Amino acid dipepetide frequency for Liberibacter phage SC2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.865AlaAla: 0.865 ± 0.242
1.297AlaCys: 1.297 ± 0.366
2.94AlaAsp: 2.94 ± 0.554
3.805AlaGlu: 3.805 ± 0.499
2.681AlaPhe: 2.681 ± 0.492
2.681AlaGly: 2.681 ± 0.491
1.989AlaHis: 1.989 ± 0.505
3.805AlaIle: 3.805 ± 0.621
5.621AlaLys: 5.621 ± 0.745
7.351AlaLeu: 7.351 ± 0.854
0.951AlaMet: 0.951 ± 0.211
3.113AlaAsn: 3.113 ± 0.515
1.557AlaPro: 1.557 ± 0.46
3.2AlaGln: 3.2 ± 0.484
3.546AlaArg: 3.546 ± 0.524
6.054AlaSer: 6.054 ± 0.824
3.546AlaThr: 3.546 ± 0.719
4.065AlaVal: 4.065 ± 0.53
1.211AlaTrp: 1.211 ± 0.351
1.643AlaTyr: 1.643 ± 0.383
0.0AlaXaa: 0.0 ± 0.0
Cys
0.519CysAla: 0.519 ± 0.213
0.173CysCys: 0.173 ± 0.116
0.865CysAsp: 0.865 ± 0.238
0.951CysGlu: 0.951 ± 0.294
0.432CysPhe: 0.432 ± 0.214
0.865CysGly: 0.865 ± 0.321
0.173CysHis: 0.173 ± 0.121
0.692CysIle: 0.692 ± 0.264
0.778CysLys: 0.778 ± 0.307
1.47CysLeu: 1.47 ± 0.287
0.086CysMet: 0.086 ± 0.078
0.346CysAsn: 0.346 ± 0.172
0.605CysPro: 0.605 ± 0.257
0.432CysGln: 0.432 ± 0.253
0.605CysArg: 0.605 ± 0.26
0.605CysSer: 0.605 ± 0.199
0.951CysThr: 0.951 ± 0.296
0.692CysVal: 0.692 ± 0.35
0.173CysTrp: 0.173 ± 0.129
0.346CysTyr: 0.346 ± 0.183
0.0CysXaa: 0.0 ± 0.0
Asp
3.113AspAla: 3.113 ± 0.632
1.384AspCys: 1.384 ± 0.397
3.373AspAsp: 3.373 ± 0.634
4.497AspGlu: 4.497 ± 0.57
2.422AspPhe: 2.422 ± 0.467
3.2AspGly: 3.2 ± 0.473
0.519AspHis: 0.519 ± 0.182
5.535AspIle: 5.535 ± 0.651
7.438AspLys: 7.438 ± 1.823
5.362AspLeu: 5.362 ± 0.715
0.951AspMet: 0.951 ± 0.259
2.681AspAsn: 2.681 ± 0.495
2.681AspPro: 2.681 ± 0.449
1.47AspGln: 1.47 ± 0.344
3.113AspArg: 3.113 ± 0.514
3.373AspSer: 3.373 ± 0.553
3.805AspThr: 3.805 ± 0.625
4.411AspVal: 4.411 ± 0.632
1.124AspTrp: 1.124 ± 0.326
1.73AspTyr: 1.73 ± 0.376
0.0AspXaa: 0.0 ± 0.0
Glu
5.621GluAla: 5.621 ± 0.717
0.259GluCys: 0.259 ± 0.15
4.324GluAsp: 4.324 ± 0.672
6.4GluGlu: 6.4 ± 0.898
3.546GluPhe: 3.546 ± 0.592
4.67GluGly: 4.67 ± 0.58
2.422GluHis: 2.422 ± 0.529
4.497GluIle: 4.497 ± 0.569
5.102GluLys: 5.102 ± 0.838
6.659GluLeu: 6.659 ± 0.806
1.384GluMet: 1.384 ± 0.338
3.113GluAsn: 3.113 ± 0.385
1.643GluPro: 1.643 ± 0.354
4.238GluGln: 4.238 ± 0.569
5.189GluArg: 5.189 ± 0.722
3.027GluSer: 3.027 ± 0.552
3.459GluThr: 3.459 ± 0.453
5.535GluVal: 5.535 ± 0.777
0.519GluTrp: 0.519 ± 0.202
2.594GluTyr: 2.594 ± 0.442
0.0GluXaa: 0.0 ± 0.0
Phe
2.94PheAla: 2.94 ± 0.511
0.778PheCys: 0.778 ± 0.322
3.027PheAsp: 3.027 ± 0.627
3.373PheGlu: 3.373 ± 0.536
1.384PhePhe: 1.384 ± 0.383
2.422PheGly: 2.422 ± 0.405
0.951PheHis: 0.951 ± 0.239
2.854PheIle: 2.854 ± 0.501
4.238PheLys: 4.238 ± 0.788
3.805PheLeu: 3.805 ± 0.592
0.259PheMet: 0.259 ± 0.123
2.249PheAsn: 2.249 ± 0.394
1.038PhePro: 1.038 ± 0.347
1.038PheGln: 1.038 ± 0.263
1.47PheArg: 1.47 ± 0.317
3.2PheSer: 3.2 ± 0.364
1.73PheThr: 1.73 ± 0.31
2.594PheVal: 2.594 ± 0.439
0.605PheTrp: 0.605 ± 0.279
1.384PheTyr: 1.384 ± 0.268
0.0PheXaa: 0.0 ± 0.0
Gly
3.373GlyAla: 3.373 ± 0.625
1.038GlyCys: 1.038 ± 0.306
3.892GlyAsp: 3.892 ± 1.646
4.238GlyGlu: 4.238 ± 0.544
2.94GlyPhe: 2.94 ± 0.438
4.411GlyGly: 4.411 ± 0.619
0.778GlyHis: 0.778 ± 0.256
3.805GlyIle: 3.805 ± 0.605
4.411GlyLys: 4.411 ± 0.715
6.659GlyLeu: 6.659 ± 0.734
1.816GlyMet: 1.816 ± 0.279
2.594GlyAsn: 2.594 ± 0.711
4.411GlyPro: 4.411 ± 4.288
3.459GlyGln: 3.459 ± 1.598
2.767GlyArg: 2.767 ± 0.467
4.238GlySer: 4.238 ± 0.56
2.94GlyThr: 2.94 ± 0.539
3.978GlyVal: 3.978 ± 0.584
0.778GlyTrp: 0.778 ± 0.264
2.422GlyTyr: 2.422 ± 0.444
0.0GlyXaa: 0.0 ± 0.0
His
0.778HisAla: 0.778 ± 0.297
0.778HisCys: 0.778 ± 0.263
0.692HisAsp: 0.692 ± 0.237
1.124HisGlu: 1.124 ± 0.312
1.297HisPhe: 1.297 ± 0.267
0.778HisGly: 0.778 ± 0.295
0.865HisHis: 0.865 ± 0.283
1.297HisIle: 1.297 ± 0.267
1.038HisLys: 1.038 ± 0.279
1.816HisLeu: 1.816 ± 0.384
0.259HisMet: 0.259 ± 0.158
1.211HisAsn: 1.211 ± 0.314
1.211HisPro: 1.211 ± 0.33
0.951HisGln: 0.951 ± 0.31
1.124HisArg: 1.124 ± 0.313
0.951HisSer: 0.951 ± 0.228
0.865HisThr: 0.865 ± 0.263
1.038HisVal: 1.038 ± 0.271
0.432HisTrp: 0.432 ± 0.193
0.778HisTyr: 0.778 ± 0.284
0.0HisXaa: 0.0 ± 0.0
Ile
5.881IleAla: 5.881 ± 0.622
0.346IleCys: 0.346 ± 0.17
4.843IleAsp: 4.843 ± 0.584
4.93IleGlu: 4.93 ± 0.662
1.557IlePhe: 1.557 ± 0.324
3.027IleGly: 3.027 ± 0.563
0.865IleHis: 0.865 ± 0.315
3.373IleIle: 3.373 ± 0.529
4.67IleLys: 4.67 ± 0.523
5.621IleLeu: 5.621 ± 0.861
0.951IleMet: 0.951 ± 0.324
3.2IleAsn: 3.2 ± 0.451
3.027IlePro: 3.027 ± 0.481
2.076IleGln: 2.076 ± 0.418
2.94IleArg: 2.94 ± 0.68
4.151IleSer: 4.151 ± 0.584
4.584IleThr: 4.584 ± 0.558
3.892IleVal: 3.892 ± 0.621
0.951IleTrp: 0.951 ± 0.245
1.816IleTyr: 1.816 ± 0.436
0.0IleXaa: 0.0 ± 0.0
Lys
6.573LysAla: 6.573 ± 0.684
0.432LysCys: 0.432 ± 0.173
5.016LysAsp: 5.016 ± 0.609
6.659LysGlu: 6.659 ± 0.956
1.643LysPhe: 1.643 ± 0.391
7.265LysGly: 7.265 ± 1.991
2.335LysHis: 2.335 ± 0.554
4.238LysIle: 4.238 ± 0.614
5.794LysLys: 5.794 ± 0.665
7.697LysLeu: 7.697 ± 0.773
1.816LysMet: 1.816 ± 0.475
3.286LysAsn: 3.286 ± 0.705
3.027LysPro: 3.027 ± 0.535
3.892LysGln: 3.892 ± 0.611
5.794LysArg: 5.794 ± 0.64
5.102LysSer: 5.102 ± 0.639
4.584LysThr: 4.584 ± 0.584
4.324LysVal: 4.324 ± 0.652
1.47LysTrp: 1.47 ± 0.353
2.076LysTyr: 2.076 ± 0.456
0.0LysXaa: 0.0 ± 0.0
Leu
6.313LeuAla: 6.313 ± 0.905
1.211LeuCys: 1.211 ± 0.346
5.794LeuAsp: 5.794 ± 0.688
7.178LeuGlu: 7.178 ± 0.957
3.892LeuPhe: 3.892 ± 0.64
4.843LeuGly: 4.843 ± 0.614
1.211LeuHis: 1.211 ± 0.273
6.4LeuIle: 6.4 ± 0.708
9.686LeuLys: 9.686 ± 1.103
6.832LeuLeu: 6.832 ± 0.713
1.816LeuMet: 1.816 ± 0.307
3.546LeuAsn: 3.546 ± 0.463
2.854LeuPro: 2.854 ± 0.479
3.978LeuGln: 3.978 ± 0.62
4.757LeuArg: 4.757 ± 0.599
7.005LeuSer: 7.005 ± 0.744
5.016LeuThr: 5.016 ± 0.683
5.448LeuVal: 5.448 ± 0.759
1.643LeuTrp: 1.643 ± 0.433
2.508LeuTyr: 2.508 ± 0.485
0.0LeuXaa: 0.0 ± 0.0
Met
1.47MetAla: 1.47 ± 0.28
0.259MetCys: 0.259 ± 0.128
1.989MetAsp: 1.989 ± 0.525
1.816MetGlu: 1.816 ± 0.485
0.692MetPhe: 0.692 ± 0.248
1.903MetGly: 1.903 ± 0.4
0.519MetHis: 0.519 ± 0.186
0.778MetIle: 0.778 ± 0.26
1.124MetLys: 1.124 ± 0.296
0.778MetLeu: 0.778 ± 0.277
0.865MetMet: 0.865 ± 0.243
0.432MetAsn: 0.432 ± 0.227
0.778MetPro: 0.778 ± 0.267
1.124MetGln: 1.124 ± 0.251
0.692MetArg: 0.692 ± 0.226
1.211MetSer: 1.211 ± 0.322
1.384MetThr: 1.384 ± 0.316
1.038MetVal: 1.038 ± 0.23
0.086MetTrp: 0.086 ± 0.072
0.692MetTyr: 0.692 ± 0.255
0.0MetXaa: 0.0 ± 0.0
Asn
4.151AsnAla: 4.151 ± 0.79
0.259AsnCys: 0.259 ± 0.147
2.076AsnAsp: 2.076 ± 0.37
2.594AsnGlu: 2.594 ± 0.446
1.643AsnPhe: 1.643 ± 0.386
2.249AsnGly: 2.249 ± 0.428
0.692AsnHis: 0.692 ± 0.237
3.2AsnIle: 3.2 ± 0.529
3.113AsnLys: 3.113 ± 0.509
2.681AsnLeu: 2.681 ± 0.501
0.692AsnMet: 0.692 ± 0.184
1.73AsnAsn: 1.73 ± 0.654
2.681AsnPro: 2.681 ± 0.557
1.124AsnGln: 1.124 ± 0.31
2.422AsnArg: 2.422 ± 0.496
2.162AsnSer: 2.162 ± 0.45
2.767AsnThr: 2.767 ± 0.422
1.47AsnVal: 1.47 ± 0.439
0.259AsnTrp: 0.259 ± 0.164
1.297AsnTyr: 1.297 ± 0.348
0.0AsnXaa: 0.0 ± 0.0
Pro
1.557ProAla: 1.557 ± 0.42
0.259ProCys: 0.259 ± 0.13
3.027ProAsp: 3.027 ± 0.594
1.989ProGlu: 1.989 ± 0.386
2.162ProPhe: 2.162 ± 0.459
0.951ProGly: 0.951 ± 0.305
0.346ProHis: 0.346 ± 0.148
1.816ProIle: 1.816 ± 0.337
2.767ProLys: 2.767 ± 0.622
5.016ProLeu: 5.016 ± 0.649
0.951ProMet: 0.951 ± 0.3
1.124ProAsn: 1.124 ± 0.293
1.384ProPro: 1.384 ± 0.388
5.621ProGln: 5.621 ± 3.767
1.816ProArg: 1.816 ± 0.329
2.767ProSer: 2.767 ± 0.413
1.643ProThr: 1.643 ± 0.424
1.816ProVal: 1.816 ± 0.28
0.778ProTrp: 0.778 ± 0.237
1.384ProTyr: 1.384 ± 0.349
0.0ProXaa: 0.0 ± 0.0
Gln
3.027GlnAla: 3.027 ± 0.586
0.259GlnCys: 0.259 ± 0.141
2.594GlnAsp: 2.594 ± 0.446
3.805GlnGlu: 3.805 ± 0.602
1.297GlnPhe: 1.297 ± 0.326
6.14GlnGly: 6.14 ± 3.738
0.432GlnHis: 0.432 ± 0.211
1.816GlnIle: 1.816 ± 0.395
3.892GlnLys: 3.892 ± 0.652
3.286GlnLeu: 3.286 ± 0.492
1.384GlnMet: 1.384 ± 0.371
1.47GlnAsn: 1.47 ± 0.335
1.124GlnPro: 1.124 ± 0.27
1.903GlnGln: 1.903 ± 0.425
2.681GlnArg: 2.681 ± 0.445
2.594GlnSer: 2.594 ± 0.586
3.892GlnThr: 3.892 ± 1.672
1.989GlnVal: 1.989 ± 0.452
0.778GlnTrp: 0.778 ± 0.238
1.73GlnTyr: 1.73 ± 0.421
0.0GlnXaa: 0.0 ± 0.0
Arg
2.681ArgAla: 2.681 ± 0.428
0.432ArgCys: 0.432 ± 0.182
3.632ArgAsp: 3.632 ± 0.664
4.497ArgGlu: 4.497 ± 0.719
3.113ArgPhe: 3.113 ± 0.489
3.805ArgGly: 3.805 ± 0.458
0.432ArgHis: 0.432 ± 0.181
3.546ArgIle: 3.546 ± 0.498
3.546ArgLys: 3.546 ± 0.646
5.275ArgLeu: 5.275 ± 0.715
1.297ArgMet: 1.297 ± 0.353
1.557ArgAsn: 1.557 ± 0.411
1.643ArgPro: 1.643 ± 0.378
2.94ArgGln: 2.94 ± 0.384
3.546ArgArg: 3.546 ± 0.763
2.94ArgSer: 2.94 ± 0.441
2.681ArgThr: 2.681 ± 0.588
3.027ArgVal: 3.027 ± 0.431
1.643ArgTrp: 1.643 ± 0.344
2.422ArgTyr: 2.422 ± 0.447
0.0ArgXaa: 0.0 ± 0.0
Ser
4.238SerAla: 4.238 ± 0.77
0.951SerCys: 0.951 ± 0.324
5.016SerAsp: 5.016 ± 0.58
4.67SerGlu: 4.67 ± 0.564
3.632SerPhe: 3.632 ± 0.593
3.805SerGly: 3.805 ± 0.454
1.989SerHis: 1.989 ± 0.347
4.757SerIle: 4.757 ± 0.791
5.362SerLys: 5.362 ± 0.703
6.14SerLeu: 6.14 ± 0.618
1.038SerMet: 1.038 ± 0.313
1.73SerAsn: 1.73 ± 0.443
2.94SerPro: 2.94 ± 0.361
3.2SerGln: 3.2 ± 0.632
2.076SerArg: 2.076 ± 0.366
5.535SerSer: 5.535 ± 0.841
4.497SerThr: 4.497 ± 0.655
4.584SerVal: 4.584 ± 0.571
0.519SerTrp: 0.519 ± 0.167
1.211SerTyr: 1.211 ± 0.278
0.0SerXaa: 0.0 ± 0.0
Thr
3.113ThrAla: 3.113 ± 0.468
0.173ThrCys: 0.173 ± 0.126
1.989ThrAsp: 1.989 ± 0.425
4.238ThrGlu: 4.238 ± 0.696
2.681ThrPhe: 2.681 ± 0.452
4.93ThrGly: 4.93 ± 1.624
0.865ThrHis: 0.865 ± 0.208
3.027ThrIle: 3.027 ± 0.649
5.275ThrLys: 5.275 ± 0.635
5.275ThrLeu: 5.275 ± 0.586
0.865ThrMet: 0.865 ± 0.316
2.076ThrAsn: 2.076 ± 0.415
3.459ThrPro: 3.459 ± 0.485
2.422ThrGln: 2.422 ± 0.446
3.373ThrArg: 3.373 ± 0.393
3.978ThrSer: 3.978 ± 0.871
2.681ThrThr: 2.681 ± 0.597
3.373ThrVal: 3.373 ± 0.472
0.259ThrTrp: 0.259 ± 0.137
1.47ThrTyr: 1.47 ± 0.336
0.0ThrXaa: 0.0 ± 0.0
Val
2.94ValAla: 2.94 ± 0.564
0.951ValCys: 0.951 ± 0.357
4.238ValAsp: 4.238 ± 0.544
4.324ValGlu: 4.324 ± 0.568
2.508ValPhe: 2.508 ± 0.433
3.892ValGly: 3.892 ± 0.627
0.951ValHis: 0.951 ± 0.356
3.113ValIle: 3.113 ± 0.543
5.794ValLys: 5.794 ± 0.67
5.621ValLeu: 5.621 ± 0.647
1.47ValMet: 1.47 ± 0.35
2.076ValAsn: 2.076 ± 0.536
1.816ValPro: 1.816 ± 0.36
1.73ValGln: 1.73 ± 0.401
3.373ValArg: 3.373 ± 0.778
5.967ValSer: 5.967 ± 0.778
2.076ValThr: 2.076 ± 0.339
2.94ValVal: 2.94 ± 0.546
0.951ValTrp: 0.951 ± 0.236
1.557ValTyr: 1.557 ± 0.31
0.0ValXaa: 0.0 ± 0.0
Trp
0.865TrpAla: 0.865 ± 0.285
0.086TrpCys: 0.086 ± 0.085
1.124TrpAsp: 1.124 ± 0.283
1.124TrpGlu: 1.124 ± 0.383
1.038TrpPhe: 1.038 ± 0.284
0.605TrpGly: 0.605 ± 0.178
0.173TrpHis: 0.173 ± 0.112
1.73TrpIle: 1.73 ± 0.38
1.384TrpLys: 1.384 ± 0.335
1.47TrpLeu: 1.47 ± 0.427
0.346TrpMet: 0.346 ± 0.165
0.605TrpAsn: 0.605 ± 0.2
0.0TrpPro: 0.0 ± 0.0
0.259TrpGln: 0.259 ± 0.112
0.519TrpArg: 0.519 ± 0.219
0.951TrpSer: 0.951 ± 0.301
0.432TrpThr: 0.432 ± 0.18
0.951TrpVal: 0.951 ± 0.267
0.432TrpTrp: 0.432 ± 0.191
0.778TrpTyr: 0.778 ± 0.207
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.903TyrAla: 1.903 ± 0.378
0.432TyrCys: 0.432 ± 0.173
1.816TyrAsp: 1.816 ± 0.334
1.989TyrGlu: 1.989 ± 0.421
0.778TyrPhe: 0.778 ± 0.285
2.508TyrGly: 2.508 ± 0.469
0.778TyrHis: 0.778 ± 0.201
2.422TyrIle: 2.422 ± 0.555
1.989TyrLys: 1.989 ± 0.433
3.113TyrLeu: 3.113 ± 0.578
0.346TyrMet: 0.346 ± 0.185
1.124TyrAsn: 1.124 ± 0.263
1.297TyrPro: 1.297 ± 0.312
1.038TyrGln: 1.038 ± 0.245
2.854TyrArg: 2.854 ± 0.536
2.076TyrSer: 2.076 ± 0.437
1.989TyrThr: 1.989 ± 0.381
1.124TyrVal: 1.124 ± 0.285
0.259TyrTrp: 0.259 ± 0.157
1.47TyrTyr: 1.47 ± 0.439
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 47 proteins (11564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski