Amino acid dipepetide frequency for Novimethylophilus kurashikiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.424AlaAla: 12.424 ± 0.152	1.087AlaCys: 1.087 ± 0.036	5.554AlaAsp: 5.554 ± 0.082	6.917AlaGlu: 6.917 ± 0.085	3.613AlaPhe: 3.613 ± 0.058	7.903AlaGly: 7.903 ± 0.104	2.242AlaHis: 2.242 ± 0.051	5.634AlaIle: 5.634 ± 0.069	4.681AlaLys: 4.681 ± 0.083	11.702AlaLeu: 11.702 ± 0.117	3.23AlaMet: 3.23 ± 0.057	3.305AlaAsn: 3.305 ± 0.075	4.104AlaPro: 4.104 ± 0.066	4.53AlaGln: 4.53 ± 0.078	5.634AlaArg: 5.634 ± 0.08	5.935AlaSer: 5.935 ± 0.086	5.202AlaThr: 5.202 ± 0.116	7.485AlaVal: 7.485 ± 0.083	1.466AlaTrp: 1.466 ± 0.047	2.541AlaTyr: 2.541 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.862CysAla: 0.862 ± 0.037	0.147CysCys: 0.147 ± 0.012	0.551CysAsp: 0.551 ± 0.025	0.567CysGlu: 0.567 ± 0.021	0.309CysPhe: 0.309 ± 0.015	0.938CysGly: 0.938 ± 0.036	0.399CysHis: 0.399 ± 0.076	0.472CysIle: 0.472 ± 0.021	0.359CysLys: 0.359 ± 0.019	0.873CysLeu: 0.873 ± 0.032	0.215CysMet: 0.215 ± 0.014	0.325CysAsn: 0.325 ± 0.018	0.501CysPro: 0.501 ± 0.023	0.301CysGln: 0.301 ± 0.018	0.597CysArg: 0.597 ± 0.026	0.568CysSer: 0.568 ± 0.033	0.467CysThr: 0.467 ± 0.026	0.668CysVal: 0.668 ± 0.03	0.115CysTrp: 0.115 ± 0.011	0.254CysTyr: 0.254 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.81AspAla: 5.81 ± 0.086	0.546AspCys: 0.546 ± 0.025	2.837AspAsp: 2.837 ± 0.059	3.585AspGlu: 3.585 ± 0.052	2.239AspPhe: 2.239 ± 0.046	4.255AspGly: 4.255 ± 0.071	1.153AspHis: 1.153 ± 0.033	3.454AspIle: 3.454 ± 0.058	2.531AspLys: 2.531 ± 0.057	5.342AspLeu: 5.342 ± 0.075	1.368AspMet: 1.368 ± 0.038	1.673AspAsn: 1.673 ± 0.043	2.476AspPro: 2.476 ± 0.046	1.899AspGln: 1.899 ± 0.044	2.991AspArg: 2.991 ± 0.058	2.54AspSer: 2.54 ± 0.055	2.798AspThr: 2.798 ± 0.059	3.902AspVal: 3.902 ± 0.07	0.884AspTrp: 0.884 ± 0.031	1.753AspTyr: 1.753 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.796GluAla: 6.796 ± 0.091	0.481GluCys: 0.481 ± 0.024	2.79GluAsp: 2.79 ± 0.055	3.562GluGlu: 3.562 ± 0.073	2.211GluPhe: 2.211 ± 0.046	3.814GluGly: 3.814 ± 0.06	1.614GluHis: 1.614 ± 0.041	3.782GluIle: 3.782 ± 0.063	3.003GluLys: 3.003 ± 0.054	6.152GluLeu: 6.152 ± 0.077	1.716GluMet: 1.716 ± 0.042	2.068GluAsn: 2.068 ± 0.047	2.282GluPro: 2.282 ± 0.049	2.887GluGln: 2.887 ± 0.063	4.108GluArg: 4.108 ± 0.073	3.374GluSer: 3.374 ± 0.06	3.193GluThr: 3.193 ± 0.056	4.307GluVal: 4.307 ± 0.085	0.753GluTrp: 0.753 ± 0.027	1.496GluTyr: 1.496 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.565PheAla: 3.565 ± 0.06	0.41PheCys: 0.41 ± 0.021	2.447PheAsp: 2.447 ± 0.05	2.132PheGlu: 2.132 ± 0.048	1.515PhePhe: 1.515 ± 0.044	3.163PheGly: 3.163 ± 0.059	0.804PheHis: 0.804 ± 0.024	2.052PheIle: 2.052 ± 0.047	1.583PheLys: 1.583 ± 0.033	3.309PheLeu: 3.309 ± 0.06	0.929PheMet: 0.929 ± 0.027	1.508PheAsn: 1.508 ± 0.034	1.566PhePro: 1.566 ± 0.038	1.207PheGln: 1.207 ± 0.035	1.87PheArg: 1.87 ± 0.045	2.626PheSer: 2.626 ± 0.053	1.976PheThr: 1.976 ± 0.05	2.688PheVal: 2.688 ± 0.055	0.556PheTrp: 0.556 ± 0.025	1.139PheTyr: 1.139 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.686GlyAla: 6.686 ± 0.096	0.819GlyCys: 0.819 ± 0.03	3.793GlyAsp: 3.793 ± 0.062	4.493GlyGlu: 4.493 ± 0.07	3.202GlyPhe: 3.202 ± 0.055	5.748GlyGly: 5.748 ± 0.093	1.909GlyHis: 1.909 ± 0.047	4.651GlyIle: 4.651 ± 0.062	4.355GlyLys: 4.355 ± 0.073	7.778GlyLeu: 7.778 ± 0.096	2.426GlyMet: 2.426 ± 0.046	2.694GlyAsn: 2.694 ± 0.061	2.174GlyPro: 2.174 ± 0.05	2.801GlyGln: 2.801 ± 0.05	4.295GlyArg: 4.295 ± 0.07	4.162GlySer: 4.162 ± 0.068	4.184GlyThr: 4.184 ± 0.102	5.755GlyVal: 5.755 ± 0.08	1.215GlyTrp: 1.215 ± 0.034	2.533GlyTyr: 2.533 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.53HisAla: 2.53 ± 0.05	0.317HisCys: 0.317 ± 0.018	1.313HisAsp: 1.313 ± 0.04	1.385HisGlu: 1.385 ± 0.043	0.996HisPhe: 0.996 ± 0.034	1.974HisGly: 1.974 ± 0.049	0.774HisHis: 0.774 ± 0.03	1.291HisIle: 1.291 ± 0.04	0.866HisLys: 0.866 ± 0.035	2.422HisLeu: 2.422 ± 0.053	0.623HisMet: 0.623 ± 0.024	0.71HisAsn: 0.71 ± 0.031	1.546HisPro: 1.546 ± 0.042	0.957HisGln: 0.957 ± 0.027	1.409HisArg: 1.409 ± 0.039	1.165HisSer: 1.165 ± 0.041	1.124HisThr: 1.124 ± 0.052	1.533HisVal: 1.533 ± 0.037	0.412HisTrp: 0.412 ± 0.018	0.788HisTyr: 0.788 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.48IleAla: 6.48 ± 0.086	0.526IleCys: 0.526 ± 0.023	3.424IleAsp: 3.424 ± 0.051	3.64IleGlu: 3.64 ± 0.07	1.695IlePhe: 1.695 ± 0.04	4.535IleGly: 4.535 ± 0.063	1.182IleHis: 1.182 ± 0.033	2.548IleIle: 2.548 ± 0.047	2.438IleLys: 2.438 ± 0.055	4.829IleLeu: 4.829 ± 0.083	1.08IleMet: 1.08 ± 0.034	2.026IleAsn: 2.026 ± 0.046	2.688IlePro: 2.688 ± 0.052	1.917IleGln: 1.917 ± 0.045	3.004IleArg: 3.004 ± 0.054	3.424IleSer: 3.424 ± 0.058	3.043IleThr: 3.043 ± 0.059	3.968IleVal: 3.968 ± 0.057	0.523IleTrp: 0.523 ± 0.021	1.386IleTyr: 1.386 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.627LysAla: 4.627 ± 0.075	0.294LysCys: 0.294 ± 0.023	2.215LysAsp: 2.215 ± 0.051	2.469LysGlu: 2.469 ± 0.045	1.376LysPhe: 1.376 ± 0.038	2.954LysGly: 2.954 ± 0.065	1.113LysHis: 1.113 ± 0.035	2.405LysIle: 2.405 ± 0.053	2.116LysLys: 2.116 ± 0.057	4.938LysLeu: 4.938 ± 0.07	1.159LysMet: 1.159 ± 0.035	1.568LysAsn: 1.568 ± 0.042	2.566LysPro: 2.566 ± 0.061	2.088LysGln: 2.088 ± 0.047	2.626LysArg: 2.626 ± 0.056	2.684LysSer: 2.684 ± 0.05	2.586LysThr: 2.586 ± 0.049	3.3LysVal: 3.3 ± 0.058	0.442LysTrp: 0.442 ± 0.022	1.028LysTyr: 1.028 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.966LeuAla: 11.966 ± 0.118	0.921LeuCys: 0.921 ± 0.031	5.983LeuAsp: 5.983 ± 0.075	6.165LeuGlu: 6.165 ± 0.094	3.714LeuPhe: 3.714 ± 0.071	7.93LeuGly: 7.93 ± 0.089	2.438LeuHis: 2.438 ± 0.047	5.27LeuIle: 5.27 ± 0.066	4.922LeuLys: 4.922 ± 0.077	10.922LeuLeu: 10.922 ± 0.125	2.847LeuMet: 2.847 ± 0.053	3.608LeuAsn: 3.608 ± 0.062	5.591LeuPro: 5.591 ± 0.07	4.036LeuGln: 4.036 ± 0.067	6.071LeuArg: 6.071 ± 0.076	6.655LeuSer: 6.655 ± 0.083	5.579LeuThr: 5.579 ± 0.072	7.03LeuVal: 7.03 ± 0.082	1.218LeuTrp: 1.218 ± 0.041	2.334LeuTyr: 2.334 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.938MetAla: 2.938 ± 0.049	0.172MetCys: 0.172 ± 0.012	1.267MetAsp: 1.267 ± 0.033	1.426MetGlu: 1.426 ± 0.034	0.808MetPhe: 0.808 ± 0.026	1.878MetGly: 1.878 ± 0.047	0.652MetHis: 0.652 ± 0.026	1.182MetIle: 1.182 ± 0.035	1.306MetLys: 1.306 ± 0.034	3.013MetLeu: 3.013 ± 0.053	0.77MetMet: 0.77 ± 0.027	1.005MetAsn: 1.005 ± 0.032	1.483MetPro: 1.483 ± 0.034	1.377MetGln: 1.377 ± 0.034	1.75MetArg: 1.75 ± 0.045	1.755MetSer: 1.755 ± 0.037	1.616MetThr: 1.616 ± 0.042	1.759MetVal: 1.759 ± 0.042	0.211MetTrp: 0.211 ± 0.014	0.525MetTyr: 0.525 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.613AsnAla: 3.613 ± 0.07	0.355AsnCys: 0.355 ± 0.031	1.823AsnAsp: 1.823 ± 0.053	1.71AsnGlu: 1.71 ± 0.038	1.264AsnPhe: 1.264 ± 0.036	2.866AsnGly: 2.866 ± 0.063	0.758AsnHis: 0.758 ± 0.031	2.062AsnIle: 2.062 ± 0.042	1.375AsnLys: 1.375 ± 0.039	3.545AsnLeu: 3.545 ± 0.054	0.81AsnMet: 0.81 ± 0.028	1.26AsnAsn: 1.26 ± 0.045	2.068AsnPro: 2.068 ± 0.046	1.399AsnGln: 1.399 ± 0.037	2.036AsnArg: 2.036 ± 0.041	1.8AsnSer: 1.8 ± 0.045	1.893AsnThr: 1.893 ± 0.048	2.455AsnVal: 2.455 ± 0.058	0.463AsnTrp: 0.463 ± 0.022	0.936AsnTyr: 0.936 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.792ProAla: 4.792 ± 0.084	0.357ProCys: 0.357 ± 0.015	3.007ProAsp: 3.007 ± 0.055	3.584ProGlu: 3.584 ± 0.056	1.704ProPhe: 1.704 ± 0.046	3.534ProGly: 3.534 ± 0.064	1.116ProHis: 1.116 ± 0.036	2.21ProIle: 2.21 ± 0.048	1.927ProLys: 1.927 ± 0.043	4.54ProLeu: 4.54 ± 0.068	1.169ProMet: 1.169 ± 0.036	1.589ProAsn: 1.589 ± 0.044	2.081ProPro: 2.081 ± 0.062	2.087ProGln: 2.087 ± 0.048	2.06ProArg: 2.06 ± 0.048	2.624ProSer: 2.624 ± 0.047	2.341ProThr: 2.341 ± 0.058	3.75ProVal: 3.75 ± 0.061	0.665ProTrp: 0.665 ± 0.027	1.265ProTyr: 1.265 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.927GlnAla: 4.927 ± 0.074	0.347GlnCys: 0.347 ± 0.023	2.004GlnAsp: 2.004 ± 0.052	2.276GlnGlu: 2.276 ± 0.046	1.403GlnPhe: 1.403 ± 0.035	2.86GlnGly: 2.86 ± 0.048	1.165GlnHis: 1.165 ± 0.034	2.05GlnIle: 2.05 ± 0.044	1.633GlnLys: 1.633 ± 0.042	4.389GlnLeu: 4.389 ± 0.067	1.088GlnMet: 1.088 ± 0.028	1.261GlnAsn: 1.261 ± 0.033	2.108GlnPro: 2.108 ± 0.052	2.218GlnGln: 2.218 ± 0.057	2.656GlnArg: 2.656 ± 0.056	2.278GlnSer: 2.278 ± 0.047	2.011GlnThr: 2.011 ± 0.045	2.949GlnVal: 2.949 ± 0.056	0.558GlnTrp: 0.558 ± 0.024	1.026GlnTyr: 1.026 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.822ArgAla: 4.822 ± 0.064	0.491ArgCys: 0.491 ± 0.023	3.219ArgAsp: 3.219 ± 0.059	3.929ArgGlu: 3.929 ± 0.07	2.479ArgPhe: 2.479 ± 0.052	3.566ArgGly: 3.566 ± 0.062	1.632ArgHis: 1.632 ± 0.04	3.682ArgIle: 3.682 ± 0.061	2.606ArgLys: 2.606 ± 0.049	6.593ArgLeu: 6.593 ± 0.089	1.705ArgMet: 1.705 ± 0.041	2.266ArgAsn: 2.266 ± 0.049	2.268ArgPro: 2.268 ± 0.053	2.791ArgGln: 2.791 ± 0.054	3.692ArgArg: 3.692 ± 0.074	2.844ArgSer: 2.844 ± 0.055	2.563ArgThr: 2.563 ± 0.045	3.866ArgVal: 3.866 ± 0.073	0.857ArgTrp: 0.857 ± 0.03	1.956ArgTyr: 1.956 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.83SerAla: 5.83 ± 0.084	0.573SerCys: 0.573 ± 0.042	3.054SerAsp: 3.054 ± 0.056	3.187SerGlu: 3.187 ± 0.049	2.237SerPhe: 2.237 ± 0.053	5.085SerGly: 5.085 ± 0.083	1.369SerHis: 1.369 ± 0.038	3.227SerIle: 3.227 ± 0.05	2.331SerLys: 2.331 ± 0.053	6.23SerLeu: 6.23 ± 0.078	1.588SerMet: 1.588 ± 0.037	1.988SerAsn: 1.988 ± 0.043	2.637SerPro: 2.637 ± 0.048	2.269SerGln: 2.269 ± 0.045	3.378SerArg: 3.378 ± 0.058	3.602SerSer: 3.602 ± 0.065	3.162SerThr: 3.162 ± 0.062	4.004SerVal: 4.004 ± 0.069	0.746SerTrp: 0.746 ± 0.027	1.572SerTyr: 1.572 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.421ThrAla: 5.421 ± 0.097	0.479ThrCys: 0.479 ± 0.034	2.606ThrAsp: 2.606 ± 0.054	2.875ThrGlu: 2.875 ± 0.059	1.921ThrPhe: 1.921 ± 0.047	4.523ThrGly: 4.523 ± 0.109	1.278ThrHis: 1.278 ± 0.034	2.617ThrIle: 2.617 ± 0.054	1.78ThrLys: 1.78 ± 0.046	6.221ThrLeu: 6.221 ± 0.093	1.098ThrMet: 1.098 ± 0.034	1.721ThrAsn: 1.721 ± 0.064	3.185ThrPro: 3.185 ± 0.057	2.053ThrGln: 2.053 ± 0.048	2.79ThrArg: 2.79 ± 0.058	3.147ThrSer: 3.147 ± 0.092	2.991ThrThr: 2.991 ± 0.108	4.124ThrVal: 4.124 ± 0.1	0.663ThrTrp: 0.663 ± 0.027	1.388ThrTyr: 1.388 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.477ValAla: 7.477 ± 0.085	0.703ValCys: 0.703 ± 0.024	3.959ValAsp: 3.959 ± 0.063	4.46ValGlu: 4.46 ± 0.064	2.716ValPhe: 2.716 ± 0.054	5.117ValGly: 5.117 ± 0.079	1.498ValHis: 1.498 ± 0.038	3.903ValIle: 3.903 ± 0.067	3.122ValLys: 3.122 ± 0.054	7.598ValLeu: 7.598 ± 0.097	2.098ValMet: 2.098 ± 0.045	2.56ValAsn: 2.56 ± 0.058	3.245ValPro: 3.245 ± 0.061	2.493ValGln: 2.493 ± 0.053	4.017ValArg: 4.017 ± 0.065	4.517ValSer: 4.517 ± 0.071	4.18ValThr: 4.18 ± 0.102	5.704ValVal: 5.704 ± 0.083	0.884ValTrp: 0.884 ± 0.032	1.78ValTyr: 1.78 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.056TrpAla: 1.056 ± 0.032	0.139TrpCys: 0.139 ± 0.01	0.618TrpAsp: 0.618 ± 0.023	0.65TrpGlu: 0.65 ± 0.024	0.504TrpPhe: 0.504 ± 0.022	0.811TrpGly: 0.811 ± 0.03	0.422TrpHis: 0.422 ± 0.021	0.68TrpIle: 0.68 ± 0.025	0.618TrpLys: 0.618 ± 0.026	1.916TrpLeu: 1.916 ± 0.043	0.423TrpMet: 0.423 ± 0.02	0.501TrpAsn: 0.501 ± 0.021	0.521TrpPro: 0.521 ± 0.021	0.713TrpGln: 0.713 ± 0.027	0.887TrpArg: 0.887 ± 0.029	0.706TrpSer: 0.706 ± 0.028	0.604TrpThr: 0.604 ± 0.031	0.934TrpVal: 0.934 ± 0.028	0.222TrpTrp: 0.222 ± 0.015	0.339TrpTyr: 0.339 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.567TyrAla: 2.567 ± 0.048	0.327TyrCys: 0.327 ± 0.016	1.572TyrAsp: 1.572 ± 0.037	1.38TyrGlu: 1.38 ± 0.035	1.14TyrPhe: 1.14 ± 0.031	2.218TyrGly: 2.218 ± 0.042	0.618TyrHis: 0.618 ± 0.027	1.182TyrIle: 1.182 ± 0.034	1.001TyrLys: 1.001 ± 0.032	2.886TyrLeu: 2.886 ± 0.065	0.55TyrMet: 0.55 ± 0.021	0.854TyrAsn: 0.854 ± 0.029	1.313TyrPro: 1.313 ± 0.039	1.183TyrGln: 1.183 ± 0.036	1.959TyrArg: 1.959 ± 0.042	1.662TyrSer: 1.662 ± 0.039	1.367TyrThr: 1.367 ± 0.037	1.847TyrVal: 1.847 ± 0.045	0.41TyrTrp: 0.41 ± 0.021	0.828TyrTyr: 0.828 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3579 proteins (1118851 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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