Amino acid dipepetide frequency for Nakamurella sp. s14-144

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.586AlaAla: 20.586 ± 0.252
0.95AlaCys: 0.95 ± 0.033
7.649AlaAsp: 7.649 ± 0.101
7.159AlaGlu: 7.159 ± 0.108
3.534AlaPhe: 3.534 ± 0.065
12.728AlaGly: 12.728 ± 0.151
2.376AlaHis: 2.376 ± 0.059
5.66AlaIle: 5.66 ± 0.079
3.521AlaLys: 3.521 ± 0.074
13.088AlaLeu: 13.088 ± 0.137
2.635AlaMet: 2.635 ± 0.053
2.792AlaAsn: 2.792 ± 0.062
6.326AlaPro: 6.326 ± 0.103
4.282AlaGln: 4.282 ± 0.076
7.326AlaArg: 7.326 ± 0.103
7.89AlaSer: 7.89 ± 0.107
7.672AlaThr: 7.672 ± 0.101
11.141AlaVal: 11.141 ± 0.112
1.53AlaTrp: 1.53 ± 0.041
2.185AlaTyr: 2.185 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.008CysAla: 1.008 ± 0.034
0.091CysCys: 0.091 ± 0.01
0.464CysAsp: 0.464 ± 0.022
0.395CysGlu: 0.395 ± 0.02
0.219CysPhe: 0.219 ± 0.016
0.8CysGly: 0.8 ± 0.03
0.177CysHis: 0.177 ± 0.013
0.274CysIle: 0.274 ± 0.018
0.125CysLys: 0.125 ± 0.011
0.675CysLeu: 0.675 ± 0.028
0.132CysMet: 0.132 ± 0.013
0.174CysAsn: 0.174 ± 0.013
0.421CysPro: 0.421 ± 0.024
0.202CysGln: 0.202 ± 0.014
0.442CysArg: 0.442 ± 0.024
0.497CysSer: 0.497 ± 0.025
0.477CysThr: 0.477 ± 0.026
0.649CysVal: 0.649 ± 0.028
0.119CysTrp: 0.119 ± 0.012
0.141CysTyr: 0.141 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.935AspAla: 6.935 ± 0.11
0.382AspCys: 0.382 ± 0.021
3.098AspAsp: 3.098 ± 0.067
3.219AspGlu: 3.219 ± 0.067
1.756AspPhe: 1.756 ± 0.05
5.375AspGly: 5.375 ± 0.089
1.263AspHis: 1.263 ± 0.042
2.565AspIle: 2.565 ± 0.058
1.346AspLys: 1.346 ± 0.043
6.314AspLeu: 6.314 ± 0.084
0.878AspMet: 0.878 ± 0.035
1.169AspAsn: 1.169 ± 0.035
4.075AspPro: 4.075 ± 0.083
1.688AspGln: 1.688 ± 0.049
3.645AspArg: 3.645 ± 0.066
3.314AspSer: 3.314 ± 0.066
2.842AspThr: 2.842 ± 0.054
4.729AspVal: 4.729 ± 0.074
0.82AspTrp: 0.82 ± 0.032
1.221AspTyr: 1.221 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
5.831GluAla: 5.831 ± 0.08
0.333GluCys: 0.333 ± 0.017
2.157GluAsp: 2.157 ± 0.045
2.296GluGlu: 2.296 ± 0.058
1.698GluPhe: 1.698 ± 0.045
3.328GluGly: 3.328 ± 0.067
1.259GluHis: 1.259 ± 0.038
2.941GluIle: 2.941 ± 0.065
1.571GluLys: 1.571 ± 0.044
6.1GluLeu: 6.1 ± 0.096
1.17GluMet: 1.17 ± 0.038
1.294GluAsn: 1.294 ± 0.036
2.47GluPro: 2.47 ± 0.055
2.03GluGln: 2.03 ± 0.051
3.457GluArg: 3.457 ± 0.071
3.155GluSer: 3.155 ± 0.062
2.682GluThr: 2.682 ± 0.06
4.312GluVal: 4.312 ± 0.069
0.735GluTrp: 0.735 ± 0.032
1.029GluTyr: 1.029 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.997PheAla: 3.997 ± 0.071
0.279PheCys: 0.279 ± 0.019
2.258PheAsp: 2.258 ± 0.061
1.508PheGlu: 1.508 ± 0.038
1.021PhePhe: 1.021 ± 0.036
3.231PheGly: 3.231 ± 0.063
0.573PheHis: 0.573 ± 0.025
1.145PheIle: 1.145 ± 0.038
0.647PheLys: 0.647 ± 0.029
2.681PheLeu: 2.681 ± 0.059
0.442PheMet: 0.442 ± 0.027
0.855PheAsn: 0.855 ± 0.033
1.45PhePro: 1.45 ± 0.04
0.79PheGln: 0.79 ± 0.034
1.657PheArg: 1.657 ± 0.043
2.101PheSer: 2.101 ± 0.056
2.133PheThr: 2.133 ± 0.05
2.522PheVal: 2.522 ± 0.06
0.426PheTrp: 0.426 ± 0.024
0.68PheTyr: 0.68 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
10.338GlyAla: 10.338 ± 0.129
0.777GlyCys: 0.777 ± 0.031
4.479GlyAsp: 4.479 ± 0.073
4.322GlyGlu: 4.322 ± 0.067
3.182GlyPhe: 3.182 ± 0.058
7.516GlyGly: 7.516 ± 0.112
1.841GlyHis: 1.841 ± 0.042
4.519GlyIle: 4.519 ± 0.072
2.803GlyLys: 2.803 ± 0.06
8.683GlyLeu: 8.683 ± 0.115
2.045GlyMet: 2.045 ± 0.051
2.168GlyAsn: 2.168 ± 0.057
4.192GlyPro: 4.192 ± 0.076
2.858GlyGln: 2.858 ± 0.065
5.726GlyArg: 5.726 ± 0.093
6.19GlySer: 6.19 ± 0.102
5.492GlyThr: 5.492 ± 0.093
7.932GlyVal: 7.932 ± 0.108
1.504GlyTrp: 1.504 ± 0.041
2.309GlyTyr: 2.309 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.211HisAla: 2.211 ± 0.057
0.185HisCys: 0.185 ± 0.014
1.074HisAsp: 1.074 ± 0.038
0.939HisGlu: 0.939 ± 0.033
0.606HisPhe: 0.606 ± 0.025
1.789HisGly: 1.789 ± 0.045
0.615HisHis: 0.615 ± 0.027
0.85HisIle: 0.85 ± 0.031
0.368HisLys: 0.368 ± 0.02
2.118HisLeu: 2.118 ± 0.045
0.393HisMet: 0.393 ± 0.023
0.438HisAsn: 0.438 ± 0.023
1.454HisPro: 1.454 ± 0.044
0.746HisGln: 0.746 ± 0.03
1.537HisArg: 1.537 ± 0.045
1.174HisSer: 1.174 ± 0.039
1.136HisThr: 1.136 ± 0.038
1.485HisVal: 1.485 ± 0.044
0.261HisTrp: 0.261 ± 0.015
0.449HisTyr: 0.449 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.609IleAla: 6.609 ± 0.09
0.428IleCys: 0.428 ± 0.025
3.18IleAsp: 3.18 ± 0.064
2.486IleGlu: 2.486 ± 0.059
1.406IlePhe: 1.406 ± 0.041
4.552IleGly: 4.552 ± 0.076
0.81IleHis: 0.81 ± 0.032
1.853IleIle: 1.853 ± 0.054
1.177IleLys: 1.177 ± 0.039
3.788IleLeu: 3.788 ± 0.073
0.662IleMet: 0.662 ± 0.028
1.251IleAsn: 1.251 ± 0.037
2.51IlePro: 2.51 ± 0.054
1.089IleGln: 1.089 ± 0.036
2.683IleArg: 2.683 ± 0.059
3.189IleSer: 3.189 ± 0.06
3.448IleThr: 3.448 ± 0.064
3.99IleVal: 3.99 ± 0.075
0.522IleTrp: 0.522 ± 0.027
0.851IleTyr: 0.851 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
