Amino acid dipepetide frequency for Pseudomonas phage D3 (Bacteriophage D3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.204AlaAla: 14.204 ± 1.618
1.438AlaCys: 1.438 ± 0.257
6.556AlaAsp: 6.556 ± 0.642
8.396AlaGlu: 8.396 ± 1.068
4.026AlaPhe: 4.026 ± 0.607
8.109AlaGly: 8.109 ± 0.694
1.323AlaHis: 1.323 ± 0.33
4.773AlaIle: 4.773 ± 0.485
5.463AlaLys: 5.463 ± 0.688
11.099AlaLeu: 11.099 ± 0.895
3.911AlaMet: 3.911 ± 0.504
3.623AlaAsn: 3.623 ± 0.499
3.796AlaPro: 3.796 ± 0.577
5.233AlaGln: 5.233 ± 0.735
6.901AlaArg: 6.901 ± 0.688
6.901AlaSer: 6.901 ± 0.697
4.658AlaThr: 4.658 ± 0.665
5.981AlaVal: 5.981 ± 0.611
2.588AlaTrp: 2.588 ± 0.327
2.703AlaTyr: 2.703 ± 0.281
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.213
0.23CysCys: 0.23 ± 0.097
1.093CysAsp: 1.093 ± 0.239
1.035CysGlu: 1.035 ± 0.277
0.46CysPhe: 0.46 ± 0.179
1.668CysGly: 1.668 ± 0.369
0.46CysHis: 0.46 ± 0.153
0.518CysIle: 0.518 ± 0.206
0.575CysLys: 0.575 ± 0.178
0.978CysLeu: 0.978 ± 0.22
0.46CysMet: 0.46 ± 0.168
0.46CysAsn: 0.46 ± 0.163
0.978CysPro: 0.978 ± 0.249
0.92CysGln: 0.92 ± 0.231
1.495CysArg: 1.495 ± 0.289
0.92CysSer: 0.92 ± 0.228
0.633CysThr: 0.633 ± 0.204
0.748CysVal: 0.748 ± 0.243
0.403CysTrp: 0.403 ± 0.146
0.345CysTyr: 0.345 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
6.268AspAla: 6.268 ± 0.612
0.748AspCys: 0.748 ± 0.219
3.105AspAsp: 3.105 ± 0.481
3.335AspGlu: 3.335 ± 0.424
2.3AspPhe: 2.3 ± 0.354
5.923AspGly: 5.923 ± 0.6
1.323AspHis: 1.323 ± 0.266
3.22AspIle: 3.22 ± 0.439
2.3AspLys: 2.3 ± 0.324
5.176AspLeu: 5.176 ± 0.54
1.668AspMet: 1.668 ± 0.248
1.783AspAsn: 1.783 ± 0.316
1.898AspPro: 1.898 ± 0.325
2.07AspGln: 2.07 ± 0.359
4.371AspArg: 4.371 ± 0.466
2.415AspSer: 2.415 ± 0.404
2.013AspThr: 2.013 ± 0.368
3.911AspVal: 3.911 ± 0.498
1.495AspTrp: 1.495 ± 0.298
1.668AspTyr: 1.668 ± 0.252
0.0AspXaa: 0.0 ± 0.0
Glu
6.498GluAla: 6.498 ± 0.884
1.61GluCys: 1.61 ± 0.288
2.703GluAsp: 2.703 ± 0.37
3.68GluGlu: 3.68 ± 0.539
2.818GluPhe: 2.818 ± 0.361
3.68GluGly: 3.68 ± 0.407
1.553GluHis: 1.553 ± 0.296
3.623GluIle: 3.623 ± 0.474
3.048GluLys: 3.048 ± 0.404
6.268GluLeu: 6.268 ± 0.686
1.783GluMet: 1.783 ± 0.285
2.128GluAsn: 2.128 ± 0.404
2.933GluPro: 2.933 ± 0.488
3.623GluGln: 3.623 ± 0.452
6.268GluArg: 6.268 ± 0.776
4.371GluSer: 4.371 ± 0.541
3.738GluThr: 3.738 ± 0.521
5.061GluVal: 5.061 ± 0.524
1.553GluTrp: 1.553 ± 0.309
1.61GluTyr: 1.61 ± 0.271
0.0GluXaa: 0.0 ± 0.0
Phe
3.623PheAla: 3.623 ± 0.433
0.575PheCys: 0.575 ± 0.195
1.84PheAsp: 1.84 ± 0.249
2.185PheGlu: 2.185 ± 0.397
0.92PhePhe: 0.92 ± 0.26
3.163PheGly: 3.163 ± 0.472
0.518PheHis: 0.518 ± 0.166
1.553PheIle: 1.553 ± 0.305
1.495PheLys: 1.495 ± 0.274
2.99PheLeu: 2.99 ± 0.476
0.575PheMet: 0.575 ± 0.195
0.863PheAsn: 0.863 ± 0.227
1.323PhePro: 1.323 ± 0.251
0.69PheGln: 0.69 ± 0.195
2.07PheArg: 2.07 ± 0.295
1.955PheSer: 1.955 ± 0.419
1.955PheThr: 1.955 ± 0.353
2.588PheVal: 2.588 ± 0.444
0.46PheTrp: 0.46 ± 0.162
0.863PheTyr: 0.863 ± 0.235
0.0PheXaa: 0.0 ± 0.0
Gly
6.843GlyAla: 6.843 ± 0.564
1.265GlyCys: 1.265 ± 0.31
4.313GlyAsp: 4.313 ± 0.581
5.003GlyGlu: 5.003 ± 0.48
2.53GlyPhe: 2.53 ± 0.37
6.038GlyGly: 6.038 ± 0.622
1.38GlyHis: 1.38 ± 0.263
3.796GlyIle: 3.796 ± 0.485
4.141GlyLys: 4.141 ± 0.469
6.843GlyLeu: 6.843 ± 0.664
2.415GlyMet: 2.415 ± 0.322
2.588GlyAsn: 2.588 ± 0.405
2.013GlyPro: 2.013 ± 0.315
2.588GlyGln: 2.588 ± 0.325
5.291GlyArg: 5.291 ± 0.643
4.313GlySer: 4.313 ± 0.562
3.68GlyThr: 3.68 ± 0.486
5.693GlyVal: 5.693 ± 0.636
1.668GlyTrp: 1.668 ± 0.274
2.645GlyTyr: 2.645 ± 0.445
0.0GlyXaa: 0.0 ± 0.0
His
2.185HisAla: 2.185 ± 0.336
0.288HisCys: 0.288 ± 0.13
0.748HisAsp: 0.748 ± 0.195
1.438HisGlu: 1.438 ± 0.41
0.633HisPhe: 0.633 ± 0.201
1.955HisGly: 1.955 ± 0.325
0.288HisHis: 0.288 ± 0.115
1.093HisIle: 1.093 ± 0.272
0.863HisLys: 0.863 ± 0.221
1.438HisLeu: 1.438 ± 0.252
0.403HisMet: 0.403 ± 0.118
0.403HisAsn: 0.403 ± 0.16
1.438HisPro: 1.438 ± 0.299
0.69HisGln: 0.69 ± 0.205
1.265HisArg: 1.265 ± 0.249
1.208HisSer: 1.208 ± 0.283
0.403HisThr: 0.403 ± 0.173
1.035HisVal: 1.035 ± 0.267
0.748HisTrp: 0.748 ± 0.198
0.633HisTyr: 0.633 ± 0.184
0.0HisXaa: 0.0 ± 0.0
Ile
7.533IleAla: 7.533 ± 0.839
0.805IleCys: 0.805 ± 0.232
4.198IleAsp: 4.198 ± 0.439
3.105IleGlu: 3.105 ± 0.379
1.668IlePhe: 1.668 ± 0.39
4.428IleGly: 4.428 ± 0.541
0.748IleHis: 0.748 ± 0.183
2.473IleIle: 2.473 ± 0.396
1.955IleLys: 1.955 ± 0.352
3.853IleLeu: 3.853 ± 0.565
0.863IleMet: 0.863 ± 0.185
2.128IleAsn: 2.128 ± 0.361
2.818IlePro: 2.818 ± 0.366
1.38IleGln: 1.38 ± 0.265
2.818IleArg: 2.818 ± 0.386
3.911IleSer: 3.911 ± 0.516
2.933IleThr: 2.933 ± 0.375
3.163IleVal: 3.163 ± 0.366
0.575IleTrp: 0.575 ± 0.182
2.07IleTyr: 2.07 ± 0.385
0.0IleXaa: 0.0 ± 0.0
Lys
5.061LysAla: 5.061 ± 0.691
0.748LysCys: 0.748 ± 0.254
1.84LysAsp: 1.84 ± 0.307
3.565LysGlu: 3.565 ± 0.476
1.323LysPhe: 1.323 ± 0.33
2.818LysGly: 2.818 ± 0.43
0.978LysHis: 0.978 ± 0.234
1.323LysIle: 1.323 ± 0.202
2.473LysLys: 2.473 ± 0.384
3.45LysLeu: 3.45 ± 0.566
0.748LysMet: 0.748 ± 0.215
1.553LysAsn: 1.553 ± 0.275
1.898LysPro: 1.898 ± 0.34
2.818LysGln: 2.818 ± 0.406
3.968LysArg: 3.968 ± 0.546
2.76LysSer: 2.76 ± 0.411
2.53LysThr: 2.53 ± 0.323
2.99LysVal: 2.99 ± 0.423
0.633LysTrp: 0.633 ± 0.21
1.438LysTyr: 1.438 ± 0.274
0.0LysXaa: 0.0 ± 0.0
Leu
10.294LeuAla: 10.294 ± 1.059
1.495LeuCys: 1.495 ± 0.322
5.176LeuAsp: 5.176 ± 0.649
6.326LeuGlu: 6.326 ± 0.549
2.3LeuPhe: 2.3 ± 0.431
5.521LeuGly: 5.521 ± 0.5
1.553LeuHis: 1.553 ± 0.426
5.176LeuIle: 5.176 ± 0.506
3.623LeuLys: 3.623 ± 0.515
8.109LeuLeu: 8.109 ± 0.799
2.128LeuMet: 2.128 ± 0.303
2.645LeuAsn: 2.645 ± 0.419
4.083LeuPro: 4.083 ± 0.671
2.645LeuGln: 2.645 ± 0.342
7.246LeuArg: 7.246 ± 0.703
5.348LeuSer: 5.348 ± 0.588
4.658LeuThr: 4.658 ± 0.616
5.866LeuVal: 5.866 ± 0.625
1.093LeuTrp: 1.093 ± 0.234
2.3LeuTyr: 2.3 ± 0.429
0.0LeuXaa: 0.0 ± 0.0
Met
2.875MetAla: 2.875 ± 0.428
0.288MetCys: 0.288 ± 0.129
1.323MetAsp: 1.323 ± 0.251
1.15MetGlu: 1.15 ± 0.239
0.46MetPhe: 0.46 ± 0.154
1.15MetGly: 1.15 ± 0.275
0.46MetHis: 0.46 ± 0.186
1.38MetIle: 1.38 ± 0.234
1.208MetLys: 1.208 ± 0.266
2.358MetLeu: 2.358 ± 0.342
0.345MetMet: 0.345 ± 0.16
1.553MetAsn: 1.553 ± 0.253
1.783MetPro: 1.783 ± 0.324
1.208MetGln: 1.208 ± 0.312
2.013MetArg: 2.013 ± 0.388
1.84MetSer: 1.84 ± 0.373
1.955MetThr: 1.955 ± 0.31
1.265MetVal: 1.265 ± 0.316
0.23MetTrp: 0.23 ± 0.11
0.46MetTyr: 0.46 ± 0.191
0.0MetXaa: 0.0 ± 0.0
Asn
3.508AsnAla: 3.508 ± 0.528
0.92AsnCys: 0.92 ± 0.228
1.955AsnAsp: 1.955 ± 0.322
1.955AsnGlu: 1.955 ± 0.301
0.575AsnPhe: 0.575 ± 0.173
3.393AsnGly: 3.393 ± 0.405
0.863AsnHis: 0.863 ± 0.244
2.128AsnIle: 2.128 ± 0.331
0.978AsnLys: 0.978 ± 0.308
2.703AsnLeu: 2.703 ± 0.405
0.805AsnMet: 0.805 ± 0.228
0.863AsnAsn: 0.863 ± 0.218
2.243AsnPro: 2.243 ± 0.387
1.265AsnGln: 1.265 ± 0.261
2.358AsnArg: 2.358 ± 0.383
2.3AsnSer: 2.3 ± 0.403
1.38AsnThr: 1.38 ± 0.296
1.495AsnVal: 1.495 ± 0.331
0.69AsnTrp: 0.69 ± 0.19
0.92AsnTyr: 0.92 ± 0.178
0.0AsnXaa: 0.0 ± 0.0
Pro
4.946ProAla: 4.946 ± 0.547
0.69ProCys: 0.69 ± 0.203
3.163ProAsp: 3.163 ± 0.446
3.508ProGlu: 3.508 ± 0.523
1.38ProPhe: 1.38 ± 0.304
3.623ProGly: 3.623 ± 0.573
0.92ProHis: 0.92 ± 0.221
2.243ProIle: 2.243 ± 0.257
1.725ProLys: 1.725 ± 0.27
3.738ProLeu: 3.738 ± 0.382
1.15ProMet: 1.15 ± 0.297
1.208ProAsn: 1.208 ± 0.236
1.553ProPro: 1.553 ± 0.295
1.61ProGln: 1.61 ± 0.307
2.358ProArg: 2.358 ± 0.346
2.588ProSer: 2.588 ± 0.407
1.553ProThr: 1.553 ± 0.306
3.508ProVal: 3.508 ± 0.383
0.92ProTrp: 0.92 ± 0.222
1.438ProTyr: 1.438 ± 0.307
0.0ProXaa: 0.0 ± 0.0
Gln
5.406GlnAla: 5.406 ± 0.792
0.92GlnCys: 0.92 ± 0.227
1.438GlnAsp: 1.438 ± 0.262
2.415GlnGlu: 2.415 ± 0.398
1.15GlnPhe: 1.15 ± 0.295
2.875GlnGly: 2.875 ± 0.352
0.92GlnHis: 0.92 ± 0.295
2.3GlnIle: 2.3 ± 0.447
2.07GlnLys: 2.07 ± 0.336
3.796GlnLeu: 3.796 ± 0.483
1.265GlnMet: 1.265 ± 0.261
1.323GlnAsn: 1.323 ± 0.27
0.748GlnPro: 0.748 ± 0.218
2.013GlnGln: 2.013 ± 0.253
3.565GlnArg: 3.565 ± 0.481
2.07GlnSer: 2.07 ± 0.391
1.783GlnThr: 1.783 ± 0.309
2.07GlnVal: 2.07 ± 0.323
0.518GlnTrp: 0.518 ± 0.169
0.805GlnTyr: 0.805 ± 0.233
0.0GlnXaa: 0.0 ± 0.0
Arg
5.693ArgAla: 5.693 ± 0.547
0.748ArgCys: 0.748 ± 0.213
4.428ArgAsp: 4.428 ± 0.538
6.498ArgGlu: 6.498 ± 0.784
2.013ArgPhe: 2.013 ± 0.342
4.716ArgGly: 4.716 ± 0.605
1.725ArgHis: 1.725 ± 0.281
4.141ArgIle: 4.141 ± 0.598
3.853ArgLys: 3.853 ± 0.46
6.556ArgLeu: 6.556 ± 0.602
1.725ArgMet: 1.725 ± 0.359
2.358ArgAsn: 2.358 ± 0.316
3.68ArgPro: 3.68 ± 0.476
3.278ArgGln: 3.278 ± 0.414
5.866ArgArg: 5.866 ± 0.73
3.738ArgSer: 3.738 ± 0.5
3.22ArgThr: 3.22 ± 0.373
3.738ArgVal: 3.738 ± 0.443
1.495ArgTrp: 1.495 ± 0.334
2.185ArgTyr: 2.185 ± 0.373
0.0ArgXaa: 0.0 ± 0.0
Ser
7.591SerAla: 7.591 ± 0.698
0.748SerCys: 0.748 ± 0.174
3.623SerAsp: 3.623 ± 0.371
4.831SerGlu: 4.831 ± 0.524
1.783SerPhe: 1.783 ± 0.373
5.233SerGly: 5.233 ± 0.592
1.265SerHis: 1.265 ± 0.355
4.428SerIle: 4.428 ± 0.417
2.818SerLys: 2.818 ± 0.391
4.888SerLeu: 4.888 ± 0.593
1.783SerMet: 1.783 ± 0.295
2.875SerAsn: 2.875 ± 0.36
2.933SerPro: 2.933 ± 0.427
2.013SerGln: 2.013 ± 0.41
3.278SerArg: 3.278 ± 0.406
4.083SerSer: 4.083 ± 0.613
2.875SerThr: 2.875 ± 0.488
3.738SerVal: 3.738 ± 0.581
0.92SerTrp: 0.92 ± 0.235
1.553SerTyr: 1.553 ± 0.261
0.0SerXaa: 0.0 ± 0.0
Thr
5.578ThrAla: 5.578 ± 0.629
0.518ThrCys: 0.518 ± 0.156
2.76ThrAsp: 2.76 ± 0.438
2.76ThrGlu: 2.76 ± 0.338
2.128ThrPhe: 2.128 ± 0.288
3.911ThrGly: 3.911 ± 0.488
0.69ThrHis: 0.69 ± 0.222
3.565ThrIle: 3.565 ± 0.359
1.84ThrLys: 1.84 ± 0.353
3.22ThrLeu: 3.22 ± 0.526
0.978ThrMet: 0.978 ± 0.226
1.38ThrAsn: 1.38 ± 0.349
2.645ThrPro: 2.645 ± 0.421
1.725ThrGln: 1.725 ± 0.357
2.07ThrArg: 2.07 ± 0.311
3.623ThrSer: 3.623 ± 0.542
2.703ThrThr: 2.703 ± 0.444
3.623ThrVal: 3.623 ± 0.475
0.978ThrTrp: 0.978 ± 0.279
1.093ThrTyr: 1.093 ± 0.237
0.0ThrXaa: 0.0 ± 0.0
Val
6.843ValAla: 6.843 ± 0.732
0.805ValCys: 0.805 ± 0.246
4.256ValAsp: 4.256 ± 0.613
5.061ValGlu: 5.061 ± 0.538
2.07ValPhe: 2.07 ± 0.343
4.256ValGly: 4.256 ± 0.686
1.208ValHis: 1.208 ± 0.329
3.163ValIle: 3.163 ± 0.498
2.76ValLys: 2.76 ± 0.351
5.578ValLeu: 5.578 ± 0.737
1.38ValMet: 1.38 ± 0.299
2.3ValAsn: 2.3 ± 0.37
3.048ValPro: 3.048 ± 0.449
1.668ValGln: 1.668 ± 0.32
3.393ValArg: 3.393 ± 0.427
5.636ValSer: 5.636 ± 0.625
3.22ValThr: 3.22 ± 0.453
3.796ValVal: 3.796 ± 0.452
0.633ValTrp: 0.633 ± 0.193
2.185ValTyr: 2.185 ± 0.492
0.0ValXaa: 0.0 ± 0.0
Trp
2.185TrpAla: 2.185 ± 0.369
0.288TrpCys: 0.288 ± 0.142
0.92TrpAsp: 0.92 ± 0.224
1.035TrpGlu: 1.035 ± 0.249
0.633TrpPhe: 0.633 ± 0.233
0.633TrpGly: 0.633 ± 0.278
0.46TrpHis: 0.46 ± 0.133
1.265TrpIle: 1.265 ± 0.268
0.805TrpLys: 0.805 ± 0.154
2.473TrpLeu: 2.473 ± 0.402
0.518TrpMet: 0.518 ± 0.239
0.69TrpAsn: 0.69 ± 0.207
0.805TrpPro: 0.805 ± 0.197
0.575TrpGln: 0.575 ± 0.208
1.898TrpArg: 1.898 ± 0.254
1.093TrpSer: 1.093 ± 0.255
0.575TrpThr: 0.575 ± 0.192
0.92TrpVal: 0.92 ± 0.224
0.403TrpTrp: 0.403 ± 0.109
0.518TrpTyr: 0.518 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.45TyrAla: 3.45 ± 0.393
0.345TyrCys: 0.345 ± 0.121
1.553TyrAsp: 1.553 ± 0.274
1.265TyrGlu: 1.265 ± 0.233
1.093TyrPhe: 1.093 ± 0.246
1.955TyrGly: 1.955 ± 0.525
0.518TyrHis: 0.518 ± 0.145
1.265TyrIle: 1.265 ± 0.364
0.92TyrLys: 0.92 ± 0.177
2.07TyrLeu: 2.07 ± 0.272
0.345TyrMet: 0.345 ± 0.143
0.575TyrAsn: 0.575 ± 0.166
1.208TyrPro: 1.208 ± 0.301
1.438TyrGln: 1.438 ± 0.29
3.163TyrArg: 3.163 ± 0.49
2.185TyrSer: 2.185 ± 0.382
1.323TyrThr: 1.323 ± 0.256
2.07TyrVal: 2.07 ± 0.309
0.69TyrTrp: 0.69 ± 0.2
1.035TyrTyr: 1.035 ± 0.226
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 98 proteins (17390 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski