Amino acid dipepetide frequency for Clostridium sp. CAG:470

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.383AlaAla: 2.383 ± 0.088
0.535AlaCys: 0.535 ± 0.04
2.56AlaAsp: 2.56 ± 0.081
3.698AlaGlu: 3.698 ± 0.103
1.886AlaPhe: 1.886 ± 0.075
3.558AlaGly: 3.558 ± 0.125
0.725AlaHis: 0.725 ± 0.038
5.531AlaIle: 5.531 ± 0.111
5.399AlaLys: 5.399 ± 0.121
4.2AlaLeu: 4.2 ± 0.102
1.349AlaMet: 1.349 ± 0.059
3.379AlaAsn: 3.379 ± 0.107
1.038AlaPro: 1.038 ± 0.054
1.6AlaGln: 1.6 ± 0.059
1.788AlaArg: 1.788 ± 0.067
2.909AlaSer: 2.909 ± 0.1
3.233AlaThr: 3.233 ± 0.157
3.135AlaVal: 3.135 ± 0.09
0.383AlaTrp: 0.383 ± 0.034
1.962AlaTyr: 1.962 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.506CysAla: 0.506 ± 0.037
0.195CysCys: 0.195 ± 0.023
0.595CysAsp: 0.595 ± 0.044
0.658CysGlu: 0.658 ± 0.045
0.447CysPhe: 0.447 ± 0.038
0.924CysGly: 0.924 ± 0.052
0.17CysHis: 0.17 ± 0.022
1.067CysIle: 1.067 ± 0.054
1.063CysLys: 1.063 ± 0.047
0.808CysLeu: 0.808 ± 0.043
0.271CysMet: 0.271 ± 0.026
0.703CysAsn: 0.703 ± 0.035
0.416CysPro: 0.416 ± 0.033
0.239CysGln: 0.239 ± 0.019
0.298CysArg: 0.298 ± 0.024
0.698CysSer: 0.698 ± 0.048
0.555CysThr: 0.555 ± 0.035
0.673CysVal: 0.673 ± 0.042
0.074CysTrp: 0.074 ± 0.013
0.463CysTyr: 0.463 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
2.499AspAla: 2.499 ± 0.084
0.597AspCys: 0.597 ± 0.038
2.976AspAsp: 2.976 ± 0.092
4.907AspGlu: 4.907 ± 0.138
2.39AspPhe: 2.39 ± 0.088
3.895AspGly: 3.895 ± 0.161
0.459AspHis: 0.459 ± 0.035
5.981AspIle: 5.981 ± 0.129
5.73AspLys: 5.73 ± 0.135
4.634AspLeu: 4.634 ± 0.121
1.385AspMet: 1.385 ± 0.055
3.783AspAsn: 3.783 ± 0.106
1.069AspPro: 1.069 ± 0.056
0.926AspGln: 0.926 ± 0.046
1.512AspArg: 1.512 ± 0.056
2.931AspSer: 2.931 ± 0.088
3.054AspThr: 3.054 ± 0.091
3.631AspVal: 3.631 ± 0.09
0.362AspTrp: 0.362 ± 0.032
2.79AspTyr: 2.79 ± 0.082
0.0AspXaa: 0.0 ± 0.0
Glu
3.654GluAla: 3.654 ± 0.102
0.694GluCys: 0.694 ± 0.045
4.486GluAsp: 4.486 ± 0.131
7.947GluGlu: 7.947 ± 0.179
2.877GluPhe: 2.877 ± 0.097
3.408GluGly: 3.408 ± 0.101
0.895GluHis: 0.895 ± 0.044
8.079GluIle: 8.079 ± 0.161
10.225GluLys: 10.225 ± 0.213
6.766GluLeu: 6.766 ± 0.151
2.067GluMet: 2.067 ± 0.072
7.697GluAsn: 7.697 ± 0.156
1.499GluPro: 1.499 ± 0.059
2.886GluGln: 2.886 ± 0.074
2.475GluArg: 2.475 ± 0.089
3.094GluSer: 3.094 ± 0.081
4.079GluThr: 4.079 ± 0.098
4.455GluVal: 4.455 ± 0.111
0.501GluTrp: 0.501 ± 0.034
3.79GluTyr: 3.79 ± 0.093
0.0GluXaa: 0.0 ± 0.0
Phe
2.197PheAla: 2.197 ± 0.081
0.51PheCys: 0.51 ± 0.036
2.535PheAsp: 2.535 ± 0.094
3.164PheGlu: 3.164 ± 0.082
1.454PhePhe: 1.454 ± 0.072
2.416PheGly: 2.416 ± 0.077
0.378PheHis: 0.378 ± 0.031
3.674PheIle: 3.674 ± 0.126
3.49PheLys: 3.49 ± 0.1
3.276PheLeu: 3.276 ± 0.114
0.98PheMet: 0.98 ± 0.051
2.43PheAsn: 2.43 ± 0.086
0.991PhePro: 0.991 ± 0.056
0.81PheGln: 0.81 ± 0.048
1.099PheArg: 1.099 ± 0.058
2.515PheSer: 2.515 ± 0.093
2.088PheThr: 2.088 ± 0.061
2.508PheVal: 2.508 ± 0.071
0.307PheTrp: 0.307 ± 0.03
1.544PheTyr: 1.544 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
3.188GlyAla: 3.188 ± 0.096
0.62GlyCys: 0.62 ± 0.046
2.759GlyAsp: 2.759 ± 0.093
4.012GlyGlu: 4.012 ± 0.107
2.461GlyPhe: 2.461 ± 0.086
3.399GlyGly: 3.399 ± 0.125
0.962GlyHis: 0.962 ± 0.041
6.117GlyIle: 6.117 ± 0.128
6.066GlyLys: 6.066 ± 0.122
4.522GlyLeu: 4.522 ± 0.113
1.512GlyMet: 1.512 ± 0.073
3.801GlyAsn: 3.801 ± 0.165
0.976GlyPro: 0.976 ± 0.045
1.687GlyGln: 1.687 ± 0.109
1.944GlyArg: 1.944 ± 0.07
2.871GlySer: 2.871 ± 0.094
4.188GlyThr: 4.188 ± 0.219
3.772GlyVal: 3.772 ± 0.097
0.392GlyTrp: 0.392 ± 0.034
3.126GlyTyr: 3.126 ± 0.176
0.0GlyXaa: 0.0 ± 0.0
His
0.557HisAla: 0.557 ± 0.035
0.161HisCys: 0.161 ± 0.019
0.535HisAsp: 0.535 ± 0.034
0.709HisGlu: 0.709 ± 0.042
0.515HisPhe: 0.515 ± 0.032
0.774HisGly: 0.774 ± 0.046
0.21HisHis: 0.21 ± 0.02
1.175HisIle: 1.175 ± 0.046
1.045HisLys: 1.045 ± 0.051
0.913HisLeu: 0.913 ± 0.048
0.282HisMet: 0.282 ± 0.026
0.772HisAsn: 0.772 ± 0.042
0.488HisPro: 0.488 ± 0.037
0.338HisGln: 0.338 ± 0.028
0.407HisArg: 0.407 ± 0.034
0.797HisSer: 0.797 ± 0.045
0.687HisThr: 0.687 ± 0.047
0.568HisVal: 0.568 ± 0.039
0.069HisTrp: 0.069 ± 0.014
0.533HisTyr: 0.533 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.853IleAla: 5.853 ± 0.131
1.271IleCys: 1.271 ± 0.06
5.929IleAsp: 5.929 ± 0.132
8.052IleGlu: 8.052 ± 0.176
3.94IlePhe: 3.94 ± 0.137
5.361IleGly: 5.361 ± 0.128
1.085IleHis: 1.085 ± 0.048
9.607IleIle: 9.607 ± 0.226
9.845IleLys: 9.845 ± 0.173
8.838IleLeu: 8.838 ± 0.193
2.17IleMet: 2.17 ± 0.073
6.486IleAsn: 6.486 ± 0.137
3.018IlePro: 3.018 ± 0.087
2.564IleGln: 2.564 ± 0.071
2.723IleArg: 2.723 ± 0.086
6.654IleSer: 6.654 ± 0.121
5.869IleThr: 5.869 ± 0.146
5.846IleVal: 5.846 ± 0.121
0.506IleTrp: 0.506 ± 0.036
4.039IleTyr: 4.039 ± 0.102
