Amino acid dipepetide frequency for Cutibacterium acnes JCM 18918

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.444AlaAla: 12.444 ± 0.175
1.448AlaCys: 1.448 ± 0.05
6.316AlaAsp: 6.316 ± 0.112
5.829AlaGlu: 5.829 ± 0.107
2.806AlaPhe: 2.806 ± 0.066
9.382AlaGly: 9.382 ± 0.127
2.472AlaHis: 2.472 ± 0.055
5.262AlaIle: 5.262 ± 0.098
3.221AlaLys: 3.221 ± 0.088
9.392AlaLeu: 9.392 ± 0.131
3.249AlaMet: 3.249 ± 0.078
2.43AlaAsn: 2.43 ± 0.066
4.84AlaPro: 4.84 ± 0.092
3.243AlaGln: 3.243 ± 0.069
7.501AlaArg: 7.501 ± 0.113
7.001AlaSer: 7.001 ± 0.096
6.756AlaThr: 6.756 ± 0.106
8.825AlaVal: 8.825 ± 0.135
1.883AlaTrp: 1.883 ± 0.052
1.787AlaTyr: 1.787 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.394CysAla: 1.394 ± 0.046
0.461CysCys: 0.461 ± 0.028
0.741CysAsp: 0.741 ± 0.032
0.513CysGlu: 0.513 ± 0.023
0.336CysPhe: 0.336 ± 0.021
1.403CysGly: 1.403 ± 0.045
0.435CysHis: 0.435 ± 0.023
0.416CysIle: 0.416 ± 0.026
0.211CysLys: 0.211 ± 0.02
1.216CysLeu: 1.216 ± 0.044
0.375CysMet: 0.375 ± 0.024
0.248CysAsn: 0.248 ± 0.02
0.877CysPro: 0.877 ± 0.037
0.494CysGln: 0.494 ± 0.022
1.3CysArg: 1.3 ± 0.05
1.18CysSer: 1.18 ± 0.041
0.732CysThr: 0.732 ± 0.03
0.977CysVal: 0.977 ± 0.036
0.365CysTrp: 0.365 ± 0.019
0.26CysTyr: 0.26 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
6.141AspAla: 6.141 ± 0.114
0.503AspCys: 0.503 ± 0.028
4.343AspAsp: 4.343 ± 0.1
4.063AspGlu: 4.063 ± 0.08
1.515AspPhe: 1.515 ± 0.043
5.159AspGly: 5.159 ± 0.097
1.709AspHis: 1.709 ± 0.059
2.635AspIle: 2.635 ± 0.063
1.606AspLys: 1.606 ± 0.057
6.154AspLeu: 6.154 ± 0.089
1.252AspMet: 1.252 ± 0.041
1.271AspAsn: 1.271 ± 0.04
3.87AspPro: 3.87 ± 0.074
1.807AspGln: 1.807 ± 0.053
4.074AspArg: 4.074 ± 0.084
3.109AspSer: 3.109 ± 0.065
2.798AspThr: 2.798 ± 0.06
5.242AspVal: 5.242 ± 0.091
0.813AspTrp: 0.813 ± 0.035
1.225AspTyr: 1.225 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.559GluAla: 5.559 ± 0.107
0.447GluCys: 0.447 ± 0.025
2.64GluAsp: 2.64 ± 0.077
2.902GluGlu: 2.902 ± 0.069
1.502GluPhe: 1.502 ± 0.05
3.458GluGly: 3.458 ± 0.077
1.347GluHis: 1.347 ± 0.045
2.568GluIle: 2.568 ± 0.071
1.68GluLys: 1.68 ± 0.054
5.226GluLeu: 5.226 ± 0.083
1.214GluMet: 1.214 ± 0.041
1.214GluAsn: 1.214 ± 0.043
2.637GluPro: 2.637 ± 0.062
1.791GluGln: 1.791 ± 0.054
3.602GluArg: 3.602 ± 0.071
2.852GluSer: 2.852 ± 0.065
2.642GluThr: 2.642 ± 0.063
4.463GluVal: 4.463 ± 0.09
0.788GluTrp: 0.788 ± 0.037
1.018GluTyr: 1.018 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
2.966PheAla: 2.966 ± 0.062
0.45PheCys: 0.45 ± 0.025
2.003PheAsp: 2.003 ± 0.05
1.166PheGlu: 1.166 ± 0.041
1.249PhePhe: 1.249 ± 0.047
2.798PheGly: 2.798 ± 0.068
0.679PheHis: 0.679 ± 0.031
1.357PheIle: 1.357 ± 0.051
0.629PheLys: 0.629 ± 0.034
2.678PheLeu: 2.678 ± 0.07
0.698PheMet: 0.698 ± 0.032
0.807PheAsn: 0.807 ± 0.034
1.389PhePro: 1.389 ± 0.046
0.74PheGln: 0.74 ± 0.032
1.636PheArg: 1.636 ± 0.048
1.992PheSer: 1.992 ± 0.055
1.847PheThr: 1.847 ± 0.06
2.406PheVal: 2.406 ± 0.065
0.465PheTrp: 0.465 ± 0.025
0.562PheTyr: 0.562 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
7.785GlyAla: 7.785 ± 0.114
1.221GlyCys: 1.221 ± 0.046
4.359GlyAsp: 4.359 ± 0.089
3.925GlyGlu: 3.925 ± 0.077
2.792GlyPhe: 2.792 ± 0.065
6.328GlyGly: 6.328 ± 0.121
2.357GlyHis: 2.357 ± 0.056
4.462GlyIle: 4.462 ± 0.085
2.759GlyLys: 2.759 ± 0.067
7.876GlyLeu: 7.876 ± 0.124
2.558GlyMet: 2.558 ± 0.063
2.034GlyAsn: 2.034 ± 0.062
3.855GlyPro: 3.855 ± 0.077
2.673GlyGln: 2.673 ± 0.063
6.23GlyArg: 6.23 ± 0.096
5.569GlySer: 5.569 ± 0.091
5.009GlyThr: 5.009 ± 0.085
7.096GlyVal: 7.096 ± 0.1
1.789GlyTrp: 1.789 ± 0.051
2.034GlyTyr: 2.034 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.249HisAla: 2.249 ± 0.055
0.362HisCys: 0.362 ± 0.021
1.794HisAsp: 1.794 ± 0.052
1.305HisGlu: 1.305 ± 0.043
0.635HisPhe: 0.635 ± 0.031
2.248HisGly: 2.248 ± 0.052
0.889HisHis: 0.889 ± 0.037
1.018HisIle: 1.018 ± 0.039
0.507HisLys: 0.507 ± 0.027
2.364HisLeu: 2.364 ± 0.063
0.564HisMet: 0.564 ± 0.029
0.626HisAsn: 0.626 ± 0.029
1.857HisPro: 1.857 ± 0.06
0.854HisGln: 0.854 ± 0.034
2.266HisArg: 2.266 ± 0.061
1.393HisSer: 1.393 ± 0.049
1.27HisThr: 1.27 ± 0.046
1.982HisVal: 1.982 ± 0.055
0.372HisTrp: 0.372 ± 0.022
0.526HisTyr: 0.526 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.47IleAla: 5.47 ± 0.108
0.698IleCys: 0.698 ± 0.032
3.553IleAsp: 3.553 ± 0.072
2.403IleGlu: 2.403 ± 0.058
1.382IlePhe: 1.382 ± 0.053
4.514IleGly: 4.514 ± 0.088
0.991IleHis: 0.991 ± 0.039
2.428IleIle: 2.428 ± 0.07
1.209IleLys: 1.209 ± 0.045
3.987IleLeu: 3.987 ± 0.081
1.097IleMet: 1.097 ± 0.043
1.264IleAsn: 1.264 ± 0.046
2.677IlePro: 2.677 ± 0.069
1.015IleGln: 1.015 ± 0.038
2.907IleArg: 2.907 ± 0.069
3.023IleSer: 3.023 ± 0.061
3.109IleThr: 3.109 ± 0.072
4.372IleVal: 4.372 ± 0.088
0.564IleTrp: 0.564 ± 0.032
0.852IleTyr: 0.852 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.429LysAla: 3.429 ± 0.082
0.195LysCys: 0.195 ± 0.018
1.524LysAsp: 1.524 ± 0.048
1.337LysGlu: 1.337 ± 0.047
0.684LysPhe: 0.684 ± 0.036
1.956LysGly: 1.956 ± 0.061
0.564LysHis: 0.564 ± 0.03
1.489LysIle: 1.489 ± 0.046
1.43LysLys: 1.43 ± 0.062
2.533LysLeu: 2.533 ± 0.058
0.658LysMet: 0.658 ± 0.032
0.676LysAsn: 0.676 ± 0.036
1.723LysPro: 1.723 ± 0.049
0.819LysGln: 0.819 ± 0.033
1.923LysArg: 1.923 ± 0.054
1.675LysSer: 1.675 ± 0.055
1.702LysThr: 1.702 ± 0.054
2.706LysVal: 2.706 ± 0.064
0.335LysTrp: 0.335 ± 0.02
0.613LysTyr: 0.613 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
11.334LeuAla: 11.334 ± 0.136
1.166LeuCys: 1.166 ± 0.035
6.022LeuAsp: 6.022 ± 0.101
4.127LeuGlu: 4.127 ± 0.08
2.421LeuPhe: 2.421 ± 0.062
7.843LeuGly: 7.843 ± 0.125
2.011LeuHis: 2.011 ± 0.046
4.103LeuIle: 4.103 ± 0.095
2.306LeuLys: 2.306 ± 0.062
8.444LeuLeu: 8.444 ± 0.127
2.196LeuMet: 2.196 ± 0.05
2.141LeuAsn: 2.141 ± 0.051
5.561LeuPro: 5.561 ± 0.09
2.075LeuGln: 2.075 ± 0.055
6.437LeuArg: 6.437 ± 0.105
6.432LeuSer: 6.432 ± 0.1
6.628LeuThr: 6.628 ± 0.103
8.572LeuVal: 8.572 ± 0.115
1.303LeuTrp: 1.303 ± 0.044
1.413LeuTyr: 1.413 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.461MetAla: 3.461 ± 0.071
0.312MetCys: 0.312 ± 0.023
1.234MetAsp: 1.234 ± 0.046
1.056MetGlu: 1.056 ± 0.04
0.679MetPhe: 0.679 ± 0.032
2.156MetGly: 2.156 ± 0.056
0.528MetHis: 0.528 ± 0.026
1.284MetIle: 1.284 ± 0.046
0.816MetLys: 0.816 ± 0.032
2.338MetLeu: 2.338 ± 0.061
0.622MetMet: 0.622 ± 0.03
0.711MetAsn: 0.711 ± 0.034
1.588MetPro: 1.588 ± 0.048
0.595MetGln: 0.595 ± 0.03
1.818MetArg: 1.818 ± 0.046
2.253MetSer: 2.253 ± 0.052
2.383MetThr: 2.383 ± 0.056
2.204MetVal: 2.204 ± 0.056
0.434MetTrp: 0.434 ± 0.027
0.392MetTyr: 0.392 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.456AsnAla: 2.456 ± 0.061
0.29AsnCys: 0.29 ± 0.022
1.494AsnAsp: 1.494 ± 0.046
1.16AsnGlu: 1.16 ± 0.038
0.717AsnPhe: 0.717 ± 0.031
2.143AsnGly: 2.143 ± 0.061
0.714AsnHis: 0.714 ± 0.034
1.011AsnIle: 1.011 ± 0.035
0.681AsnLys: 0.681 ± 0.036
2.318AsnLeu: 2.318 ± 0.055
0.491AsnMet: 0.491 ± 0.029
0.666AsnAsn: 0.666 ± 0.033
1.924AsnPro: 1.924 ± 0.056
0.827AsnGln: 0.827 ± 0.035
1.647AsnArg: 1.647 ± 0.041
1.466AsnSer: 1.466 ± 0.043
1.435AsnThr: 1.435 ± 0.048
1.781AsnVal: 1.781 ± 0.054
0.353AsnTrp: 0.353 ± 0.023
0.612AsnTyr: 0.612 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
5.641ProAla: 5.641 ± 0.102
0.81ProCys: 0.81 ± 0.037
3.794ProAsp: 3.794 ± 0.084
3.25ProGlu: 3.25 ± 0.081
1.471ProPhe: 1.471 ± 0.041
4.914ProGly: 4.914 ± 0.096
1.486ProHis: 1.486 ± 0.048
2.282ProIle: 2.282 ± 0.054
1.519ProLys: 1.519 ± 0.05
4.57ProLeu: 4.57 ± 0.082
1.534ProMet: 1.534 ± 0.05
1.428ProAsn: 1.428 ± 0.046
2.621ProPro: 2.621 ± 0.064
1.867ProGln: 1.867 ± 0.054
4.241ProArg: 4.241 ± 0.093
4.613ProSer: 4.613 ± 0.093
4.102ProThr: 4.102 ± 0.076
4.62ProVal: 4.62 ± 0.086
1.05ProTrp: 1.05 ± 0.042
1.031ProTyr: 1.031 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.593GlnAla: 3.593 ± 0.076
0.332GlnCys: 0.332 ± 0.021
1.281GlnAsp: 1.281 ± 0.042
1.307GlnGlu: 1.307 ± 0.045
0.809GlnPhe: 0.809 ± 0.039
2.105GlnGly: 2.105 ± 0.061
0.684GlnHis: 0.684 ± 0.032
1.616GlnIle: 1.616 ± 0.046
0.718GlnLys: 0.718 ± 0.032
3.114GlnLeu: 3.114 ± 0.075
0.846GlnMet: 0.846 ± 0.033
0.688GlnAsn: 0.688 ± 0.034
1.716GlnPro: 1.716 ± 0.058
1.09GlnGln: 1.09 ± 0.044
2.398GlnArg: 2.398 ± 0.058
1.593GlnSer: 1.593 ± 0.051
1.679GlnThr: 1.679 ± 0.05
2.714GlnVal: 2.714 ± 0.061
0.599GlnTrp: 0.599 ± 0.029
0.622GlnTyr: 0.622 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.585ArgAla: 6.585 ± 0.115
1.504ArgCys: 1.504 ± 0.049
3.758ArgAsp: 3.758 ± 0.071
3.454ArgGlu: 3.454 ± 0.082
2.105ArgPhe: 2.105 ± 0.057
5.169ArgGly: 5.169 ± 0.098
2.388ArgHis: 2.388 ± 0.066
3.639ArgIle: 3.639 ± 0.074
2.003ArgLys: 2.003 ± 0.06
6.852ArgLeu: 6.852 ± 0.112
2.449ArgMet: 2.449 ± 0.065
1.788ArgAsn: 1.788 ± 0.047
4.422ArgPro: 4.422 ± 0.087
2.574ArgGln: 2.574 ± 0.066
7.814ArgArg: 7.814 ± 0.138
5.414ArgSer: 5.414 ± 0.089
4.36ArgThr: 4.36 ± 0.094
5.044ArgVal: 5.044 ± 0.09
1.603ArgTrp: 1.603 ± 0.049
1.538ArgTyr: 1.538 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.464SerAla: 6.464 ± 0.102
1.129SerCys: 1.129 ± 0.037
3.361SerAsp: 3.361 ± 0.076
2.813SerGlu: 2.813 ± 0.067
1.922SerPhe: 1.922 ± 0.05
6.033SerGly: 6.033 ± 0.107
1.739SerHis: 1.739 ± 0.055
2.69SerIle: 2.69 ± 0.068
1.762SerLys: 1.762 ± 0.053
6.032SerLeu: 6.032 ± 0.083
2.171SerMet: 2.171 ± 0.059
1.432SerAsn: 1.432 ± 0.051
4.42SerPro: 4.42 ± 0.078
2.209SerGln: 2.209 ± 0.057
5.704SerArg: 5.704 ± 0.107
6.351SerSer: 6.351 ± 0.122
4.805SerThr: 4.805 ± 0.092
4.97SerVal: 4.97 ± 0.076
1.57SerTrp: 1.57 ± 0.055
1.311SerTyr: 1.311 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.633ThrAla: 6.633 ± 0.091
0.892ThrCys: 0.892 ± 0.038
3.567ThrAsp: 3.567 ± 0.073
2.733ThrGlu: 2.733 ± 0.068
1.855ThrPhe: 1.855 ± 0.048
5.365ThrGly: 5.365 ± 0.088
1.393ThrHis: 1.393 ± 0.047
3.277ThrIle: 3.277 ± 0.077
1.758ThrLys: 1.758 ± 0.053
5.456ThrLeu: 5.456 ± 0.08
1.751ThrMet: 1.751 ± 0.049
1.55ThrAsn: 1.55 ± 0.05
4.198ThrPro: 4.198 ± 0.07
1.518ThrGln: 1.518 ± 0.048
4.356ThrArg: 4.356 ± 0.09
4.884ThrSer: 4.884 ± 0.087
4.858ThrThr: 4.858 ± 0.109
5.823ThrVal: 5.823 ± 0.098
1.254ThrTrp: 1.254 ± 0.042
1.203ThrTyr: 1.203 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
9.253ValAla: 9.253 ± 0.125
1.103ValCys: 1.103 ± 0.042
5.464ValAsp: 5.464 ± 0.096
4.709ValGlu: 4.709 ± 0.094
2.332ValPhe: 2.332 ± 0.056
6.763ValGly: 6.763 ± 0.118
1.756ValHis: 1.756 ± 0.047
4.557ValIle: 4.557 ± 0.087
2.275ValLys: 2.275 ± 0.058
7.939ValLeu: 7.939 ± 0.115
2.265ValMet: 2.265 ± 0.053
2.262ValAsn: 2.262 ± 0.064
4.443ValPro: 4.443 ± 0.077
1.883ValGln: 1.883 ± 0.055
5.46ValArg: 5.46 ± 0.081
5.5ValSer: 5.5 ± 0.084
6.065ValThr: 6.065 ± 0.094
8.421ValVal: 8.421 ± 0.12
1.231ValTrp: 1.231 ± 0.047
1.33ValTyr: 1.33 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.475TrpAla: 1.475 ± 0.048
0.363TrpCys: 0.363 ± 0.022
0.744TrpAsp: 0.744 ± 0.033
0.592TrpGlu: 0.592 ± 0.027
0.672TrpPhe: 0.672 ± 0.031
1.196TrpGly: 1.196 ± 0.043
0.485TrpHis: 0.485 ± 0.028
0.794TrpIle: 0.794 ± 0.034
0.458TrpLys: 0.458 ± 0.026
1.914TrpLeu: 1.914 ± 0.06
0.518TrpMet: 0.518 ± 0.027
0.477TrpAsn: 0.477 ± 0.028
1.109TrpPro: 1.109 ± 0.044
0.735TrpGln: 0.735 ± 0.034
1.557TrpArg: 1.557 ± 0.041
1.326TrpSer: 1.326 ± 0.044
1.083TrpThr: 1.083 ± 0.039
1.303TrpVal: 1.303 ± 0.043
0.472TrpTrp: 0.472 ± 0.026
0.355TrpTyr: 0.355 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.754TyrAla: 1.754 ± 0.055
0.253TyrCys: 0.253 ± 0.018
1.297TyrAsp: 1.297 ± 0.046
0.906TyrGlu: 0.906 ± 0.038
0.632TyrPhe: 0.632 ± 0.032
1.776TyrGly: 1.776 ± 0.049
0.452TyrHis: 0.452 ± 0.027
0.625TyrIle: 0.625 ± 0.027
0.422TyrLys: 0.422 ± 0.026
2.133TyrLeu: 2.133 ± 0.057
0.355TyrMet: 0.355 ± 0.023
0.474TyrAsn: 0.474 ± 0.031
1.116TyrPro: 1.116 ± 0.04
0.695TyrGln: 0.695 ± 0.031
1.591TyrArg: 1.591 ± 0.055
1.261TyrSer: 1.261 ± 0.043
1.064TyrThr: 1.064 ± 0.041
1.491TyrVal: 1.491 ± 0.047
0.386TyrTrp: 0.386 ± 0.021
0.424TyrTyr: 0.424 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4111 proteins (696319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski