Amino acid dipepetide frequency for Ciceribacter sp. F8825

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.503AlaAla: 16.503 ± 0.184	0.992AlaCys: 0.992 ± 0.028	6.773AlaAsp: 6.773 ± 0.074	8.117AlaGlu: 8.117 ± 0.076	4.705AlaPhe: 4.705 ± 0.064	10.779AlaGly: 10.779 ± 0.098	2.051AlaHis: 2.051 ± 0.037	6.651AlaIle: 6.651 ± 0.077	4.022AlaLys: 4.022 ± 0.056	12.821AlaLeu: 12.821 ± 0.137	3.402AlaMet: 3.402 ± 0.045	2.79AlaAsn: 2.79 ± 0.047	4.965AlaPro: 4.965 ± 0.083	3.096AlaGln: 3.096 ± 0.056	8.342AlaArg: 8.342 ± 0.082	6.293AlaSer: 6.293 ± 0.085	5.906AlaThr: 5.906 ± 0.061	9.124AlaVal: 9.124 ± 0.081	1.346AlaTrp: 1.346 ± 0.031	2.521AlaTyr: 2.521 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.887CysAla: 0.887 ± 0.027	0.125CysCys: 0.125 ± 0.01	0.533CysAsp: 0.533 ± 0.019	0.469CysGlu: 0.469 ± 0.017	0.327CysPhe: 0.327 ± 0.015	0.967CysGly: 0.967 ± 0.03	0.247CysHis: 0.247 ± 0.013	0.371CysIle: 0.371 ± 0.017	0.192CysLys: 0.192 ± 0.012	0.777CysLeu: 0.777 ± 0.023	0.164CysMet: 0.164 ± 0.01	0.206CysAsn: 0.206 ± 0.011	0.423CysPro: 0.423 ± 0.017	0.21CysGln: 0.21 ± 0.013	0.675CysArg: 0.675 ± 0.022	0.474CysSer: 0.474 ± 0.018	0.406CysThr: 0.406 ± 0.019	0.587CysVal: 0.587 ± 0.018	0.113CysTrp: 0.113 ± 0.01	0.216CysTyr: 0.216 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.466AspAla: 6.466 ± 0.066	0.529AspCys: 0.529 ± 0.019	3.044AspAsp: 3.044 ± 0.051	3.719AspGlu: 3.719 ± 0.053	2.36AspPhe: 2.36 ± 0.04	5.296AspGly: 5.296 ± 0.057	1.263AspHis: 1.263 ± 0.035	3.262AspIle: 3.262 ± 0.049	1.731AspLys: 1.731 ± 0.038	5.832AspLeu: 5.832 ± 0.075	1.393AspMet: 1.393 ± 0.029	1.356AspAsn: 1.356 ± 0.032	3.458AspPro: 3.458 ± 0.047	1.525AspGln: 1.525 ± 0.035	4.298AspArg: 4.298 ± 0.058	2.011AspSer: 2.011 ± 0.035	2.458AspThr: 2.458 ± 0.041	4.174AspVal: 4.174 ± 0.062	0.944AspTrp: 0.944 ± 0.028	1.517AspTyr: 1.517 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.813GluAla: 7.813 ± 0.078	0.387GluCys: 0.387 ± 0.017	2.988GluAsp: 2.988 ± 0.044	3.84GluGlu: 3.84 ± 0.069	1.87GluPhe: 1.87 ± 0.034	4.649GluGly: 4.649 ± 0.065	1.211GluHis: 1.211 ± 0.03	3.951GluIle: 3.951 ± 0.051	2.833GluLys: 2.833 ± 0.053	5.381GluLeu: 5.381 ± 0.058	1.649GluMet: 1.649 ± 0.035	1.863GluAsn: 1.863 ± 0.032	2.745GluPro: 2.745 ± 0.049	2.093GluGln: 2.093 ± 0.051	5.194GluArg: 5.194 ± 0.07	2.535GluSer: 2.535 ± 0.04	3.883GluThr: 3.883 ± 0.058	4.117GluVal: 4.117 ± 0.052	0.713GluTrp: 0.713 ± 0.022	1.064GluTyr: 1.064 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.631PheAla: 4.631 ± 0.061	0.376PheCys: 0.376 ± 0.015	2.693PheAsp: 2.693 ± 0.046	2.369PheGlu: 2.369 ± 0.04	1.617PhePhe: 1.617 ± 0.038	3.817PheGly: 3.817 ± 0.06	0.814PheHis: 0.814 ± 0.024	1.831PheIle: 1.831 ± 0.039	1.017PheLys: 1.017 ± 0.027	3.651PheLeu: 3.651 ± 0.065	0.866PheMet: 0.866 ± 0.023	1.012PheAsn: 1.012 ± 0.027	1.612PhePro: 1.612 ± 0.027	1.006PheGln: 1.006 ± 0.029	2.458PheArg: 2.458 ± 0.042	2.533PheSer: 2.533 ± 0.046	1.976PheThr: 1.976 ± 0.037	3.114PheVal: 3.114 ± 0.04	0.548PheTrp: 0.548 ± 0.022	0.973PheTyr: 0.973 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.766GlyAla: 8.766 ± 0.087	0.853GlyCys: 0.853 ± 0.024	4.496GlyAsp: 4.496 ± 0.052	5.181GlyGlu: 5.181 ± 0.069	3.683GlyPhe: 3.683 ± 0.057	7.011GlyGly: 7.011 ± 0.088	1.939GlyHis: 1.939 ± 0.04	4.899GlyIle: 4.899 ± 0.057	3.543GlyLys: 3.543 ± 0.058	8.731GlyLeu: 8.731 ± 0.085	2.383GlyMet: 2.383 ± 0.042	2.274GlyAsn: 2.274 ± 0.047	3.252GlyPro: 3.252 ± 0.054	2.514GlyGln: 2.514 ± 0.053	6.3GlyArg: 6.3 ± 0.076	4.596GlySer: 4.596 ± 0.062	4.624GlyThr: 4.624 ± 0.061	6.076GlyVal: 6.076 ± 0.057	1.271GlyTrp: 1.271 ± 0.032	2.461GlyTyr: 2.461 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.116HisAla: 2.116 ± 0.043	0.221HisCys: 0.221 ± 0.012	1.221HisAsp: 1.221 ± 0.032	1.073HisGlu: 1.073 ± 0.028	0.925HisPhe: 0.925 ± 0.022	1.913HisGly: 1.913 ± 0.041	0.54HisHis: 0.54 ± 0.024	0.965HisIle: 0.965 ± 0.027	0.512HisLys: 0.512 ± 0.017	2.077HisLeu: 2.077 ± 0.039	0.536HisMet: 0.536 ± 0.022	0.47HisAsn: 0.47 ± 0.017	1.333HisPro: 1.333 ± 0.031	0.561HisGln: 0.561 ± 0.019	1.398HisArg: 1.398 ± 0.033	0.904HisSer: 0.904 ± 0.026	0.802HisThr: 0.802 ± 0.028	1.588HisVal: 1.588 ± 0.033	0.276HisTrp: 0.276 ± 0.013	0.545HisTyr: 0.545 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.645IleAla: 7.645 ± 0.087	0.529IleCys: 0.529 ± 0.018	3.79IleAsp: 3.79 ± 0.059	3.698IleGlu: 3.698 ± 0.058	1.882IlePhe: 1.882 ± 0.039	5.088IleGly: 5.088 ± 0.062	0.929IleHis: 0.929 ± 0.029	2.381IleIle: 2.381 ± 0.052	1.427IleLys: 1.427 ± 0.036	4.715IleLeu: 4.715 ± 0.059	1.035IleMet: 1.035 ± 0.027	1.479IleAsn: 1.479 ± 0.034	2.379IlePro: 2.379 ± 0.04	1.087IleGln: 1.087 ± 0.028	3.587IleArg: 3.587 ± 0.05	3.098IleSer: 3.098 ± 0.048	2.715IleThr: 2.715 ± 0.045	4.462IleVal: 4.462 ± 0.053	0.572IleTrp: 0.572 ± 0.02	1.2IleTyr: 1.2 