Amino acid dipepetide frequency for Escherichia phage HK022 (Bacteriophage HK022)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.426AlaAla: 9.426 ± 1.333
0.644AlaCys: 0.644 ± 0.255
6.525AlaAsp: 6.525 ± 0.626
5.881AlaGlu: 5.881 ± 0.675
3.303AlaPhe: 3.303 ± 0.444
7.331AlaGly: 7.331 ± 0.786
1.531AlaHis: 1.531 ± 0.369
7.25AlaIle: 7.25 ± 0.635
4.431AlaLys: 4.431 ± 0.733
7.009AlaLeu: 7.009 ± 0.629
3.867AlaMet: 3.867 ± 0.575
4.35AlaAsn: 4.35 ± 0.601
1.772AlaPro: 1.772 ± 0.349
4.109AlaGln: 4.109 ± 0.595
4.834AlaArg: 4.834 ± 0.541
6.203AlaSer: 6.203 ± 0.96
5.075AlaThr: 5.075 ± 0.546
5.559AlaVal: 5.559 ± 0.63
1.45AlaTrp: 1.45 ± 0.367
2.659AlaTyr: 2.659 ± 0.523
0.0AlaXaa: 0.0 ± 0.0
Cys
1.128CysAla: 1.128 ± 0.323
0.242CysCys: 0.242 ± 0.132
0.967CysAsp: 0.967 ± 0.258
0.806CysGlu: 0.806 ± 0.262
0.322CysPhe: 0.322 ± 0.172
0.806CysGly: 0.806 ± 0.288
0.483CysHis: 0.483 ± 0.201
0.806CysIle: 0.806 ± 0.253
0.644CysLys: 0.644 ± 0.215
0.644CysLeu: 0.644 ± 0.247
0.161CysMet: 0.161 ± 0.12
0.564CysAsn: 0.564 ± 0.219
0.322CysPro: 0.322 ± 0.161
0.242CysGln: 0.242 ± 0.148
0.725CysArg: 0.725 ± 0.271
0.644CysSer: 0.644 ± 0.228
0.242CysThr: 0.242 ± 0.131
0.725CysVal: 0.725 ± 0.272
0.161CysTrp: 0.161 ± 0.161
0.161CysTyr: 0.161 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
5.881AspAla: 5.881 ± 0.724
0.564AspCys: 0.564 ± 0.271
3.464AspAsp: 3.464 ± 0.524
3.464AspGlu: 3.464 ± 0.471
1.933AspPhe: 1.933 ± 0.512
5.236AspGly: 5.236 ± 0.703
0.483AspHis: 0.483 ± 0.229
2.739AspIle: 2.739 ± 0.487
3.867AspLys: 3.867 ± 0.597
5.236AspLeu: 5.236 ± 0.676
1.531AspMet: 1.531 ± 0.345
2.659AspAsn: 2.659 ± 0.4
2.256AspPro: 2.256 ± 0.383
1.692AspGln: 1.692 ± 0.4
4.35AspArg: 4.35 ± 0.547
3.947AspSer: 3.947 ± 0.608
1.853AspThr: 1.853 ± 0.397
4.995AspVal: 4.995 ± 0.66
0.886AspTrp: 0.886 ± 0.277
2.659AspTyr: 2.659 ± 0.52
0.0AspXaa: 0.0 ± 0.0
Glu
4.995GluAla: 4.995 ± 0.685
0.806GluCys: 0.806 ± 0.243
2.659GluAsp: 2.659 ± 0.421
3.706GluGlu: 3.706 ± 0.698
2.175GluPhe: 2.175 ± 0.309
3.384GluGly: 3.384 ± 0.625
1.208GluHis: 1.208 ± 0.307
3.706GluIle: 3.706 ± 0.494
3.947GluLys: 3.947 ± 0.502
5.961GluLeu: 5.961 ± 0.648
1.289GluMet: 1.289 ± 0.348
2.739GluAsn: 2.739 ± 0.452
1.853GluPro: 1.853 ± 0.355
3.625GluGln: 3.625 ± 0.588
4.27GluArg: 4.27 ± 0.701
4.27GluSer: 4.27 ± 0.599
3.222GluThr: 3.222 ± 0.412
