Amino acid dipepetide frequency for Nosema ceranae (strain BRL01) (Microsporidian parasite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.321AlaAla: 1.321 ± 0.059	0.706AlaCys: 0.706 ± 0.033	1.591AlaAsp: 1.591 ± 0.057	1.886AlaGlu: 1.886 ± 0.065	1.803AlaPhe: 1.803 ± 0.052	1.243AlaGly: 1.243 ± 0.057	0.529AlaHis: 0.529 ± 0.027	2.805AlaIle: 2.805 ± 0.073	2.644AlaLys: 2.644 ± 0.07	3.563AlaLeu: 3.563 ± 0.074	0.584AlaMet: 0.584 ± 0.028	1.777AlaAsn: 1.777 ± 0.042	0.76AlaPro: 0.76 ± 0.041	0.842AlaGln: 0.842 ± 0.039	1.159AlaArg: 1.159 ± 0.051	2.177AlaSer: 2.177 ± 0.073	1.414AlaThr: 1.414 ± 0.049	1.813AlaVal: 1.813 ± 0.056	0.155AlaTrp: 0.155 ± 0.017	1.429AlaTyr: 1.429 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.653CysAla: 0.653 ± 0.032	0.463CysCys: 0.463 ± 0.028	1.255CysAsp: 1.255 ± 0.045	1.157CysGlu: 1.157 ± 0.042	1.227CysPhe: 1.227 ± 0.045	0.935CysGly: 0.935 ± 0.042	0.297CysHis: 0.297 ± 0.02	2.168CysIle: 2.168 ± 0.064	2.317CysLys: 2.317 ± 0.062	1.975CysLeu: 1.975 ± 0.053	0.388CysMet: 0.388 ± 0.022	1.539CysAsn: 1.539 ± 0.049	0.509CysPro: 0.509 ± 0.026	0.458CysGln: 0.458 ± 0.025	0.744CysArg: 0.744 ± 0.036	1.37CysSer: 1.37 ± 0.05	1.176CysThr: 1.176 ± 0.047	1.072CysVal: 1.072 ± 0.043	0.112CysTrp: 0.112 ± 0.014	0.882CysTyr: 0.882 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	1.694AspAla: 1.694 ± 0.053	1.112AspCys: 1.112 ± 0.038	3.297AspAsp: 3.297 ± 0.079	3.974AspGlu: 3.974 ± 0.088	4.289AspPhe: 4.289 ± 0.092	1.838AspGly: 1.838 ± 0.058	0.677AspHis: 0.677 ± 0.034	6.374AspIle: 6.374 ± 0.095	5.665AspLys: 5.665 ± 0.092	6.514AspLeu: 6.514 ± 0.115	1.102AspMet: 1.102 ± 0.041	4.088AspAsn: 4.088 ± 0.085	1.319AspPro: 1.319 ± 0.051	1.2AspGln: 1.2 ± 0.046	1.614AspArg: 1.614 ± 0.057	3.666AspSer: 3.666 ± 0.082	2.922AspThr: 2.922 ± 0.066	3.367AspVal: 3.367 ± 0.078	0.357AspTrp: 0.357 ± 0.02	2.662AspTyr: 2.662 ± 0.071	0.0AspXaa: 0.0 ± 0.0
Glu	2.151GluAla: 2.151 ± 0.066	1.422GluCys: 1.422 ± 0.043	4.55GluAsp: 4.55 ± 0.084	5.78GluGlu: 5.78 ± 0.129	3.26GluPhe: 3.26 ± 0.079	2.252GluGly: 2.252 ± 0.063	1.202GluHis: 1.202 ± 0.046	7.39GluIle: 7.39 ± 0.126	7.16GluLys: 7.16 ± 0.132	5.788GluLeu: 5.788 ± 0.095	1.654GluMet: 1.654 ± 0.052	6.196GluAsn: 6.196 ± 0.122	1.246GluPro: 1.246 ± 0.047	1.902GluGln: 1.902 ± 0.052	2.234GluArg: 2.234 ± 0.063	4.066GluSer: 4.066 ± 0.087	2.894GluThr: 2.894 ± 0.075	3.245GluVal: 3.245 ± 0.072	0.405GluTrp: 0.405 ± 0.024	3.391GluTyr: 3.391 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	1.67PheAla: 1.67 ± 0.055	1.492PheCys: 1.492 ± 0.055	3.519PheAsp: 3.519 ± 0.077	3.514PheGlu: 3.514 ± 0.093	4.06PhePhe: 4.06 ± 0.117	2.136PheGly: 2.136 ± 0.064	0.8PheHis: 0.8 ± 0.036	6.302PheIle: 6.302 ± 0.117	5.696PheLys: 5.696 ± 0.111	6.798PheLeu: 6.798 ± 0.125	1.254PheMet: 1.254 ± 0.045	4.689PheAsn: 4.689 ± 0.092	1.239PhePro: 1.239 ± 0.048	1.166PheGln: 1.166 ± 0.046	1.786PheArg: 1.786 ± 0.05	4.56PheSer: 4.56 ± 0.098	3.334PheThr: 3.334 ± 0.069	3.32PheVal: 3.32 ± 0.066	0.363PheTrp: 0.363 ± 0.023	3.926PheTyr: 3.926 ± 0.086	0.0PheXaa: 0.0 ± 0.0
Gly	1.136GlyAla: 1.136 ± 0.051	0.809GlyCys: 0.809 ± 0.033	1.944GlyAsp: 1.944 ± 0.061	1.994GlyGlu: 1.994 ± 0.058	2.109GlyPhe: 2.109 ± 0.058	1.704GlyGly: 1.704 ± 0.074	0.799GlyHis: 0.799 ± 0.042	3.498GlyIle: 3.498 ± 0.081	3.27GlyLys: 3.27 ± 0.07	3.284GlyLeu: 3.284 ± 0.085	0.821GlyMet: 0.821 ± 0.035	2.066GlyAsn: 2.066 ± 0.066	0.781GlyPro: 0.781 ± 0.032	0.892GlyGln: 0.892 ± 0.042	1.428GlyArg: 1.428 ± 0.05	2.497GlySer: 2.497 ± 0.074	2.046GlyThr: 2.046 ± 0.066	2.109GlyVal: 2.109 ± 0.064	0.26GlyTrp: 0.26 ± 0.019	1.776GlyTyr: 1.776 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.501HisAla: 0.501 ± 0.027	0.351HisCys: 0.351 ± 0.023	0.772HisAsp: 0.772 ± 0.033	1.005HisGlu: 1.005 ± 0.034	1.117HisPhe: 1.117 ± 0.036	0.638HisGly: 0.638 ± 0.035	0.312HisHis: 0.312 ± 0.024	1.411HisIle: 1.411 ± 0.043	1.874HisLys: 1.874 ± 0.054	1.673HisLeu: 1.673 ± 0.055	0.308HisMet: 0.308 ± 0.025	1.154HisAsn: 1.154 ± 0.039	0.576HisPro: 0.576 ± 0.033	0.394HisGln: 0.394 ± 0.027	0.648HisArg: 0.648 ± 0.032	1.285HisSer: 1.285 ± 0.047	0.836HisThr: 0.836 ± 0.031	0.901HisVal: 0.901 ± 0.035	0.094HisTrp: 0.094 ± 0.011	0.706HisTyr: 0.706 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	2.698IleAla: 2.698 ± 0.063	2.261IleCys: 2.261 ± 0.062	5.744IleAsp: 5.744 ± 0.09	6.413IleGlu: 6.413 ± 0.11	6.841IlePhe: 6.841 ± 0.132	3.146IleGly: 3.146 ± 0.079	1.591IleHis: 1.591 ± 0.046	8.364IleIle: 8.364 ± 0.124	10.317IleLys: 10.317 ± 0.134	10.635IleLeu: 10.635 ± 0.164	1.484IleMet: 1.484 ± 0.048	8.122IleAsn: 8.122 ± 0.12	2.577IlePro: 2.577 ± 0.069	2.677IleGln: 2.677 ± 0.064	3.117IleArg: 3.117 ± 0.073	7.062IleSer: 7.062 ± 0.1	4.268IleThr: 4.268 ± 0.083	4.506IleVal: 4.506 ± 0.088	0.501IleTrp: 0.501 ± 0.029	4.957IleTyr: 4.957 ± 0.1	0.0IleXaa: 0.0 ± 0.0
Lys	2.811LysAla: 2.811 ± 0.077	1.927LysCys: 1.927 ± 0.056	6.205LysAsp: 6.205 ± 0.087	7.749LysGlu: 7.749 ± 0.135	5.143LysPhe: 5.143 ± 0.093	3.122LysGly: 3.122 ± 0.074	1.847LysHis: 1.847 ± 0.051	11.101LysIle: 11.101 ± 0.152	11.807LysLys: 11.807 ± 0.169	8.886LysLeu: 8.886 ± 0.12	2.656LysMet: 2.656 ± 0.064	9.984LysAsn: 9.984 ± 0.141	2.079LysPro: 2.079 ± 0.057	2.867LysGln: 2.867 ± 0.077	3.76LysArg: 3.76 ± 0.079	6.809LysSer: 6.809 ± 0.106	4.679LysThr: 4.679 ± 0.084	4.532LysVal: 4.532 ± 0.076	0.537LysTrp: 0.537 ± 0.029	5.473LysTyr: 5.473 ± 0.094	0.0LysXaa: 0.0 ± 0.0
Leu	3.0LeuAla: 3.0 ± 0.07	2.136LeuCys: 2.136 ± 0.05	5.739LeuAsp: 5.739 ± 0.102	7.228LeuGlu: 7.228 ± 0.127	6.178LeuPhe: 6.178 ± 0.12	3.358LeuGly: 3.358 ± 0.086	1.78LeuHis: 1.78 ± 0.053	9.007LeuIle: 9.007 ± 0.137	10.485LeuLys: 10.485 ± 0.142	10.295LeuLeu: 10.295 ± 0.17	1.817LeuMet: 1.817 ± 0.052	7.609LeuAsn: 7.609 ± 0.122	2.494LeuPro: 2.494 ± 0.068	3.369LeuGln: 3.369 ± 0.083	3.456LeuArg: 3.456 ± 0.072	7.413LeuSer: 7.413 ± 0.114	4.234LeuThr: 4.234 ± 0.077	5.122LeuVal: 5.122 ± 0.08	0.525LeuTrp: 0.525 ± 0.028	4.893LeuTyr: 4.893 ± 0.111	0.0LeuXaa: 0.0 ± 0.0
Met	0.778MetAla: 0.778 ± 0.029	0.468MetCys: 0.468 ± 0.027	1.022MetAsp: 1.022 ± 0.04	1.135MetGlu: 1.135 ± 0.048	1.291MetPhe: 1.291 ± 0.043	0.759MetGly: 0.759 ± 0.038	0.393MetHis: 0.393 ± 0.023	1.727MetIle: 1.727 ± 0.051	2.029MetLys: 2.029 ± 0.052	1.919MetLeu: 1.919 ± 0.061	0.439MetMet: 0.439 ± 0.028	1.496MetAsn: 1.496 ± 0.049	0.625MetPro: 0.625 ± 0.03	0.552MetGln: 0.552 ± 0.03	0.686MetArg: 0.686 ± 0.034	1.499MetSer: 1.499 ± 0.046	0.998MetThr: 0.998 ± 0.038	0.949MetVal: 0.949 ± 0.038	0.132MetTrp: 0.132 ± 0.015	1.059MetTyr: 1.059 ± 0.045	0.0MetXaa: 0.0 ± 0.0
Asn	2.091AsnAla: 2.091 ± 0.054	1.346AsnCys: 1.346 ± 0.047	4.335AsnAsp: 4.335 ± 0.099	5.466AsnGlu: 5.466 ± 0.095	5.079AsnPhe: 5.079 ± 0.106	2.408AsnGly: 2.408 ± 0.056	0.986AsnHis: 0.986 ± 0.042	9.169AsnIle: 9.169 ± 0.143	8.309AsnLys: 8.309 ± 0.141	8.57AsnLeu: 8.57 ± 0.137	1.734AsnMet: 1.734 ± 0.05	6.731AsnAsn: 6.731 ± 0.142	1.77AsnPro: 1.77 ± 0.059	1.956AsnGln: 1.956 ± 0.051	2.307AsnArg: 2.307 ± 0.05	4.906AsnSer: 4.906 ± 0.099	4.05AsnThr: 4.05 ± 0.083	4.151AsnVal: 4.151 ± 0.079	0.4AsnTrp: 0.4 ± 0.021	3.54AsnTyr: 3.54 ± 0.077	0.0AsnXaa: 0.0 ± 0.0
Pro	0.753ProAla: 0.753 ± 0.038	0.44ProCys: 0.44 ± 0.027	1.319ProAsp: 1.319 ± 0.048	1.633ProGlu: 1.633 ± 0.059	1.669ProPhe: 1.669 ± 0.059	1.013ProGly: 1.013 ± 0.046	0.434ProHis: 0.434 ± 0.029	2.081ProIle: 2.081 ± 0.064	2.057ProLys: 2.057 ± 0.053	2.393ProLeu: 2.393 ± 0.063	0.466ProMet: 0.466 ± 0.029	1.652ProAsn: 1.652 ± 0.06	0.791ProPro: 0.791 ± 0.045	0.8ProGln: 0.8 ± 0.053	0.852ProArg: 0.852 ± 0.038	1.905ProSer: 1.905 ± 0.069	1.178ProThr: 1.178 ± 0.056	1.605ProVal: 1.605 ± 0.054	0.125ProTrp: 0.125 ± 0.014	1.109ProTyr: 1.109 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	0.904GlnAla: 0.904 ± 0.042	0.431GlnCys: 0.431 ± 0.025	1.46GlnAsp: 1.46 ± 0.043	2.058GlnGlu: 2.058 ± 0.057	1.324GlnPhe: 1.324 ± 0.045	0.861GlnGly: 0.861 ± 0.039	0.479GlnHis: 0.479 ± 0.03	2.696GlnIle: 2.696 ± 0.075	3.055GlnLys: 3.055 ± 0.065	2.189GlnLeu: 2.189 ± 0.054	0.648GlnMet: 0.648 ± 0.031	2.45GlnAsn: 2.45 ± 0.063	0.702GlnPro: 0.702 ± 0.049	0.935GlnGln: 0.935 ± 0.053	0.968GlnArg: 0.968 ± 0.041	1.771GlnSer: 1.771 ± 0.063	1.246GlnThr: 1.246 ± 0.045	1.228GlnVal: 1.228 ± 0.039	0.158GlnTrp: 0.158 ± 0.017	1.316GlnTyr: 1.316 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	1.098ArgAla: 1.098 ± 0.044	0.712ArgCys: 0.712 ± 0.034	1.695ArgAsp: 1.695 ± 0.054	2.186ArgGlu: 2.186 ± 0.053	1.933ArgPhe: 1.933 ± 0.055	1.267ArgGly: 1.267 ± 0.052	0.702ArgHis: 0.702 ± 0.032	3.201ArgIle: 3.201 ± 0.068	3.577ArgLys: 3.577 ± 0.075	3.169ArgLeu: 3.169 ± 0.063	0.802ArgMet: 0.802 ± 0.036	2.68ArgAsn: 2.68 ± 0.061	0.866ArgPro: 0.866 ± 0.052	0.967ArgGln: 0.967 ± 0.034	1.682ArgArg: 1.682 ± 0.065	2.268ArgSer: 2.268 ± 0.069	1.471ArgThr: 1.471 ± 0.051	1.569ArgVal: 1.569 ± 0.057	0.219ArgTrp: 0.219 ± 0.016	1.645ArgTyr: 1.645 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	2.161SerAla: 2.161 ± 0.052	1.34SerCys: 1.34 ± 0.051	4.02SerAsp: 4.02 ± 0.081	4.561SerGlu: 4.561 ± 0.104	4.373SerPhe: 4.373 ± 0.079	2.579SerGly: 2.579 ± 0.073	1.209SerHis: 1.209 ± 0.041	6.254SerIle: 6.254 ± 0.107	7.148SerLys: 7.148 ± 0.122	7.249SerLeu: 7.249 ± 0.112	1.153SerMet: 1.153 ± 0.038	5.101SerAsn: 5.101 ± 0.097	1.71SerPro: 1.71 ± 0.078	1.867SerGln: 1.867 ± 0.059	2.344SerArg: 2.344 ± 0.067	5.659SerSer: 5.659 ± 0.136	3.812SerThr: 3.812 ± 0.085	3.851SerVal: 3.851 ± 0.086	0.408SerTrp: 0.408 ± 0.028	3.152SerTyr: 3.152 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	1.594ThrAla: 1.594 ± 0.054	0.944ThrCys: 0.944 ± 0.042	2.771ThrAsp: 2.771 ± 0.061	3.326ThrGlu: 3.326 ± 0.069	3.028ThrPhe: 3.028 ± 0.071	2.112ThrGly: 2.112 ± 0.062	0.793ThrHis: 0.793 ± 0.034	4.141ThrIle: 4.141 ± 0.079	4.829ThrLys: 4.829 ± 0.079	4.605ThrLeu: 4.605 ± 0.071	0.732ThrMet: 0.732 ± 0.032	3.732ThrAsn: 3.732 ± 0.084	1.446ThrPro: 1.446 ± 0.055	1.264ThrGln: 1.264 ± 0.047	1.544ThrArg: 1.544 ± 0.049	3.674ThrSer: 3.674 ± 0.077	2.58ThrThr: 2.58 ± 0.078	2.737ThrVal: 2.737 ± 0.071	0.242ThrTrp: 0.242 ± 0.019	1.997ThrTyr: 1.997 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	1.587ValAla: 1.587 ± 0.047	1.168ValCys: 1.168 ± 0.048	3.279ValAsp: 3.279 ± 0.073	3.647ValGlu: 3.647 ± 0.08	3.207ValPhe: 3.207 ± 0.069	2.008ValGly: 2.008 ± 0.061	0.903ValHis: 0.903 ± 0.039	4.509ValIle: 4.509 ± 0.091	5.07ValLys: 5.07 ± 0.097	5.153ValLeu: 5.153 ± 0.088	0.866ValMet: 0.866 ± 0.04	3.712ValAsn: 3.712 ± 0.079	1.514ValPro: 1.514 ± 0.05	1.499ValGln: 1.499 ± 0.048	1.614ValArg: 1.614 ± 0.051	3.599ValSer: 3.599 ± 0.08	2.277ValThr: 2.277 ± 0.064	2.905ValVal: 2.905 ± 0.072	0.357ValTrp: 0.357 ± 0.024	2.674ValTyr: 2.674 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.201TrpAla: 0.201 ± 0.016	0.143TrpCys: 0.143 ± 0.015	0.369TrpAsp: 0.369 ± 0.027	0.339TrpGlu: 0.339 ± 0.023	0.332TrpPhe: 0.332 ± 0.023	0.208TrpGly: 0.208 ± 0.02	0.104TrpHis: 0.104 ± 0.013	0.568TrpIle: 0.568 ± 0.03	0.537TrpLys: 0.537 ± 0.023	0.506TrpLeu: 0.506 ± 0.027	0.156TrpMet: 0.156 ± 0.015	0.464TrpAsn: 0.464 ± 0.03	0.143TrpPro: 0.143 ± 0.014	0.122TrpGln: 0.122 ± 0.013	0.222TrpArg: 0.222 ± 0.019	0.406TrpSer: 0.406 ± 0.022	0.268TrpThr: 0.268 ± 0.023	0.259TrpVal: 0.259 ± 0.02	0.049TrpTrp: 0.049 ± 0.009	0.275TrpTyr: 0.275 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.402TyrAla: 1.402 ± 0.052	1.026TyrCys: 1.026 ± 0.041	2.847TyrAsp: 2.847 ± 0.065	3.135TyrGlu: 3.135 ± 0.07	3.363TyrPhe: 3.363 ± 0.082	1.637TyrGly: 1.637 ± 0.05	0.72TyrHis: 0.72 ± 0.033	4.517TyrIle: 4.517 ± 0.098	6.128TyrLys: 6.128 ± 0.116	4.975TyrLeu: 4.975 ± 0.108	0.888TyrMet: 0.888 ± 0.029	4.06TyrAsn: 4.06 ± 0.085	1.129TyrPro: 1.129 ± 0.049	1.153TyrGln: 1.153 ± 0.042	1.545TyrArg: 1.545 ± 0.048	3.357TyrSer: 3.357 ± 0.079	2.403TyrThr: 2.403 ± 0.061	2.307TyrVal: 2.307 ± 0.064	0.272TyrTrp: 0.272 ± 0.02	2.133TyrTyr: 2.133 ± 0.066	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2060 proteins (672377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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