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.666LysAla: 4.666 ± 0.062	0.178LysCys: 0.178 ± 0.014	1.92LysAsp: 1.92 ± 0.046	1.872LysGlu: 1.872 ± 0.043	0.946LysPhe: 0.946 ± 0.027	2.828LysGly: 2.828 ± 0.045	0.6LysHis: 0.6 ± 0.021	1.922LysIle: 1.922 ± 0.039	1.441LysLys: 1.441 ± 0.039	3.297LysLeu: 3.297 ± 0.046	0.896LysMet: 0.896 ± 0.026	0.986LysAsn: 0.986 ± 0.029	2.072LysPro: 2.072 ± 0.045	0.952LysGln: 0.952 ± 0.023	2.402LysArg: 2.402 ± 0.043	1.931LysSer: 1.931 ± 0.036	2.157LysThr: 2.157 ± 0.043	2.695LysVal: 2.695 ± 0.053	0.395LysTrp: 0.395 ± 0.018	0.677LysTyr: 0.677 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.268LeuAla: 13.268 ± 0.105	0.852LeuCys: 0.852 ± 0.025	5.878LeuAsp: 5.878 ± 0.065	5.386LeuGlu: 5.386 ± 0.063	3.776LeuPhe: 3.776 ± 0.063	8.007LeuGly: 8.007 ± 0.076	1.795LeuHis: 1.795 ± 0.04	4.75LeuIle: 4.75 ± 0.067	3.955LeuLys: 3.955 ± 0.056	9.437LeuLeu: 9.437 ± 0.113	2.409LeuMet: 2.409 ± 0.04	2.518LeuAsn: 2.518 ± 0.04	5.381LeuPro: 5.381 ± 0.064	2.677LeuGln: 2.677 ± 0.046	6.38LeuArg: 6.38 ± 0.078	6.978LeuSer: 6.978 ± 0.102	5.56LeuThr: 5.56 ± 0.072	7.735LeuVal: 7.735 ± 0.083	1.102LeuTrp: 1.102 ± 0.03	2.12LeuTyr: 2.12 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.19MetAla: 3.19 ± 0.054	0.153MetCys: 0.153 ± 0.011	1.134MetAsp: 1.134 ± 0.026	1.278MetGlu: 1.278 ± 0.03	0.677MetPhe: 0.677 ± 0.022	1.731MetGly: 1.731 ± 0.029	0.445MetHis: 0.445 ± 0.017	1.47MetIle: 1.47 ± 0.037	1.131MetLys: 1.131 ± 0.029	2.537MetLeu: 2.537 ± 0.039	0.688MetMet: 0.688 ± 0.023	0.852MetAsn: 0.852 ± 0.025	1.508MetPro: 1.508 ± 0.034	0.864MetGln: 0.864 ± 0.022	1.853MetArg: 1.853 ± 0.036	1.668MetSer: 1.668 ± 0.033	1.991MetThr: 1.991 ± 0.04	1.793MetVal: 1.793 ± 0.037	0.226MetTrp: 0.226 ± 0.012	0.309MetTyr: 0.309 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.05	0.241AsnCys: 0.241 ± 0.013	1.482AsnAsp: 1.482 ± 0.034	1.328AsnGlu: 1.328 ± 0.032	1.001AsnPhe: 1.001 ± 0.028	2.44AsnGly: 2.44 ± 0.051	0.542AsnHis: 0.542 ± 0.019	1.384AsnIle: 1.384 ± 0.03	0.739AsnLys: 0.739 ± 0.021	2.629AsnLeu: 2.629 ± 0.04	0.668AsnMet: 0.668 ± 0.024	0.679AsnAsn: 0.679 ± 0.023	1.784AsnPro: 1.784 ± 0.035	0.735AsnGln: 0.735 ± 0.024	1.916AsnArg: 1.916 ± 0.034	1.237AsnSer: 1.237 ± 0.029	1.303AsnThr: 1.303 ± 0.033	1.961AsnVal: 1.961 ± 0.041	0.42AsnTrp: 0.42 ± 0.016	0.695AsnTyr: 0.695 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.983ProAla: 5.983 ± 0.076	0.318ProCys: 0.318 ± 0.015	3.413ProAsp: 3.413 ± 0.053	3.857ProGlu: 3.857 ± 0.06	1.995ProPhe: 1.995 ± 0.04	4.159ProGly: 4.159 ± 0.057	1.027ProHis: 1.027 ± 0.03	2.168ProIle: 2.168 ± 0.037	1.719ProLys: 1.719 ± 0.039	4.672ProLeu: 4.672 ± 0.067	1.144ProMet: 1.144 ± 0.03	1.229ProAsn: 1.229 ± 0.032	2.305ProPro: 2.305 ± 0.052	1.651ProGln: 1.651 ± 0.032	2.684ProArg: 2.684 ± 0.047	2.74ProSer: 2.74 ± 0.045	2.297ProThr: 2.297 ± 0.036	4.412ProVal: 4.412 ± 0.055	0.597ProTrp: 0.597 ± 0.02	1.197ProTyr: 1.197 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.574GlnAla: 3.574 ± 0.055	0.193GlnCys: 0.193 ± 0.013	1.285GlnAsp: 1.285 ± 0.028	1.558GlnGlu: 1.558 ± 0.037	1.012GlnPhe: 1.012 ± 0.026	2.008GlnGly: 2.008 ± 0.041	0.56GlnHis: 0.56 ± 0.021	1.859GlnIle: 1.859 ± 0.061	1.097GlnLys: 1.097 ± 0.029	2.589GlnLeu: 2.589 ± 0.048	0.893GlnMet: 0.893 ± 0.025	0.787GlnAsn: 0.787 ± 0.022	1.524GlnPro: 1.524 ± 0.034	1.131GlnGln: 1.131 ± 0.031	2.115GlnArg: 2.115 ± 0.04	1.651GlnSer: 1.651 ± 0.034	1.594GlnThr: 1.594 ± 0.03	2.199GlnVal: 2.199 ± 0.054	0.368GlnTrp: 0.368 ± 0.014	0.572GlnTyr: 0.572 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.227ArgAla: 7.227 ± 0.083	0.487ArgCys: 0.487 ± 0.018	3.899ArgAsp: 3.899 ± 0.056	4.355ArgGlu: 4.355 ± 0.064	3.079ArgPhe: 3.079 ± 0.043	4.677ArgGly: 4.677 ± 0.06	1.734ArgHis: 1.734 ± 0.036	4.078ArgIle: 4.078 ± 0.052	2.602ArgLys: 2.602 ± 0.046	7.907ArgLeu: 7.907 ± 0.088	1.941ArgMet: 1.941 ± 0.037	1.963ArgAsn: 1.963 ± 0.037	3.496ArgPro: 3.496 ± 0.055	2.568ArgGln: 2.568 ± 0.041	5.734ArgArg: 5.734 ± 0.074	3.877ArgSer: 3.877 ± 0.048	3.408ArgThr: 3.408 ± 0.051	4.51ArgVal: 4.51 ± 0.062	0.898ArgTrp: 0.898 ± 0.024	1.78ArgTyr: 1.78 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.292SerAla: 6.292 ± 0.069	0.433SerCys: 0.433 ± 0.019	2.947SerAsp: 2.947 ± 0.05	3.115SerGlu: 3.115 ± 0.05	2.38SerPhe: 2.38 ± 0.046	5.744SerGly: 5.744 ± 0.073	1.075SerHis: 1.075 ± 0.026	2.856SerIle: 2.856 ± 0.052	1.679SerLys: 1.679 ± 0.036	5.755SerLeu: 5.755 ± 0.065	1.388SerMet: 1.388 ± 0.029	1.388SerAsn: 1.388 ± 0.03	2.794SerPro: 2.794 ± 0.041	1.557SerGln: 1.557 ± 0.035	3.748SerArg: 3.748 ± 0.058	3.185SerSer: 3.185 ± 0.055	2.731SerThr: 2.731 ± 0.074	4.228SerVal: 4.228 ± 0.055	0.71SerTrp: 0.71 ± 0.022	1.363SerTyr: 1.363 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.351ThrAla: 6.351 ± 0.072	0.462ThrCys: 0.462 ± 0.02	2.871ThrAsp: 2.871 ± 0.05	2.86ThrGlu: 2.86 ± 0.046	2.103ThrPhe: 2.103 ± 0.045	5.222ThrGly: 5.222 ± 0.069	0.998ThrHis: 0.998 ± 0.024	3.121ThrIle: 3.121 ± 0.048	1.519ThrLys: 1.519 ± 0.035	5.546ThrLeu: 5.546 ± 0.06	1.25ThrMet: 1.25 ± 0.028	1.325ThrAsn: 1.325 ± 0.029	2.987ThrPro: 2.987 ± 0.046	1.254ThrGln: 1.254 ± 0.03	3.176ThrArg: 3.176 ± 0.047	2.835ThrSer: 2.835 ± 0.045	2.9ThrThr: 2.9 ± 0.05	4.698ThrVal: 4.698 ± 0.056	0.68ThrTrp: 0.68 ± 0.021	1.208ThrTyr: 1.208 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.238ValAla: 9.238 ± 0.088	0.639ValCys: 0.639 ± 0.023	4.218ValAsp: 4.218 ± 0.046	4.839ValGlu: 4.839 ± 0.058	3.052ValPhe: 3.052 ± 0.046	5.551ValGly: 5.551 ± 0.067	1.412ValHis: 1.412 ± 0.029	4.166ValIle: 4.166 ± 0.049	2.479ValLys: 2.479 ± 0.048	7.698ValLeu: 7.698 ± 0.084	1.983ValMet: 1.983 ± 0.038	1.994ValAsn: 1.994 ± 0.034	3.801ValPro: 3.801 ± 0.05	1.864ValGln: 1.864 ± 0.036	4.991ValArg: 4.991 ± 0.061	4.729ValSer: 4.729 ± 0.062	4.836ValThr: 4.836 ± 0.065	6.261ValVal: 6.261 ± 0.073	0.925ValTrp: 0.925 ± 0.027	1.604ValTyr: 1.604 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.111TrpAla: 1.111 ± 0.03	0.139TrpCys: 0.139 ± 0.009	0.602TrpAsp: 0.602 ± 0.023	0.568TrpGlu: 0.568 ± 0.019	0.552TrpPhe: 0.552 ± 0.02	0.806TrpGly: 0.806 ± 0.023	0.311TrpHis: 0.311 ± 0.014	0.652TrpIle: 0.652 ± 0.023	0.512TrpLys: 0.512 ± 0.019	1.576TrpLeu: 1.576 ± 0.034	0.349TrpMet: 0.349 ± 0.015	0.459TrpAsn: 0.459 ± 0.017	0.641TrpPro: 0.641 ± 0.021	0.529TrpGln: 0.529 ± 0.018	1.046TrpArg: 1.046 ± 0.026	0.827TrpSer: 0.827 ± 0.024	0.71TrpThr: 0.71 ± 0.022	0.756TrpVal: 0.756 ± 0.026	0.218TrpTrp: 0.218 ± 0.012	0.314TrpTyr: 0.314 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.417TyrAla: 2.417 ± 0.041	0.26TyrCys: 0.26 ± 0.013	1.444TyrAsp: 1.444 ± 0.031	1.294TyrGlu: 1.294 ± 0.031	0.975TyrPhe: 0.975 ± 0.03	2.161TyrGly: 2.161 ± 0.04	0.485TyrHis: 0.485 ± 0.016	0.964TyrIle: 0.964 ± 0.026	0.683TyrLys: 0.683 ± 0.021	2.337TyrLeu: 2.337 ± 0.039	0.461TyrMet: 0.461 ± 0.017	0.608TyrAsn: 0.608 ± 0.022	1.11TyrPro: 1.11 ± 0.026	0.695TyrGln: 0.695 ± 0.022	1.922TyrArg: 1.922 ± 0.039	1.267TyrSer: 1.267 ± 0.032	1.11TyrThr: 1.11 ± 0.032	1.792TyrVal: 1.792 ± 0.033	0.355TyrTrp: 0.355 ± 0.016	0.651TyrTyr: 0.651 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4841 proteins (1479523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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