: 4.796 ± 0.071	7.184LeuGly: 7.184 ± 0.086	2.247LeuHis: 2.247 ± 0.041	6.262LeuIle: 6.262 ± 0.073	4.786LeuLys: 4.786 ± 0.067	11.429LeuLeu: 11.429 ± 0.119	2.417LeuMet: 2.417 ± 0.044	2.898LeuAsn: 2.898 ± 0.042	4.772LeuPro: 4.772 ± 0.063	4.235LeuGln: 4.235 ± 0.055	5.345LeuArg: 5.345 ± 0.075	6.858LeuSer: 6.858 ± 0.074	5.602LeuThr: 5.602 ± 0.063	7.187LeuVal: 7.187 ± 0.07	0.983LeuTrp: 0.983 ± 0.029	3.094LeuTyr: 3.094 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.559MetAla: 2.559 ± 0.036	0.169MetCys: 0.169 ± 0.01	1.376MetAsp: 1.376 ± 0.027	2.061MetGlu: 2.061 ± 0.041	1.019MetPhe: 1.019 ± 0.03	1.901MetGly: 1.901 ± 0.043	0.455MetHis: 0.455 ± 0.018	1.871MetIle: 1.871 ± 0.037	1.927MetLys: 1.927 ± 0.034	2.767MetLeu: 2.767 ± 0.043	0.778MetMet: 0.778 ± 0.023	1.201MetAsn: 1.201 ± 0.029	1.159MetPro: 1.159 ± 0.031	1.075MetGln: 1.075 ± 0.032	1.425MetArg: 1.425 ± 0.028	1.654MetSer: 1.654 ± 0.032	1.556MetThr: 1.556 ± 0.032	1.833MetVal: 1.833 ± 0.033	0.248MetTrp: 0.248 ± 0.014	0.744MetTyr: 0.744 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.516AsnAla: 2.516 ± 0.045	0.245AsnCys: 0.245 ± 0.013	1.457AsnAsp: 1.457 ± 0.031	2.114AsnGlu: 2.114 ± 0.037	1.005AsnPhe: 1.005 ± 0.028	2.896AsnGly: 2.896 ± 0.052	0.748AsnHis: 0.748 ± 0.023	1.916AsnIle: 1.916 ± 0.041	1.702AsnLys: 1.702 ± 0.036	2.985AsnLeu: 2.985 ± 0.045	0.868AsnMet: 0.868 ± 0.024	1.094AsnAsn: 1.094 ± 0.031	1.982AsnPro: 1.982 ± 0.041	1.489AsnGln: 1.489 ± 0.035	2.069AsnArg: 2.069 ± 0.041	1.553AsnSer: 1.553 ± 0.038	1.626AsnThr: 1.626 ± 0.034	2.355AsnVal: 2.355 ± 0.043	0.427AsnTrp: 0.427 ± 0.017	0.915AsnTyr: 0.915 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.646ProAla: 3.646 ± 0.057	0.233ProCys: 0.233 ± 0.014	2.705ProAsp: 2.705 ± 0.046	3.569ProGlu: 3.569 ± 0.058	2.09ProPhe: 2.09 ± 0.036	3.279ProGly: 3.279 ± 0.058	0.977ProHis: 0.977 ± 0.024	2.539ProIle: 2.539 ± 0.044	1.936ProLys: 1.936 ± 0.042	4.25ProLeu: 4.25 ± 0.059	0.944ProMet: 0.944 ± 0.025	1.322ProAsn: 1.322 ± 0.035	1.592ProPro: 1.592 ± 0.045	1.508ProGln: 1.508 ± 0.035	1.742ProArg: 1.742 ± 0.036	2.437ProSer: 2.437 ± 0.046	2.08ProThr: 2.08 ± 0.037	3.649ProVal: 3.649 ± 0.051	0.466ProTrp: 0.466 ± 0.018	1.567ProTyr: 1.567 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.995GlnAla: 3.995 ± 0.053	0.205GlnCys: 0.205 ± 0.012	1.643GlnAsp: 1.643 ± 0.033	3.091GlnGlu: 3.091 ± 0.048	1.429GlnPhe: 1.429 ± 0.028	2.505GlnGly: 2.505 ± 0.041	0.815GlnHis: 0.815 ± 0.022	2.517GlnIle: 2.517 ± 0.046	2.465GlnLys: 2.465 ± 0.044	4.21GlnLeu: 4.21 ± 0.059	1.279GlnMet: 1.279 ± 0.029	1.313GlnAsn: 1.313 ± 0.031	1.86GlnPro: 1.86 ± 0.044	2.061GlnGln: 2.061 ± 0.042	2.15GlnArg: 2.15 ± 0.042	2.215GlnSer: 2.215 ± 0.042	2.251GlnThr: 2.251 ± 0.037	2.986GlnVal: 2.986 ± 0.043	0.504GlnTrp: 0.504 ± 0.018	1.201GlnTyr: 1.201 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	3.772ArgAla: 3.772 ± 0.051	0.385ArgCys: 0.385 ± 0.018	2.62ArgAsp: 2.62 ± 0.04	4.557ArgGlu: 4.557 ± 0.063	2.433ArgPhe: 2.433 ± 0.043	3.218ArgGly: 3.218 ± 0.054	1.199ArgHis: 1.199 ± 0.027	3.683ArgIle: 3.683 ± 0.054	3.272ArgLys: 3.272 ± 0.043	5.95ArgLeu: 5.95 ± 0.072	1.806ArgMet: 1.806 ± 0.036	1.825ArgAsn: 1.825 ± 0.033	2.007ArgPro: 2.007 ± 0.046	2.503ArgGln: 2.503 ± 0.045	