Amino acid dipepetide frequency for Amphritea opalescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.554AlaAla: 9.554 ± 0.119	1.011AlaCys: 1.011 ± 0.032	5.633AlaAsp: 5.633 ± 0.079	6.37AlaGlu: 6.37 ± 0.092	3.284AlaPhe: 3.284 ± 0.057	6.989AlaGly: 6.989 ± 0.108	1.688AlaHis: 1.688 ± 0.044	5.842AlaIle: 5.842 ± 0.084	4.035AlaLys: 4.035 ± 0.069	10.48AlaLeu: 10.48 ± 0.118	2.641AlaMet: 2.641 ± 0.053	3.07AlaAsn: 3.07 ± 0.052	3.254AlaPro: 3.254 ± 0.06	3.917AlaGln: 3.917 ± 0.074	4.316AlaArg: 4.316 ± 0.074	5.447AlaSer: 5.447 ± 0.078	4.646AlaThr: 4.646 ± 0.073	6.541AlaVal: 6.541 ± 0.081	1.016AlaTrp: 1.016 ± 0.033	2.358AlaTyr: 2.358 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.839CysAla: 0.839 ± 0.028	0.205CysCys: 0.205 ± 0.015	0.639CysAsp: 0.639 ± 0.025	0.569CysGlu: 0.569 ± 0.022	0.476CysPhe: 0.476 ± 0.019	0.935CysGly: 0.935 ± 0.03	0.356CysHis: 0.356 ± 0.02	0.6CysIle: 0.6 ± 0.024	0.364CysLys: 0.364 ± 0.019	1.067CysLeu: 1.067 ± 0.036	0.238CysMet: 0.238 ± 0.014	0.319CysAsn: 0.319 ± 0.016	0.49CysPro: 0.49 ± 0.023	0.515CysGln: 0.515 ± 0.02	0.556CysArg: 0.556 ± 0.023	0.742CysSer: 0.742 ± 0.028	0.496CysThr: 0.496 ± 0.022	0.616CysVal: 0.616 ± 0.024	0.16CysTrp: 0.16 ± 0.012	0.367CysTyr: 0.367 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.963AspAla: 4.963 ± 0.085	0.544AspCys: 0.544 ± 0.021	3.41AspAsp: 3.41 ± 0.1	3.863AspGlu: 3.863 ± 0.049	2.147AspPhe: 2.147 ± 0.05	3.983AspGly: 3.983 ± 0.1	1.306AspHis: 1.306 ± 0.034	4.011AspIle: 4.011 ± 0.066	2.656AspLys: 2.656 ± 0.05	5.878AspLeu: 5.878 ± 0.091	1.54AspMet: 1.54 ± 0.037	2.367AspAsn: 2.367 ± 0.067	2.409AspPro: 2.409 ± 0.046	2.799AspGln: 2.799 ± 0.062	2.809AspArg: 2.809 ± 0.052	3.361AspSer: 3.361 ± 0.067	2.899AspThr: 2.899 ± 0.077	3.675AspVal: 3.675 ± 0.075	0.791AspTrp: 0.791 ± 0.029	1.923AspTyr: 1.923 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.701GluAla: 5.701 ± 0.083	0.488GluCys: 0.488 ± 0.021	2.751GluAsp: 2.751 ± 0.05	3.698GluGlu: 3.698 ± 0.075	2.099GluPhe: 2.099 ± 0.04	4.091GluGly: 4.091 ± 0.066	1.555GluHis: 1.555 ± 0.038	3.62GluIle: 3.62 ± 0.061	2.997GluLys: 2.997 ± 0.056	7.046GluLeu: 7.046 ± 0.076	1.788GluMet: 1.788 ± 0.044	2.171GluAsn: 2.171 ± 0.043	2.156GluPro: 2.156 ± 0.047	4.111GluGln: 4.111 ± 0.071	3.585GluArg: 3.585 ± 0.072	3.351GluSer: 3.351 ± 0.059	3.205GluThr: 3.205 ± 0.059	4.329GluVal: 4.329 ± 0.067	0.758GluTrp: 0.758 ± 0.027	1.655GluTyr: 1.655 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.349PheAla: 3.349 ± 0.052	0.527PheCys: 0.527 ± 0.025	2.575PheAsp: 2.575 ± 0.047	2.16PheGlu: 2.16 ± 0.041	1.597PhePhe: 1.597 ± 0.044	3.097PheGly: 3.097 ± 0.056	0.758PheHis: 0.758 ± 0.025	2.565PheIle: 2.565 ± 0.046	1.68PheLys: 1.68 ± 0.034	3.331PheLeu: 3.331 ± 0.064	1.016PheMet: 1.016 ± 0.031	1.732PheAsn: 1.732 ± 0.045	1.438PhePro: 1.438 ± 0.032	1.214PheGln: 1.214 ± 0.034	1.664PheArg: 1.664 ± 0.038	3.152PheSer: 3.152 ± 0.06	2.192PheThr: 2.192 ± 0.043	2.505PheVal: 2.505 ± 0.049	0.49PheTrp: 0.49 ± 0.025	1.236PheTyr: 1.236 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.859GlyAla: 5.859 ± 0.088	0.983GlyCys: 0.983 ± 0.032	4.046GlyAsp: 4.046 ± 0.106	4.31GlyGlu: 4.31 ± 0.067	3.383GlyPhe: 3.383 ± 0.056	5.164GlyGly: 5.164 ± 0.099	1.744GlyHis: 1.744 ± 0.042	4.893GlyIle: 4.893 ± 0.055	3.422GlyLys: 3.422 ± 0.056	7.839GlyLeu: 7.839 ± 0.092	2.215GlyMet: 2.215 ± 0.045	2.432GlyAsn: 2.432 ± 0.066	1.965GlyPro: 1.965 ± 0.039	3.041GlyGln: 3.041 ± 0.061	3.698GlyArg: 3.698 ± 0.065	4.355GlySer: 4.355 ± 0.076	3.593GlyThr: 3.593 ± 0.072	5.598GlyVal: 5.598 ± 0.079	1.037GlyTrp: 1.037 ± 0.037	2.632GlyTyr: 2.632 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.689HisAla: 1.689 ± 0.036	0.335HisCys: 0.335 ± 0.018	1.122HisAsp: 1.122 ± 0.035	1.132HisGlu: 1.132 ± 0.033	1.022HisPhe: 1.022 ± 0.029	1.56HisGly: 1.56 ± 0.042	0.708HisHis: 0.708 ± 0.029	1.362HisIle: 1.362 ± 0.033	0.898HisLys: 0.898 ± 0.028	2.369HisLeu: 2.369 ± 0.046	0.546HisMet: 0.546 ± 0.021	0.829HisAsn: 0.829 ± 0.026	1.339HisPro: 1.339 ± 0.036	1.274HisGln: 1.274 ± 0.039	1.222HisArg: 1.222 ± 0.037	1.387HisSer: 1.387 ± 0.036	1.012HisThr: 1.012 ± 0.03	1.143HisVal: 1.143 ± 0.031	0.388HisTrp: 0.388 ± 0.018	0.859HisTyr: 0.859 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.278IleAla: 6.278 ± 0.088	0.75IleCys: 0.75 ± 0.026	4.373IleAsp: 4.373 ± 0.078	4.255IleGlu: 4.255 ± 0.064	2.031IlePhe: 2.031 ± 0.048	4.666IleGly: 4.666 ± 0.07	1.271IleHis: 1.271 ± 0.034	3.683IleIle: 3.683 ± 0.07	2.899IleLys: 2.899 ± 0.046	5.293IleLeu: 5.293 ± 0.077	1.425IleMet: 1.425 ± 0.038	2.867IleAsn: 2.867 ± 0.06	2.756IlePro: 2.756 ± 0.05	2.25IleGln: 2.25 ± 0.045	3.247IleArg: 3.247 ± 0.059	4.442IleSer: 4.442 ± 0.075	3.691IleThr: 3.691 ± 0.067	3.936IleVal: 3.936 ± 0.062	0.656IleTrp: 0.656 ± 0.026	1.635IleTyr: 1.635 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.364LysAla: 4.364 ± 0.084	0.258LysCys: 0.258 ± 0.017	2.194LysAsp: 2.194 ± 0.042	2.662LysGlu: 2.662 ± 0.057	1.198LysPhe: 1.198 ± 0.031	3.041LysGly: 3.041 ± 0.044	1.015LysHis: 1.015 ± 0.03	2.52LysIle: 2.52 ± 0.049	2.28LysLys: 2.28 ± 0.057	4.544LysLeu: 4.544 ± 0.067	1.191LysMet: 1.191 ± 0.035	1.542LysAsn: 1.542 ± 0.036	2.28LysPro: 2.28 ± 0.053	2.472LysGln: 2.472 ± 0.055	2.543LysArg: 2.543 ± 0.049	2.527LysSer: 2.527 ± 0.044	2.598LysThr: 2.598 ± 0.054	3.212LysVal: 3.212 ± 0.049	0.385LysTrp: 0.385 ± 0.02	1.015LysTyr: 1.015 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.363LeuAla: 10.363 ± 0.121	1.16LeuCys: 1.16 ± 0.037	6.065LeuAsp: 6.065 ± 0.078	6.244LeuGlu: 6.244 ± 0.083	4.39LeuPhe: 4.39 ± 0.081	7.425LeuGly: 7.425 ± 0.096	2.08LeuHis: 2.08 ± 0.053	6.832LeuIle: 6.832 ± 0.083	5.171LeuLys: 5.171 ± 0.073	11.949LeuLeu: 11.949 ± 0.166	2.962LeuMet: 2.962 ± 0.058	4.464LeuAsn: 4.464 ± 0.066	5.093LeuPro: 5.093 ± 0.077	4.837LeuGln: 4.837 ± 0.079	5.129LeuArg: 5.129 ± 0.072	7.986LeuSer: 7.986 ± 0.088	6.137LeuThr: 6.137 ± 0.079	6.923LeuVal: 6.923 ± 0.097	1.141LeuTrp: 1.141 ± 0.04	2.67LeuTyr: 2.67 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.751MetAla: 2.751 ± 0.06	0.19MetCys: 0.19 ± 0.011	1.35MetAsp: 1.35 ± 0.034	1.331MetGlu: 1.331 ± 0.034	0.89MetPhe: 0.89 ± 0.029	1.945MetGly: 1.945 ± 0.048	0.468MetHis: 0.468 ± 0.018	1.713MetIle: 1.713 ± 0.04	1.379MetLys: 1.379 ± 0.042	3.03MetLeu: 3.03 ± 0.061	0.793MetMet: 0.793 ± 0.028	1.104MetAsn: 1.104 ± 0.026	1.323MetPro: 1.323 ± 0.039	1.187MetGln: 1.187 ± 0.035	1.293MetArg: 1.293 ± 0.034	2.029MetSer: 2.029 ± 0.038	1.709MetThr: 1.709 ± 0.036	1.819MetVal: 1.819 ± 0.041	0.176MetTrp: 0.176 ± 0.013	0.428MetTyr: 0.428 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.156AsnAla: 3.156 ± 0.059	0.412AsnCys: 0.412 ± 0.022	2.123AsnAsp: 2.123 ± 0.058	2.041AsnGlu: 2.041 ± 0.044	1.317AsnPhe: 1.317 ± 0.037	2.817AsnGly: 2.817 ± 0.071	0.89AsnHis: 0.89 ± 0.03	2.567AsnIle: 2.567 ± 0.059	1.6AsnLys: 1.6 ± 0.034	3.742AsnLeu: 3.742 ± 0.065	0.878AsnMet: 0.878 ± 0.025	1.529AsnAsn: 1.529 ± 0.045	2.083AsnPro: 2.083 ± 0.047	1.789AsnGln: 1.789 ± 0.047	2.156AsnArg: 2.156 ± 0.046	2.257AsnSer: 2.257 ± 0.059	2.045AsnThr: 2.045 ± 0.048	2.131AsnVal: 2.131 ± 0.06	0.512AsnTrp: 0.512 ± 0.019	1.092AsnTyr: 1.092 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.99ProAla: 3.99 ± 0.069	0.321ProCys: 0.321 ± 0.017	2.832ProAsp: 2.832 ± 0.051	3.463ProGlu: 3.463 ± 0.055	1.674ProPhe: 1.674 ± 0.037	2.913ProGly: 2.913 ± 0.049	0.844ProHis: 0.844 ± 0.029	2.39ProIle: 2.39 ± 0.043	1.665ProLys: 1.665 ± 0.041	4.761ProLeu: 4.761 ± 0.071	1.083ProMet: 1.083 ± 0.032	1.466ProAsn: 1.466 ± 0.038	1.388ProPro: 1.388 ± 0.036	1.818ProGln: 1.818 ± 0.041	1.62ProArg: 1.62 ± 0.046	2.513ProSer: 2.513 ± 0.053	2.107ProThr: 2.107 ± 0.043	3.567ProVal: 3.567 ± 0.071	0.505ProTrp: 0.505 ± 0.02	1.122ProTyr: 1.122 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.666GlnAla: 4.666 ± 0.074	0.387GlnCys: 0.387 ± 0.018	1.991GlnAsp: 1.991 ± 0.048	2.336GlnGlu: 2.336 ± 0.048	1.609GlnPhe: 1.609 ± 0.034	3.255GlnGly: 3.255 ± 0.058	1.306GlnHis: 1.306 ± 0.04	2.575GlnIle: 2.575 ± 0.052	1.799GlnLys: 1.799 ± 0.04	6.087GlnLeu: 6.087 ± 0.101	1.219GlnMet: 1.219 ± 0.03	1.421GlnAsn: 1.421 ± 0.036	2.216GlnPro: 2.216 ± 0.05	3.843GlnGln: 3.843 ± 0.084	2.905GlnArg: 2.905 ± 0.052	2.653GlnSer: 2.653 ± 0.056	2.273GlnThr: 2.273 ± 0.05	3.184GlnVal: 3.184 ± 0.049	0.666GlnTrp: 0.666 ± 0.026	1.244GlnTyr: 1.244 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.923ArgAla: 3.923 ± 0.07	0.582ArgCys: 0.582 ± 0.023	2.65ArgAsp: 2.65 ± 0.048	3.333ArgGlu: 3.333 ± 0.061	2.318ArgPhe: 2.318 ± 0.052	2.939ArgGly: 2.939 ± 0.054	1.301ArgHis: 1.301 ± 0.034	3.281ArgIle: 3.281 ± 0.058	2.329ArgLys: 2.329 ± 0.053	6.017ArgLeu: 6.017 ± 0.088	1.45ArgMet: 1.45 ± 0.038	1.839ArgAsn: 1.839 ± 0.04	1.927ArgPro: 1.927 ± 0.047	2.791ArgGln: 2.791 ± 0.058	2.885ArgArg: 2.885 ± 0.061	2.986ArgSer: 2.986 ± 0.052	2.34ArgThr: 2.34 ± 0.046	3.532ArgVal: 3.532 ± 0.055	0.796ArgTrp: 0.796 ± 0.029	1.934ArgTyr: 1.934 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.878SerAla: 5.878 ± 0.073	0.662SerCys: 0.662 ± 0.026	3.775SerAsp: 3.775 ± 0.07	3.706SerGlu: 3.706 ± 0.065	2.613SerPhe: 2.613 ± 0.052	5.339SerGly: 5.339 ± 0.084	1.506SerHis: 1.506 ± 0.04	3.809SerIle: 3.809 ± 0.064	2.293SerLys: 2.293 ± 0.048	7.111SerLeu: 7.111 ± 0.086	1.723SerMet: 1.723 ± 0.041	2.15SerAsn: 2.15 ± 0.056	2.589SerPro: 2.589 ± 0.045	2.711SerGln: 2.711 ± 0.044	3.375SerArg: 3.375 ± 0.061	4.187SerSer: 4.187 ± 0.083	3.216SerThr: 3.216 ± 0.065	4.527SerVal: 4.527 ± 0.075	0.836SerTrp: 0.836 ± 0.03	1.819SerTyr: 1.819 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.068ThrAla: 5.068 ± 0.086	0.452ThrCys: 0.452 ± 0.022	3.302ThrAsp: 3.302 ± 0.084	3.305ThrGlu: 3.305 ± 0.053	1.887ThrPhe: 1.887 ± 0.052	4.422ThrGly: 4.422 ± 0.079	1.116ThrHis: 1.116 ± 0.035	3.077ThrIle: 3.077 ± 0.062	1.735ThrLys: 1.735 ± 0.038	6.553ThrLeu: 6.553 ± 0.068	1.17ThrMet: 1.17 ± 0.036	1.645ThrAsn: 1.645 ± 0.046	2.825ThrPro: 2.825 ± 0.053	2.244ThrGln: 2.244 ± 0.047	2.465ThrArg: 2.465 ± 0.04	3.056ThrSer: 3.056 ± 0.065	2.919ThrThr: 2.919 ± 0.081	3.883ThrVal: 3.883 ± 0.092	0.518ThrTrp: 0.518 ± 0.019	1.34ThrTyr: 1.34 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.639ValAla: 6.639 ± 0.093	0.776ValCys: 0.776 ± 0.029	4.279ValAsp: 4.279 ± 0.08	4.374ValGlu: 4.374 ± 0.067	2.594ValPhe: 2.594 ± 0.053	4.739ValGly: 4.739 ± 0.083	1.242ValHis: 1.242 ± 0.031	4.773ValIle: 4.773 ± 0.07	3.102ValLys: 3.102 ± 0.055	6.929ValLeu: 6.929 ± 0.088	2.014ValMet: 2.014 ± 0.049	2.713ValAsn: 2.713 ± 0.05	2.618ValPro: 2.618 ± 0.055	2.276ValGln: 2.276 ± 0.042	3.195ValArg: 3.195 ± 0.058	4.767ValSer: 4.767 ± 0.07	3.978ValThr: 3.978 ± 0.093	5.2ValVal: 5.2 ± 0.083	0.735ValTrp: 0.735 ± 0.026	1.777ValTyr: 1.777 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.864TrpAla: 0.864 ± 0.03	0.155TrpCys: 0.155 ± 0.011	0.613TrpAsp: 0.613 ± 0.026	0.552TrpGlu: 0.552 ± 0.021	0.564TrpPhe: 0.564 ± 0.026	0.8TrpGly: 0.8 ± 0.029	0.316TrpHis: 0.316 ± 0.019	0.698TrpIle: 0.698 ± 0.023	0.423TrpLys: 0.423 ± 0.022	1.755TrpLeu: 1.755 ± 0.046	0.344TrpMet: 0.344 ± 0.016	0.441TrpAsn: 0.441 ± 0.02	0.517TrpPro: 0.517 ± 0.021	0.877TrpGln: 0.877 ± 0.029	0.659TrpArg: 0.659 ± 0.025	0.758TrpSer: 0.758 ± 0.029	0.47TrpThr: 0.47 ± 0.019	0.835TrpVal: 0.835 ± 0.027	0.181TrpTrp: 0.181 ± 0.013	0.334TrpTyr: 0.334 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.199TyrAla: 2.199 ± 0.047	0.351TyrCys: 0.351 ± 0.018	1.613TyrAsp: 1.613 ± 0.045	1.453TyrGlu: 1.453 ± 0.035	1.185TyrPhe: 1.185 ± 0.033	2.091TyrGly: 2.091 ± 0.044	0.727TyrHis: 0.727 ± 0.024	1.59TyrIle: 1.59 ± 0.04	1.113TyrLys: 1.113 ± 0.033	3.242TyrLeu: 3.242 ± 0.052	0.671TyrMet: 0.671 ± 0.018	1.034TyrAsn: 1.034 ± 0.029	1.376TyrPro: 1.376 ± 0.032	1.67TyrGln: 1.67 ± 0.039	1.829TyrArg: 1.829 ± 0.044	1.871TyrSer: 1.871 ± 0.04	1.456TyrThr: 1.456 ± 0.041	1.563TyrVal: 1.563 ± 0.04	0.408TyrTrp: 0.408 ± 0.019	0.926TyrTyr: 0.926 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3573 proteins (1184853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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