3.253LysAla: 3.253 ± 0.067
0.154LysCys: 0.154 ± 0.013
1.298LysAsp: 1.298 ± 0.04
1.108LysGlu: 1.108 ± 0.039
0.776LysPhe: 0.776 ± 0.025
1.808LysGly: 1.808 ± 0.05
0.466LysHis: 0.466 ± 0.024
1.465LysIle: 1.465 ± 0.047
0.958LysLys: 0.958 ± 0.042
2.552LysLeu: 2.552 ± 0.057
0.599LysMet: 0.599 ± 0.022
0.737LysAsn: 0.737 ± 0.032
1.533LysPro: 1.533 ± 0.04
0.854LysGln: 0.854 ± 0.035
1.603LysArg: 1.603 ± 0.042
1.79LysSer: 1.79 ± 0.043
1.587LysThr: 1.587 ± 0.041
2.326LysVal: 2.326 ± 0.047
0.363LysTrp: 0.363 ± 0.017
0.632LysTyr: 0.632 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
14.206LeuAla: 14.206 ± 0.134
0.693LeuCys: 0.693 ± 0.026
5.764LeuAsp: 5.764 ± 0.078
4.48LeuGlu: 4.48 ± 0.076
2.671LeuPhe: 2.671 ± 0.064
8.911LeuGly: 8.911 ± 0.124
1.796LeuHis: 1.796 ± 0.044
4.719LeuIle: 4.719 ± 0.089
2.234LeuLys: 2.234 ± 0.05
10.384LeuLeu: 10.384 ± 0.147
1.914LeuMet: 1.914 ± 0.041
2.17LeuAsn: 2.17 ± 0.056
5.913LeuPro: 5.913 ± 0.081
2.835LeuGln: 2.835 ± 0.052
6.841LeuArg: 6.841 ± 0.097
6.107LeuSer: 6.107 ± 0.09
6.836LeuThr: 6.836 ± 0.077
8.761LeuVal: 8.761 ± 0.098
1.205LeuTrp: 1.205 ± 0.046
1.632LeuTyr: 1.632 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.513MetAla: 2.513 ± 0.053
0.164MetCys: 0.164 ± 0.015
0.965MetAsp: 0.965 ± 0.035
0.77MetGlu: 0.77 ± 0.031
0.521MetPhe: 0.521 ± 0.024
1.501MetGly: 1.501 ± 0.039
0.368MetHis: 0.368 ± 0.019
0.877MetIle: 0.877 ± 0.03
0.554MetLys: 0.554 ± 0.021
2.0MetLeu: 2.0 ± 0.055
0.453MetMet: 0.453 ± 0.022
0.528MetAsn: 0.528 ± 0.024
1.159MetPro: 1.159 ± 0.037
0.563MetGln: 0.563 ± 0.025
1.342MetArg: 1.342 ± 0.039
1.576MetSer: 1.576 ± 0.038
1.865MetThr: 1.865 ± 0.048
1.671MetVal: 1.671 ± 0.041
0.237MetTrp: 0.237 ± 0.017
0.322MetTyr: 0.322 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.658AsnAla: 2.658 ± 0.049
0.192AsnCys: 0.192 ± 0.016
1.316AsnAsp: 1.316 ± 0.038
1.063AsnGlu: 1.063 ± 0.034
0.775AsnPhe: 0.775 ± 0.031
2.149AsnGly: 2.149 ± 0.059
0.424AsnHis: 0.424 ± 0.023
1.088AsnIle: 1.088 ± 0.034
0.621AsnLys: 0.621 ± 0.024
2.336AsnLeu: 2.336 ± 0.052
0.469AsnMet: 0.469 ± 0.021
0.69AsnAsn: 0.69 ± 0.03
1.911AsnPro: 1.911 ± 0.045
0.765AsnGln: 0.765 ± 0.03
1.452AsnArg: 1.452 ± 0.039
1.581AsnSer: 1.581 ± 0.044
1.555AsnThr: 1.555 ± 0.059
1.809AsnVal: 1.809 ± 0.044
0.376AsnTrp: 0.376 ± 0.019
0.592AsnTyr: 0.592 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
7.731ProAla: 7.731 ± 0.109
0.297ProCys: 0.297 ± 0.018
3.513ProAsp: 3.513 ± 0.072
3.435ProGlu: 3.435 ± 0.065
1.528ProPhe: 1.528 ± 0.044
5.255ProGly: 5.255 ± 0.091
1.131ProHis: 1.131 ± 0.034
2.204ProIle: 2.204 ± 0.052
1.302ProLys: 1.302 ± 0.04
4.733ProLeu: 4.733 ± 0.072
1.026ProMet: 1.026 ± 0.035
1.278ProAsn: 1.278 ± 0.038
2.65ProPro: 2.65 ± 0.072
1.759ProGln: 1.759 ± 0.041
2.899ProArg: 2.899 ± 0.063
3.602ProSer: 3.602 ± 0.073
3.612ProThr: 3.612 ± 0.076
4.921ProVal: 4.921 ± 0.085
0.872ProTrp: 0.872 ± 0.033
1.047ProTyr: 1.047 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.002GlnAla: 4.002 ± 0.079
0.182GlnCys: 0.182 ± 0.014
1.344GlnAsp: 1.344 ± 0.046
1.247GlnGlu: 1.247 ± 0.035
0.986GlnPhe: 0.986 ± 0.029
2.298GlnGly: 2.298 ± 0.052
0.71GlnHis: 0.71 ± 0.028
1.714GlnIle: 1.714 ± 0.043
0.701GlnLys: 0.701 ± 0.026
3.473GlnLeu: 3.473 ± 0.062
0.773GlnMet: 0.773 ± 0.03
0.732GlnAsn: 0.732 ± 0.031
1.73GlnPro: 1.73 ± 0.052
1.47GlnGln: 1.47 ± 0.059
2.431GlnArg: 2.431 ± 0.051
1.75GlnSer: 1.75 ± 0.049
1.775GlnThr: 1.775 ± 0.059
2.964GlnVal: 2.964 ± 0.055
0.517GlnTrp: 0.517 ± 0.025
0.662GlnTyr: 0.662 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
7.194ArgAla: 7.194 ± 0.111
0.464ArgCys: 0.464 ± 0.021
3.349ArgAsp: 3.349 ± 0.062
3.354ArgGlu: 3.354 ± 0.061
2.019ArgPhe: 2.019 ± 0.048
4.862ArgGly: 4.862 ± 0.083
1.33ArgHis: 1.33 ± 0.04
3.185ArgIle: 3.185 ± 0.062
1.809ArgLys: 1.809 ± 0.046
6.203ArgLeu: 6.203 ± 0.092
1.548ArgMet: 1.548 ± 0.042
1.536ArgAsn: 1.536 ± 0.048
3.32ArgPro: 3.32 ± 0.072
2.084ArgGln: 2.084 ± 0.044
5.278ArgArg: 5.278 ± 0.112
4.327ArgSer: 4.327 ± 0.071
3.897ArgThr: 3.897 ± 0.067
5.02ArgVal: 5.02 ± 0.076
1.113ArgTrp: 1.113 ± 0.036
1.501ArgTyr: 1.501 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
8.657SerAla: 8.657 ± 0.124
0.454SerCys: 0.454 ± 0.03
3.634SerAsp: 3.634 ± 0.063
3.106SerGlu: 3.106 ± 0.057
1.999SerPhe: 1.999 ± 0.049
6.559SerGly: 6.559 ± 0.082
1.187SerHis: 1.187 ± 0.033
2.744SerIle: 2.744 ± 0.055
1.582SerLys: 1.582 ± 0.041
5.971SerLeu: 5.971 ± 0.087
1.465SerMet: 1.465 ± 0.038
1.498SerAsn: 1.498 ± 0.04
3.424SerPro: 3.424 ± 0.076
1.943SerGln: 1.943 ± 0.045
4.019SerArg: 4.019 ± 0.071
4.607SerSer: 4.607 ± 0.092
4.231SerThr: 4.231 ± 0.083
5.594SerVal: 5.594 ± 0.085
1.003SerTrp: 1.003 ± 0.035
1.355SerTyr: 1.355 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
8.109ThrAla: 8.109 ± 0.11
0.488ThrCys: 0.488 ± 0.024
3.725ThrAsp: 3.725 ± 0.08
3.039ThrGlu: 3.039 ± 0.063
1.999ThrPhe: 1.999 ± 0.051
5.971ThrGly: 5.971 ± 0.096
1.186ThrHis: 1.186 ± 0.035
2.754ThrIle: 2.754 ± 0.051
1.683ThrLys: 1.683 ± 0.042
6.001ThrLeu: 6.001 ± 0.091
1.16ThrMet: 1.16 ± 0.039
1.434ThrAsn: 1.434 ± 0.049
3.906ThrPro: 3.906 ± 0.073
1.785ThrGln: 1.785 ± 0.049
3.261ThrArg: 3.261 ± 0.059
4.405ThrSer: 4.405 ± 0.095
4.342ThrThr: 4.342 ± 0.125
6.062ThrVal: 6.062 ± 0.1
0.849ThrTrp: 0.849 ± 0.029
1.435ThrTyr: 1.435 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
11.388ValAla: 11.388 ± 0.137
0.664ValCys: 0.664 ± 0.03
5.316ValAsp: 5.316 ± 0.076
4.271ValGlu: 4.271 ± 0.082
2.485ValPhe: 2.485 ± 0.056
7.329ValGly: 7.329 ± 0.086
1.663ValHis: 1.663 ± 0.044
4.62ValIle: 4.62 ± 0.078
2.027ValLys: 2.027 ± 0.046
9.045ValLeu: 9.045 ± 0.108
1.631ValMet: 1.631 ± 0.041
2.1ValAsn: 2.1 ± 0.046
4.468ValPro: 4.468 ± 0.074
2.363ValGln: 2.363 ± 0.052
5.288ValArg: 5.288 ± 0.08
5.538ValSer: 5.538 ± 0.074
5.932ValThr: 5.932 ± 0.132
8.562ValVal: 8.562 ± 0.121
1.045ValTrp: 1.045 ± 0.04
1.424ValTyr: 1.424 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.541TrpAla: 1.541 ± 0.046
0.126TrpCys: 0.126 ± 0.014
0.718TrpAsp: 0.718 ± 0.03
0.616TrpGlu: 0.616 ± 0.024
0.469TrpPhe: 0.469 ± 0.023
0.956TrpGly: 0.956 ± 0.033
0.346TrpHis: 0.346 ± 0.018
0.652TrpIle: 0.652 ± 0.03
0.417TrpLys: 0.417 ± 0.021
1.635TrpLeu: 1.635 ± 0.044
0.319TrpMet: 0.319 ± 0.018
0.439TrpAsn: 0.439 ± 0.023
0.739TrpPro: 0.739 ± 0.029
0.614TrpGln: 0.614 ± 0.028
1.03TrpArg: 1.03 ± 0.032
0.925TrpSer: 0.925 ± 0.033
0.877TrpThr: 0.877 ± 0.033
1.098TrpVal: 1.098 ± 0.039
0.353TrpTrp: 0.353 ± 0.022
0.241TrpTyr: 0.241 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.261TyrAla: 2.261 ± 0.054
0.178TyrCys: 0.178 ± 0.013
1.335TyrAsp: 1.335 ± 0.054
1.036TyrGlu: 1.036 ± 0.035
0.746TyrPhe: 0.746 ± 0.032
1.957TyrGly: 1.957 ± 0.056
0.31TyrHis: 0.31 ± 0.018
0.654TyrIle: 0.654 ± 0.027
0.416TyrLys: 0.416 ± 0.024
2.29TyrLeu: 2.29 ± 0.055
0.235TyrMet: 0.235 ± 0.016
0.54TyrAsn: 0.54 ± 0.028
1.145TyrPro: 1.145 ± 0.039
0.742TyrGln: 0.742 ± 0.029
1.474TyrArg: 1.474 ± 0.04
1.314TyrSer: 1.314 ± 0.042
1.203TyrThr: 1.203 ± 0.046
1.61TyrVal: 1.61 ± 0.049
0.262TyrTrp: 0.262 ± 0.018
0.468TyrTyr: 0.468 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2873 proteins (946164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski