Amino acid dipepetide frequency for Caldanaerobius fijiensis DSM 17918

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.102AlaAla: 5.102 ± 0.098	0.733AlaCys: 0.733 ± 0.035	3.515AlaAsp: 3.515 ± 0.057	4.227AlaGlu: 4.227 ± 0.081	2.781AlaPhe: 2.781 ± 0.074	4.861AlaGly: 4.861 ± 0.09	1.122AlaHis: 1.122 ± 0.037	6.355AlaIle: 6.355 ± 0.109	4.548AlaLys: 4.548 ± 0.071	6.835AlaLeu: 6.835 ± 0.093	2.059AlaMet: 2.059 ± 0.054	2.541AlaAsn: 2.541 ± 0.063	1.727AlaPro: 1.727 ± 0.042	2.112AlaGln: 2.112 ± 0.053	3.397AlaArg: 3.397 ± 0.077	3.395AlaSer: 3.395 ± 0.071	2.958AlaThr: 2.958 ± 0.057	5.577AlaVal: 5.577 ± 0.096	0.537AlaTrp: 0.537 ± 0.027	2.584AlaTyr: 2.584 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.586CysAla: 0.586 ± 0.027	0.139CysCys: 0.139 ± 0.014	0.716CysAsp: 0.716 ± 0.032	0.676CysGlu: 0.676 ± 0.028	0.368CysPhe: 0.368 ± 0.022	1.073CysGly: 1.073 ± 0.044	0.251CysHis: 0.251 ± 0.018	0.874CysIle: 0.874 ± 0.035	0.658CysLys: 0.658 ± 0.031	0.714CysLeu: 0.714 ± 0.029	0.269CysMet: 0.269 ± 0.019	0.428CysAsn: 0.428 ± 0.027	0.563CysPro: 0.563 ± 0.032	0.28CysGln: 0.28 ± 0.019	0.496CysArg: 0.496 ± 0.027	0.645CysSer: 0.645 ± 0.028	0.482CysThr: 0.482 ± 0.024	0.653CysVal: 0.653 ± 0.029	0.098CysTrp: 0.098 ± 0.011	0.422CysTyr: 0.422 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	3.584AspAla: 3.584 ± 0.077	0.551AspCys: 0.551 ± 0.029	3.288AspAsp: 3.288 ± 0.069	4.689AspGlu: 4.689 ± 0.087	2.756AspPhe: 2.756 ± 0.057	3.881AspGly: 3.881 ± 0.079	0.682AspHis: 0.682 ± 0.028	6.717AspIle: 6.717 ± 0.093	4.465AspLys: 4.465 ± 0.085	4.837AspLeu: 4.837 ± 0.077	1.988AspMet: 1.988 ± 0.053	2.555AspAsn: 2.555 ± 0.059	2.057AspPro: 2.057 ± 0.057	1.172AspGln: 1.172 ± 0.039	2.674AspArg: 2.674 ± 0.055	2.643AspSer: 2.643 ± 0.061	2.532AspThr: 2.532 ± 0.054	4.929AspVal: 4.929 ± 0.072	0.549AspTrp: 0.549 ± 0.026	2.693AspTyr: 2.693 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.425GluAla: 4.425 ± 0.081	0.578GluCys: 0.578 ± 0.025	3.903GluAsp: 3.903 ± 0.071	5.262GluGlu: 5.262 ± 0.096	2.447GluPhe: 2.447 ± 0.062	4.241GluGly: 4.241 ± 0.07	1.006GluHis: 1.006 ± 0.034	6.193GluIle: 6.193 ± 0.102	6.368GluLys: 6.368 ± 0.104	6.331GluLeu: 6.331 ± 0.094	2.034GluMet: 2.034 ± 0.046	3.672GluAsn: 3.672 ± 0.073	1.654GluPro: 1.654 ± 0.044	2.05GluGln: 2.05 ± 0.055	3.442GluArg: 3.442 ± 0.063	2.816GluSer: 2.816 ± 0.066	2.435GluThr: 2.435 ± 0.059	4.867GluVal: 4.867 ± 0.089	0.577GluTrp: 0.577 ± 0.027	2.821GluTyr: 2.821 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.502PheAla: 2.502 ± 0.056	0.458PheCys: 0.458 ± 0.025	2.658PheAsp: 2.658 ± 0.064	2.444PheGlu: 2.444 ± 0.057	1.714PhePhe: 1.714 ± 0.054	2.953PheGly: 2.953 ± 0.065	0.557PheHis: 0.557 ± 0.028	3.91PheIle: 3.91 ± 0.08	3.085PheLys: 3.085 ± 0.07	3.568PheLeu: 3.568 ± 0.071	1.176PheMet: 1.176 ± 0.045	2.031PheAsn: 2.031 ± 0.047	1.269PhePro: 1.269 ± 0.043	0.921PheGln: 0.921 ± 0.033	1.494PheArg: 1.494 ± 0.042	2.61PheSer: 2.61 ± 0.055	2.1PheThr: 2.1 ± 0.052	2.746PheVal: 2.746 ± 0.062	0.387PheTrp: 0.387 ± 0.024	1.693PheTyr: 1.693 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.46GlyAla: 4.46 ± 0.101	0.975GlyCys: 0.975 ± 0.039	3.775GlyAsp: 3.775 ± 0.073	4.191GlyGlu: 4.191 ± 0.074	3.131GlyPhe: 3.131 ± 0.063	4.85GlyGly: 4.85 ± 0.111	1.231GlyHis: 1.231 ± 0.041	7.304GlyIle: 7.304 ± 0.105	5.319GlyLys: 5.319 ± 0.089	6.17GlyLeu: 6.17 ± 0.085	2.113GlyMet: 2.113 ± 0.052	3.016GlyAsn: 3.016 ± 0.065	1.968GlyPro: 1.968 ± 0.058	1.951GlyGln: 1.951 ± 0.052	3.099GlyArg: 3.099 ± 0.068	3.66GlySer: 3.66 ± 0.071	3.551GlyThr: 3.551 ± 0.074	5.189GlyVal: 5.189 ± 0.091	0.716GlyTrp: 0.716 ± 0.033	3.498GlyTyr: 3.498 ± 0.066	0.001GlyXaa: 0.001 ± 0.001
His	0.951HisAla: 0.951 ± 0.035	0.207HisCys: 0.207 ± 0.017	0.858HisAsp: 0.858 ± 0.033	0.895HisGlu: 0.895 ± 0.031	0.651HisPhe: 0.651 ± 0.029	1.276HisGly: 1.276 ± 0.032	0.361HisHis: 0.361 ± 0.024	1.496HisIle: 1.496 ± 0.044	0.969HisLys: 0.969 ± 0.035	1.342HisLeu: 1.342 ± 0.038	0.456HisMet: 0.456 ± 0.026	0.674HisAsn: 0.674 ± 0.029	0.893HisPro: 0.893 ± 0.04	0.382HisGln: 0.382 ± 0.025	0.788HisArg: 0.788 ± 0.032	0.768HisSer: 0.768 ± 0.029	0.726HisThr: 0.726 ± 0.032	1.071HisVal: 1.071 ± 0.037	0.19HisTrp: 0.19 ± 0.016	0.646HisTyr: 0.646 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.722IleAla: 6.722 ± 0.106	0.966IleCys: 0.966 ± 0.035	5.916IleAsp: 5.916 ± 0.089	6.016IleGlu: 6.016 ± 0.096	3.471IlePhe: 3.471 ± 0.067	6.277IleGly: 6.277 ± 0.112	1.21IleHis: 1.21 ± 0.042	7.791IleIle: 7.791 ± 0.132	7.739IleLys: 7.739 ± 0.098	7.966IleLeu: 7.966 ± 0.127	2.403IleMet: 2.403 ± 0.057	4.695IleAsn: 4.695 ± 0.083	3.797IlePro: 3.797 ± 0.064	2.211IleGln: 2.211 ± 0.055	3.773IleArg: 3.773 ± 0.068	5.908IleSer: 5.908 ± 0.091	4.395IleThr: 4.395 ± 0.079	6.366IleVal: 6.366 ± 0.108	0.664IleTrp: 0.664 ± 0.027	3.394IleTyr: 3.394 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	5.42LysAla: 5.42 ± 0.085	0.599LysCys: 0.599 ± 0.031	4.859LysAsp: 4.859 ± 0.072	6.279LysGlu: 6.279 ± 0.088	2.267LysPhe: 2.267 ± 0.052	5.25LysGly: 5.25 ± 0.081	1.086LysHis: 1.086 ± 0.037	6.572LysIle: 6.572 ± 0.102	6.515LysLys: 6.515 ± 0.1	6.448LysLeu: 6.448 ± 0.096	2.146LysMet: 2.146 ± 0.056	4.562LysAsn: 4.562 ± 0.085	2.621LysPro: 2.621 ± 0.057	2.027LysGln: 2.027 ± 0.056	3.571LysArg: 3.571 ± 0.064	3.972LysSer: 3.972 ± 0.072	3.355LysThr: 3.355 ± 0.073	5.432LysVal: 5.432 ± 0.082	0.693LysTrp: 0.693 ± 0.032	3.503LysTyr: 3.503 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.902LeuAla: 5.902 ± 0.076	0.947LeuCys: 0.947 ± 0.036	5.187LeuAsp: 5.187 ± 0.08	5.525LeuGlu: 5.525 ± 0.092	3.571LeuPhe: 3.571 ± 0.069	6.035LeuGly: 6.035 ± 0.096	1.342LeuHis: 1.342 ± 0.041	7.62LeuIle: 7.62 ± 0.118	8.44LeuLys: 8.44 ± 0.096	8.398LeuLeu: 8.398 ± 0.127	2.538LeuMet: 2.538 ± 0.053	5.051LeuAsn: 5.051 ± 0.08	3.511LeuPro: 3.511 ± 0.063	2.376LeuGln: 2.376 ± 0.049	3.867LeuArg: 3.867 ± 0.078	6.234LeuSer: 6.234 ± 0.105	4.279LeuThr: 4.279 ± 0.067	5.454LeuVal: 5.454 ± 0.084	0.773LeuTrp: 0.773 ± 0.037	3.634LeuTyr: 3.634 ± 0.088	0.0LeuXaa: 0.0 ± 0.0
Met	2.389MetAla: 2.389 ± 0.064	0.219MetCys: 0.219 ± 0.018	1.684MetAsp: 1.684 ± 0.044	1.827MetGlu: 1.827 ± 0.05	0.937MetPhe: 0.937 ± 0.039	2.231MetGly: 2.231 ± 0.059	0.44MetHis: 0.44 ± 0.024	2.266MetIle: 2.266 ± 0.061	2.135MetLys: 2.135 ± 0.057	2.687MetLeu: 2.687 ± 0.062	0.861MetMet: 0.861 ± 0.033	1.278MetAsn: 1.278 ± 0.04	1.26MetPro: 1.26 ± 0.045	0.703MetGln: 0.703 ± 0.033	1.334MetArg: 1.334 ± 0.039	1.697MetSer: 1.697 ± 0.051	1.339MetThr: 1.339 ± 0.043	2.176MetVal: 2.176 ± 0.056	0.239MetTrp: 0.239 ± 0.018	0.989MetTyr: 0.989 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.165AsnAla: 3.165 ± 0.058	0.516AsnCys: 0.516 ± 0.031	2.454AsnAsp: 2.454 ± 0.06	2.856AsnGlu: 2.856 ± 0.066	1.844AsnPhe: 1.844 ± 0.059	3.527AsnGly: 3.527 ± 0.074	0.665AsnHis: 0.665 ± 0.031	5.015AsnIle: 5.015 ± 0.077	3.601AsnLys: 3.601 ± 0.08	4.099AsnLeu: 4.099 ± 0.071	1.494AsnMet: 1.494 ± 0.039	2.527AsnAsn: 2.527 ± 0.067	2.231AsnPro: 2.231 ± 0.063	1.227AsnGln: 1.227 ± 0.043	2.166AsnArg: 2.166 ± 0.055	2.646AsnSer: 2.646 ± 0.058	2.354AsnThr: 2.354 ± 0.056	3.521AsnVal: 3.521 ± 0.068	0.499AsnTrp: 0.499 ± 0.026	2.049AsnTyr: 2.049 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.155ProAla: 2.155 ± 0.051	0.326ProCys: 0.326 ± 0.02	2.747ProAsp: 2.747 ± 0.061	3.104ProGlu: 3.104 ± 0.063	1.65ProPhe: 1.65 ± 0.044	2.651ProGly: 2.651 ± 0.056	0.691ProHis: 0.691 ± 0.028	2.747ProIle: 2.747 ± 0.067	1.949ProLys: 1.949 ± 0.049	3.222ProLeu: 3.222 ± 0.062	0.888ProMet: 0.888 ± 0.035	1.323ProAsn: 1.323 ± 0.043	1.168ProPro: 1.168 ± 0.037	1.213ProGln: 1.213 ± 0.041	1.302ProArg: 1.302 ± 0.038	1.902ProSer: 1.902 ± 0.045	1.631ProThr: 1.631 ± 0.045	3.132ProVal: 3.132 ± 0.057	0.41ProTrp: 0.41 ± 0.024	1.739ProTyr: 1.739 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.831GlnAla: 1.831 ± 0.055	0.276GlnCys: 0.276 ± 0.019	1.478GlnAsp: 1.478 ± 0.046	1.855GlnGlu: 1.855 ± 0.043	0.983GlnPhe: 0.983 ± 0.033	1.633GlnGly: 1.633 ± 0.043	0.425GlnHis: 0.425 ± 0.026	2.289GlnIle: 2.289 ± 0.063	2.392GlnLys: 2.392 ± 0.058	2.738GlnLeu: 2.738 ± 0.065	0.828GlnMet: 0.828 ± 0.031	1.403GlnAsn: 1.403 ± 0.051	0.963GlnPro: 0.963 ± 0.041	1.014GlnGln: 1.014 ± 0.047	1.433GlnArg: 1.433 ± 0.041	1.333GlnSer: 1.333 ± 0.041	1.038GlnThr: 1.038 ± 0.038	1.803GlnVal: 1.803 ± 0.047	0.361GlnTrp: 0.361 ± 0.024	1.176GlnTyr: 1.176 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.759ArgAla: 2.759 ± 0.061	0.568ArgCys: 0.568 ± 0.031	2.624ArgAsp: 2.624 ± 0.062	3.566ArgGlu: 3.566 ± 0.066	1.988ArgPhe: 1.988 ± 0.049	2.8ArgGly: 2.8 ± 0.061	0.704ArgHis: 0.704 ± 0.033	3.955ArgIle: 3.955 ± 0.072	3.126ArgLys: 3.126 ± 0.056	4.356ArgLeu: 4.356 ± 0.076	1.356ArgMet: 1.356 ± 0.04	2.08ArgAsn: 2.08 ± 0.05	1.511ArgPro: 1.511 ± 0.037	1.375ArgGln: 1.375 ± 0.041	2.234ArgArg: 2.234 ± 0.051	2.183ArgSer: 2.183 ± 0.054	1.877ArgThr: 1.877 ± 0.056	3.04ArgVal: 3.04 ± 0.068	0.47ArgTrp: 0.47 ± 0.025	2.267ArgTyr: 2.267 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	3.493SerAla: 3.493 ± 0.069	0.568SerCys: 0.568 ± 0.031	3.246SerAsp: 3.246 ± 0.067	3.36SerGlu: 3.36 ± 0.061	2.46SerPhe: 2.46 ± 0.06	4.339SerGly: 4.339 ± 0.068	0.934SerHis: 0.934 ± 0.036	5.315SerIle: 5.315 ± 0.091	3.796SerLys: 3.796 ± 0.059	5.171SerLeu: 5.171 ± 0.082	1.581SerMet: 1.581 ± 0.046	2.462SerAsn: 2.462 ± 0.062	2.008SerPro: 2.008 ± 0.05	1.657SerGln: 1.657 ± 0.046	2.529SerArg: 2.529 ± 0.057	3.3SerSer: 3.3 ± 0.074	2.713SerThr: 2.713 ± 0.062	3.796SerVal: 3.796 ± 0.067	0.559SerTrp: 0.559 ± 0.028	2.268SerTyr: 2.268 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.416ThrAla: 3.416 ± 0.069	0.44ThrCys: 0.44 ± 0.025	2.515ThrAsp: 2.515 ± 0.06	2.37ThrGlu: 2.37 ± 0.053	1.9ThrPhe: 1.9 ± 0.058	4.024ThrGly: 4.024 ± 0.085	0.836ThrHis: 0.836 ± 0.032	4.113ThrIle: 4.113 ± 0.076	2.636ThrLys: 2.636 ± 0.055	4.262ThrLeu: 4.262 ± 0.075	1.112ThrMet: 1.112 ± 0.036	1.954ThrAsn: 1.954 ± 0.047	2.137ThrPro: 2.137 ± 0.058	1.292ThrGln: 1.292 ± 0.033	1.891ThrArg: 1.891 ± 0.05	2.743ThrSer: 2.743 ± 0.06	2.355ThrThr: 2.355 ± 0.06	3.636ThrVal: 3.636 ± 0.08	0.38ThrTrp: 0.38 ± 0.023	1.897ThrTyr: 1.897 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.821ValAla: 4.821 ± 0.077	0.798ValCys: 0.798 ± 0.033	4.631ValAsp: 4.631 ± 0.076	4.74ValGlu: 4.74 ± 0.084	3.091ValPhe: 3.091 ± 0.064	4.468ValGly: 4.468 ± 0.078	1.109ValHis: 1.109 ± 0.039	6.475ValIle: 6.475 ± 0.084	5.765ValLys: 5.765 ± 0.088	6.94ValLeu: 6.94 ± 0.1	2.004ValMet: 2.004 ± 0.048	3.416ValAsn: 3.416 ± 0.065	2.643ValPro: 2.643 ± 0.054	1.863ValGln: 1.863 ± 0.055	2.878ValArg: 2.878 ± 0.067	4.267ValSer: 4.267 ± 0.079	3.356ValThr: 3.356 ± 0.07	5.454ValVal: 5.454 ± 0.09	0.562ValTrp: 0.562 ± 0.034	2.984ValTyr: 2.984 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.608TrpAla: 0.608 ± 0.028	0.107TrpCys: 0.107 ± 0.011	0.58TrpAsp: 0.58 ± 0.031	0.569TrpGlu: 0.569 ± 0.029	0.43TrpPhe: 0.43 ± 0.025	0.68TrpGly: 0.68 ± 0.034	0.214TrpHis: 0.214 ± 0.018	0.679TrpIle: 0.679 ± 0.028	0.571TrpLys: 0.571 ± 0.03	0.908TrpLeu: 0.908 ± 0.038	0.252TrpMet: 0.252 ± 0.017	0.538TrpAsn: 0.538 ± 0.031	0.328TrpPro: 0.328 ± 0.02	0.316TrpGln: 0.316 ± 0.019	0.445TrpArg: 0.445 ± 0.026	0.493TrpSer: 0.493 ± 0.029	0.4TrpThr: 0.4 ± 0.026	0.568TrpVal: 0.568 ± 0.024	0.151TrpTrp: 0.151 ± 0.013	0.355TrpTyr: 0.355 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.674TyrAla: 2.674 ± 0.06	0.418TyrCys: 0.418 ± 0.028	2.609TyrAsp: 2.609 ± 0.064	2.67TyrGlu: 2.67 ± 0.064	1.833TyrPhe: 1.833 ± 0.045	3.119TyrGly: 3.119 ± 0.068	0.733TyrHis: 0.733 ± 0.025	3.996TyrIle: 3.996 ± 0.064	3.097TyrLys: 3.097 ± 0.067	3.693TyrLeu: 3.693 ± 0.078	1.132TyrMet: 1.132 ± 0.032	2.25TyrAsn: 2.25 ± 0.055	1.642TyrPro: 1.642 ± 0.048	1.111TyrGln: 1.111 ± 0.042	2.026TyrArg: 2.026 ± 0.049	2.34TyrSer: 2.34 ± 0.057	2.036TyrThr: 2.036 ± 0.051	2.856TyrVal: 2.856 ± 0.058	0.378TyrTrp: 0.378 ± 0.02	1.969TyrTyr: 1.969 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.003

Statistics based on 2707 proteins (825341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---