0.0IleXaa: 0.0 ± 0.0
Lys
4.925LysAla: 4.925 ± 0.112
0.973LysCys: 0.973 ± 0.056
6.05LysAsp: 6.05 ± 0.12
10.165LysGlu: 10.165 ± 0.201
3.524LysPhe: 3.524 ± 0.093
4.605LysGly: 4.605 ± 0.102
1.056LysHis: 1.056 ± 0.048
11.062LysIle: 11.062 ± 0.198
10.25LysLys: 10.25 ± 0.221
7.659LysLeu: 7.659 ± 0.137
3.088LysMet: 3.088 ± 0.089
8.337LysAsn: 8.337 ± 0.176
2.025LysPro: 2.025 ± 0.07
3.564LysGln: 3.564 ± 0.095
3.157LysArg: 3.157 ± 0.1
4.891LysSer: 4.891 ± 0.125
6.066LysThr: 6.066 ± 0.156
5.873LysVal: 5.873 ± 0.139
0.626LysTrp: 0.626 ± 0.037
5.269LysTyr: 5.269 ± 0.117
0.0LysXaa: 0.0 ± 0.0
Leu
4.473LeuAla: 4.473 ± 0.101
0.873LeuCys: 0.873 ± 0.045
4.775LeuAsp: 4.775 ± 0.137
6.847LeuGlu: 6.847 ± 0.171
3.106LeuPhe: 3.106 ± 0.108
4.844LeuGly: 4.844 ± 0.115
0.924LeuHis: 0.924 ± 0.045
7.307LeuIle: 7.307 ± 0.176
8.605LeuLys: 8.605 ± 0.164
6.509LeuLeu: 6.509 ± 0.177
1.741LeuMet: 1.741 ± 0.061
5.544LeuAsn: 5.544 ± 0.143
2.36LeuPro: 2.36 ± 0.077
2.347LeuGln: 2.347 ± 0.083
2.611LeuArg: 2.611 ± 0.082
4.81LeuSer: 4.81 ± 0.113
4.602LeuThr: 4.602 ± 0.112
4.607LeuVal: 4.607 ± 0.11
0.519LeuTrp: 0.519 ± 0.04
3.153LeuTyr: 3.153 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
1.548MetAla: 1.548 ± 0.067
0.311MetCys: 0.311 ± 0.024
1.345MetAsp: 1.345 ± 0.057
1.792MetGlu: 1.792 ± 0.065
0.958MetPhe: 0.958 ± 0.058
1.275MetGly: 1.275 ± 0.059
0.262MetHis: 0.262 ± 0.024
1.969MetIle: 1.969 ± 0.069
2.743MetLys: 2.743 ± 0.077
2.211MetLeu: 2.211 ± 0.068
0.611MetMet: 0.611 ± 0.04
1.586MetAsn: 1.586 ± 0.057
0.946MetPro: 0.946 ± 0.051
0.964MetGln: 0.964 ± 0.047
0.638MetArg: 0.638 ± 0.045
1.548MetSer: 1.548 ± 0.062
1.134MetThr: 1.134 ± 0.054
1.316MetVal: 1.316 ± 0.054
0.139MetTrp: 0.139 ± 0.017
1.031MetTyr: 1.031 ± 0.051
0.0MetXaa: 0.0 ± 0.0
Asn
3.17AsnAla: 3.17 ± 0.11
0.826AsnCys: 0.826 ± 0.05
3.376AsnAsp: 3.376 ± 0.094
5.249AsnGlu: 5.249 ± 0.118
2.683AsnPhe: 2.683 ± 0.091
4.728AsnGly: 4.728 ± 0.182
0.718AsnHis: 0.718 ± 0.046
7.853AsnIle: 7.853 ± 0.154
7.623AsnLys: 7.623 ± 0.139
5.799AsnLeu: 5.799 ± 0.123
1.788AsnMet: 1.788 ± 0.076
5.517AsnAsn: 5.517 ± 0.177
2.043AsnPro: 2.043 ± 0.079
2.197AsnGln: 2.197 ± 0.074
1.922AsnArg: 1.922 ± 0.077
4.37AsnSer: 4.37 ± 0.128
4.35AsnThr: 4.35 ± 0.148
4.159AsnVal: 4.159 ± 0.101
0.497AsnTrp: 0.497 ± 0.034
3.271AsnTyr: 3.271 ± 0.09
0.0AsnXaa: 0.0 ± 0.0
Pro
1.231ProAla: 1.231 ± 0.06
0.309ProCys: 0.309 ± 0.025
1.649ProAsp: 1.649 ± 0.076
2.45ProGlu: 2.45 ± 0.077
1.092ProPhe: 1.092 ± 0.049
1.392ProGly: 1.392 ± 0.058
0.331ProHis: 0.331 ± 0.028
2.383ProIle: 2.383 ± 0.079
2.157ProLys: 2.157 ± 0.076
1.777ProLeu: 1.777 ± 0.076
0.564ProMet: 0.564 ± 0.039
1.584ProAsn: 1.584 ± 0.062
0.445ProPro: 0.445 ± 0.041
0.718ProGln: 0.718 ± 0.036
0.758ProArg: 0.758 ± 0.045
1.322ProSer: 1.322 ± 0.062
1.495ProThr: 1.495 ± 0.069
1.689ProVal: 1.689 ± 0.062
0.17ProTrp: 0.17 ± 0.022
1.11ProTyr: 1.11 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
1.526GlnAla: 1.526 ± 0.059
0.21GlnCys: 0.21 ± 0.024
1.6GlnAsp: 1.6 ± 0.058
2.754GlnGlu: 2.754 ± 0.102
1.007GlnPhe: 1.007 ± 0.047
1.524GlnGly: 1.524 ± 0.064
0.284GlnHis: 0.284 ± 0.025
3.085GlnIle: 3.085 ± 0.078
3.332GlnLys: 3.332 ± 0.092
2.173GlnLeu: 2.173 ± 0.094
0.752GlnMet: 0.752 ± 0.045
2.501GlnAsn: 2.501 ± 0.079
0.521GlnPro: 0.521 ± 0.04
0.886GlnGln: 0.886 ± 0.046
1.011GlnArg: 1.011 ± 0.056
1.34GlnSer: 1.34 ± 0.058
1.696GlnThr: 1.696 ± 0.073
1.752GlnVal: 1.752 ± 0.068
0.154GlnTrp: 0.154 ± 0.019
1.32GlnTyr: 1.32 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
1.517ArgAla: 1.517 ± 0.059
0.345ArgCys: 0.345 ± 0.03
1.606ArgAsp: 1.606 ± 0.057
2.492ArgGlu: 2.492 ± 0.079
1.215ArgPhe: 1.215 ± 0.055
1.551ArgGly: 1.551 ± 0.068
0.421ArgHis: 0.421 ± 0.028
2.895ArgIle: 2.895 ± 0.085
3.464ArgLys: 3.464 ± 0.093
2.443ArgLeu: 2.443 ± 0.09
0.812ArgMet: 0.812 ± 0.043
2.19ArgAsn: 2.19 ± 0.078
0.852ArgPro: 0.852 ± 0.048
0.969ArgGln: 0.969 ± 0.047
1.26ArgArg: 1.26 ± 0.065
1.266ArgSer: 1.266 ± 0.058
1.835ArgThr: 1.835 ± 0.068
1.752ArgVal: 1.752 ± 0.068
0.224ArgTrp: 0.224 ± 0.021
1.524ArgTyr: 1.524 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
2.721SerAla: 2.721 ± 0.09
0.544SerCys: 0.544 ± 0.039
2.92SerAsp: 2.92 ± 0.091
3.79SerGlu: 3.79 ± 0.107
2.213SerPhe: 2.213 ± 0.076
3.683SerGly: 3.683 ± 0.108
0.64SerHis: 0.64 ± 0.043
5.766SerIle: 5.766 ± 0.124
6.023SerLys: 6.023 ± 0.122
4.235SerLeu: 4.235 ± 0.111
1.264SerMet: 1.264 ± 0.05
4.41SerAsn: 4.41 ± 0.123
1.175SerPro: 1.175 ± 0.054
1.671SerGln: 1.671 ± 0.066
1.799SerArg: 1.799 ± 0.061
3.994SerSer: 3.994 ± 0.127
3.584SerThr: 3.584 ± 0.121
3.39SerVal: 3.39 ± 0.094
0.434SerTrp: 0.434 ± 0.032
2.383SerTyr: 2.383 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
3.132ThrAla: 3.132 ± 0.13
0.512ThrCys: 0.512 ± 0.036
3.379ThrAsp: 3.379 ± 0.092
4.39ThrGlu: 4.39 ± 0.101
2.249ThrPhe: 2.249 ± 0.078
4.226ThrGly: 4.226 ± 0.139
0.723ThrHis: 0.723 ± 0.043
5.641ThrIle: 5.641 ± 0.147
5.345ThrLys: 5.345 ± 0.147
4.634ThrLeu: 4.634 ± 0.103
1.246ThrMet: 1.246 ± 0.056
3.75ThrAsn: 3.75 ± 0.134
1.808ThrPro: 1.808 ± 0.078
1.808ThrGln: 1.808 ± 0.077
1.712ThrArg: 1.712 ± 0.067
3.81ThrSer: 3.81 ± 0.152
4.068ThrThr: 4.068 ± 0.252
3.978ThrVal: 3.978 ± 0.175
0.407ThrTrp: 0.407 ± 0.038
2.701ThrTyr: 2.701 ± 0.114
0.0ThrXaa: 0.0 ± 0.0
Val
3.698ValAla: 3.698 ± 0.101
0.671ValCys: 0.671 ± 0.041
3.425ValAsp: 3.425 ± 0.09
4.942ValGlu: 4.942 ± 0.112
2.217ValPhe: 2.217 ± 0.076
3.544ValGly: 3.544 ± 0.105
0.651ValHis: 0.651 ± 0.038
5.703ValIle: 5.703 ± 0.119
5.721ValLys: 5.721 ± 0.119
4.996ValLeu: 4.996 ± 0.114
1.257ValMet: 1.257 ± 0.055
3.558ValAsn: 3.558 ± 0.097
1.676ValPro: 1.676 ± 0.059
1.765ValGln: 1.765 ± 0.072
1.859ValArg: 1.859 ± 0.063
3.616ValSer: 3.616 ± 0.107
3.851ValThr: 3.851 ± 0.144
4.108ValVal: 4.108 ± 0.126
0.483ValTrp: 0.483 ± 0.069
2.486ValTyr: 2.486 ± 0.085
0.0ValXaa: 0.0 ± 0.0
Trp
0.298TrpAla: 0.298 ± 0.026
0.103TrpCys: 0.103 ± 0.016
0.327TrpAsp: 0.327 ± 0.028
0.374TrpGlu: 0.374 ± 0.028
0.295TrpPhe: 0.295 ± 0.026
0.524TrpGly: 0.524 ± 0.065
0.116TrpHis: 0.116 ± 0.016
0.593TrpIle: 0.593 ± 0.037
0.584TrpLys: 0.584 ± 0.043
0.537TrpLeu: 0.537 ± 0.041
0.163TrpMet: 0.163 ± 0.021
0.533TrpAsn: 0.533 ± 0.039
0.125TrpPro: 0.125 ± 0.018
0.28TrpGln: 0.28 ± 0.028
0.239TrpArg: 0.239 ± 0.02
0.383TrpSer: 0.383 ± 0.038
0.383TrpThr: 0.383 ± 0.04
0.371TrpVal: 0.371 ± 0.03
0.101TrpTrp: 0.101 ± 0.017
0.345TrpTyr: 0.345 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.173TyrAla: 2.173 ± 0.082
0.564TyrCys: 0.564 ± 0.039
2.687TyrAsp: 2.687 ± 0.081
3.182TyrGlu: 3.182 ± 0.091
1.837TyrPhe: 1.837 ± 0.081
2.745TyrGly: 2.745 ± 0.129
0.524TyrHis: 0.524 ± 0.033
4.168TyrIle: 4.168 ± 0.115
4.457TyrLys: 4.457 ± 0.112
3.629TyrLeu: 3.629 ± 0.106
1.023TyrMet: 1.023 ± 0.051
3.578TyrAsn: 3.578 ± 0.131
1.152TyrPro: 1.152 ± 0.053
1.208TyrGln: 1.208 ± 0.056
1.421TyrArg: 1.421 ± 0.064
2.819TyrSer: 2.819 ± 0.089
2.703TyrThr: 2.703 ± 0.113
2.645TyrVal: 2.645 ± 0.082
0.324TyrTrp: 0.324 ± 0.025
2.146TyrTyr: 2.146 ± 0.076
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1535 proteins (446944 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski