Amino acid dipepetide frequency for Onchocerca ochengi (Filarial nematode worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.155AlaAla: 5.155 ± 0.067	1.186AlaCys: 1.186 ± 0.017	3.16AlaAsp: 3.16 ± 0.025	4.276AlaGlu: 4.276 ± 0.038	2.511AlaPhe: 2.511 ± 0.023	2.981AlaGly: 2.981 ± 0.03	1.353AlaHis: 1.353 ± 0.018	4.145AlaIle: 4.145 ± 0.033	3.754AlaLys: 3.754 ± 0.034	5.918AlaLeu: 5.918 ± 0.047	1.561AlaMet: 1.561 ± 0.018	2.935AlaAsn: 2.935 ± 0.027	2.309AlaPro: 2.309 ± 0.028	2.396AlaGln: 2.396 ± 0.025	3.131AlaArg: 3.131 ± 0.028	4.807AlaSer: 4.807 ± 0.033	3.648AlaThr: 3.648 ± 0.028	4.496AlaVal: 4.496 ± 0.031	0.567AlaTrp: 0.567 ± 0.011	1.788AlaTyr: 1.788 ± 0.022	0.003AlaXaa: 0.003 ± 0.001
Cys	1.258CysAla: 1.258 ± 0.017	0.596CysCys: 0.596 ± 0.014	1.227CysAsp: 1.227 ± 0.024	1.256CysGlu: 1.256 ± 0.022	0.926CysPhe: 0.926 ± 0.014	1.256CysGly: 1.256 ± 0.021	0.54CysHis: 0.54 ± 0.013	1.424CysIle: 1.424 ± 0.024	1.207CysLys: 1.207 ± 0.018	1.88CysLeu: 1.88 ± 0.026	0.492CysMet: 0.492 ± 0.011	1.06CysAsn: 1.06 ± 0.017	1.047CysPro: 1.047 ± 0.023	0.789CysGln: 0.789 ± 0.016	1.247CysArg: 1.247 ± 0.017	1.863CysSer: 1.863 ± 0.027	1.09CysThr: 1.09 ± 0.016	1.159CysVal: 1.159 ± 0.021	0.25CysTrp: 0.25 ± 0.009	0.671CysTyr: 0.671 ± 0.014	0.001CysXaa: 0.001 ± 0.0
Asp	3.267AspAla: 3.267 ± 0.03	1.125AspCys: 1.125 ± 0.02	4.34AspAsp: 4.34 ± 0.048	4.865AspGlu: 4.865 ± 0.039	2.421AspPhe: 2.421 ± 0.027	3.368AspGly: 3.368 ± 0.032	1.108AspHis: 1.108 ± 0.015	3.756AspIle: 3.756 ± 0.031	2.965AspLys: 2.965 ± 0.029	4.906AspLeu: 4.906 ± 0.035	1.274AspMet: 1.274 ± 0.016	2.678AspAsn: 2.678 ± 0.027	2.074AspPro: 2.074 ± 0.021	1.859AspGln: 1.859 ± 0.021	2.813AspArg: 2.813 ± 0.03	4.129AspSer: 4.129 ± 0.04	2.506AspThr: 2.506 ± 0.026	3.402AspVal: 3.402 ± 0.028	0.645AspTrp: 0.645 ± 0.011	1.839AspTyr: 1.839 ± 0.02	0.003AspXaa: 0.003 ± 0.001
Glu	4.012GluAla: 4.012 ± 0.039	1.273GluCys: 1.273 ± 0.022	3.452GluAsp: 3.452 ± 0.034	5.757GluGlu: 5.757 ± 0.063	2.326GluPhe: 2.326 ± 0.025	2.689GluGly: 2.689 ± 0.028	1.503GluHis: 1.503 ± 0.022	4.762GluIle: 4.762 ± 0.031	5.643GluLys: 5.643 ± 0.061	6.089GluLeu: 6.089 ± 0.05	2.126GluMet: 2.126 ± 0.023	4.154GluAsn: 4.154 ± 0.036	2.113GluPro: 2.113 ± 0.028	3.221GluGln: 3.221 ± 0.039	4.165GluArg: 4.165 ± 0.04	4.523GluSer: 4.523 ± 0.039	3.587GluThr: 3.587 ± 0.033	3.498GluVal: 3.498 ± 0.029	0.772GluTrp: 0.772 ± 0.015	2.008GluTyr: 2.008 ± 0.025	0.001GluXaa: 0.001 ± 0.001
Phe	2.666PheAla: 2.666 ± 0.028	1.027PheCys: 1.027 ± 0.017	2.539PheAsp: 2.539 ± 0.025	2.546PheGlu: 2.546 ± 0.026	1.787PhePhe: 1.787 ± 0.025	2.642PheGly: 2.642 ± 0.028	1.034PheHis: 1.034 ± 0.016	2.762PheIle: 2.762 ± 0.024	1.962PheLys: 1.962 ± 0.022	3.872PheLeu: 3.872 ± 0.033	1.021PheMet: 1.021 ± 0.017	1.795PheAsn: 1.795 ± 0.02	1.754PhePro: 1.754 ± 0.019	1.424PheGln: 1.424 ± 0.02	2.212PheArg: 2.212 ± 0.026	3.276PheSer: 3.276 ± 0.027	2.239PheThr: 2.239 ± 0.024	2.665PheVal: 2.665 ± 0.026	0.531PheTrp: 0.531 ± 0.011	1.44PheTyr: 1.44 ± 0.02	0.001PheXaa: 0.001 ± 0.0
Gly	2.811GlyAla: 2.811 ± 0.032	1.016GlyCys: 1.016 ± 0.02	2.736GlyAsp: 2.736 ± 0.029	3.08GlyGlu: 3.08 ± 0.032	2.163GlyPhe: 2.163 ± 0.022	3.089GlyGly: 3.089 ± 0.054	1.232GlyHis: 1.232 ± 0.018	3.598GlyIle: 3.598 ± 0.03	3.307GlyLys: 3.307 ± 0.032	3.984GlyLeu: 3.984 ± 0.036	1.283GlyMet: 1.283 ± 0.017	2.659GlyAsn: 2.659 ± 0.026	1.988GlyPro: 1.988 ± 0.044	1.947GlyGln: 1.947 ± 0.028	3.035GlyArg: 3.035 ± 0.035	4.056GlySer: 4.056 ± 0.03	3.022GlyThr: 3.022 ± 0.032	2.723GlyVal: 2.723 ± 0.027	0.593GlyTrp: 0.593 ± 0.011	1.79GlyTyr: 1.79 ± 0.025	0.003GlyXaa: 0.003 ± 0.001
His	1.358HisAla: 1.358 ± 0.017	0.618HisCys: 0.618 ± 0.013	1.164HisAsp: 1.164 ± 0.014	1.419HisGlu: 1.419 ± 0.019	1.206HisPhe: 1.206 ± 0.015	1.233HisGly: 1.233 ± 0.016	0.739HisHis: 0.739 ± 0.016	1.552HisIle: 1.552 ± 0.019	1.103HisLys: 1.103 ± 0.014	2.408HisLeu: 2.408 ± 0.024	0.574HisMet: 0.574 ± 0.011	1.046HisAsn: 1.046 ± 0.016	1.156HisPro: 1.156 ± 0.016	1.018HisGln: 1.018 ± 0.017	1.454HisArg: 1.454 ± 0.019	1.958HisSer: 1.958 ± 0.021	1.091HisThr: 1.091 ± 0.014	1.341HisVal: 1.341 ± 0.016	0.324HisTrp: 0.324 ± 0.008	0.89HisTyr: 0.89 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.571IleAla: 4.571 ± 0.035	1.627IleCys: 1.627 ± 0.022	4.029IleAsp: 4.029 ± 0.032	4.234IleGlu: 4.234 ± 0.035	2.823IlePhe: 2.823 ± 0.029	3.459IleGly: 3.459 ± 0.028	1.569IleHis: 1.569 ± 0.019	4.478IleIle: 4.478 ± 0.04	3.525IleLys: 3.525 ± 0.03	5.843IleLeu: 5.843 ± 0.05	1.514IleMet: 1.514 ± 0.017	3.292IleAsn: 3.292 ± 0.025	3.246IlePro: 3.246 ± 0.03	2.444IleGln: 2.444 ± 0.023	3.803IleArg: 3.803 ± 0.03	5.752IleSer: 5.752 ± 0.038	3.79IleThr: 3.79 ± 0.031	4.011IleVal: 4.011 ± 0.037	0.72IleTrp: 0.72 ± 0.012	2.111IleTyr: 2.111 ± 0.023	0.002IleXaa: 0.002 ± 0.001
Lys	3.442LysAla: 3.442 ± 0.035	1.348LysCys: 1.348 ± 0.021	3.04LysAsp: 3.04 ± 0.028	4.673LysGlu: 4.673 ± 0.05	2.305LysPhe: 2.305 ± 0.022	2.594LysGly: 2.594 ± 0.031	1.482LysHis: 1.482 ± 0.02	4.27LysIle: 4.27 ± 0.034	5.31LysLys: 5.31 ± 0.059	5.958LysLeu: 5.958 ± 0.043	1.794LysMet: 1.794 ± 0.021	3.531LysAsn: 3.531 ± 0.03	2.344LysPro: 2.344 ± 0.028	2.872LysGln: 2.872 ± 0.029	4.077LysArg: 4.077 ± 0.037	4.342LysSer: 4.342 ± 0.036	3.384LysThr: 3.384 ± 0.03	3.163LysVal: 3.163 ± 0.026	0.766LysTrp: 0.766 ± 0.014	2.067LysTyr: 2.067 ± 0.024	0.002LysXaa: 0.002 ± 0.001
Leu	5.812LeuAla: 5.812 ± 0.04	2.054LeuCys: 2.054 ± 0.025	4.758LeuAsp: 4.758 ± 0.033	5.924LeuGlu: 5.924 ± 0.053	3.88LeuPhe: 3.88 ± 0.036	3.704LeuGly: 3.704 ± 0.029	2.456LeuHis: 2.456 ± 0.025	5.864LeuIle: 5.864 ± 0.043	6.083LeuLys: 6.083 ± 0.04	9.551LeuLeu: 9.551 ± 0.069	2.302LeuMet: 2.302 ± 0.023	4.605LeuAsn: 4.605 ± 0.033	4.621LeuPro: 4.621 ± 0.041	4.278LeuGln: 4.278 ± 0.033	5.644LeuArg: 5.644 ± 0.04	7.628LeuSer: 7.628 ± 0.051	4.82LeuThr: 4.82 ± 0.037	4.608LeuVal: 4.608 ± 0.035	1.005LeuTrp: 1.005 ± 0.016	2.805LeuTyr: 2.805 ± 0.03	0.001LeuXaa: 0.001 ± 0.001
Met	1.618MetAla: 1.618 ± 0.018	0.461MetCys: 0.461 ± 0.011	1.514MetAsp: 1.514 ± 0.018	1.94MetGlu: 1.94 ± 0.021	0.9MetPhe: 0.9 ± 0.013	1.068MetGly: 1.068 ± 0.016	0.631MetHis: 0.631 ± 0.012	1.69MetIle: 1.69 ± 0.02	1.868MetLys: 1.868 ± 0.022	2.37MetLeu: 2.37 ± 0.024	0.717MetMet: 0.717 ± 0.014	1.415MetAsn: 1.415 ± 0.016	1.134MetPro: 1.134 ± 0.017	1.226MetGln: 1.226 ± 0.017	1.431MetArg: 1.431 ± 0.018	1.768MetSer: 1.768 ± 0.02	1.299MetThr: 1.299 ± 0.015	1.298MetVal: 1.298 ± 0.016	0.235MetTrp: 0.235 ± 0.007	0.654MetTyr: 0.654 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.266AsnAla: 3.266 ± 0.027	1.083AsnCys: 1.083 ± 0.017	3.446AsnAsp: 3.446 ± 0.028	3.993AsnGlu: 3.993 ± 0.033	2.163AsnPhe: 2.163 ± 0.023	3.206AsnGly: 3.206 ± 0.033	1.116AsnHis: 1.116 ± 0.016	3.638AsnIle: 3.638 ± 0.029	2.761AsnLys: 2.761 ± 0.026	4.435AsnLeu: 4.435 ± 0.032	1.255AsnMet: 1.255 ± 0.019	2.898AsnAsn: 2.898 ± 0.033	2.028AsnPro: 2.028 ± 0.027	1.869AsnGln: 1.869 ± 0.019	2.707AsnArg: 2.707 ± 0.027	4.136AsnSer: 4.136 ± 0.038	2.5AsnThr: 2.5 ± 0.027	3.146AsnVal: 3.146 ± 0.027	0.544AsnTrp: 0.544 ± 0.01	1.74AsnTyr: 1.74 ± 0.02	0.002AsnXaa: 0.002 ± 0.001
Pro	2.381ProAla: 2.381 ± 0.026	0.778ProCys: 0.778 ± 0.018	2.176ProAsp: 2.176 ± 0.025	2.815ProGlu: 2.815 ± 0.03	1.864ProPhe: 1.864 ± 0.025	2.316ProGly: 2.316 ± 0.063	0.941ProHis: 0.941 ± 0.016	2.677ProIle: 2.677 ± 0.026	2.448ProLys: 2.448 ± 0.027	3.815ProLeu: 3.815 ± 0.033	0.905ProMet: 0.905 ± 0.014	2.131ProAsn: 2.131 ± 0.023	3.047ProPro: 3.047 ± 0.064	1.707ProGln: 1.707 ± 0.024	2.062ProArg: 2.062 ± 0.025	4.024ProSer: 4.024 ± 0.038	2.601ProThr: 2.601 ± 0.033	2.79ProVal: 2.79 ± 0.027	0.426ProTrp: 0.426 ± 0.01	1.42ProTyr: 1.42 ± 0.021	0.002ProXaa: 0.002 ± 0.001
Gln	2.189GlnAla: 2.189 ± 0.026	0.92GlnCys: 0.92 ± 0.016	1.494GlnAsp: 1.494 ± 0.019	2.427GlnGlu: 2.427 ± 0.028	1.73GlnPhe: 1.73 ± 0.021	1.441GlnGly: 1.441 ± 0.021	1.101GlnHis: 1.101 ± 0.017	2.883GlnIle: 2.883 ± 0.028	2.928GlnLys: 2.928 ± 0.029	4.449GlnLeu: 4.449 ± 0.039	1.3GlnMet: 1.3 ± 0.018	2.297GlnAsn: 2.297 ± 0.022	1.715GlnPro: 1.715 ± 0.024	3.397GlnGln: 3.397 ± 0.074	2.542GlnArg: 2.542 ± 0.027	2.998GlnSer: 2.998 ± 0.028	2.163GlnThr: 2.163 ± 0.022	1.946GlnVal: 1.946 ± 0.02	0.503GlnTrp: 0.503 ± 0.011	1.362GlnTyr: 1.362 ± 0.018	0.003GlnXaa: 0.003 ± 0.001
Arg	3.045ArgAla: 3.045 ± 0.028	1.298ArgCys: 1.298 ± 0.023	2.679ArgAsp: 2.679 ± 0.026	3.531ArgGlu: 3.531 ± 0.04	2.397ArgPhe: 2.397 ± 0.026	2.499ArgGly: 2.499 ± 0.035	1.46ArgHis: 1.46 ± 0.017	3.983ArgIle: 3.983 ± 0.03	4.263ArgLys: 4.263 ± 0.04	5.425ArgLeu: 5.425 ± 0.036	1.457ArgMet: 1.457 ± 0.016	3.291ArgAsn: 3.291 ± 0.028	2.192ArgPro: 2.192 ± 0.025	2.514ArgGln: 2.514 ± 0.03	4.374ArgArg: 4.374 ± 0.046	4.505ArgSer: 4.505 ± 0.039	2.985ArgThr: 2.985 ± 0.025	2.716ArgVal: 2.716 ± 0.025	0.663ArgTrp: 0.663 ± 0.013	1.895ArgTyr: 1.895 ± 0.019	0.002ArgXaa: 0.002 ± 0.001
Ser	5.019SerAla: 5.019 ± 0.034	1.563SerCys: 1.563 ± 0.021	4.593SerAsp: 4.593 ± 0.045	4.891SerGlu: 4.891 ± 0.039	3.337SerPhe: 3.337 ± 0.028	4.427SerGly: 4.427 ± 0.034	1.722SerHis: 1.722 ± 0.021	4.916SerIle: 4.916 ± 0.038	4.528SerLys: 4.528 ± 0.032	7.307SerLeu: 7.307 ± 0.054	1.838SerMet: 1.838 ± 0.019	4.247SerAsn: 4.247 ± 0.032	3.529SerPro: 3.529 ± 0.041	2.935SerGln: 2.935 ± 0.033	4.254SerArg: 4.254 ± 0.037	9.0SerSer: 9.0 ± 0.082	5.117SerThr: 5.117 ± 0.037	4.921SerVal: 4.921 ± 0.036	0.797SerTrp: 0.797 ± 0.012	2.196SerTyr: 2.196 ± 0.023	0.003SerXaa: 0.003 ± 0.001
Thr	3.878ThrAla: 3.878 ± 0.031	1.08ThrCys: 1.08 ± 0.021	3.039ThrAsp: 3.039 ± 0.031	3.466ThrGlu: 3.466 ± 0.033	2.237ThrPhe: 2.237 ± 0.021	2.937ThrGly: 2.937 ± 0.03	1.108ThrHis: 1.108 ± 0.016	3.752ThrIle: 3.752 ± 0.033	3.122ThrLys: 3.122 ± 0.028	4.807ThrLeu: 4.807 ± 0.034	1.282ThrMet: 1.282 ± 0.018	2.832ThrAsn: 2.832 ± 0.025	2.476ThrPro: 2.476 ± 0.027	1.785ThrGln: 1.785 ± 0.021	2.475ThrArg: 2.475 ± 0.024	4.952ThrSer: 4.952 ± 0.043	3.93ThrThr: 3.93 ± 0.057	3.999ThrVal: 3.999 ± 0.034	0.514ThrTrp: 0.514 ± 0.011	1.55ThrTyr: 1.55 ± 0.019	0.003ThrXaa: 0.003 ± 0.001
Val	3.902ValAla: 3.902 ± 0.031	1.182ValCys: 1.182 ± 0.022	3.475ValAsp: 3.475 ± 0.032	4.029ValGlu: 4.029 ± 0.033	2.276ValPhe: 2.276 ± 0.022	2.834ValGly: 2.834 ± 0.028	1.403ValHis: 1.403 ± 0.017	3.952ValIle: 3.952 ± 0.034	3.453ValLys: 3.453 ± 0.028	5.307ValLeu: 5.307 ± 0.04	1.416ValMet: 1.416 ± 0.018	2.8ValAsn: 2.8 ± 0.029	2.744ValPro: 2.744 ± 0.023	2.385ValGln: 2.385 ± 0.026	3.096ValArg: 3.096 ± 0.025	4.256ValSer: 4.256 ± 0.028	3.347ValThr: 3.347 ± 0.03	3.781ValVal: 3.781 ± 0.043	0.609ValTrp: 0.609 ± 0.011	1.713ValTyr: 1.713 ± 0.023	0.002ValXaa: 0.002 ± 0.001
Trp	0.544TrpAla: 0.544 ± 0.011	0.219TrpCys: 0.219 ± 0.007	0.585TrpAsp: 0.585 ± 0.012	0.599TrpGlu: 0.599 ± 0.012	0.476TrpPhe: 0.476 ± 0.01	0.414TrpGly: 0.414 ± 0.009	0.281TrpHis: 0.281 ± 0.008	0.804TrpIle: 0.804 ± 0.013	0.884TrpLys: 0.884 ± 0.015	1.13TrpLeu: 1.13 ± 0.017	0.337TrpMet: 0.337 ± 0.009	0.705TrpAsn: 0.705 ± 0.012	0.439TrpPro: 0.439 ± 0.011	0.456TrpGln: 0.456 ± 0.011	0.695TrpArg: 0.695 ± 0.012	0.841TrpSer: 0.841 ± 0.015	0.622TrpThr: 0.622 ± 0.011	0.461TrpVal: 0.461 ± 0.011	0.167TrpTrp: 0.167 ± 0.006	0.366TrpTyr: 0.366 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.882TyrAla: 1.882 ± 0.025	0.783TyrCys: 0.783 ± 0.013	1.896TyrAsp: 1.896 ± 0.023	1.951TyrGlu: 1.951 ± 0.021	1.464TyrPhe: 1.464 ± 0.019	1.956TyrGly: 1.956 ± 0.024	0.873TyrHis: 0.873 ± 0.014	1.937TyrIle: 1.937 ± 0.021	1.65TyrLys: 1.65 ± 0.021	2.947TyrLeu: 2.947 ± 0.029	0.788TyrMet: 0.788 ± 0.013	1.557TyrAsn: 1.557 ± 0.019	1.369TyrPro: 1.369 ± 0.024	1.263TyrGln: 1.263 ± 0.02	1.958TyrArg: 1.958 ± 0.022	2.324TyrSer: 2.324 ± 0.026	1.477TyrThr: 1.477 ± 0.021	1.838TyrVal: 1.838 ± 0.022	0.393TyrTrp: 0.393 ± 0.009	1.227TyrTyr: 1.227 ± 0.019	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.001XaaLys: 0.001 ± 0.0	0.004XaaLeu: 0.004 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.003XaaGln: 0.003 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.322XaaXaa: 0.322 ± 0.038

Statistics based on 13353 proteins (4611093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---