Amino acid dipepetide frequency for Nocardioides caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.572AlaAla: 19.572 ± 0.197	1.0AlaCys: 1.0 ± 0.029	8.856AlaAsp: 8.856 ± 0.094	8.443AlaGlu: 8.443 ± 0.111	3.499AlaPhe: 3.499 ± 0.054	12.57AlaGly: 12.57 ± 0.115	2.517AlaHis: 2.517 ± 0.053	5.003AlaIle: 5.003 ± 0.066	2.439AlaLys: 2.439 ± 0.055	13.316AlaLeu: 13.316 ± 0.126	2.696AlaMet: 2.696 ± 0.048	2.046AlaAsn: 2.046 ± 0.046	6.487AlaPro: 6.487 ± 0.099	3.526AlaGln: 3.526 ± 0.051	9.302AlaArg: 9.302 ± 0.11	6.491AlaSer: 6.491 ± 0.08	8.004AlaThr: 8.004 ± 0.093	11.6AlaVal: 11.6 ± 0.117	1.967AlaTrp: 1.967 ± 0.044	2.274AlaTyr: 2.274 ± 0.041	0.001AlaXaa: 0.001 ± 0.001
Cys	0.91CysAla: 0.91 ± 0.028	0.077CysCys: 0.077 ± 0.007	0.488CysAsp: 0.488 ± 0.019	0.362CysGlu: 0.362 ± 0.015	0.215CysPhe: 0.215 ± 0.014	0.881CysGly: 0.881 ± 0.029	0.174CysHis: 0.174 ± 0.013	0.205CysIle: 0.205 ± 0.012	0.089CysLys: 0.089 ± 0.008	0.637CysLeu: 0.637 ± 0.026	0.1CysMet: 0.1 ± 0.009	0.136CysAsn: 0.136 ± 0.011	0.47CysPro: 0.47 ± 0.019	0.192CysGln: 0.192 ± 0.013	0.544CysArg: 0.544 ± 0.023	0.45CysSer: 0.45 ± 0.019	0.443CysThr: 0.443 ± 0.017	0.597CysVal: 0.597 ± 0.021	0.126CysTrp: 0.126 ± 0.01	0.147CysTyr: 0.147 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.5AspAla: 8.5 ± 0.094	0.379AspCys: 0.379 ± 0.016	5.055AspAsp: 5.055 ± 0.074	4.62AspGlu: 4.62 ± 0.066	1.796AspPhe: 1.796 ± 0.043	6.933AspGly: 6.933 ± 0.089	1.598AspHis: 1.598 ± 0.04	2.156AspIle: 2.156 ± 0.045	1.146AspLys: 1.146 ± 0.037	7.653AspLeu: 7.653 ± 0.085	0.813AspMet: 0.813 ± 0.025	1.096AspAsn: 1.096 ± 0.035	4.599AspPro: 4.599 ± 0.066	1.895AspGln: 1.895 ± 0.037	5.024AspArg: 5.024 ± 0.082	2.452AspSer: 2.452 ± 0.049	3.025AspThr: 3.025 ± 0.052	6.114AspVal: 6.114 ± 0.072	1.034AspTrp: 1.034 ± 0.032	1.34AspTyr: 1.34 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.204GluAla: 7.204 ± 0.085	0.356GluCys: 0.356 ± 0.017	3.216GluAsp: 3.216 ± 0.061	3.597GluGlu: 3.597 ± 0.067	1.606GluPhe: 1.606 ± 0.039	4.36GluGly: 4.36 ± 0.06	1.519GluHis: 1.519 ± 0.036	2.789GluIle: 2.789 ± 0.052	1.345GluLys: 1.345 ± 0.04	6.728GluLeu: 6.728 ± 0.072	1.005GluMet: 1.005 ± 0.03	0.88GluAsn: 0.88 ± 0.026	3.24GluPro: 3.24 ± 0.07	2.323GluGln: 2.323 ± 0.043	5.164GluArg: 5.164 ± 0.068	2.716GluSer: 2.716 ± 0.053	2.989GluThr: 2.989 ± 0.052	5.449GluVal: 5.449 ± 0.066	0.82GluTrp: 0.82 ± 0.026	0.91GluTyr: 0.91 ± 0.031	0.002GluXaa: 0.002 ± 0.001
Phe	3.579PheAla: 3.579 ± 0.054	0.286PheCys: 0.286 ± 0.016	2.165PheAsp: 2.165 ± 0.044	1.612PheGlu: 1.612 ± 0.039	0.893PhePhe: 0.893 ± 0.034	3.099PheGly: 3.099 ± 0.062	0.61PheHis: 0.61 ± 0.023	0.831PheIle: 0.831 ± 0.027	0.511PheLys: 0.511 ± 0.024	2.631PheLeu: 2.631 ± 0.057	0.396PheMet: 0.396 ± 0.018	0.621PheAsn: 0.621 ± 0.022	1.299PhePro: 1.299 ± 0.034	0.682PheGln: 0.682 ± 0.024	1.764PheArg: 1.764 ± 0.042	1.494PheSer: 1.494 ± 0.038	1.859PheThr: 1.859 ± 0.042	2.527PheVal: 2.527 ± 0.045	0.433PheTrp: 0.433 ± 0.018	0.576PheTyr: 0.576 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.774GlyAla: 10.774 ± 0.107	0.777GlyCys: 0.777 ± 0.028	5.895GlyAsp: 5.895 ± 0.074	5.36GlyGlu: 5.36 ± 0.07	3.028GlyPhe: 3.028 ± 0.053	8.433GlyGly: 8.433 ± 0.108	2.046GlyHis: 2.046 ± 0.037	4.002GlyIle: 4.002 ± 0.063	2.094GlyLys: 2.094 ± 0.043	9.495GlyLeu: 9.495 ± 0.103	1.887GlyMet: 1.887 ± 0.044	1.828GlyAsn: 1.828 ± 0.053	4.555GlyPro: 4.555 ± 0.065	2.816GlyGln: 2.816 ± 0.054	7.246GlyArg: 7.246 ± 0.085	5.366GlySer: 5.366 ± 0.071	5.648GlyThr: 5.648 ± 0.082	7.952GlyVal: 7.952 ± 0.093	1.699GlyTrp: 1.699 ± 0.037	2.072GlyTyr: 2.072 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.406HisAla: 2.406 ± 0.045	0.193HisCys: 0.193 ± 0.012	1.523HisAsp: 1.523 ± 0.033	1.172HisGlu: 1.172 ± 0.027	0.629HisPhe: 0.629 ± 0.024	2.155HisGly: 2.155 ± 0.045	0.736HisHis: 0.736 ± 0.03	0.54HisIle: 0.54 ± 0.023	0.312HisLys: 0.312 ± 0.016	2.381HisLeu: 2.381 ± 0.044	0.275HisMet: 0.275 ± 0.015	0.36HisAsn: 0.36 ± 0.02	1.586HisPro: 1.586 ± 0.038	0.632HisGln: 0.632 ± 0.023	1.914HisArg: 1.914 ± 0.047	0.816HisSer: 0.816 ± 0.028	1.009HisThr: 1.009 ± 0.029	1.963HisVal: 1.963 ± 0.04	0.304HisTrp: 0.304 ± 0.017	0.475HisTyr: 0.475 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.636IleAla: 5.636 ± 0.067	0.292IleCys: 0.292 ± 0.015	3.063IleAsp: 3.063 ± 0.051	2.593IleGlu: 2.593 ± 0.048	0.868IlePhe: 0.868 ± 0.03	4.081IleGly: 4.081 ± 0.057	0.692IleHis: 0.692 ± 0.025	1.131IleIle: 1.131 ± 0.029	0.779IleLys: 0.779 ± 0.03	2.814IleLeu: 2.814 ± 0.057	0.478IleMet: 0.478 ± 0.021	0.953IleAsn: 0.953 ± 0.03	2.003IlePro: 2.003 ± 0.043	0.854IleGln: 0.854 ± 0.026	2.431IleArg: 2.431 ± 0.044	1.898IleSer: 1.898 ± 0.038	2.477IleThr: 2.477 ± 0.046	3.472IleVal: 3.472 ± 0.046	0.409IleTrp: 0.409 ± 0.02	0.665IleTyr: 0.665 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.609LysAla: 2.609 ± 0.054	0.093LysCys: 0.093 ± 0.009	1.209LysAsp: 1.209 ± 0.038	1.079LysGlu: 1.079 ± 0.036	0.461LysPhe: 0.461 ± 0.023	1.572LysGly: 1.572 ± 0.037	0.411LysHis: 0.411 ± 0.017	0.798LysIle: 0.798 ± 0.03	0.669LysLys: 0.669 ± 0.03	1.692LysLeu: 1.692 ± 0.043	0.383LysMet: 0.383 ± 0.018	0.445LysAsn: 0.445 ± 0.019	1.103LysPro: 1.103 ± 0.03	0.64LysGln: 0.64 ± 0.024	1.355LysArg: 1.355 ± 0.032	1.022LysSer: 1.022 ± 0.032	1.051LysThr: 1.051 ± 0.03	2.039LysVal: 2.039 ± 0.04	0.232LysTrp: 0.232 ± 0.016	0.412LysTyr: 0.412 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.051LeuAla: 15.051 ± 0.147	0.722LeuCys: 0.722 ± 0.022	7.257LeuAsp: 7.257 ± 0.076	5.341LeuGlu: 5.341 ± 0.069	2.38LeuPhe: 2.38 ± 0.051	9.602LeuGly: 9.602 ± 0.109	2.042LeuHis: 2.042 ± 0.04	3.302LeuIle: 3.302 ± 0.049	1.767LeuLys: 1.767 ± 0.041	10.755LeuLeu: 10.755 ± 0.138	1.614LeuMet: 1.614 ± 0.041	1.61LeuAsn: 1.61 ± 0.041	5.839LeuPro: 5.839 ± 0.076	2.496LeuGln: 2.496 ± 0.044	7.694LeuArg: 7.694 ± 0.087	5.137LeuSer: 5.137 ± 0.067	6.436LeuThr: 6.436 ± 0.075	10.087LeuVal: 10.087 ± 0.102	1.2LeuTrp: 1.2 ± 0.034	1.398LeuTyr: 1.398 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.291MetAla: 2.291 ± 0.043	0.114MetCys: 0.114 ± 0.008	0.896MetAsp: 0.896 ± 0.03	0.719MetGlu: 0.719 ± 0.028	0.438MetPhe: 0.438 ± 0.022	1.397MetGly: 1.397 ± 0.033	0.34MetHis: 0.34 ± 0.015	0.714MetIle: 0.714 ± 0.026	0.439MetLys: 0.439 ± 0.019	1.747MetLeu: 1.747 ± 0.041	0.321MetMet: 0.321 ± 0.018	0.382MetAsn: 0.382 ± 0.018	1.036MetPro: 1.036 ± 0.033	0.469MetGln: 0.469 ± 0.021	1.348MetArg: 1.348 ± 0.034	1.411MetSer: 1.411 ± 0.029	1.627MetThr: 1.627 ± 0.036	1.548MetVal: 1.548 ± 0.036	0.193MetTrp: 0.193 ± 0.012	0.258MetTyr: 0.258 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.227AsnAla: 2.227 ± 0.056	0.155AsnCys: 0.155 ± 0.011	1.136AsnAsp: 1.136 ± 0.03	0.902AsnGlu: 0.902 ± 0.03	0.49AsnPhe: 0.49 ± 0.023	1.76AsnGly: 1.76 ± 0.046	0.392AsnHis: 0.392 ± 0.018	0.685AsnIle: 0.685 ± 0.022	0.391AsnLys: 0.391 ± 0.018	1.804AsnLeu: 1.804 ± 0.044	0.279AsnMet: 0.279 ± 0.015	0.426AsnAsn: 0.426 ± 0.022	1.37AsnPro: 1.37 ± 0.035	0.562AsnGln: 0.562 ± 0.024	1.246AsnArg: 1.246 ± 0.035	0.792AsnSer: 0.792 ± 0.028	0.998AsnThr: 0.998 ± 0.032	1.515AsnVal: 1.515 ± 0.035	0.255AsnTrp: 0.255 ± 0.014	0.414AsnTyr: 0.414 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.584ProAla: 7.584 ± 0.101	0.297ProCys: 0.297 ± 0.016	4.57ProAsp: 4.57 ± 0.066	3.826ProGlu: 3.826 ± 0.059	1.496ProPhe: 1.496 ± 0.035	5.688ProGly: 5.688 ± 0.084	1.181ProHis: 1.181 ± 0.034	1.838ProIle: 1.838 ± 0.035	0.984ProLys: 0.984 ± 0.031	4.796ProLeu: 4.796 ± 0.066	0.94ProMet: 0.94 ± 0.03	0.827ProAsn: 0.827 ± 0.03	3.024ProPro: 3.024 ± 0.084	1.41ProGln: 1.41 ± 0.035	3.629ProArg: 3.629 ± 0.063	3.111ProSer: 3.111 ± 0.056	3.723ProThr: 3.723 ± 0.061	5.266ProVal: 5.266 ± 0.073	0.913ProTrp: 0.913 ± 0.029	1.093ProTyr: 1.093 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.454GlnAla: 3.454 ± 0.062	0.172GlnCys: 0.172 ± 0.012	1.279GlnAsp: 1.279 ± 0.036	1.344GlnGlu: 1.344 ± 0.036	0.732GlnPhe: 0.732 ± 0.025	2.173GlnGly: 2.173 ± 0.042	0.662GlnHis: 0.662 ± 0.025	1.215GlnIle: 1.215 ± 0.033	0.561GlnLys: 0.561 ± 0.024	3.223GlnLeu: 3.223 ± 0.051	0.539GlnMet: 0.539 ± 0.02	0.411GlnAsn: 0.411 ± 0.02	1.706GlnPro: 1.706 ± 0.04	1.192GlnGln: 1.192 ± 0.032	2.605GlnArg: 2.605 ± 0.049	1.233GlnSer: 1.233 ± 0.034	1.443GlnThr: 1.443 ± 0.039	2.858GlnVal: 2.858 ± 0.052	0.444GlnTrp: 0.444 ± 0.019	0.511GlnTyr: 0.511 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.991ArgAla: 8.991 ± 0.091	0.483ArgCys: 0.483 ± 0.021	4.575ArgAsp: 4.575 ± 0.058	4.291ArgGlu: 4.291 ± 0.063	2.271ArgPhe: 2.271 ± 0.048	5.605ArgGly: 5.605 ± 0.064	1.829ArgHis: 1.829 ± 0.04	3.448ArgIle: 3.448 ± 0.052	1.457ArgLys: 1.457 ± 0.042	7.981ArgLeu: 7.981 ± 0.096	1.747ArgMet: 1.747 ± 0.038	1.353ArgAsn: 1.353 ± 0.035	4.258ArgPro: 4.258 ± 0.07	2.148ArgGln: 2.148 ± 0.051	7.161ArgArg: 7.161 ± 0.098	4.284ArgSer: 4.284 ± 0.066	4.605ArgThr: 4.605 ± 0.065	6.085ArgVal: 6.085 ± 0.083	1.43ArgTrp: 1.43 ± 0.034	1.507ArgTyr: 1.507 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.465SerAla: 6.465 ± 0.076	0.383SerCys: 0.383 ± 0.019	3.13SerAsp: 3.13 ± 0.051	2.473SerGlu: 2.473 ± 0.051	1.59SerPhe: 1.59 ± 0.038	5.708SerGly: 5.708 ± 0.081	0.984SerHis: 0.984 ± 0.031	1.959SerIle: 1.959 ± 0.04	0.922SerLys: 0.922 ± 0.03	4.866SerLeu: 4.866 ± 0.065	1.155SerMet: 1.155 ± 0.031	0.939SerAsn: 0.939 ± 0.03	3.011SerPro: 3.011 ± 0.055	1.284SerGln: 1.284 ± 0.034	3.651SerArg: 3.651 ± 0.054	3.258SerSer: 3.258 ± 0.06	3.591SerThr: 3.591 ± 0.063	4.32SerVal: 4.32 ± 0.069	0.902SerTrp: 0.902 ± 0.03	1.431SerTyr: 1.431 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	7.782ThrAla: 7.782 ± 0.083	0.486ThrCys: 0.486 ± 0.022	3.859ThrAsp: 3.859 ± 0.061	3.111ThrGlu: 3.111 ± 0.052	1.914ThrPhe: 1.914 ± 0.045	6.282ThrGly: 6.282 ± 0.099	1.134ThrHis: 1.134 ± 0.028	2.353ThrIle: 2.353 ± 0.043	1.106ThrLys: 1.106 ± 0.033	5.659ThrLeu: 5.659 ± 0.073	1.048ThrMet: 1.048 ± 0.028	1.12ThrAsn: 1.12 ± 0.036	3.875ThrPro: 3.875 ± 0.065	1.369ThrGln: 1.369 ± 0.036	3.911ThrArg: 3.911 ± 0.054	3.661ThrSer: 3.661 ± 0.066	4.357ThrThr: 4.357 ± 0.085	5.791ThrVal: 5.791 ± 0.085	1.024ThrTrp: 1.024 ± 0.03	1.421ThrTyr: 1.421 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	12.579ValAla: 12.579 ± 0.136	0.678ValCys: 0.678 ± 0.024	6.452ValAsp: 6.452 ± 0.07	5.576ValGlu: 5.576 ± 0.075	2.341ValPhe: 2.341 ± 0.044	7.716ValGly: 7.716 ± 0.099	1.876ValHis: 1.876 ± 0.046	3.556ValIle: 3.556 ± 0.054	1.653ValLys: 1.653 ± 0.038	9.749ValLeu: 9.749 ± 0.09	1.52ValMet: 1.52 ± 0.031	1.699ValAsn: 1.699 ± 0.043	5.059ValPro: 5.059 ± 0.073	2.174ValGln: 2.174 ± 0.041	6.744ValArg: 6.744 ± 0.087	4.454ValSer: 4.454 ± 0.061	6.058ValThr: 6.058 ± 0.091	10.256ValVal: 10.256 ± 0.124	1.096ValTrp: 1.096 ± 0.031	1.316ValTyr: 1.316 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.651TrpAla: 1.651 ± 0.036	0.143TrpCys: 0.143 ± 0.013	0.842TrpAsp: 0.842 ± 0.024	0.736TrpGlu: 0.736 ± 0.026	0.55TrpPhe: 0.55 ± 0.024	1.076TrpGly: 1.076 ± 0.03	0.321TrpHis: 0.321 ± 0.016	0.597TrpIle: 0.597 ± 0.023	0.294TrpLys: 0.294 ± 0.017	1.804TrpLeu: 1.804 ± 0.035	0.289TrpMet: 0.289 ± 0.017	0.342TrpAsn: 0.342 ± 0.017	0.743TrpPro: 0.743 ± 0.026	0.578TrpGln: 0.578 ± 0.025	1.261TrpArg: 1.261 ± 0.033	1.092TrpSer: 1.092 ± 0.029	0.998TrpThr: 0.998 ± 0.031	1.168TrpVal: 1.168 ± 0.037	0.382TrpTrp: 0.382 ± 0.019	0.292TrpTyr: 0.292 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.344TyrAla: 2.344 ± 0.045	0.154TyrCys: 0.154 ± 0.012	1.759TyrAsp: 1.759 ± 0.042	1.065TyrGlu: 1.065 ± 0.035	0.667TyrPhe: 0.667 ± 0.025	1.88TyrGly: 1.88 ± 0.037	0.314TyrHis: 0.314 ± 0.019	0.468TyrIle: 0.468 ± 0.022	0.315TyrLys: 0.315 ± 0.018	2.001TyrLeu: 2.001 ± 0.044	0.201TyrMet: 0.201 ± 0.014	0.325TyrAsn: 0.325 ± 0.017	0.931TyrPro: 0.931 ± 0.025	0.512TyrGln: 0.512 ± 0.025	1.516TyrArg: 1.516 ± 0.037	0.888TyrSer: 0.888 ± 0.031	0.922TyrThr: 0.922 ± 0.028	1.946TyrVal: 1.946 ± 0.043	0.299TyrTrp: 0.299 ± 0.015	0.434TyrTyr: 0.434 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3779 proteins (1241243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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