Amino acid dipepetide frequency for Arenicella xantha

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.913AlaAla: 8.913 ± 0.109	1.029AlaCys: 1.029 ± 0.032	5.519AlaAsp: 5.519 ± 0.086	5.563AlaGlu: 5.563 ± 0.079	3.416AlaPhe: 3.416 ± 0.049	6.917AlaGly: 6.917 ± 0.105	1.865AlaHis: 1.865 ± 0.041	5.924AlaIle: 5.924 ± 0.084	4.39AlaLys: 4.39 ± 0.077	9.73AlaLeu: 9.73 ± 0.113	2.406AlaMet: 2.406 ± 0.054	4.044AlaAsn: 4.044 ± 0.072	3.343AlaPro: 3.343 ± 0.058	3.939AlaGln: 3.939 ± 0.055	4.47AlaArg: 4.47 ± 0.068	6.442AlaSer: 6.442 ± 0.076	4.983AlaThr: 4.983 ± 0.068	6.327AlaVal: 6.327 ± 0.088	1.111AlaTrp: 1.111 ± 0.033	2.611AlaTyr: 2.611 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.86CysAla: 0.86 ± 0.028	0.138CysCys: 0.138 ± 0.011	0.638CysAsp: 0.638 ± 0.026	0.525CysGlu: 0.525 ± 0.022	0.431CysPhe: 0.431 ± 0.023	0.858CysGly: 0.858 ± 0.03	0.303CysHis: 0.303 ± 0.025	0.51CysIle: 0.51 ± 0.018	0.313CysLys: 0.313 ± 0.018	1.046CysLeu: 1.046 ± 0.033	0.191CysMet: 0.191 ± 0.012	0.324CysAsn: 0.324 ± 0.018	0.381CysPro: 0.381 ± 0.017	0.401CysGln: 0.401 ± 0.019	0.49CysArg: 0.49 ± 0.022	0.633CysSer: 0.633 ± 0.023	0.47CysThr: 0.47 ± 0.019	0.73CysVal: 0.73 ± 0.023	0.121CysTrp: 0.121 ± 0.01	0.308CysTyr: 0.308 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.481AspAla: 5.481 ± 0.079	0.532AspCys: 0.532 ± 0.023	3.631AspAsp: 3.631 ± 0.083	3.572AspGlu: 3.572 ± 0.066	2.569AspPhe: 2.569 ± 0.044	4.61AspGly: 4.61 ± 0.121	1.158AspHis: 1.158 ± 0.033	3.761AspIle: 3.761 ± 0.06	2.351AspLys: 2.351 ± 0.048	5.623AspLeu: 5.623 ± 0.075	1.378AspMet: 1.378 ± 0.037	2.502AspAsn: 2.502 ± 0.088	2.535AspPro: 2.535 ± 0.059	2.728AspGln: 2.728 ± 0.058	2.876AspArg: 2.876 ± 0.051	3.89AspSer: 3.89 ± 0.08	3.086AspThr: 3.086 ± 0.066	4.13AspVal: 4.13 ± 0.084	0.903AspTrp: 0.903 ± 0.029	2.17AspTyr: 2.17 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.857GluAla: 4.857 ± 0.074	0.438GluCys: 0.438 ± 0.019	2.559GluAsp: 2.559 ± 0.056	2.812GluGlu: 2.812 ± 0.058	2.582GluPhe: 2.582 ± 0.043	3.088GluGly: 3.088 ± 0.049	1.468GluHis: 1.468 ± 0.032	3.652GluIle: 3.652 ± 0.061	2.594GluLys: 2.594 ± 0.055	6.853GluLeu: 6.853 ± 0.087	1.379GluMet: 1.379 ± 0.036	2.289GluAsn: 2.289 ± 0.039	2.254GluPro: 2.254 ± 0.057	3.312GluGln: 3.312 ± 0.056	3.495GluArg: 3.495 ± 0.065	4.149GluSer: 4.149 ± 0.057	2.857GluThr: 2.857 ± 0.055	3.962GluVal: 3.962 ± 0.074	0.701GluTrp: 0.701 ± 0.026	1.737GluTyr: 1.737 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.713PheAla: 3.713 ± 0.058	0.497PheCys: 0.497 ± 0.022	3.016PheAsp: 3.016 ± 0.065	2.551PheGlu: 2.551 ± 0.053	1.706PhePhe: 1.706 ± 0.041	3.41PheGly: 3.41 ± 0.057	0.767PheHis: 0.767 ± 0.029	2.423PheIle: 2.423 ± 0.046	1.725PheLys: 1.725 ± 0.036	3.4PheLeu: 3.4 ± 0.067	0.903PheMet: 0.903 ± 0.029	1.832PheAsn: 1.832 ± 0.048	1.449PhePro: 1.449 ± 0.033	1.222PheGln: 1.222 ± 0.029	1.739PheArg: 1.739 ± 0.039	3.414PheSer: 3.414 ± 0.062	2.309PheThr: 2.309 ± 0.046	2.824PheVal: 2.824 ± 0.054	0.585PheTrp: 0.585 ± 0.023	1.389PheTyr: 1.389 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.17GlyAla: 6.17 ± 0.093	0.771GlyCys: 0.771 ± 0.023	4.291GlyAsp: 4.291 ± 0.104	4.103GlyGlu: 4.103 ± 0.071	3.383GlyPhe: 3.383 ± 0.053	5.613GlyGly: 5.613 ± 0.132	1.505GlyHis: 1.505 ± 0.035	4.405GlyIle: 4.405 ± 0.079	3.199GlyLys: 3.199 ± 0.058	7.269GlyLeu: 7.269 ± 0.075	1.835GlyMet: 1.835 ± 0.043	2.85GlyAsn: 2.85 ± 0.121	1.938GlyPro: 1.938 ± 0.043	2.771GlyGln: 2.771 ± 0.045	3.386GlyArg: 3.386 ± 0.057	4.888GlySer: 4.888 ± 0.096	3.66GlyThr: 3.66 ± 0.091	5.605GlyVal: 5.605 ± 0.085	0.978GlyTrp: 0.978 ± 0.03	2.434GlyTyr: 2.434 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.97HisAla: 1.97 ± 0.041	0.283HisCys: 0.283 ± 0.016	1.191HisAsp: 1.191 ± 0.034	1.09HisGlu: 1.09 ± 0.031	0.976HisPhe: 0.976 ± 0.028	1.602HisGly: 1.602 ± 0.038	0.622HisHis: 0.622 ± 0.023	1.164HisIle: 1.164 ± 0.032	0.858HisLys: 0.858 ± 0.025	2.034HisLeu: 2.034 ± 0.047	0.465HisMet: 0.465 ± 0.017	0.846HisAsn: 0.846 ± 0.029	1.008HisPro: 1.008 ± 0.032	1.015HisGln: 1.015 ± 0.028	1.199HisArg: 1.199 ± 0.033	1.457HisSer: 1.457 ± 0.034	1.165HisThr: 1.165 ± 0.027	1.35HisVal: 1.35 ± 0.036	0.355HisTrp: 0.355 ± 0.018	0.822HisTyr: 0.822 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.078IleAla: 6.078 ± 0.086	0.593IleCys: 0.593 ± 0.022	4.654IleAsp: 4.654 ± 0.072	4.431IleGlu: 4.431 ± 0.068	2.038IlePhe: 2.038 ± 0.053	4.609IleGly: 4.609 ± 0.068	1.123IleHis: 1.123 ± 0.027	3.301IleIle: 3.301 ± 0.058	2.757IleLys: 2.757 ± 0.051	4.976IleLeu: 4.976 ± 0.079	1.139IleMet: 1.139 ± 0.036	2.853IleAsn: 2.853 ± 0.067	2.463IlePro: 2.463 ± 0.049	2.192IleGln: 2.192 ± 0.043	2.968IleArg: 2.968 ± 0.05	4.457IleSer: 4.457 ± 0.058	3.401IleThr: 3.401 ± 0.057	4.3IleVal: 4.3 ± 0.063	0.635IleTrp: 0.635 ± 0.025	1.649IleTyr: 1.649 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	3.727LysAla: 3.727 ± 0.073	0.275LysCys: 0.275 ± 0.016	1.981LysAsp: 1.981 ± 0.043	2.134LysGlu: 2.134 ± 0.05	1.409LysPhe: 1.409 ± 0.037	2.531LysGly: 2.531 ± 0.056	1.085LysHis: 1.085 ± 0.033	2.645LysIle: 2.645 ± 0.051	2.154LysLys: 2.154 ± 0.074	4.66LysLeu: 4.66 ± 0.075	1.075LysMet: 1.075 ± 0.035	1.691LysAsn: 1.691 ± 0.042	2.127LysPro: 2.127 ± 0.043	2.415LysGln: 2.415 ± 0.047	2.63LysArg: 2.63 ± 0.049	2.877LysSer: 2.877 ± 0.053	2.606LysThr: 2.606 ± 0.045	3.079LysVal: 3.079 ± 0.061	0.494LysTrp: 0.494 ± 0.022	1.157LysTyr: 1.157 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	10.302LeuAla: 10.302 ± 0.11	1.035LeuCys: 1.035 ± 0.03	5.905LeuAsp: 5.905 ± 0.077	5.717LeuGlu: 5.717 ± 0.077	4.195LeuPhe: 4.195 ± 0.064	7.029LeuGly: 7.029 ± 0.072	2.036LeuHis: 2.036 ± 0.04	6.27LeuIle: 6.27 ± 0.083	4.325LeuLys: 4.325 ± 0.07	10.207LeuLeu: 10.207 ± 0.146	2.465LeuMet: 2.465 ± 0.052	4.403LeuAsn: 4.403 ± 0.058	4.622LeuPro: 4.622 ± 0.061	3.569LeuGln: 3.569 ± 0.061	5.126LeuArg: 5.126 ± 0.075	8.103LeuSer: 8.103 ± 0.084	5.757LeuThr: 5.757 ± 0.075	7.2LeuVal: 7.2 ± 0.096	1.025LeuTrp: 1.025 ± 0.036	2.503LeuTyr: 2.503 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.176MetAla: 2.176 ± 0.051	0.179MetCys: 0.179 ± 0.012	1.072MetAsp: 1.072 ± 0.031	1.012MetGlu: 1.012 ± 0.033	0.805MetPhe: 0.805 ± 0.027	1.481MetGly: 1.481 ± 0.045	0.506MetHis: 0.506 ± 0.018	1.285MetIle: 1.285 ± 0.036	1.117MetLys: 1.117 ± 0.034	2.564MetLeu: 2.564 ± 0.053	0.576MetMet: 0.576 ± 0.025	1.019MetAsn: 1.019 ± 0.027	1.143MetPro: 1.143 ± 0.032	1.206MetGln: 1.206 ± 0.035	1.375MetArg: 1.375 ± 0.04	1.908MetSer: 1.908 ± 0.039	1.467MetThr: 1.467 ± 0.038	1.658MetVal: 1.658 ± 0.038	0.21MetTrp: 0.21 ± 0.013	0.453MetTyr: 0.453 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.786AsnAla: 3.786 ± 0.061	0.418AsnCys: 0.418 ± 0.02	2.461AsnAsp: 2.461 ± 0.071	2.142AsnGlu: 2.142 ± 0.041	1.547AsnPhe: 1.547 ± 0.038	3.236AsnGly: 3.236 ± 0.089	0.903AsnHis: 0.903 ± 0.026	2.57AsnIle: 2.57 ± 0.054	1.771AsnLys: 1.771 ± 0.042	3.928AsnLeu: 3.928 ± 0.066	0.893AsnMet: 0.893 ± 0.028	1.979AsnAsn: 1.979 ± 0.078	2.141AsnPro: 2.141 ± 0.042	2.015AsnGln: 2.015 ± 0.047	2.234AsnArg: 2.234 ± 0.049	2.931AsnSer: 2.931 ± 0.065	2.512AsnThr: 2.512 ± 0.082	2.785AsnVal: 2.785 ± 0.063	0.592AsnTrp: 0.592 ± 0.025	1.4AsnTyr: 1.4 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.529ProAla: 3.529 ± 0.06	0.306ProCys: 0.306 ± 0.018	2.673ProAsp: 2.673 ± 0.049	2.911ProGlu: 2.911 ± 0.052	1.666ProPhe: 1.666 ± 0.035	2.613ProGly: 2.613 ± 0.048	0.84ProHis: 0.84 ± 0.025	2.59ProIle: 2.59 ± 0.046	1.761ProLys: 1.761 ± 0.041	3.84ProLeu: 3.84 ± 0.06	0.937ProMet: 0.937 ± 0.03	2.002ProAsn: 2.002 ± 0.048	1.345ProPro: 1.345 ± 0.038	1.535ProGln: 1.535 ± 0.039	1.649ProArg: 1.649 ± 0.039	3.105ProSer: 3.105 ± 0.06	2.464ProThr: 2.464 ± 0.051	3.11ProVal: 3.11 ± 0.055	0.481ProTrp: 0.481 ± 0.019	1.178ProTyr: 1.178 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.598GlnAla: 4.598 ± 0.071	0.366GlnCys: 0.366 ± 0.016	2.091GlnAsp: 2.091 ± 0.053	1.946GlnGlu: 1.946 ± 0.039	1.747GlnPhe: 1.747 ± 0.04	2.636GlnGly: 2.636 ± 0.043	1.143GlnHis: 1.143 ± 0.034	2.426GlnIle: 2.426 ± 0.049	1.595GlnLys: 1.595 ± 0.043	4.671GlnLeu: 4.671 ± 0.066	0.918GlnMet: 0.918 ± 0.025	1.62GlnAsn: 1.62 ± 0.045	1.757GlnPro: 1.757 ± 0.036	2.614GlnGln: 2.614 ± 0.058	2.691GlnArg: 2.691 ± 0.052	3.052GlnSer: 3.052 ± 0.06	2.497GlnThr: 2.497 ± 0.05	3.042GlnVal: 3.042 ± 0.062	0.606GlnTrp: 0.606 ± 0.022	1.255GlnTyr: 1.255 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.491ArgAla: 4.491 ± 0.065	0.495ArgCys: 0.495 ± 0.023	3.03ArgAsp: 3.03 ± 0.047	2.993ArgGlu: 2.993 ± 0.05	2.466ArgPhe: 2.466 ± 0.049	3.15ArgGly: 3.15 ± 0.053	1.196ArgHis: 1.196 ± 0.035	3.197ArgIle: 3.197 ± 0.055	2.131ArgLys: 2.131 ± 0.05	5.595ArgLeu: 5.595 ± 0.083	1.197ArgMet: 1.197 ± 0.032	2.039ArgAsn: 2.039 ± 0.043	1.859ArgPro: 1.859 ± 0.04	2.272ArgGln: 2.272 ± 0.052	2.942ArgArg: 2.942 ± 0.062	3.424ArgSer: 3.424 ± 0.062	2.363ArgThr: 2.363 ± 0.038	3.773ArgVal: 3.773 ± 0.059	0.697ArgTrp: 0.697 ± 0.03	1.929ArgTyr: 1.929 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.793SerAla: 6.793 ± 0.069	0.618SerCys: 0.618 ± 0.026	4.512SerAsp: 4.512 ± 0.076	4.166SerGlu: 4.166 ± 0.068	2.874SerPhe: 2.874 ± 0.056	5.573SerGly: 5.573 ± 0.113	1.491SerHis: 1.491 ± 0.037	4.544SerIle: 4.544 ± 0.067	3.122SerLys: 3.122 ± 0.06	7.394SerLeu: 7.394 ± 0.089	1.745SerMet: 1.745 ± 0.04	3.359SerAsn: 3.359 ± 0.078	2.772SerPro: 2.772 ± 0.048	2.846SerGln: 2.846 ± 0.052	3.414SerArg: 3.414 ± 0.057	5.258SerSer: 5.258 ± 0.079	3.781SerThr: 3.781 ± 0.052	5.459SerVal: 5.459 ± 0.081	0.829SerTrp: 0.829 ± 0.023	2.07SerTyr: 2.07 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.036ThrAla: 5.036 ± 0.066	0.417ThrCys: 0.417 ± 0.019	3.258ThrAsp: 3.258 ± 0.073	3.066ThrGlu: 3.066 ± 0.048	1.998ThrPhe: 1.998 ± 0.043	4.123ThrGly: 4.123 ± 0.085	1.214ThrHis: 1.214 ± 0.029	3.473ThrIle: 3.473 ± 0.066	2.149ThrLys: 2.149 ± 0.045	5.951ThrLeu: 5.951 ± 0.077	1.123ThrMet: 1.123 ± 0.034	2.158ThrAsn: 2.158 ± 0.052	2.797ThrPro: 2.797 ± 0.063	2.315ThrGln: 2.315 ± 0.051	2.467ThrArg: 2.467 ± 0.047	3.85ThrSer: 3.85 ± 0.075	3.033ThrThr: 3.033 ± 0.073	4.251ThrVal: 4.251 ± 0.076	0.563ThrTrp: 0.563 ± 0.024	1.435ThrTyr: 1.435 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	7.04ValAla: 7.04 ± 0.075	0.781ValCys: 0.781 ± 0.028	4.72ValAsp: 4.72 ± 0.092	4.314ValGlu: 4.314 ± 0.078	3.057ValPhe: 3.057 ± 0.054	5.101ValGly: 5.101 ± 0.072	1.236ValHis: 1.236 ± 0.032	4.321ValIle: 4.321 ± 0.06	2.904ValLys: 2.904 ± 0.049	7.176ValLeu: 7.176 ± 0.085	1.714ValMet: 1.714 ± 0.04	2.886ValAsn: 2.886 ± 0.053	2.884ValPro: 2.884 ± 0.057	2.321ValGln: 2.321 ± 0.047	3.327ValArg: 3.327 ± 0.057	5.687ValSer: 5.687 ± 0.096	4.147ValThr: 4.147 ± 0.094	5.823ValVal: 5.823 ± 0.086	0.836ValTrp: 0.836 ± 0.029	1.964ValTyr: 1.964 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.874TrpAla: 0.874 ± 0.029	0.156TrpCys: 0.156 ± 0.011	0.568TrpAsp: 0.568 ± 0.022	0.547TrpGlu: 0.547 ± 0.023	0.617TrpPhe: 0.617 ± 0.027	0.784TrpGly: 0.784 ± 0.024	0.354TrpHis: 0.354 ± 0.015	0.653TrpIle: 0.653 ± 0.025	0.454TrpLys: 0.454 ± 0.021	1.613TrpLeu: 1.613 ± 0.038	0.329TrpMet: 0.329 ± 0.017	0.49TrpAsn: 0.49 ± 0.02	0.471TrpPro: 0.471 ± 0.02	0.765TrpGln: 0.765 ± 0.028	0.807TrpArg: 0.807 ± 0.028	0.937TrpSer: 0.937 ± 0.027	0.517TrpThr: 0.517 ± 0.019	0.891TrpVal: 0.891 ± 0.029	0.215TrpTrp: 0.215 ± 0.013	0.369TrpTyr: 0.369 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.548TyrAla: 2.548 ± 0.047	0.344TyrCys: 0.344 ± 0.017	1.714TyrAsp: 1.714 ± 0.053	1.442TyrGlu: 1.442 ± 0.031	1.393TyrPhe: 1.393 ± 0.035	2.091TyrGly: 2.091 ± 0.039	0.657TyrHis: 0.657 ± 0.022	1.503TyrIle: 1.503 ± 0.038	1.08TyrLys: 1.08 ± 0.031	3.264TyrLeu: 3.264 ± 0.052	0.545TyrMet: 0.545 ± 0.021	1.056TyrAsn: 1.056 ± 0.03	1.245TyrPro: 1.245 ± 0.031	1.821TyrGln: 1.821 ± 0.041	1.956TyrArg: 1.956 ± 0.045	2.159TyrSer: 2.159 ± 0.046	1.603TyrThr: 1.603 ± 0.037	1.941TyrVal: 1.941 ± 0.033	0.473TyrTrp: 0.473 ± 0.02	1.012TyrTyr: 1.012 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3918 proteins (1304793 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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