3.464GluVal: 3.464 ± 0.427
0.806GluTrp: 0.806 ± 0.266
2.095GluTyr: 2.095 ± 0.434
0.0GluXaa: 0.0 ± 0.0
Phe
2.659PheAla: 2.659 ± 0.542
0.322PheCys: 0.322 ± 0.145
2.497PheAsp: 2.497 ± 0.463
2.175PheGlu: 2.175 ± 0.414
0.564PhePhe: 0.564 ± 0.251
3.464PheGly: 3.464 ± 0.439
0.483PheHis: 0.483 ± 0.177
2.175PheIle: 2.175 ± 0.535
2.095PheLys: 2.095 ± 0.398
1.289PheLeu: 1.289 ± 0.317
0.644PheMet: 0.644 ± 0.204
1.772PheAsn: 1.772 ± 0.304
1.289PhePro: 1.289 ± 0.316
0.644PheGln: 0.644 ± 0.222
2.095PheArg: 2.095 ± 0.56
2.336PheSer: 2.336 ± 0.467
2.981PheThr: 2.981 ± 0.577
1.933PheVal: 1.933 ± 0.393
0.644PheTrp: 0.644 ± 0.228
1.128PheTyr: 1.128 ± 0.294
0.0PheXaa: 0.0 ± 0.0
Gly
6.364GlyAla: 6.364 ± 0.777
0.806GlyCys: 0.806 ± 0.225
4.995GlyAsp: 4.995 ± 0.745
4.834GlyGlu: 4.834 ± 0.602
2.659GlyPhe: 2.659 ± 0.461
5.559GlyGly: 5.559 ± 0.787
1.289GlyHis: 1.289 ± 0.339
4.431GlyIle: 4.431 ± 0.538
4.995GlyLys: 4.995 ± 0.651
6.767GlyLeu: 6.767 ± 0.85
2.417GlyMet: 2.417 ± 0.432
3.947GlyAsn: 3.947 ± 0.626
1.289GlyPro: 1.289 ± 0.347
3.061GlyGln: 3.061 ± 0.417
4.995GlyArg: 4.995 ± 0.535
3.947GlySer: 3.947 ± 0.605
4.914GlyThr: 4.914 ± 0.891
4.995GlyVal: 4.995 ± 0.786
0.806GlyTrp: 0.806 ± 0.294
2.739GlyTyr: 2.739 ± 0.428
0.0GlyXaa: 0.0 ± 0.0
His
1.289HisAla: 1.289 ± 0.404
0.161HisCys: 0.161 ± 0.125
0.806HisAsp: 0.806 ± 0.226
1.289HisGlu: 1.289 ± 0.335
0.564HisPhe: 0.564 ± 0.284
1.853HisGly: 1.853 ± 0.38
0.564HisHis: 0.564 ± 0.233
0.967HisIle: 0.967 ± 0.307
1.047HisLys: 1.047 ± 0.274
1.289HisLeu: 1.289 ± 0.391
0.0HisMet: 0.0 ± 0.0
0.403HisAsn: 0.403 ± 0.168
0.886HisPro: 0.886 ± 0.321
0.886HisGln: 0.886 ± 0.296
1.289HisArg: 1.289 ± 0.365
0.967HisSer: 0.967 ± 0.308
0.483HisThr: 0.483 ± 0.201
0.725HisVal: 0.725 ± 0.324
0.403HisTrp: 0.403 ± 0.164
0.242HisTyr: 0.242 ± 0.138
0.0HisXaa: 0.0 ± 0.0
Ile
6.203IleAla: 6.203 ± 0.619
0.806IleCys: 0.806 ± 0.301
4.511IleAsp: 4.511 ± 0.583
3.786IleGlu: 3.786 ± 0.632
2.336IlePhe: 2.336 ± 0.445
4.511IleGly: 4.511 ± 0.711
1.289IleHis: 1.289 ± 0.3
3.142IleIle: 3.142 ± 0.446
2.9IleLys: 2.9 ± 0.423
4.511IleLeu: 4.511 ± 0.464
0.806IleMet: 0.806 ± 0.283
2.981IleAsn: 2.981 ± 0.463
2.175IlePro: 2.175 ± 0.334
3.142IleGln: 3.142 ± 0.547
4.511IleArg: 4.511 ± 0.745
4.592IleSer: 4.592 ± 0.572
4.834IleThr: 4.834 ± 0.621
3.061IleVal: 3.061 ± 0.524