3.004ArgArg: 3.004 ± 0.046	2.96ArgSer: 2.96 ± 0.051	2.734ArgThr: 2.734 ± 0.043	3.764ArgVal: 3.764 ± 0.051	0.651ArgTrp: 0.651 ± 0.022	2.017ArgTyr: 2.017 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.692SerAla: 4.692 ± 0.07	0.441SerCys: 0.441 ± 0.019	2.652SerAsp: 2.652 ± 0.042	3.575SerGlu: 3.575 ± 0.046	2.908SerPhe: 2.908 ± 0.047	4.887SerGly: 4.887 ± 0.068	1.244SerHis: 1.244 ± 0.032	3.819SerIle: 3.819 ± 0.048	2.737SerLys: 2.737 ± 0.05	6.404SerLeu: 6.404 ± 0.071	1.728SerMet: 1.728 ± 0.035	1.567SerAsn: 1.567 ± 0.038	2.602SerPro: 2.602 ± 0.047	2.109SerGln: 2.109 ± 0.036	3.054SerArg: 3.054 ± 0.049	3.56SerSer: 3.56 ± 0.064	2.888SerThr: 2.888 ± 0.047	4.427SerVal: 4.427 ± 0.06	0.726SerTrp: 0.726 ± 0.024	1.973SerTyr: 1.973 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.837ThrAla: 4.837 ± 0.057	0.358ThrCys: 0.358 ± 0.015	2.647ThrAsp: 2.647 ± 0.045	3.359ThrGlu: 3.359 ± 0.05	2.273ThrPhe: 2.273 ± 0.042	4.69ThrGly: 4.69 ± 0.06	1.025ThrHis: 1.025 ± 0.028	3.563ThrIle: 3.563 ± 0.055	2.481ThrLys: 2.481 ± 0.039	5.283ThrLeu: 5.283 ± 0.066	1.359ThrMet: 1.359 ± 0.035	1.696ThrAsn: 1.696 ± 0.037	2.636ThrPro: 2.636 ± 0.053	1.574ThrGln: 1.574 ± 0.031	2.453ThrArg: 2.453 ± 0.05	3.014ThrSer: 3.014 ± 0.044	2.645ThrThr: 2.645 ± 0.044	4.504ThrVal: 4.504 ± 0.059	0.553ThrTrp: 0.553 ± 0.019	1.757ThrTyr: 1.757 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.381ValAla: 6.381 ± 0.075	0.649ValCys: 0.649 ± 0.018	3.795ValAsp: 3.795 ± 0.049	5.105ValGlu: 5.105 ± 0.054	3.007ValPhe: 3.007 ± 0.038	5.041ValGly: 5.041 ± 0.066	1.494ValHis: 1.494 ± 0.035	5.174ValIle: 5.174 ± 0.065	4.245ValLys: 4.245 ± 0.056	7.549ValLeu: 7.549 ± 0.088	2.059ValMet: 2.059 ± 0.037	2.602ValAsn: 2.602 ± 0.045	3.349ValPro: 3.349 ± 0.049	2.812ValGln: 2.812 ± 0.046	3.87ValArg: 3.87 ± 0.052	4.918ValSer: 4.918 ± 0.056	4.446ValThr: 4.446 ± 0.057	5.826ValVal: 5.826 ± 0.068	0.819ValTrp: 0.819 ± 0.024	2.31ValTyr: 2.31 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.81TrpAla: 0.81 ± 0.023	0.087TrpCys: 0.087 ± 0.007	0.555TrpAsp: 0.555 ± 0.019	0.84TrpGlu: 0.84 ± 0.023	0.527TrpPhe: 0.527 ± 0.021	0.821TrpGly: 0.821 ± 0.024	0.197TrpHis: 0.197 ± 0.012	0.754TrpIle: 0.754 ± 0.025	0.817TrpLys: 0.817 ± 0.023	1.448TrpLeu: 1.448 ± 0.036	0.441TrpMet: 0.441 ± 0.019	0.512TrpAsn: 0.512 ± 0.022	0.359TrpPro: 0.359 ± 0.015	0.518TrpGln: 0.518 ± 0.02	0.654TrpArg: 0.654 ± 0.023	0.68TrpSer: 0.68 ± 0.023	0.607TrpThr: 0.607 ± 0.024	0.763TrpVal: 0.763 ± 0.022	0.17TrpTrp: 0.17 ± 0.011	0.376TrpTyr: 0.376 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.492TyrAla: 2.492 ± 0.045	0.267TyrCys: 0.267 ± 0.014	1.731TyrAsp: 1.731 ± 0.037	2.13TyrGlu: 2.13 ± 0.039	1.342TyrPhe: 1.342 ± 0.031	2.484TyrGly: 2.484 ± 0.041	0.768TyrHis: 0.768 ± 0.024	1.742TyrIle: 1.742 ± 0.036	1.463TyrLys: 1.463 ± 0.035	3.381TyrLeu: 3.381 ± 0.05	0.726TyrMet: 0.726 ± 0.024	1.002TyrAsn: 1.002 ± 0.034	1.492TyrPro: 1.492 ± 0.034	1.417TyrGln: 1.417 ± 0.031	2.082TyrArg: 2.082 ± 0.045	1.824TyrSer: 1.824 ± 0.04	1.727TyrThr: 1.727 ± 0.03	2.328TyrVal: 2.328 ± 0.042	0.4TyrTrp: 0.4 ± 0.018	1.16TyrTyr: 1.16 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4951 proteins (1481559 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---