Amino acid dipepetide frequency for Salmonella phage S137

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.016AlaAla: 9.016 ± 1.34
0.724AlaCys: 0.724 ± 0.264
4.146AlaAsp: 4.146 ± 0.633
6.779AlaGlu: 6.779 ± 0.81
2.962AlaPhe: 2.962 ± 0.412
5.923AlaGly: 5.923 ± 0.637
0.921AlaHis: 0.921 ± 0.202
5.989AlaIle: 5.989 ± 0.636
5.726AlaLys: 5.726 ± 0.609
6.976AlaLeu: 6.976 ± 0.754
3.159AlaMet: 3.159 ± 0.499
4.014AlaAsn: 4.014 ± 0.561
2.435AlaPro: 2.435 ± 0.505
2.962AlaGln: 2.962 ± 0.489
4.738AlaArg: 4.738 ± 0.533
5.989AlaSer: 5.989 ± 0.76
4.87AlaThr: 4.87 ± 0.644
5.923AlaVal: 5.923 ± 0.695
2.501AlaTrp: 2.501 ± 0.406
2.369AlaTyr: 2.369 ± 0.467
0.0AlaXaa: 0.0 ± 0.0
Cys
1.185CysAla: 1.185 ± 0.299
0.132CysCys: 0.132 ± 0.076
0.526CysAsp: 0.526 ± 0.166
0.921CysGlu: 0.921 ± 0.26
0.329CysPhe: 0.329 ± 0.151
1.514CysGly: 1.514 ± 0.356
0.329CysHis: 0.329 ± 0.148
0.461CysIle: 0.461 ± 0.175
0.987CysLys: 0.987 ± 0.294
0.856CysLeu: 0.856 ± 0.275
0.329CysMet: 0.329 ± 0.147
0.592CysAsn: 0.592 ± 0.171
0.526CysPro: 0.526 ± 0.187
0.461CysGln: 0.461 ± 0.158
1.382CysArg: 1.382 ± 0.275
0.79CysSer: 0.79 ± 0.238
0.592CysThr: 0.592 ± 0.182
0.526CysVal: 0.526 ± 0.176
0.263CysTrp: 0.263 ± 0.119
0.263CysTyr: 0.263 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
5.199AspAla: 5.199 ± 0.669
0.79AspCys: 0.79 ± 0.232
4.344AspAsp: 4.344 ± 0.641
4.541AspGlu: 4.541 ± 0.441
1.777AspPhe: 1.777 ± 0.307
4.87AspGly: 4.87 ± 0.557
0.921AspHis: 0.921 ± 0.267
3.488AspIle: 3.488 ± 0.561
4.08AspLys: 4.08 ± 0.512
2.896AspLeu: 2.896 ± 0.438
1.843AspMet: 1.843 ± 0.306
2.896AspAsn: 2.896 ± 0.558
2.303AspPro: 2.303 ± 0.373
1.579AspGln: 1.579 ± 0.311
2.698AspArg: 2.698 ± 0.366
2.962AspSer: 2.962 ± 0.372
2.501AspThr: 2.501 ± 0.394
3.751AspVal: 3.751 ± 0.607
1.25AspTrp: 1.25 ± 0.326
1.843AspTyr: 1.843 ± 0.333
0.0AspXaa: 0.0 ± 0.0
Glu
5.265GluAla: 5.265 ± 0.657
1.448GluCys: 1.448 ± 0.387
3.291GluAsp: 3.291 ± 0.471
5.199GluGlu: 5.199 ± 0.594
3.356GluPhe: 3.356 ± 0.471
4.344GluGly: 4.344 ± 0.523
0.79GluHis: 0.79 ± 0.206
5.067GluIle: 5.067 ± 0.731
5.002GluLys: 5.002 ± 0.767
6.318GluLeu: 6.318 ± 0.738
2.238GluMet: 2.238 ± 0.407
2.238GluAsn: 2.238 ± 0.341
1.777GluPro: 1.777 ± 0.355
3.291GluGln: 3.291 ± 0.462
4.475GluArg: 4.475 ± 0.65
4.409GluSer: 4.409 ± 0.417
3.883GluThr: 3.883 ± 0.46
3.685GluVal: 3.685 ± 0.52
1.645GluTrp: 1.645 ± 0.35
2.369GluTyr: 2.369 ± 0.377
0.0GluXaa: 0.0 ± 0.0
Phe
2.435PheAla: 2.435 ± 0.408
0.724PheCys: 0.724 ± 0.183
2.106PheAsp: 2.106 ± 0.348
2.435PheGlu: 2.435 ± 0.453
1.514PhePhe: 1.514 ± 0.34
2.567PheGly: 2.567 ± 0.384
0.592PheHis: 0.592 ± 0.211
2.106PheIle: 2.106 ± 0.357
1.909PheLys: 1.909 ± 0.308
1.777PheLeu: 1.777 ± 0.325
0.79PheMet: 0.79 ± 0.251
1.579PheAsn: 1.579 ± 0.285
1.185PhePro: 1.185 ± 0.268
0.921PheGln: 0.921 ± 0.191
2.303PheArg: 2.303 ± 0.538
2.238PheSer: 2.238 ± 0.381
2.567PheThr: 2.567 ± 0.374
1.777PheVal: 1.777 ± 0.336
0.658PheTrp: 0.658 ± 0.229
1.053PheTyr: 1.053 ± 0.257
0.0PheXaa: 0.0 ± 0.0
Gly
4.738GlyAla: 4.738 ± 0.618
1.119GlyCys: 1.119 ± 0.337
3.685GlyAsp: 3.685 ± 0.644
5.002GlyGlu: 5.002 ± 0.618
2.698GlyPhe: 2.698 ± 0.414
6.12GlyGly: 6.12 ± 0.864
1.448GlyHis: 1.448 ± 0.331
4.87GlyIle: 4.87 ± 0.489
5.594GlyLys: 5.594 ± 0.582
4.673GlyLeu: 4.673 ± 0.497
2.303GlyMet: 2.303 ± 0.43
3.685GlyAsn: 3.685 ± 0.425
1.316GlyPro: 1.316 ± 0.319
3.291GlyGln: 3.291 ± 0.513
3.751GlyArg: 3.751 ± 0.499
3.883GlySer: 3.883 ± 0.49
4.344GlyThr: 4.344 ± 0.551
5.002GlyVal: 5.002 ± 0.6
1.448GlyTrp: 1.448 ± 0.392
2.238GlyTyr: 2.238 ± 0.35
0.0GlyXaa: 0.0 ± 0.0
His
1.382HisAla: 1.382 ± 0.323
0.395HisCys: 0.395 ± 0.155
0.987HisAsp: 0.987 ± 0.279
1.316HisGlu: 1.316 ± 0.33
0.724HisPhe: 0.724 ± 0.188
1.843HisGly: 1.843 ± 0.363
0.921HisHis: 0.921 ± 0.244
0.856HisIle: 0.856 ± 0.259
0.921HisLys: 0.921 ± 0.304
1.711HisLeu: 1.711 ± 0.351
0.461HisMet: 0.461 ± 0.159
0.724HisAsn: 0.724 ± 0.203
0.856HisPro: 0.856 ± 0.227
0.526HisGln: 0.526 ± 0.173
1.053HisArg: 1.053 ± 0.256
1.053HisSer: 1.053 ± 0.252
0.526HisThr: 0.526 ± 0.177
0.987HisVal: 0.987 ± 0.277
0.263HisTrp: 0.263 ± 0.137
0.724HisTyr: 0.724 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
5.199IleAla: 5.199 ± 0.575
0.395IleCys: 0.395 ± 0.192
4.409IleAsp: 4.409 ± 0.593
4.08IleGlu: 4.08 ± 0.459
1.119IlePhe: 1.119 ± 0.244
3.027IleGly: 3.027 ± 0.518
1.25IleHis: 1.25 ± 0.257
3.422IleIle: 3.422 ± 0.459
3.093IleLys: 3.093 ± 0.557
4.278IleLeu: 4.278 ± 0.664
1.25IleMet: 1.25 ± 0.38
3.159IleAsn: 3.159 ± 0.43
3.751IlePro: 3.751 ± 0.491
1.909IleGln: 1.909 ± 0.353
3.225IleArg: 3.225 ± 0.445
4.673IleSer: 4.673 ± 0.584
3.422IleThr: 3.422 ± 0.729
3.027IleVal: 3.027 ± 0.475
1.579IleTrp: 1.579 ± 0.276
1.316IleTyr: 1.316 ± 0.307
0.0IleXaa: 0.0 ± 0.0
Lys
6.581LysAla: 6.581 ± 0.745
0.921LysCys: 0.921 ± 0.233
2.83LysAsp: 2.83 ± 0.458
4.409LysGlu: 4.409 ± 0.564
1.579LysPhe: 1.579 ± 0.317
4.146LysGly: 4.146 ± 0.515
0.79LysHis: 0.79 ± 0.188
3.225LysIle: 3.225 ± 0.435
3.751LysLys: 3.751 ± 0.479
5.857LysLeu: 5.857 ± 0.799
1.711LysMet: 1.711 ± 0.329
3.093LysAsn: 3.093 ± 0.466
2.567LysPro: 2.567 ± 0.428
2.962LysGln: 2.962 ± 0.51
5.002LysArg: 5.002 ± 0.54
4.278LysSer: 4.278 ± 0.581
3.027LysThr: 3.027 ± 0.339
4.014LysVal: 4.014 ± 0.506
0.921LysTrp: 0.921 ± 0.24
2.04LysTyr: 2.04 ± 0.389
0.0LysXaa: 0.0 ± 0.0
Leu
7.766LeuAla: 7.766 ± 0.791
1.053LeuCys: 1.053 ± 0.273
4.409LeuAsp: 4.409 ± 0.501
5.528LeuGlu: 5.528 ± 0.531
2.435LeuPhe: 2.435 ± 0.426
4.146LeuGly: 4.146 ± 0.568
1.514LeuHis: 1.514 ± 0.257
3.488LeuIle: 3.488 ± 0.393
4.146LeuLys: 4.146 ± 0.521
4.607LeuLeu: 4.607 ± 0.498
1.711LeuMet: 1.711 ± 0.368
4.409LeuAsn: 4.409 ± 0.589
3.356LeuPro: 3.356 ± 0.461
3.225LeuGln: 3.225 ± 0.43
4.87LeuArg: 4.87 ± 0.676
6.252LeuSer: 6.252 ± 0.72
4.541LeuThr: 4.541 ± 0.69
4.146LeuVal: 4.146 ± 0.519
1.316LeuTrp: 1.316 ± 0.302
2.106LeuTyr: 2.106 ± 0.345
0.0LeuXaa: 0.0 ± 0.0
Met
2.962MetAla: 2.962 ± 0.413
0.526MetCys: 0.526 ± 0.193
1.514MetAsp: 1.514 ± 0.266
0.987MetGlu: 0.987 ± 0.237
0.592MetPhe: 0.592 ± 0.172
1.448MetGly: 1.448 ± 0.299
0.263MetHis: 0.263 ± 0.115
1.25MetIle: 1.25 ± 0.305
2.172MetLys: 2.172 ± 0.458
2.369MetLeu: 2.369 ± 0.318
0.658MetMet: 0.658 ± 0.254
1.579MetAsn: 1.579 ± 0.301
1.25MetPro: 1.25 ± 0.246
1.579MetGln: 1.579 ± 0.349
1.25MetArg: 1.25 ± 0.242
3.093MetSer: 3.093 ± 0.383
2.698MetThr: 2.698 ± 0.406
1.514MetVal: 1.514 ± 0.311
0.329MetTrp: 0.329 ± 0.15
0.526MetTyr: 0.526 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
3.554AsnAla: 3.554 ± 0.423
0.329AsnCys: 0.329 ± 0.146
2.764AsnAsp: 2.764 ± 0.445
3.225AsnGlu: 3.225 ± 0.467
1.185AsnPhe: 1.185 ± 0.235
5.133AsnGly: 5.133 ± 0.686
1.382AsnHis: 1.382 ± 0.269
2.567AsnIle: 2.567 ± 0.356
2.698AsnLys: 2.698 ± 0.372
3.883AsnLeu: 3.883 ± 0.467
1.25AsnMet: 1.25 ± 0.252
2.764AsnAsn: 2.764 ± 0.519
2.698AsnPro: 2.698 ± 0.379
2.303AsnGln: 2.303 ± 0.508
1.777AsnArg: 1.777 ± 0.367
3.488AsnSer: 3.488 ± 0.454
2.632AsnThr: 2.632 ± 0.468
2.896AsnVal: 2.896 ± 0.556
0.526AsnTrp: 0.526 ± 0.167
2.106AsnTyr: 2.106 ± 0.369
0.0AsnXaa: 0.0 ± 0.0
Pro
3.422ProAla: 3.422 ± 0.469
0.395ProCys: 0.395 ± 0.16
2.567ProAsp: 2.567 ± 0.454
4.014ProGlu: 4.014 ± 0.407
1.382ProPhe: 1.382 ± 0.295
2.303ProGly: 2.303 ± 0.47
0.592ProHis: 0.592 ± 0.186
2.567ProIle: 2.567 ± 0.439
2.303ProLys: 2.303 ± 0.306
2.896ProLeu: 2.896 ± 0.532
0.987ProMet: 0.987 ± 0.264
1.909ProAsn: 1.909 ± 0.322
2.04ProPro: 2.04 ± 0.406
1.514ProGln: 1.514 ± 0.319
1.448ProArg: 1.448 ± 0.386
3.291ProSer: 3.291 ± 0.445
1.711ProThr: 1.711 ± 0.326
3.62ProVal: 3.62 ± 0.665
0.263ProTrp: 0.263 ± 0.154
1.185ProTyr: 1.185 ± 0.299
0.0ProXaa: 0.0 ± 0.0
Gln
3.949GlnAla: 3.949 ± 0.743
0.197GlnCys: 0.197 ± 0.113
1.185GlnAsp: 1.185 ± 0.27
2.435GlnGlu: 2.435 ± 0.332
1.25GlnPhe: 1.25 ± 0.335
2.106GlnGly: 2.106 ± 0.398
1.053GlnHis: 1.053 ± 0.236
3.225GlnIle: 3.225 ± 0.447
2.567GlnLys: 2.567 ± 0.346
2.764GlnLeu: 2.764 ± 0.449
1.382GlnMet: 1.382 ± 0.273
1.382GlnAsn: 1.382 ± 0.305
1.711GlnPro: 1.711 ± 0.406
2.303GlnGln: 2.303 ± 0.474
2.764GlnArg: 2.764 ± 0.478
2.83GlnSer: 2.83 ± 0.44
1.579GlnThr: 1.579 ± 0.419
2.83GlnVal: 2.83 ± 0.415
0.856GlnTrp: 0.856 ± 0.248
1.514GlnTyr: 1.514 ± 0.411
0.0GlnXaa: 0.0 ± 0.0
Arg
3.883ArgAla: 3.883 ± 0.456
1.119ArgCys: 1.119 ± 0.275
3.159ArgAsp: 3.159 ± 0.528
4.278ArgGlu: 4.278 ± 0.725
2.172ArgPhe: 2.172 ± 0.466
3.488ArgGly: 3.488 ± 0.479
1.382ArgHis: 1.382 ± 0.303
3.291ArgIle: 3.291 ± 0.512
3.949ArgLys: 3.949 ± 0.61
5.594ArgLeu: 5.594 ± 0.58
1.645ArgMet: 1.645 ± 0.334
3.159ArgAsn: 3.159 ± 0.566
1.711ArgPro: 1.711 ± 0.364
2.698ArgGln: 2.698 ± 0.422
4.146ArgArg: 4.146 ± 0.688
2.501ArgSer: 2.501 ± 0.419
2.632ArgThr: 2.632 ± 0.41
3.751ArgVal: 3.751 ± 0.559
1.25ArgTrp: 1.25 ± 0.272
2.106ArgTyr: 2.106 ± 0.333
0.0ArgXaa: 0.0 ± 0.0
Ser
5.462SerAla: 5.462 ± 0.662
0.658SerCys: 0.658 ± 0.212
4.014SerAsp: 4.014 ± 0.488
4.541SerGlu: 4.541 ± 0.562
2.764SerPhe: 2.764 ± 0.461
5.791SerGly: 5.791 ± 0.751
1.579SerHis: 1.579 ± 0.337
3.225SerIle: 3.225 ± 0.467
3.159SerLys: 3.159 ± 0.509
5.726SerLeu: 5.726 ± 0.834
2.764SerMet: 2.764 ± 0.424
2.83SerAsn: 2.83 ± 0.458
2.83SerPro: 2.83 ± 0.421
2.369SerGln: 2.369 ± 0.386
3.751SerArg: 3.751 ± 0.418
4.673SerSer: 4.673 ± 0.697
3.685SerThr: 3.685 ± 0.674
4.87SerVal: 4.87 ± 0.514
0.921SerTrp: 0.921 ± 0.223
1.909SerTyr: 1.909 ± 0.336
0.0SerXaa: 0.0 ± 0.0
Thr
5.923ThrAla: 5.923 ± 0.807
0.592ThrCys: 0.592 ± 0.203
3.685ThrAsp: 3.685 ± 0.592
4.08ThrGlu: 4.08 ± 0.516
1.777ThrPhe: 1.777 ± 0.387
4.936ThrGly: 4.936 ± 0.655
0.526ThrHis: 0.526 ± 0.153
2.698ThrIle: 2.698 ± 0.384
3.949ThrLys: 3.949 ± 0.506
3.291ThrLeu: 3.291 ± 0.479
1.316ThrMet: 1.316 ± 0.331
2.632ThrAsn: 2.632 ± 0.39
2.896ThrPro: 2.896 ± 0.569
1.448ThrGln: 1.448 ± 0.397
2.962ThrArg: 2.962 ± 0.398
3.685ThrSer: 3.685 ± 0.453
2.962ThrThr: 2.962 ± 0.543
3.685ThrVal: 3.685 ± 0.631
0.921ThrTrp: 0.921 ± 0.24
2.106ThrTyr: 2.106 ± 0.347
0.0ThrXaa: 0.0 ± 0.0
Val
5.923ValAla: 5.923 ± 0.66
0.724ValCys: 0.724 ± 0.257
4.08ValAsp: 4.08 ± 0.533
3.751ValGlu: 3.751 ± 0.498
2.106ValPhe: 2.106 ± 0.447
4.344ValGly: 4.344 ± 0.562
0.724ValHis: 0.724 ± 0.221
3.093ValIle: 3.093 ± 0.308
4.673ValLys: 4.673 ± 0.521
4.541ValLeu: 4.541 ± 0.518
2.04ValMet: 2.04 ± 0.419
4.08ValAsn: 4.08 ± 0.498
2.962ValPro: 2.962 ± 0.438
1.909ValGln: 1.909 ± 0.356
2.698ValArg: 2.698 ± 0.492
4.409ValSer: 4.409 ± 0.439
4.936ValThr: 4.936 ± 0.65
4.344ValVal: 4.344 ± 0.538
0.592ValTrp: 0.592 ± 0.19
2.172ValTyr: 2.172 ± 0.384
0.0ValXaa: 0.0 ± 0.0
Trp
1.185TrpAla: 1.185 ± 0.284
0.395TrpCys: 0.395 ± 0.131
1.053TrpAsp: 1.053 ± 0.222
1.119TrpGlu: 1.119 ± 0.247
0.658TrpPhe: 0.658 ± 0.197
0.724TrpGly: 0.724 ± 0.236
0.526TrpHis: 0.526 ± 0.224
1.119TrpIle: 1.119 ± 0.254
1.514TrpLys: 1.514 ± 0.296
1.777TrpLeu: 1.777 ± 0.389
0.197TrpMet: 0.197 ± 0.097
0.856TrpAsn: 0.856 ± 0.198
0.592TrpPro: 0.592 ± 0.201
1.053TrpGln: 1.053 ± 0.249
1.25TrpArg: 1.25 ± 0.29
1.119TrpSer: 1.119 ± 0.351
1.119TrpThr: 1.119 ± 0.403
1.316TrpVal: 1.316 ± 0.287
0.263TrpTrp: 0.263 ± 0.167
0.592TrpTyr: 0.592 ± 0.192
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.093TyrAla: 3.093 ± 0.403
0.329TyrCys: 0.329 ± 0.174
1.777TyrAsp: 1.777 ± 0.316
1.448TyrGlu: 1.448 ± 0.256
0.856TyrPhe: 0.856 ± 0.208
2.435TyrGly: 2.435 ± 0.376
0.724TyrHis: 0.724 ± 0.195
1.579TyrIle: 1.579 ± 0.338
1.579TyrLys: 1.579 ± 0.288
2.238TyrLeu: 2.238 ± 0.395
0.461TyrMet: 0.461 ± 0.173
1.579TyrAsn: 1.579 ± 0.344
1.645TyrPro: 1.645 ± 0.322
1.579TyrGln: 1.579 ± 0.284
2.369TyrArg: 2.369 ± 0.357
1.909TyrSer: 1.909 ± 0.416
1.843TyrThr: 1.843 ± 0.339
2.435TyrVal: 2.435 ± 0.504
0.658TyrTrp: 0.658 ± 0.226
0.724TyrTyr: 0.724 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (15196 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski