Amino acid dipepetide frequency for Raineyella antarctica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.358AlaAla: 18.358 ± 0.185	0.888AlaCys: 0.888 ± 0.031	8.143AlaAsp: 8.143 ± 0.096	7.77AlaGlu: 7.77 ± 0.103	3.202AlaPhe: 3.202 ± 0.054	12.408AlaGly: 12.408 ± 0.11	2.558AlaHis: 2.558 ± 0.05	5.074AlaIle: 5.074 ± 0.075	2.485AlaLys: 2.485 ± 0.06	13.218AlaLeu: 13.218 ± 0.143	3.11AlaMet: 3.11 ± 0.053	2.154AlaAsn: 2.154 ± 0.051	6.129AlaPro: 6.129 ± 0.08	3.779AlaGln: 3.779 ± 0.066	8.927AlaArg: 8.927 ± 0.12	6.067AlaSer: 6.067 ± 0.088	7.58AlaThr: 7.58 ± 0.092	10.707AlaVal: 10.707 ± 0.122	1.934AlaTrp: 1.934 ± 0.043	2.748AlaTyr: 2.748 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.771CysAla: 0.771 ± 0.027	0.102CysCys: 0.102 ± 0.011	0.43CysAsp: 0.43 ± 0.021	0.342CysGlu: 0.342 ± 0.017	0.22CysPhe: 0.22 ± 0.014	0.808CysGly: 0.808 ± 0.033	0.199CysHis: 0.199 ± 0.013	0.234CysIle: 0.234 ± 0.016	0.098CysLys: 0.098 ± 0.009	0.622CysLeu: 0.622 ± 0.023	0.093CysMet: 0.093 ± 0.009	0.136CysAsn: 0.136 ± 0.011	0.464CysPro: 0.464 ± 0.021	0.197CysGln: 0.197 ± 0.016	0.53CysArg: 0.53 ± 0.024	0.417CysSer: 0.417 ± 0.019	0.455CysThr: 0.455 ± 0.021	0.5CysVal: 0.5 ± 0.021	0.1CysTrp: 0.1 ± 0.008	0.129CysTyr: 0.129 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.044AspAla: 7.044 ± 0.111	0.359AspCys: 0.359 ± 0.018	3.665AspAsp: 3.665 ± 0.07	3.978AspGlu: 3.978 ± 0.073	1.716AspPhe: 1.716 ± 0.043	5.347AspGly: 5.347 ± 0.081	1.503AspHis: 1.503 ± 0.048	2.331AspIle: 2.331 ± 0.047	1.195AspLys: 1.195 ± 0.035	6.887AspLeu: 6.887 ± 0.093	1.138AspMet: 1.138 ± 0.034	0.992AspAsn: 0.992 ± 0.034	4.817AspPro: 4.817 ± 0.072	2.038AspGln: 2.038 ± 0.042	5.168AspArg: 5.168 ± 0.078	2.539AspSer: 2.539 ± 0.049	2.991AspThr: 2.991 ± 0.05	5.301AspVal: 5.301 ± 0.07	1.027AspTrp: 1.027 ± 0.029	1.215AspTyr: 1.215 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.351GluAla: 7.351 ± 0.087	0.302GluCys: 0.302 ± 0.019	3.206GluAsp: 3.206 ± 0.059	3.397GluGlu: 3.397 ± 0.076	1.482GluPhe: 1.482 ± 0.038	4.444GluGly: 4.444 ± 0.069	1.599GluHis: 1.599 ± 0.037	2.281GluIle: 2.281 ± 0.048	1.276GluLys: 1.276 ± 0.04	6.101GluLeu: 6.101 ± 0.091	1.107GluMet: 1.107 ± 0.029	1.04GluAsn: 1.04 ± 0.031	2.927GluPro: 2.927 ± 0.054	2.45GluGln: 2.45 ± 0.053	4.735GluArg: 4.735 ± 0.068	2.46GluSer: 2.46 ± 0.053	2.708GluThr: 2.708 ± 0.048	5.157GluVal: 5.157 ± 0.065	0.754GluTrp: 0.754 ± 0.023	1.101GluTyr: 1.101 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.539PheAla: 3.539 ± 0.057	0.254PheCys: 0.254 ± 0.015	2.052PheAsp: 2.052 ± 0.043	1.459PheGlu: 1.459 ± 0.041	0.996PhePhe: 0.996 ± 0.034	3.075PheGly: 3.075 ± 0.053	0.589PheHis: 0.589 ± 0.024	1.038PheIle: 1.038 ± 0.035	0.451PheLys: 0.451 ± 0.021	2.713PheLeu: 2.713 ± 0.061	0.493PheMet: 0.493 ± 0.024	0.64PheAsn: 0.64 ± 0.025	1.379PhePro: 1.379 ± 0.037	0.694PheGln: 0.694 ± 0.022	1.911PheArg: 1.911 ± 0.043	1.559PheSer: 1.559 ± 0.039	1.973PheThr: 1.973 ± 0.051	2.545PheVal: 2.545 ± 0.053	0.444PheTrp: 0.444 ± 0.021	0.679PheTyr: 0.679 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.138GlyAla: 10.138 ± 0.103	0.755GlyCys: 0.755 ± 0.025	4.887GlyAsp: 4.887 ± 0.069	4.55GlyGlu: 4.55 ± 0.074	3.0GlyPhe: 3.0 ± 0.058	7.5GlyGly: 7.5 ± 0.114	2.278GlyHis: 2.278 ± 0.052	4.314GlyIle: 4.314 ± 0.071	2.158GlyLys: 2.158 ± 0.049	9.76GlyLeu: 9.76 ± 0.095	2.29GlyMet: 2.29 ± 0.046	1.767GlyAsn: 1.767 ± 0.044	4.846GlyPro: 4.846 ± 0.079	3.045GlyGln: 3.045 ± 0.053	7.067GlyArg: 7.067 ± 0.089	5.316GlySer: 5.316 ± 0.08	6.059GlyThr: 6.059 ± 0.083	7.579GlyVal: 7.579 ± 0.082	1.817GlyTrp: 1.817 ± 0.044	2.232GlyTyr: 2.232 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.423HisAla: 2.423 ± 0.051	0.174HisCys: 0.174 ± 0.013	1.417HisAsp: 1.417 ± 0.04	1.27HisGlu: 1.27 ± 0.038	0.638HisPhe: 0.638 ± 0.024	2.221HisGly: 2.221 ± 0.054	0.679HisHis: 0.679 ± 0.028	0.665HisIle: 0.665 ± 0.024	0.373HisLys: 0.373 ± 0.019	2.436HisLeu: 2.436 ± 0.045	0.415HisMet: 0.415 ± 0.019	0.429HisAsn: 0.429 ± 0.019	1.788HisPro: 1.788 ± 0.042	0.742HisGln: 0.742 ± 0.024	1.927HisArg: 1.927 ± 0.047	0.991HisSer: 0.991 ± 0.028	1.166HisThr: 1.166 ± 0.034	1.901HisVal: 1.901 ± 0.045	0.391HisTrp: 0.391 ± 0.022	0.486HisTyr: 0.486 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.439IleAla: 5.439 ± 0.074	0.324IleCys: 0.324 ± 0.018	3.105IleAsp: 3.105 ± 0.058	2.316IleGlu: 2.316 ± 0.05	1.007IlePhe: 1.007 ± 0.032	4.32IleGly: 4.32 ± 0.082	0.795IleHis: 0.795 ± 0.027	1.596IleIle: 1.596 ± 0.044	0.797IleLys: 0.797 ± 0.029	3.151IleLeu: 3.151 ± 0.058	0.671IleMet: 0.671 ± 0.026	0.912IleAsn: 0.912 ± 0.031	2.029IlePro: 2.029 ± 0.047	0.93IleGln: 0.93 ± 0.029	2.732IleArg: 2.732 ± 0.044	2.1IleSer: 2.1 ± 0.041	2.605IleThr: 2.605 ± 0.05	3.583IleVal: 3.583 ± 0.065	0.445IleTrp: 0.445 ± 0.019	0.71IleTyr: 0.71 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.516LysAla: 2.516 ± 0.067	0.092LysCys: 0.092 ± 0.009	1.26LysAsp: 1.26 ± 0.038	1.121LysGlu: 1.121 ± 0.041	0.511LysPhe: 0.511 ± 0.024	1.729LysGly: 1.729 ± 0.045	0.457LysHis: 0.457 ± 0.019	0.886LysIle: 0.886 ± 0.034	0.784LysLys: 0.784 ± 0.036	1.852LysLeu: 1.852 ± 0.048	0.428LysMet: 0.428 ± 0.019	0.471LysAsn: 0.471 ± 0.022	1.057LysPro: 1.057 ± 0.035	0.695LysGln: 0.695 ± 0.029	1.359LysArg: 1.359 ± 0.039	1.019LysSer: 1.019 ± 0.031	1.035LysThr: 1.035 ± 0.039	1.907LysVal: 1.907 ± 0.046	0.237LysTrp: 0.237 ± 0.016	0.499LysTyr: 0.499 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.043LeuAla: 15.043 ± 0.159	0.631LeuCys: 0.631 ± 0.025	6.493LeuAsp: 6.493 ± 0.092	5.31LeuGlu: 5.31 ± 0.079	2.637LeuPhe: 2.637 ± 0.053	9.55LeuGly: 9.55 ± 0.11	2.114LeuHis: 2.114 ± 0.049	3.12LeuIle: 3.12 ± 0.062	1.708LeuLys: 1.708 ± 0.049	10.413LeuLeu: 10.413 ± 0.127	1.939LeuMet: 1.939 ± 0.047	1.834LeuAsn: 1.834 ± 0.042	5.963LeuPro: 5.963 ± 0.081	2.759LeuGln: 2.759 ± 0.057	7.529LeuArg: 7.529 ± 0.098	5.437LeuSer: 5.437 ± 0.073	5.969LeuThr: 5.969 ± 0.07	10.731LeuVal: 10.731 ± 0.137	1.299LeuTrp: 1.299 ± 0.04	1.705LeuTyr: 1.705 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.758MetAla: 2.758 ± 0.05	0.145MetCys: 0.145 ± 0.011	1.096MetAsp: 1.096 ± 0.032	0.924MetGlu: 0.924 ± 0.033	0.585MetPhe: 0.585 ± 0.021	1.675MetGly: 1.675 ± 0.043	0.365MetHis: 0.365 ± 0.017	0.871MetIle: 0.871 ± 0.029	0.521MetLys: 0.521 ± 0.023	2.118MetLeu: 2.118 ± 0.047	0.446MetMet: 0.446 ± 0.019	0.506MetAsn: 0.506 ± 0.023	1.237MetPro: 1.237 ± 0.03	0.612MetGln: 0.612 ± 0.023	1.457MetArg: 1.457 ± 0.039	1.628MetSer: 1.628 ± 0.04	1.794MetThr: 1.794 ± 0.044	1.91MetVal: 1.91 ± 0.041	0.247MetTrp: 0.247 ± 0.016	0.354MetTyr: 0.354 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.286AsnAla: 2.286 ± 0.046	0.151AsnCys: 0.151 ± 0.013	1.069AsnAsp: 1.069 ± 0.029	0.985AsnGlu: 0.985 ± 0.029	0.608AsnPhe: 0.608 ± 0.022	1.832AsnGly: 1.832 ± 0.042	0.42AsnHis: 0.42 ± 0.018	0.81AsnIle: 0.81 ± 0.031	0.436AsnLys: 0.436 ± 0.023	1.877AsnLeu: 1.877 ± 0.047	0.406AsnMet: 0.406 ± 0.02	0.498AsnAsn: 0.498 ± 0.02	1.455AsnPro: 1.455 ± 0.039	0.6AsnGln: 0.6 ± 0.024	1.354AsnArg: 1.354 ± 0.036	0.911AsnSer: 0.911 ± 0.031	1.109AsnThr: 1.109 ± 0.034	1.586AsnVal: 1.586 ± 0.039	0.327AsnTrp: 0.327 ± 0.017	0.442AsnTyr: 0.442 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.532ProAla: 7.532 ± 0.101	0.263ProCys: 0.263 ± 0.013	4.388ProAsp: 4.388 ± 0.069	4.093ProGlu: 4.093 ± 0.054	1.513ProPhe: 1.513 ± 0.034	5.772ProGly: 5.772 ± 0.082	1.228ProHis: 1.228 ± 0.031	1.942ProIle: 1.942 ± 0.046	1.048ProLys: 1.048 ± 0.036	4.961ProLeu: 4.961 ± 0.074	1.096ProMet: 1.096 ± 0.033	0.972ProAsn: 0.972 ± 0.028	2.572ProPro: 2.572 ± 0.073	1.858ProGln: 1.858 ± 0.041	3.691ProArg: 3.691 ± 0.063	3.111ProSer: 3.111 ± 0.065	3.707ProThr: 3.707 ± 0.065	5.298ProVal: 5.298 ± 0.083	0.951ProTrp: 0.951 ± 0.026	1.298ProTyr: 1.298 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.154GlnAla: 4.154 ± 0.065	0.137GlnCys: 0.137 ± 0.011	1.608GlnAsp: 1.608 ± 0.04	1.604GlnGlu: 1.604 ± 0.038	0.786GlnPhe: 0.786 ± 0.026	2.539GlnGly: 2.539 ± 0.053	0.735GlnHis: 0.735 ± 0.021	1.291GlnIle: 1.291 ± 0.034	0.643GlnLys: 0.643 ± 0.028	3.322GlnLeu: 3.322 ± 0.057	0.689GlnMet: 0.689 ± 0.027	0.56GlnAsn: 0.56 ± 0.026	1.764GlnPro: 1.764 ± 0.044	1.445GlnGln: 1.445 ± 0.042	2.617GlnArg: 2.617 ± 0.051	1.329GlnSer: 1.329 ± 0.035	1.414GlnThr: 1.414 ± 0.032	3.211GlnVal: 3.211 ± 0.052	0.467GlnTrp: 0.467 ± 0.022	0.631GlnTyr: 0.631 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.508ArgAla: 8.508 ± 0.111	0.48ArgCys: 0.48 ± 0.021	4.211ArgAsp: 4.211 ± 0.06	4.223ArgGlu: 4.223 ± 0.073	2.327ArgPhe: 2.327 ± 0.046	5.411ArgGly: 5.411 ± 0.089	1.915ArgHis: 1.915 ± 0.043	3.502ArgIle: 3.502 ± 0.056	1.491ArgLys: 1.491 ± 0.041	7.984ArgLeu: 7.984 ± 0.088	1.849ArgMet: 1.849 ± 0.038	1.481ArgAsn: 1.481 ± 0.041	4.516ArgPro: 4.516 ± 0.073	2.405ArgGln: 2.405 ± 0.046	7.029ArgArg: 7.029 ± 0.102	4.09ArgSer: 4.09 ± 0.061	5.324ArgThr: 5.324 ± 0.076	5.811ArgVal: 5.811 ± 0.076	1.274ArgTrp: 1.274 ± 0.037	1.715ArgTyr: 1.715 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.298SerAla: 6.298 ± 0.089	0.375SerCys: 0.375 ± 0.021	2.771SerAsp: 2.771 ± 0.051	2.476SerGlu: 2.476 ± 0.05	1.655SerPhe: 1.655 ± 0.042	5.555SerGly: 5.555 ± 0.073	1.099SerHis: 1.099 ± 0.032	2.148SerIle: 2.148 ± 0.051	1.032SerLys: 1.032 ± 0.033	4.884SerLeu: 4.884 ± 0.073	1.313SerMet: 1.313 ± 0.034	0.992SerAsn: 0.992 ± 0.033	3.213SerPro: 3.213 ± 0.065	1.456SerGln: 1.456 ± 0.04	3.768SerArg: 3.768 ± 0.059	3.062SerSer: 3.062 ± 0.066	3.473SerThr: 3.473 ± 0.06	4.388SerVal: 4.388 ± 0.064	0.916SerTrp: 0.916 ± 0.028	1.295SerTyr: 1.295 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.289ThrAla: 7.289 ± 0.097	0.445ThrCys: 0.445 ± 0.022	3.607ThrAsp: 3.607 ± 0.059	2.936ThrGlu: 2.936 ± 0.052	1.877ThrPhe: 1.877 ± 0.038	6.232ThrGly: 6.232 ± 0.085	1.24ThrHis: 1.24 ± 0.035	2.648ThrIle: 2.648 ± 0.049	1.197ThrLys: 1.197 ± 0.036	5.815ThrLeu: 5.815 ± 0.075	1.255ThrMet: 1.255 ± 0.033	1.172ThrAsn: 1.172 ± 0.035	4.095ThrPro: 4.095 ± 0.067	1.585ThrGln: 1.585 ± 0.044	3.939ThrArg: 3.939 ± 0.057	3.566ThrSer: 3.566 ± 0.067	4.301ThrThr: 4.301 ± 0.069	5.536ThrVal: 5.536 ± 0.077	1.034ThrTrp: 1.034 ± 0.031	1.575ThrTyr: 1.575 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	11.522ValAla: 11.522 ± 0.128	0.669ValCys: 0.669 ± 0.027	5.506ValAsp: 5.506 ± 0.071	5.22ValGlu: 5.22 ± 0.077	2.468ValPhe: 2.468 ± 0.054	7.578ValGly: 7.578 ± 0.095	1.978ValHis: 1.978 ± 0.041	3.568ValIle: 3.568 ± 0.063	1.537ValLys: 1.537 ± 0.042	9.977ValLeu: 9.977 ± 0.124	1.874ValMet: 1.874 ± 0.042	1.822ValAsn: 1.822 ± 0.04	5.091ValPro: 5.091 ± 0.074	2.316ValGln: 2.316 ± 0.041	6.763ValArg: 6.763 ± 0.082	4.563ValSer: 4.563 ± 0.075	5.63ValThr: 5.63 ± 0.074	9.605ValVal: 9.605 ± 0.13	1.189ValTrp: 1.189 ± 0.039	1.466ValTyr: 1.466 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.715TrpAla: 1.715 ± 0.037	0.123TrpCys: 0.123 ± 0.01	0.815TrpAsp: 0.815 ± 0.029	0.694TrpGlu: 0.694 ± 0.025	0.549TrpPhe: 0.549 ± 0.022	1.181TrpGly: 1.181 ± 0.034	0.357TrpHis: 0.357 ± 0.021	0.666TrpIle: 0.666 ± 0.025	0.317TrpLys: 0.317 ± 0.019	1.841TrpLeu: 1.841 ± 0.048	0.333TrpMet: 0.333 ± 0.018	0.352TrpAsn: 0.352 ± 0.017	0.785TrpPro: 0.785 ± 0.025	0.647TrpGln: 0.647 ± 0.025	1.306TrpArg: 1.306 ± 0.042	0.977TrpSer: 0.977 ± 0.03	0.979TrpThr: 0.979 ± 0.031	1.229TrpVal: 1.229 ± 0.035	0.37TrpTrp: 0.37 ± 0.018	0.327TrpTyr: 0.327 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.555TyrAla: 2.555 ± 0.053	0.178TyrCys: 0.178 ± 0.012	1.519TyrAsp: 1.519 ± 0.043	1.209TyrGlu: 1.209 ± 0.034	0.705TyrPhe: 0.705 ± 0.026	2.185TyrGly: 2.185 ± 0.051	0.428TyrHis: 0.428 ± 0.021	0.579TyrIle: 0.579 ± 0.025	0.366TyrLys: 0.366 ± 0.018	2.256TyrLeu: 2.256 ± 0.046	0.303TyrMet: 0.303 ± 0.019	0.432TyrAsn: 0.432 ± 0.019	1.166TyrPro: 1.166 ± 0.033	0.69TyrGln: 0.69 ± 0.024	1.736TyrArg: 1.736 ± 0.044	1.027TyrSer: 1.027 ± 0.035	1.073TyrThr: 1.073 ± 0.035	1.858TyrVal: 1.858 ± 0.039	0.338TyrTrp: 0.338 ± 0.018	0.519TyrTyr: 0.519 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3410 proteins (1127438 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---