0.725IleTrp: 0.725 ± 0.221
1.45IleTyr: 1.45 ± 0.275
0.0IleXaa: 0.0 ± 0.0
Lys
5.075LysAla: 5.075 ± 0.632
0.242LysCys: 0.242 ± 0.128
2.981LysAsp: 2.981 ± 0.498
4.189LysGlu: 4.189 ± 0.668
1.208LysPhe: 1.208 ± 0.279
3.867LysGly: 3.867 ± 0.54
0.806LysHis: 0.806 ± 0.256
2.9LysIle: 2.9 ± 0.44
3.867LysLys: 3.867 ± 0.644
4.914LysLeu: 4.914 ± 0.78
1.933LysMet: 1.933 ± 0.401
2.417LysAsn: 2.417 ± 0.404
2.659LysPro: 2.659 ± 0.459
2.9LysGln: 2.9 ± 0.602
3.384LysArg: 3.384 ± 0.7
4.189LysSer: 4.189 ± 0.709
3.786LysThr: 3.786 ± 0.455
3.947LysVal: 3.947 ± 0.586
1.692LysTrp: 1.692 ± 0.271
2.014LysTyr: 2.014 ± 0.391
0.0LysXaa: 0.0 ± 0.0
Leu
8.781LeuAla: 8.781 ± 1.056
1.128LeuCys: 1.128 ± 0.319
4.27LeuAsp: 4.27 ± 0.458
4.511LeuGlu: 4.511 ± 0.597
2.336LeuPhe: 2.336 ± 0.391
3.706LeuGly: 3.706 ± 0.688
1.128LeuHis: 1.128 ± 0.402
4.753LeuIle: 4.753 ± 0.523
4.35LeuLys: 4.35 ± 0.62
5.8LeuLeu: 5.8 ± 0.677
1.45LeuMet: 1.45 ± 0.357
4.028LeuAsn: 4.028 ± 0.638
3.786LeuPro: 3.786 ± 0.579
3.706LeuGln: 3.706 ± 0.729
4.592LeuArg: 4.592 ± 0.493
6.687LeuSer: 6.687 ± 0.68
5.156LeuThr: 5.156 ± 0.616
4.431LeuVal: 4.431 ± 0.607
0.644LeuTrp: 0.644 ± 0.308
2.175LeuTyr: 2.175 ± 0.428
0.0LeuXaa: 0.0 ± 0.0
Met
2.739MetAla: 2.739 ± 0.358
0.242MetCys: 0.242 ± 0.131
1.37MetAsp: 1.37 ± 0.312
1.047MetGlu: 1.047 ± 0.325
0.644MetPhe: 0.644 ± 0.257
1.37MetGly: 1.37 ± 0.287
0.403MetHis: 0.403 ± 0.187
1.45MetIle: 1.45 ± 0.38
1.853MetLys: 1.853 ± 0.365
1.853MetLeu: 1.853 ± 0.324
0.483MetMet: 0.483 ± 0.196
0.886MetAsn: 0.886 ± 0.312
1.37MetPro: 1.37 ± 0.284
1.45MetGln: 1.45 ± 0.301
1.531MetArg: 1.531 ± 0.328
2.014MetSer: 2.014 ± 0.391
1.933MetThr: 1.933 ± 0.405
1.128MetVal: 1.128 ± 0.308
0.242MetTrp: 0.242 ± 0.147
0.725MetTyr: 0.725 ± 0.27
0.0MetXaa: 0.0 ± 0.0
Asn
4.673AsnAla: 4.673 ± 0.686
0.483AsnCys: 0.483 ± 0.184
2.497AsnAsp: 2.497 ± 0.366
2.739AsnGlu: 2.739 ± 0.433
1.128AsnPhe: 1.128 ± 0.273
4.753AsnGly: 4.753 ± 0.638
1.208AsnHis: 1.208 ± 0.358
3.625AsnIle: 3.625 ± 0.526
2.497AsnLys: 2.497 ± 0.394
2.659AsnLeu: 2.659 ± 0.404
0.564AsnMet: 0.564 ± 0.229
2.256AsnAsn: 2.256 ± 0.516
2.9AsnPro: 2.9 ± 0.481
2.336AsnGln: 2.336 ± 0.427
2.82AsnArg: 2.82 ± 0.614
2.175AsnSer: 2.175 ± 0.412
2.9AsnThr: 2.9 ± 0.51
1.611AsnVal: 1.611 ± 0.436
0.806AsnTrp: 0.806 ± 0.234
1.45AsnTyr: 1.45 ± 0.4
0.0AsnXaa: 0.0 ± 0.0
Pro
3.384ProAla: 3.384 ± 0.598
0.483ProCys: 0.483 ± 0.209
2.014ProAsp: 2.014 ± 0.411
3.222ProGlu: 3.222 ± 0.552
1.692ProPhe: 1.692 ± 0.388
3.625ProGly: 3.625 ± 0.521
0.806ProHis: 0.806 ± 0.247
1.45ProIle: 1.45 ± 0.39
2.336ProLys: 2.336 ± 0.428
2.82ProLeu: 2.82 ± 0.594
1.45ProMet: 1.45 ± 0.357
1.289ProAsn: 1.289 ± 0.323
2.014ProPro: 2.014 ± 0.383
1.772ProGln: 1.772 ± 0.336
2.014ProArg: 2.014 ± 0.378
2.256ProSer: 2.256 ± 0.439
1.853ProThr: 1.853 ± 0.379
2.82ProVal: 2.82 ± 0.506
0.322ProTrp: 0.322 ± 0.224
0.725ProTyr: 0.725 ± 0.208
0.0ProXaa: 0.0 ± 0.0
Gln
4.189GlnAla: 4.189 ± 0.674
0.483GlnCys: 0.483 ± 0.19
1.45GlnAsp: 1.45 ± 0.326
2.336GlnGlu: 2.336 ± 0.372
1.45GlnPhe: 1.45 ± 0.371
2.336GlnGly: 2.336 ± 0.352
0.403GlnHis: 0.403 ± 0.163
3.222GlnIle: 3.222 ± 0.442
3.303GlnLys: 3.303 ± 0.634
3.545GlnLeu: 3.545 ± 0.548
0.886GlnMet: 0.886 ± 0.246
2.256GlnAsn: 2.256 ± 0.441
1.37GlnPro: 1.37 ± 0.284
2.9GlnGln: 2.9 ± 0.462
3.222GlnArg: 3.222 ± 0.508
3.303GlnSer: 3.303 ± 0.532
2.739GlnThr: 2.739 ± 0.531
2.82GlnVal: 2.82 ± 0.538
0.403GlnTrp: 0.403 ± 0.15
1.692GlnTyr: 1.692 ± 0.482
0.0GlnXaa: 0.0 ± 0.0
Arg
4.189ArgAla: 4.189 ± 0.592
0.725ArgCys: 0.725 ± 0.262
4.27ArgAsp: 4.27 ± 0.696
4.27ArgGlu: 4.27 ± 0.762
2.175ArgPhe: 2.175 ± 0.5
3.867ArgGly: 3.867 ± 0.598
0.886ArgHis: 0.886 ± 0.286
4.914ArgIle: 4.914 ± 0.625
4.673ArgLys: 4.673 ± 0.638
5.398ArgLeu: 5.398 ± 0.659
1.853ArgMet: 1.853 ± 0.378
2.981ArgAsn: 2.981 ± 0.414
2.256ArgPro: 2.256 ± 0.5
2.659ArgGln: 2.659 ± 0.425
4.673ArgArg: 4.673 ± 0.84
3.142ArgSer: 3.142 ± 0.501
3.061ArgThr: 3.061 ± 0.457
4.028ArgVal: 4.028 ± 0.572
1.772ArgTrp: 1.772 ± 0.334
2.256ArgTyr: 2.256 ± 0.399
0.0ArgXaa: 0.0 ± 0.0
Ser
5.881SerAla: 5.881 ± 0.607
0.564SerCys: 0.564 ± 0.197
4.35SerAsp: 4.35 ± 0.544
3.384SerGlu: 3.384 ± 0.534
2.417SerPhe: 2.417 ± 0.336
6.606SerGly: 6.606 ± 0.853
0.967SerHis: 0.967 ± 0.265
4.028SerIle: 4.028 ± 0.571
3.303SerLys: 3.303 ± 0.659
5.72SerLeu: 5.72 ± 0.655
1.37SerMet: 1.37 ± 0.311
2.9SerAsn: 2.9 ± 0.487
2.82SerPro: 2.82 ± 0.443
2.659SerGln: 2.659 ± 0.539
4.431SerArg: 4.431 ± 0.658
4.673SerSer: 4.673 ± 1.014
3.625SerThr: 3.625 ± 0.573
5.075SerVal: 5.075 ± 0.98
1.531SerTrp: 1.531 ± 0.319
1.37SerTyr: 1.37 ± 0.314
0.0SerXaa: 0.0 ± 0.0
Thr
6.525ThrAla: 6.525 ± 0.918
0.644ThrCys: 0.644 ± 0.254
3.303ThrAsp: 3.303 ± 0.582
3.384ThrGlu: 3.384 ± 0.44
2.739ThrPhe: 2.739 ± 0.669
5.961ThrGly: 5.961 ± 0.612
0.644ThrHis: 0.644 ± 0.242
3.384ThrIle: 3.384 ± 0.503
2.256ThrLys: 2.256 ± 0.439
4.028ThrLeu: 4.028 ± 0.587
1.208ThrMet: 1.208 ± 0.305
2.497ThrAsn: 2.497 ± 0.4
3.061ThrPro: 3.061 ± 0.608
2.417ThrGln: 2.417 ± 0.4
2.497ThrArg: 2.497 ± 0.396
3.867ThrSer: 3.867 ± 0.533
2.9ThrThr: 2.9 ± 0.447
3.867ThrVal: 3.867 ± 0.382
1.208ThrTrp: 1.208 ± 0.281
1.531ThrTyr: 1.531 ± 0.34
0.0ThrXaa: 0.0 ± 0.0
Val
5.398ValAla: 5.398 ± 0.683
0.564ValCys: 0.564 ± 0.209
3.947ValAsp: 3.947 ± 0.566
3.142ValGlu: 3.142 ± 0.514
2.256ValPhe: 2.256 ± 0.3
4.431ValGly: 4.431 ± 0.839
0.644ValHis: 0.644 ± 0.233
4.511ValIle: 4.511 ± 0.588
4.35ValLys: 4.35 ± 0.637
4.511ValLeu: 4.511 ± 0.613
1.853ValMet: 1.853 ± 0.31
3.303ValAsn: 3.303 ± 0.529
2.336ValPro: 2.336 ± 0.447
1.772ValGln: 1.772 ± 0.324
3.545ValArg: 3.545 ± 0.373
5.317ValSer: 5.317 ± 0.653
3.786ValThr: 3.786 ± 0.411
3.867ValVal: 3.867 ± 0.518
0.967ValTrp: 0.967 ± 0.282
1.853ValTyr: 1.853 ± 0.347
0.0ValXaa: 0.0 ± 0.0
Trp
0.967TrpAla: 0.967 ± 0.274
0.403TrpCys: 0.403 ± 0.189
0.886TrpAsp: 0.886 ± 0.26
0.725TrpGlu: 0.725 ± 0.23
0.564TrpPhe: 0.564 ± 0.229
1.128TrpGly: 1.128 ± 0.313
0.483TrpHis: 0.483 ± 0.183
0.483TrpIle: 0.483 ± 0.175
0.806TrpLys: 0.806 ± 0.259
1.611TrpLeu: 1.611 ± 0.353
0.564TrpMet: 0.564 ± 0.217
0.483TrpAsn: 0.483 ± 0.187
0.483TrpPro: 0.483 ± 0.196
0.725TrpGln: 0.725 ± 0.228
1.531TrpArg: 1.531 ± 0.295
0.886TrpSer: 0.886 ± 0.262
1.208TrpThr: 1.208 ± 0.386
1.37TrpVal: 1.37 ± 0.302
0.322TrpTrp: 0.322 ± 0.157
0.725TrpTyr: 0.725 ± 0.195
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.464TyrAla: 3.464 ± 0.425
0.483TyrCys: 0.483 ± 0.169
1.933TyrAsp: 1.933 ± 0.395
1.289TyrGlu: 1.289 ± 0.288
0.725TyrPhe: 0.725 ± 0.286
2.014TyrGly: 2.014 ± 0.392
0.403TyrHis: 0.403 ± 0.186
2.336TyrIle: 2.336 ± 0.464
1.45TyrLys: 1.45 ± 0.377
1.853TyrLeu: 1.853 ± 0.393
0.403TyrMet: 0.403 ± 0.206
1.37TyrAsn: 1.37 ± 0.318
1.45TyrPro: 1.45 ± 0.378
1.611TyrGln: 1.611 ± 0.336
2.739TyrArg: 2.739 ± 0.455
2.256TyrSer: 2.256 ± 0.482
1.37TyrThr: 1.37 ± 0.366
1.933TyrVal: 1.933 ± 0.393
0.564TyrTrp: 0.564 ± 0.187
0.886TyrTyr: 0.886 ± 0.273
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (12414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski