Amino acid dipepetide frequency for Eggerthella sp. CAG:368

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.077AlaAla: 9.077 ± 0.219
1.59AlaCys: 1.59 ± 0.061
4.686AlaAsp: 4.686 ± 0.11
6.13AlaGlu: 6.13 ± 0.141
3.907AlaPhe: 3.907 ± 0.109
6.621AlaGly: 6.621 ± 0.135
1.901AlaHis: 1.901 ± 0.069
6.014AlaIle: 6.014 ± 0.13
4.889AlaLys: 4.889 ± 0.105
9.955AlaLeu: 9.955 ± 0.195
2.532AlaMet: 2.532 ± 0.082
3.169AlaAsn: 3.169 ± 0.088
2.995AlaPro: 2.995 ± 0.09
3.802AlaGln: 3.802 ± 0.104
4.636AlaArg: 4.636 ± 0.09
5.79AlaSer: 5.79 ± 0.124
4.75AlaThr: 4.75 ± 0.103
6.722AlaVal: 6.722 ± 0.128
0.859AlaTrp: 0.859 ± 0.044
2.675AlaTyr: 2.675 ± 0.073
0.011AlaXaa: 0.011 ± 0.005
Cys
1.503CysAla: 1.503 ± 0.066
0.297CysCys: 0.297 ± 0.03
0.948CysAsp: 0.948 ± 0.046
1.062CysGlu: 1.062 ± 0.051
0.754CysPhe: 0.754 ± 0.04
1.531CysGly: 1.531 ± 0.058
0.308CysHis: 0.308 ± 0.027
0.987CysIle: 0.987 ± 0.053
0.635CysLys: 0.635 ± 0.04
1.321CysLeu: 1.321 ± 0.06
0.366CysMet: 0.366 ± 0.027
0.462CysAsn: 0.462 ± 0.034
0.736CysPro: 0.736 ± 0.044
0.379CysGln: 0.379 ± 0.025
0.596CysArg: 0.596 ± 0.04
1.104CysSer: 1.104 ± 0.047
0.791CysThr: 0.791 ± 0.044
1.247CysVal: 1.247 ± 0.059
0.121CysTrp: 0.121 ± 0.016
0.393CysTyr: 0.393 ± 0.031
0.002CysXaa: 0.002 ± 0.002
Asp
5.44AspAla: 5.44 ± 0.108
0.786AspCys: 0.786 ± 0.044
2.89AspAsp: 2.89 ± 0.088
4.823AspGlu: 4.823 ± 0.1
2.36AspPhe: 2.36 ± 0.083
3.944AspGly: 3.944 ± 0.119
0.95AspHis: 0.95 ± 0.045
3.754AspIle: 3.754 ± 0.104
2.947AspLys: 2.947 ± 0.085
5.198AspLeu: 5.198 ± 0.105
1.435AspMet: 1.435 ± 0.066
1.832AspAsn: 1.832 ± 0.06
2.404AspPro: 2.404 ± 0.078
1.483AspGln: 1.483 ± 0.06
2.461AspArg: 2.461 ± 0.087
3.599AspSer: 3.599 ± 0.082
2.963AspThr: 2.963 ± 0.083
4.311AspVal: 4.311 ± 0.1
0.564AspTrp: 0.564 ± 0.039
2.038AspTyr: 2.038 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
6.95GluAla: 6.95 ± 0.144
0.809GluCys: 0.809 ± 0.045
3.683GluAsp: 3.683 ± 0.088
6.315GluGlu: 6.315 ± 0.139
2.433GluPhe: 2.433 ± 0.084
5.18GluGly: 5.18 ± 0.125
1.419GluHis: 1.419 ± 0.058
4.453GluIle: 4.453 ± 0.103
4.57GluLys: 4.57 ± 0.122
6.452GluLeu: 6.452 ± 0.148
1.91GluMet: 1.91 ± 0.066
2.911GluAsn: 2.911 ± 0.1
2.198GluPro: 2.198 ± 0.073
2.753GluGln: 2.753 ± 0.087
3.761GluArg: 3.761 ± 0.104
3.72GluSer: 3.72 ± 0.098
3.667GluThr: 3.667 ± 0.097
5.271GluVal: 5.271 ± 0.119
0.592GluTrp: 0.592 ± 0.037
2.207GluTyr: 2.207 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
3.786PheAla: 3.786 ± 0.093
0.72PheCys: 0.72 ± 0.038
2.856PheAsp: 2.856 ± 0.08
2.87PheGlu: 2.87 ± 0.085
1.89PhePhe: 1.89 ± 0.075
3.381PheGly: 3.381 ± 0.1
0.697PheHis: 0.697 ± 0.04
2.586PheIle: 2.586 ± 0.086
1.848PheLys: 1.848 ± 0.066
3.619PheLeu: 3.619 ± 0.12
1.035PheMet: 1.035 ± 0.049
1.611PheAsn: 1.611 ± 0.06
1.426PhePro: 1.426 ± 0.06
0.957PheGln: 0.957 ± 0.044
1.46PheArg: 1.46 ± 0.064
3.196PheSer: 3.196 ± 0.1
2.305PheThr: 2.305 ± 0.079
3.267PheVal: 3.267 ± 0.101
0.427PheTrp: 0.427 ± 0.032
1.184PheTyr: 1.184 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
6.429GlyAla: 6.429 ± 0.139
1.414GlyCys: 1.414 ± 0.056
3.63GlyAsp: 3.63 ± 0.092
4.483GlyGlu: 4.483 ± 0.097
3.267GlyPhe: 3.267 ± 0.088
5.305GlyGly: 5.305 ± 0.14
1.401GlyHis: 1.401 ± 0.062
5.627GlyIle: 5.627 ± 0.127
4.266GlyLys: 4.266 ± 0.112
6.585GlyLeu: 6.585 ± 0.14
2.148GlyMet: 2.148 ± 0.071
2.653GlyAsn: 2.653 ± 0.08
1.874GlyPro: 1.874 ± 0.073
2.054GlyGln: 2.054 ± 0.068
3.208GlyArg: 3.208 ± 0.102
4.981GlySer: 4.981 ± 0.122
4.307GlyThr: 4.307 ± 0.121
6.306GlyVal: 6.306 ± 0.131
0.772GlyTrp: 0.772 ± 0.049
2.691GlyTyr: 2.691 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.682HisAla: 1.682 ± 0.06
0.32HisCys: 0.32 ± 0.028
1.152HisAsp: 1.152 ± 0.056
1.316HisGlu: 1.316 ± 0.06
0.829HisPhe: 0.829 ± 0.043
1.403HisGly: 1.403 ± 0.061
0.514HisHis: 0.514 ± 0.035
1.238HisIle: 1.238 ± 0.06
0.795HisLys: 0.795 ± 0.043
1.604HisLeu: 1.604 ± 0.059
0.455HisMet: 0.455 ± 0.033
0.708HisAsn: 0.708 ± 0.039
1.021HisPro: 1.021 ± 0.048
0.489HisGln: 0.489 ± 0.036
0.893HisArg: 0.893 ± 0.044
1.188HisSer: 1.188 ± 0.053
0.944HisThr: 0.944 ± 0.048
1.497HisVal: 1.497 ± 0.064
0.169HisTrp: 0.169 ± 0.019
0.603HisTyr: 0.603 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
6.962IleAla: 6.962 ± 0.137
1.076IleCys: 1.076 ± 0.043
4.334IleAsp: 4.334 ± 0.106
4.839IleGlu: 4.839 ± 0.111
2.187IlePhe: 2.187 ± 0.084
4.718IleGly: 4.718 ± 0.123
1.078IleHis: 1.078 ± 0.051
4.225IleIle: 4.225 ± 0.108
3.256IleLys: 3.256 ± 0.075
5.038IleLeu: 5.038 ± 0.121
1.592IleMet: 1.592 ± 0.056
2.385IleAsn: 2.385 ± 0.078
3.13IlePro: 3.13 ± 0.094
1.846IleGln: 1.846 ± 0.073
2.623IleArg: 2.623 ± 0.09
4.384IleSer: 4.384 ± 0.104
3.729IleThr: 3.729 ± 0.095
5.168IleVal: 5.168 ± 0.123
0.507IleTrp: 0.507 ± 0.032
1.529IleTyr: 1.529 ± 0.062
0.005IleXaa: 0.005 ± 0.003
Lys
5.241LysAla: 5.241 ± 0.118
0.523LysCys: 0.523 ± 0.039
2.968LysAsp: 2.968 ± 0.086
4.841LysGlu: 4.841 ± 0.114
1.364LysPhe: 1.364 ± 0.057
3.793LysGly: 3.793 ± 0.098
0.994LysHis: 0.994 ± 0.047
2.934LysIle: 2.934 ± 0.089
4.181LysLys: 4.181 ± 0.135
4.058LysLeu: 4.058 ± 0.097
1.453LysMet: 1.453 ± 0.058
2.484LysAsn: 2.484 ± 0.077
2.248LysPro: 2.248 ± 0.076
2.059LysGln: 2.059 ± 0.073
3.066LysArg: 3.066 ± 0.081
2.881LysSer: 2.881 ± 0.091
3.555LysThr: 3.555 ± 0.103
3.667LysVal: 3.667 ± 0.099
0.363LysTrp: 0.363 ± 0.025
1.451LysTyr: 1.451 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
8.655LeuAla: 8.655 ± 0.14
1.56LeuCys: 1.56 ± 0.059
5.579LeuAsp: 5.579 ± 0.12
6.144LeuGlu: 6.144 ± 0.137
4.051LeuPhe: 4.051 ± 0.11
6.836LeuGly: 6.836 ± 0.137
1.62LeuHis: 1.62 ± 0.064
5.838LeuIle: 5.838 ± 0.137
4.755LeuLys: 4.755 ± 0.108
8.616LeuLeu: 8.616 ± 0.183
2.401LeuMet: 2.401 ± 0.073
3.311LeuAsn: 3.311 ± 0.102
3.884LeuPro: 3.884 ± 0.1
2.559LeuGln: 2.559 ± 0.07
4.291LeuArg: 4.291 ± 0.106
6.994LeuSer: 6.994 ± 0.147
4.91LeuThr: 4.91 ± 0.119
7.158LeuVal: 7.158 ± 0.133
0.667LeuTrp: 0.667 ± 0.041
2.429LeuTyr: 2.429 ± 0.077
0.002LeuXaa: 0.002 ± 0.002
Met
2.552MetAla: 2.552 ± 0.076
0.375MetCys: 0.375 ± 0.028
1.307MetAsp: 1.307 ± 0.05
1.542MetGlu: 1.542 ± 0.061
0.893MetPhe: 0.893 ± 0.052
2.079MetGly: 2.079 ± 0.073
0.466MetHis: 0.466 ± 0.035
1.529MetIle: 1.529 ± 0.067
1.606MetLys: 1.606 ± 0.062
2.326MetLeu: 2.326 ± 0.073
0.669MetMet: 0.669 ± 0.046
1.241MetAsn: 1.241 ± 0.061
1.177MetPro: 1.177 ± 0.053
0.788MetGln: 0.788 ± 0.041
1.506MetArg: 1.506 ± 0.059
1.741MetSer: 1.741 ± 0.066
1.567MetThr: 1.567 ± 0.057
1.787MetVal: 1.787 ± 0.063
0.19MetTrp: 0.19 ± 0.02
0.576MetTyr: 0.576 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.407AsnAla: 3.407 ± 0.098
0.455AsnCys: 0.455 ± 0.04
2.255AsnAsp: 2.255 ± 0.074
2.534AsnGlu: 2.534 ± 0.067
1.261AsnPhe: 1.261 ± 0.058
2.52AsnGly: 2.52 ± 0.088
0.754AsnHis: 0.754 ± 0.044
2.404AsnIle: 2.404 ± 0.061
2.155AsnLys: 2.155 ± 0.086
3.404AsnLeu: 3.404 ± 0.089
0.941AsnMet: 0.941 ± 0.043
1.547AsnAsn: 1.547 ± 0.068
2.223AsnPro: 2.223 ± 0.076
1.25AsnGln: 1.25 ± 0.058
1.743AsnArg: 1.743 ± 0.065
2.335AsnSer: 2.335 ± 0.078
2.244AsnThr: 2.244 ± 0.071
2.643AsnVal: 2.643 ± 0.088
0.382AsnTrp: 0.382 ± 0.03
1.27AsnTyr: 1.27 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
3.116ProAla: 3.116 ± 0.09
0.624ProCys: 0.624 ± 0.038
2.294ProAsp: 2.294 ± 0.08
3.413ProGlu: 3.413 ± 0.094
1.905ProPhe: 1.905 ± 0.066
2.675ProGly: 2.675 ± 0.09
0.884ProHis: 0.884 ± 0.045
2.271ProIle: 2.271 ± 0.075
1.88ProLys: 1.88 ± 0.069
3.541ProLeu: 3.541 ± 0.095
0.809ProMet: 0.809 ± 0.041
1.446ProAsn: 1.446 ± 0.054
0.877ProPro: 0.877 ± 0.045
1.277ProGln: 1.277 ± 0.056
1.64ProArg: 1.64 ± 0.066
2.769ProSer: 2.769 ± 0.081
2.253ProThr: 2.253 ± 0.072
3.244ProVal: 3.244 ± 0.084
0.368ProTrp: 0.368 ± 0.032
1.327ProTyr: 1.327 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
3.379GlnAla: 3.379 ± 0.105
0.359GlnCys: 0.359 ± 0.031
1.481GlnAsp: 1.481 ± 0.056
2.184GlnGlu: 2.184 ± 0.07
1.049GlnPhe: 1.049 ± 0.047
2.31GlnGly: 2.31 ± 0.076
0.663GlnHis: 0.663 ± 0.036
2.088GlnIle: 2.088 ± 0.07
1.903GlnLys: 1.903 ± 0.076
2.739GlnLeu: 2.739 ± 0.082
0.87GlnMet: 0.87 ± 0.046
1.293GlnAsn: 1.293 ± 0.065
1.136GlnPro: 1.136 ± 0.056
1.202GlnGln: 1.202 ± 0.06
1.693GlnArg: 1.693 ± 0.063
1.874GlnSer: 1.874 ± 0.068
1.944GlnThr: 1.944 ± 0.072
2.324GlnVal: 2.324 ± 0.069
0.308GlnTrp: 0.308 ± 0.028
0.896GlnTyr: 0.896 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
3.98ArgAla: 3.98 ± 0.084
0.733ArgCys: 0.733 ± 0.047
2.326ArgAsp: 2.326 ± 0.072
3.56ArgGlu: 3.56 ± 0.1
2.043ArgPhe: 2.043 ± 0.061
3.057ArgGly: 3.057 ± 0.075
0.873ArgHis: 0.873 ± 0.044
3.441ArgIle: 3.441 ± 0.08
2.893ArgLys: 2.893 ± 0.084
4.259ArgLeu: 4.259 ± 0.111
1.485ArgMet: 1.485 ± 0.064
1.8ArgAsn: 1.8 ± 0.063
1.602ArgPro: 1.602 ± 0.062
1.51ArgGln: 1.51 ± 0.066
2.532ArgArg: 2.532 ± 0.093
2.936ArgSer: 2.936 ± 0.088
2.36ArgThr: 2.36 ± 0.07
3.74ArgVal: 3.74 ± 0.091
0.395ArgTrp: 0.395 ± 0.027
1.691ArgTyr: 1.691 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.582SerAla: 5.582 ± 0.121
0.932SerCys: 0.932 ± 0.046
3.779SerAsp: 3.779 ± 0.101
4.362SerGlu: 4.362 ± 0.099
3.304SerPhe: 3.304 ± 0.092
5.026SerGly: 5.026 ± 0.123
1.19SerHis: 1.19 ± 0.051
4.348SerIle: 4.348 ± 0.103
3.354SerLys: 3.354 ± 0.092
6.626SerLeu: 6.626 ± 0.136
1.659SerMet: 1.659 ± 0.062
2.447SerAsn: 2.447 ± 0.085
2.285SerPro: 2.285 ± 0.066
2.205SerGln: 2.205 ± 0.077
3.196SerArg: 3.196 ± 0.08
5.678SerSer: 5.678 ± 0.154
3.388SerThr: 3.388 ± 0.073
4.99SerVal: 4.99 ± 0.111
0.667SerTrp: 0.667 ± 0.038
2.177SerTyr: 2.177 ± 0.075
0.002SerXaa: 0.002 ± 0.002
Thr
4.581ThrAla: 4.581 ± 0.105
0.891ThrCys: 0.891 ± 0.043
2.952ThrAsp: 2.952 ± 0.092
3.331ThrGlu: 3.331 ± 0.096
2.426ThrPhe: 2.426 ± 0.075
4.334ThrGly: 4.334 ± 0.095
1.03ThrHis: 1.03 ± 0.049
3.733ThrIle: 3.733 ± 0.101
2.81ThrLys: 2.81 ± 0.078
5.456ThrLeu: 5.456 ± 0.122
1.241ThrMet: 1.241 ± 0.058
2.136ThrAsn: 2.136 ± 0.077
2.712ThrPro: 2.712 ± 0.094
1.75ThrGln: 1.75 ± 0.071
2.351ThrArg: 2.351 ± 0.076
3.642ThrSer: 3.642 ± 0.1
3.279ThrThr: 3.279 ± 0.102
4.218ThrVal: 4.218 ± 0.102
0.484ThrTrp: 0.484 ± 0.033
1.748ThrTyr: 1.748 ± 0.081
0.002ThrXaa: 0.002 ± 0.002
Val
7.078ValAla: 7.078 ± 0.163
1.366ValCys: 1.366 ± 0.055
4.629ValAsp: 4.629 ± 0.113
4.748ValGlu: 4.748 ± 0.118
3.505ValPhe: 3.505 ± 0.107
5.547ValGly: 5.547 ± 0.121
1.309ValHis: 1.309 ± 0.056
4.997ValIle: 4.997 ± 0.102
3.571ValLys: 3.571 ± 0.1
7.478ValLeu: 7.478 ± 0.132
1.944ValMet: 1.944 ± 0.08
2.781ValAsn: 2.781 ± 0.079
3.139ValPro: 3.139 ± 0.084
1.953ValGln: 1.953 ± 0.068
3.473ValArg: 3.473 ± 0.082
5.831ValSer: 5.831 ± 0.119
4.081ValThr: 4.081 ± 0.114
6.822ValVal: 6.822 ± 0.145
0.656ValTrp: 0.656 ± 0.039
2.244ValTyr: 2.244 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.786TrpAla: 0.786 ± 0.05
0.167TrpCys: 0.167 ± 0.016
0.466TrpAsp: 0.466 ± 0.034
0.617TrpGlu: 0.617 ± 0.039
0.411TrpPhe: 0.411 ± 0.033
0.695TrpGly: 0.695 ± 0.042
0.139TrpHis: 0.139 ± 0.015
0.592TrpIle: 0.592 ± 0.033
0.457TrpLys: 0.457 ± 0.031
0.946TrpLeu: 0.946 ± 0.049
0.279TrpMet: 0.279 ± 0.026
0.414TrpAsn: 0.414 ± 0.033
0.267TrpPro: 0.267 ± 0.025
0.276TrpGln: 0.276 ± 0.028
0.441TrpArg: 0.441 ± 0.03
0.535TrpSer: 0.535 ± 0.035
0.363TrpThr: 0.363 ± 0.029
0.699TrpVal: 0.699 ± 0.046
0.096TrpTrp: 0.096 ± 0.016
0.242TrpTyr: 0.242 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.522TyrAla: 2.522 ± 0.067
0.541TyrCys: 0.541 ± 0.031
1.967TyrAsp: 1.967 ± 0.064
2.139TyrGlu: 2.139 ± 0.078
1.282TyrPhe: 1.282 ± 0.049
2.442TyrGly: 2.442 ± 0.077
0.624TyrHis: 0.624 ± 0.036
1.551TyrIle: 1.551 ± 0.067
1.355TyrLys: 1.355 ± 0.056
3.036TyrLeu: 3.036 ± 0.086
0.69TyrMet: 0.69 ± 0.042
1.097TyrAsn: 1.097 ± 0.051
1.284TyrPro: 1.284 ± 0.055
1.099TyrGln: 1.099 ± 0.054
1.643TyrArg: 1.643 ± 0.058
2.022TyrSer: 2.022 ± 0.076
1.709TyrThr: 1.709 ± 0.068
2.068TyrVal: 2.068 ± 0.069
0.299TyrTrp: 0.299 ± 0.029
1.033TyrTyr: 1.033 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.003
0.005XaaCys: 0.005 ± 0.003
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.005XaaHis: 0.005 ± 0.003
0.002XaaIle: 0.002 ± 0.002
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.002XaaArg: 0.002 ± 0.002
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.002XaaVal: 0.002 ± 0.002
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.032XaaXaa: 0.032 ± 0.01
Statistics based on 1381 proteins (437682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski