Amino acid dipepetide frequency for Moraxella phage Mcat2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.734AlaAla: 3.734 ± 0.96
0.581AlaCys: 0.581 ± 0.294
6.057AlaAsp: 6.057 ± 0.606
3.153AlaGlu: 3.153 ± 0.446
3.651AlaPhe: 3.651 ± 0.545
4.564AlaGly: 4.564 ± 0.657
1.742AlaHis: 1.742 ± 0.423
6.721AlaIle: 6.721 ± 0.688
7.883AlaLys: 7.883 ± 0.992
7.302AlaLeu: 7.302 ± 0.703
2.738AlaMet: 2.738 ± 0.636
4.564AlaAsn: 4.564 ± 0.814
2.489AlaPro: 2.489 ± 0.572
4.564AlaGln: 4.564 ± 0.658
3.236AlaArg: 3.236 ± 0.553
6.14AlaSer: 6.14 ± 0.79
6.472AlaThr: 6.472 ± 1.153
6.389AlaVal: 6.389 ± 0.743
1.742AlaTrp: 1.742 ± 0.36
3.153AlaTyr: 3.153 ± 0.464
0.0AlaXaa: 0.0 ± 0.0
Cys
0.415CysAla: 0.415 ± 0.219
0.166CysCys: 0.166 ± 0.114
0.664CysAsp: 0.664 ± 0.221
0.913CysGlu: 0.913 ± 0.282
0.415CysPhe: 0.415 ± 0.222
1.162CysGly: 1.162 ± 0.402
0.332CysHis: 0.332 ± 0.156
0.498CysIle: 0.498 ± 0.189
0.498CysLys: 0.498 ± 0.203
0.747CysLeu: 0.747 ± 0.275
0.083CysMet: 0.083 ± 0.089
0.249CysAsn: 0.249 ± 0.181
0.581CysPro: 0.581 ± 0.221
0.415CysGln: 0.415 ± 0.212
0.249CysArg: 0.249 ± 0.134
0.664CysSer: 0.664 ± 0.202
0.415CysThr: 0.415 ± 0.192
0.747CysVal: 0.747 ± 0.304
0.083CysTrp: 0.083 ± 0.083
0.83CysTyr: 0.83 ± 0.305
0.0CysXaa: 0.0 ± 0.0
Asp
3.651AspAla: 3.651 ± 0.488
0.83AspCys: 0.83 ± 0.391
5.974AspAsp: 5.974 ± 0.878
5.559AspGlu: 5.559 ± 0.629
3.07AspPhe: 3.07 ± 0.504
5.642AspGly: 5.642 ± 0.637
0.83AspHis: 0.83 ± 0.309
3.9AspIle: 3.9 ± 0.575
5.476AspLys: 5.476 ± 0.546
4.812AspLeu: 4.812 ± 0.602
1.411AspMet: 1.411 ± 0.46
4.647AspAsn: 4.647 ± 0.562
1.328AspPro: 1.328 ± 0.412
1.411AspGln: 1.411 ± 0.364
1.991AspArg: 1.991 ± 0.4
2.904AspSer: 2.904 ± 0.407
3.651AspThr: 3.651 ± 0.602
2.24AspVal: 2.24 ± 0.431
0.747AspTrp: 0.747 ± 0.295
2.406AspTyr: 2.406 ± 0.555
0.0AspXaa: 0.0 ± 0.0
Glu
3.07GluAla: 3.07 ± 0.587
0.83GluCys: 0.83 ± 0.306
1.079GluAsp: 1.079 ± 0.286
1.411GluGlu: 1.411 ± 0.386
2.572GluPhe: 2.572 ± 0.469
2.074GluGly: 2.074 ± 0.511
1.659GluHis: 1.659 ± 0.379
4.647GluIle: 4.647 ± 0.627
3.568GluLys: 3.568 ± 0.708
6.472GluLeu: 6.472 ± 0.574
1.908GluMet: 1.908 ± 0.419
2.24GluAsn: 2.24 ± 0.448
1.991GluPro: 1.991 ± 0.496
3.9GluGln: 3.9 ± 0.482
3.153GluArg: 3.153 ± 0.629
2.904GluSer: 2.904 ± 0.474
2.157GluThr: 2.157 ± 0.294
2.738GluVal: 2.738 ± 0.455
0.581GluTrp: 0.581 ± 0.263
2.157GluTyr: 2.157 ± 0.494
0.0GluXaa: 0.0 ± 0.0
Phe
4.232PheAla: 4.232 ± 0.494
0.747PheCys: 0.747 ± 0.252
2.904PheAsp: 2.904 ± 0.551
2.323PheGlu: 2.323 ± 0.348
1.079PhePhe: 1.079 ± 0.25
3.153PheGly: 3.153 ± 0.459
0.747PheHis: 0.747 ± 0.26
2.821PheIle: 2.821 ± 0.549
2.157PheLys: 2.157 ± 0.379
2.655PheLeu: 2.655 ± 0.544
1.162PheMet: 1.162 ± 0.329
1.577PheAsn: 1.577 ± 0.339
0.83PhePro: 0.83 ± 0.247
0.332PheGln: 0.332 ± 0.166
1.328PheArg: 1.328 ± 0.317
2.157PheSer: 2.157 ± 0.393
1.411PheThr: 1.411 ± 0.37
1.991PheVal: 1.991 ± 0.46
0.581PheTrp: 0.581 ± 0.207
1.577PheTyr: 1.577 ± 0.326
0.0PheXaa: 0.0 ± 0.0
Gly
4.481GlyAla: 4.481 ± 0.836
0.581GlyCys: 0.581 ± 0.217
4.73GlyAsp: 4.73 ± 0.604
4.647GlyGlu: 4.647 ± 0.824
2.489GlyPhe: 2.489 ± 0.595
5.393GlyGly: 5.393 ± 0.563
1.079GlyHis: 1.079 ± 0.336
4.564GlyIle: 4.564 ± 0.751
4.812GlyLys: 4.812 ± 0.582
5.393GlyLeu: 5.393 ± 0.633
2.074GlyMet: 2.074 ± 0.439
3.817GlyAsn: 3.817 ± 0.691
0.0GlyPro: 0.0 ± 0.0
2.655GlyGln: 2.655 ± 0.497
3.319GlyArg: 3.319 ± 0.451
3.402GlySer: 3.402 ± 0.475
3.651GlyThr: 3.651 ± 0.689
5.642GlyVal: 5.642 ± 0.657
1.577GlyTrp: 1.577 ± 0.33
2.821GlyTyr: 2.821 ± 0.477
0.0GlyXaa: 0.0 ± 0.0
His
2.738HisAla: 2.738 ± 0.5
0.166HisCys: 0.166 ± 0.134
1.245HisAsp: 1.245 ± 0.322
1.825HisGlu: 1.825 ± 0.321
0.83HisPhe: 0.83 ± 0.273
2.323HisGly: 2.323 ± 0.507
0.996HisHis: 0.996 ± 0.294
1.411HisIle: 1.411 ± 0.34
1.079HisLys: 1.079 ± 0.273
1.908HisLeu: 1.908 ± 0.334
0.415HisMet: 0.415 ± 0.146
1.494HisAsn: 1.494 ± 0.479
0.913HisPro: 0.913 ± 0.255
0.83HisGln: 0.83 ± 0.268
1.162HisArg: 1.162 ± 0.335
1.079HisSer: 1.079 ± 0.308
2.655HisThr: 2.655 ± 0.651
0.664HisVal: 0.664 ± 0.219
0.332HisTrp: 0.332 ± 0.222
0.913HisTyr: 0.913 ± 0.272
0.0HisXaa: 0.0 ± 0.0
Ile
6.555IleAla: 6.555 ± 0.95
0.581IleCys: 0.581 ± 0.259
6.057IleAsp: 6.057 ± 0.553
2.655IleGlu: 2.655 ± 0.481
2.157IlePhe: 2.157 ± 0.506
5.227IleGly: 5.227 ± 0.79
0.996IleHis: 0.996 ± 0.308
4.232IleIle: 4.232 ± 0.53
5.144IleLys: 5.144 ± 0.781
3.9IleLeu: 3.9 ± 0.57
1.079IleMet: 1.079 ± 0.285
5.227IleAsn: 5.227 ± 0.986
2.821IlePro: 2.821 ± 0.517
2.24IleGln: 2.24 ± 0.32
2.987IleArg: 2.987 ± 0.546
5.476IleSer: 5.476 ± 0.963
5.808IleThr: 5.808 ± 0.832
2.738IleVal: 2.738 ± 0.497
0.498IleTrp: 0.498 ± 0.223
2.572IleTyr: 2.572 ± 0.617
0.0IleXaa: 0.0 ± 0.0
Lys
7.136LysAla: 7.136 ± 0.742
0.332LysCys: 0.332 ± 0.154
3.734LysAsp: 3.734 ± 0.633
4.066LysGlu: 4.066 ± 0.594
2.489LysPhe: 2.489 ± 0.43
3.485LysGly: 3.485 ± 0.591
1.908LysHis: 1.908 ± 0.324
4.978LysIle: 4.978 ± 0.596
4.398LysLys: 4.398 ± 0.693
5.31LysLeu: 5.31 ± 0.589
1.659LysMet: 1.659 ± 0.435
2.738LysAsn: 2.738 ± 0.587
2.821LysPro: 2.821 ± 0.615
3.983LysGln: 3.983 ± 0.524
3.485LysArg: 3.485 ± 0.441
4.73LysSer: 4.73 ± 0.588
5.144LysThr: 5.144 ± 0.627
3.983LysVal: 3.983 ± 0.602
0.83LysTrp: 0.83 ± 0.303
1.908LysTyr: 1.908 ± 0.407
0.0LysXaa: 0.0 ± 0.0
Leu
7.717LeuAla: 7.717 ± 1.3
1.162LeuCys: 1.162 ± 0.395
6.306LeuAsp: 6.306 ± 0.725
2.904LeuGlu: 2.904 ± 0.507
2.489LeuPhe: 2.489 ± 0.534
6.306LeuGly: 6.306 ± 0.722
1.908LeuHis: 1.908 ± 0.443
5.725LeuIle: 5.725 ± 0.773
5.061LeuLys: 5.061 ± 0.632
6.057LeuLeu: 6.057 ± 0.775
1.659LeuMet: 1.659 ± 0.438
5.061LeuAsn: 5.061 ± 0.674
3.319LeuPro: 3.319 ± 0.539
3.485LeuGln: 3.485 ± 0.46
3.319LeuArg: 3.319 ± 0.456
7.053LeuSer: 7.053 ± 0.669
6.721LeuThr: 6.721 ± 0.676
4.812LeuVal: 4.812 ± 0.706
0.664LeuTrp: 0.664 ± 0.216
2.572LeuTyr: 2.572 ± 0.434
0.0LeuXaa: 0.0 ± 0.0
Met
2.406MetAla: 2.406 ± 0.574
0.249MetCys: 0.249 ± 0.137
1.245MetAsp: 1.245 ± 0.276
0.166MetGlu: 0.166 ± 0.133
0.83MetPhe: 0.83 ± 0.276
1.494MetGly: 1.494 ± 0.306
0.415MetHis: 0.415 ± 0.241
1.411MetIle: 1.411 ± 0.336
1.079MetLys: 1.079 ± 0.246
1.991MetLeu: 1.991 ± 0.515
0.581MetMet: 0.581 ± 0.25
1.245MetAsn: 1.245 ± 0.363
0.996MetPro: 0.996 ± 0.312
1.659MetGln: 1.659 ± 0.514
0.83MetArg: 0.83 ± 0.296
2.655MetSer: 2.655 ± 0.545
1.991MetThr: 1.991 ± 0.466
0.913MetVal: 0.913 ± 0.218
0.249MetTrp: 0.249 ± 0.132
0.581MetTyr: 0.581 ± 0.196
0.0MetXaa: 0.0 ± 0.0
Asn
5.476AsnAla: 5.476 ± 0.807
0.249AsnCys: 0.249 ± 0.145
2.406AsnAsp: 2.406 ± 0.543
2.572AsnGlu: 2.572 ± 0.393
1.825AsnPhe: 1.825 ± 0.375
3.651AsnGly: 3.651 ± 0.801
1.494AsnHis: 1.494 ± 0.314
2.572AsnIle: 2.572 ± 0.38
4.232AsnLys: 4.232 ± 0.899
3.983AsnLeu: 3.983 ± 0.567
0.83AsnMet: 0.83 ± 0.208
3.568AsnAsn: 3.568 ± 0.633
3.153AsnPro: 3.153 ± 0.653
3.651AsnGln: 3.651 ± 0.632
1.659AsnArg: 1.659 ± 0.307
3.983AsnSer: 3.983 ± 0.924
3.734AsnThr: 3.734 ± 0.896
2.655AsnVal: 2.655 ± 0.519
0.664AsnTrp: 0.664 ± 0.204
2.24AsnTyr: 2.24 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
3.319ProAla: 3.319 ± 0.496
0.249ProCys: 0.249 ± 0.174
1.908ProAsp: 1.908 ± 0.366
1.245ProGlu: 1.245 ± 0.373
1.411ProPhe: 1.411 ± 0.304
0.166ProGly: 0.166 ± 0.112
0.498ProHis: 0.498 ± 0.205
2.157ProIle: 2.157 ± 0.499
3.236ProLys: 3.236 ± 0.632
2.904ProLeu: 2.904 ± 0.683
0.996ProMet: 0.996 ± 0.275
2.24ProAsn: 2.24 ± 0.385
1.494ProPro: 1.494 ± 0.362
1.742ProGln: 1.742 ± 0.495
1.494ProArg: 1.494 ± 0.276
2.323ProSer: 2.323 ± 0.621
3.153ProThr: 3.153 ± 0.524
2.323ProVal: 2.323 ± 0.462
0.249ProTrp: 0.249 ± 0.114
0.996ProTyr: 0.996 ± 0.314
0.0ProXaa: 0.0 ± 0.0
Gln
5.642GlnAla: 5.642 ± 0.734
0.415GlnCys: 0.415 ± 0.178
2.323GlnAsp: 2.323 ± 0.437
1.825GlnGlu: 1.825 ± 0.339
1.659GlnPhe: 1.659 ± 0.293
2.987GlnGly: 2.987 ± 0.455
0.83GlnHis: 0.83 ± 0.234
4.066GlnIle: 4.066 ± 0.534
3.983GlnLys: 3.983 ± 0.484
3.817GlnLeu: 3.817 ± 0.62
1.079GlnMet: 1.079 ± 0.35
3.236GlnAsn: 3.236 ± 0.578
1.245GlnPro: 1.245 ± 0.393
1.659GlnGln: 1.659 ± 0.427
1.742GlnArg: 1.742 ± 0.545
3.651GlnSer: 3.651 ± 1.032
2.987GlnThr: 2.987 ± 0.404
2.074GlnVal: 2.074 ± 0.378
0.415GlnTrp: 0.415 ± 0.156
1.328GlnTyr: 1.328 ± 0.323
0.0GlnXaa: 0.0 ± 0.0
Arg
4.398ArgAla: 4.398 ± 0.871
0.332ArgCys: 0.332 ± 0.123
1.991ArgAsp: 1.991 ± 0.462
2.157ArgGlu: 2.157 ± 0.395
1.991ArgPhe: 1.991 ± 0.483
1.825ArgGly: 1.825 ± 0.378
1.991ArgHis: 1.991 ± 0.397
2.987ArgIle: 2.987 ± 0.682
2.24ArgLys: 2.24 ± 0.405
4.481ArgLeu: 4.481 ± 0.628
0.996ArgMet: 0.996 ± 0.251
0.913ArgAsn: 0.913 ± 0.252
1.742ArgPro: 1.742 ± 0.37
2.821ArgGln: 2.821 ± 0.425
2.074ArgArg: 2.074 ± 0.37
2.655ArgSer: 2.655 ± 0.472
2.821ArgThr: 2.821 ± 0.569
2.406ArgVal: 2.406 ± 0.425
0.166ArgTrp: 0.166 ± 0.115
1.742ArgTyr: 1.742 ± 0.392
0.0ArgXaa: 0.0 ± 0.0
Ser
5.559SerAla: 5.559 ± 0.77
0.747SerCys: 0.747 ± 0.282
3.9SerAsp: 3.9 ± 0.603
4.149SerGlu: 4.149 ± 0.519
1.742SerPhe: 1.742 ± 0.346
4.647SerGly: 4.647 ± 0.758
2.987SerHis: 2.987 ± 0.852
5.061SerIle: 5.061 ± 0.822
3.817SerLys: 3.817 ± 0.689
6.389SerLeu: 6.389 ± 1.038
1.328SerMet: 1.328 ± 0.259
3.402SerAsn: 3.402 ± 0.793
1.245SerPro: 1.245 ± 0.406
3.651SerGln: 3.651 ± 0.551
2.821SerArg: 2.821 ± 0.522
3.983SerSer: 3.983 ± 1.14
3.319SerThr: 3.319 ± 0.397
5.725SerVal: 5.725 ± 1.08
0.83SerTrp: 0.83 ± 0.245
1.742SerTyr: 1.742 ± 0.412
0.0SerXaa: 0.0 ± 0.0
Thr
6.389ThrAla: 6.389 ± 0.696
0.332ThrCys: 0.332 ± 0.171
4.315ThrAsp: 4.315 ± 0.653
3.485ThrGlu: 3.485 ± 0.541
1.659ThrPhe: 1.659 ± 0.304
5.476ThrGly: 5.476 ± 0.756
2.157ThrHis: 2.157 ± 0.577
3.651ThrIle: 3.651 ± 0.427
5.725ThrLys: 5.725 ± 0.832
6.804ThrLeu: 6.804 ± 0.691
1.079ThrMet: 1.079 ± 0.304
3.07ThrAsn: 3.07 ± 0.584
3.402ThrPro: 3.402 ± 0.665
2.904ThrGln: 2.904 ± 0.589
2.323ThrArg: 2.323 ± 0.491
4.481ThrSer: 4.481 ± 1.107
4.066ThrThr: 4.066 ± 0.738
3.817ThrVal: 3.817 ± 0.808
0.581ThrTrp: 0.581 ± 0.201
0.747ThrTyr: 0.747 ± 0.281
0.0ThrXaa: 0.0 ± 0.0
Val
5.061ValAla: 5.061 ± 0.775
0.664ValCys: 0.664 ± 0.217
2.821ValAsp: 2.821 ± 0.479
2.655ValGlu: 2.655 ± 0.431
2.323ValPhe: 2.323 ± 0.399
5.061ValGly: 5.061 ± 0.718
0.996ValHis: 0.996 ± 0.287
4.73ValIle: 4.73 ± 0.809
2.821ValLys: 2.821 ± 0.63
4.73ValLeu: 4.73 ± 0.676
1.079ValMet: 1.079 ± 0.352
2.987ValAsn: 2.987 ± 0.561
2.24ValPro: 2.24 ± 0.468
2.406ValGln: 2.406 ± 0.411
3.402ValArg: 3.402 ± 0.583
4.398ValSer: 4.398 ± 0.659
3.568ValThr: 3.568 ± 0.727
2.987ValVal: 2.987 ± 0.685
0.913ValTrp: 0.913 ± 0.229
2.074ValTyr: 2.074 ± 0.338
0.0ValXaa: 0.0 ± 0.0
Trp
1.494TrpAla: 1.494 ± 0.265
0.415TrpCys: 0.415 ± 0.215
0.747TrpAsp: 0.747 ± 0.26
0.996TrpGlu: 0.996 ± 0.254
0.332TrpPhe: 0.332 ± 0.172
0.581TrpGly: 0.581 ± 0.216
0.332TrpHis: 0.332 ± 0.218
0.249TrpIle: 0.249 ± 0.143
0.498TrpLys: 0.498 ± 0.206
1.411TrpLeu: 1.411 ± 0.336
0.0TrpMet: 0.0 ± 0.0
0.498TrpAsn: 0.498 ± 0.197
0.0TrpPro: 0.0 ± 0.0
1.162TrpGln: 1.162 ± 0.43
0.498TrpArg: 0.498 ± 0.189
0.747TrpSer: 0.747 ± 0.313
0.664TrpThr: 0.664 ± 0.213
1.328TrpVal: 1.328 ± 0.403
0.249TrpTrp: 0.249 ± 0.142
0.332TrpTyr: 0.332 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.402TyrAla: 3.402 ± 0.462
0.498TyrCys: 0.498 ± 0.237
2.074TyrAsp: 2.074 ± 0.453
2.406TyrGlu: 2.406 ± 0.381
0.747TyrPhe: 0.747 ± 0.244
1.908TyrGly: 1.908 ± 0.407
1.079TyrHis: 1.079 ± 0.357
2.572TyrIle: 2.572 ± 0.607
1.411TyrLys: 1.411 ± 0.295
3.236TyrLeu: 3.236 ± 0.68
0.747TyrMet: 0.747 ± 0.236
1.825TyrAsn: 1.825 ± 0.359
1.494TyrPro: 1.494 ± 0.346
1.494TyrGln: 1.494 ± 0.353
1.659TyrArg: 1.659 ± 0.328
1.659TyrSer: 1.659 ± 0.436
2.074TyrThr: 2.074 ± 0.438
1.742TyrVal: 1.742 ± 0.293
0.581TyrTrp: 0.581 ± 0.208
1.245TyrTyr: 1.245 ± 0.418
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (12053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski