Amino acid dipepetide frequency for Bacteroidaceae bacterium HV4-6-C5C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.017AlaAla: 5.017 ± 0.087	0.916AlaCys: 0.916 ± 0.028	3.831AlaAsp: 3.831 ± 0.06	4.131AlaGlu: 4.131 ± 0.063	3.068AlaPhe: 3.068 ± 0.059	4.794AlaGly: 4.794 ± 0.077	1.157AlaHis: 1.157 ± 0.034	5.026AlaIle: 5.026 ± 0.077	4.334AlaLys: 4.334 ± 0.069	6.467AlaLeu: 6.467 ± 0.086	1.735AlaMet: 1.735 ± 0.041	3.439AlaAsn: 3.439 ± 0.067	2.027AlaPro: 2.027 ± 0.043	2.482AlaGln: 2.482 ± 0.048	2.763AlaArg: 2.763 ± 0.054	4.543AlaSer: 4.543 ± 0.066	3.829AlaThr: 3.829 ± 0.065	4.286AlaVal: 4.286 ± 0.07	0.798AlaTrp: 0.798 ± 0.027	2.967AlaTyr: 2.967 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.668CysAla: 0.668 ± 0.022	0.18CysCys: 0.18 ± 0.015	0.596CysAsp: 0.596 ± 0.023	0.606CysGlu: 0.606 ± 0.024	0.594CysPhe: 0.594 ± 0.026	0.936CysGly: 0.936 ± 0.028	0.251CysHis: 0.251 ± 0.016	0.864CysIle: 0.864 ± 0.028	0.665CysLys: 0.665 ± 0.023	1.028CysLeu: 1.028 ± 0.029	0.297CysMet: 0.297 ± 0.016	0.569CysAsn: 0.569 ± 0.02	0.478CysPro: 0.478 ± 0.027	0.331CysGln: 0.331 ± 0.018	0.542CysArg: 0.542 ± 0.021	0.759CysSer: 0.759 ± 0.026	0.616CysThr: 0.616 ± 0.023	0.67CysVal: 0.67 ± 0.028	0.129CysTrp: 0.129 ± 0.011	0.514CysTyr: 0.514 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.791AspAla: 3.791 ± 0.063	0.574AspCys: 0.574 ± 0.023	2.613AspAsp: 2.613 ± 0.052	3.629AspGlu: 3.629 ± 0.064	3.044AspPhe: 3.044 ± 0.049	3.996AspGly: 3.996 ± 0.065	0.925AspHis: 0.925 ± 0.032	4.381AspIle: 4.381 ± 0.066	4.197AspLys: 4.197 ± 0.065	4.832AspLeu: 4.832 ± 0.067	1.514AspMet: 1.514 ± 0.032	2.899AspAsn: 2.899 ± 0.061	1.939AspPro: 1.939 ± 0.041	1.424AspGln: 1.424 ± 0.038	2.435AspArg: 2.435 ± 0.051	3.228AspSer: 3.228 ± 0.058	2.633AspThr: 2.633 ± 0.055	3.407AspVal: 3.407 ± 0.061	0.898AspTrp: 0.898 ± 0.032	2.852AspTyr: 2.852 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.353GluAla: 4.353 ± 0.074	0.606GluCys: 0.606 ± 0.023	3.025GluAsp: 3.025 ± 0.06	4.431GluGlu: 4.431 ± 0.081	2.33GluPhe: 2.33 ± 0.046	3.852GluGly: 3.852 ± 0.061	1.205GluHis: 1.205 ± 0.038	4.548GluIle: 4.548 ± 0.069	5.04GluLys: 5.04 ± 0.078	5.832GluLeu: 5.832 ± 0.086	1.791GluMet: 1.791 ± 0.043	3.621GluAsn: 3.621 ± 0.053	1.589GluPro: 1.589 ± 0.037	2.294GluGln: 2.294 ± 0.05	2.93GluArg: 2.93 ± 0.058	3.395GluSer: 3.395 ± 0.054	2.976GluThr: 2.976 ± 0.052	3.992GluVal: 3.992 ± 0.058	0.821GluTrp: 0.821 ± 0.027	2.676GluTyr: 2.676 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.948PheAla: 2.948 ± 0.052	0.606PheCys: 0.606 ± 0.023	2.73PheAsp: 2.73 ± 0.05	2.416PheGlu: 2.416 ± 0.047	2.26PhePhe: 2.26 ± 0.051	3.31PheGly: 3.31 ± 0.061	0.884PheHis: 0.884 ± 0.028	3.467PheIle: 3.467 ± 0.06	2.636PheLys: 2.636 ± 0.056	4.027PheLeu: 4.027 ± 0.072	1.178PheMet: 1.178 ± 0.031	2.578PheAsn: 2.578 ± 0.049	1.741PhePro: 1.741 ± 0.038	1.28PheGln: 1.28 ± 0.034	2.005PheArg: 2.005 ± 0.043	3.7PheSer: 3.7 ± 0.061	2.705PheThr: 2.705 ± 0.056	2.78PheVal: 2.78 ± 0.057	0.572PheTrp: 0.572 ± 0.024	2.08PheTyr: 2.08 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.277GlyAla: 4.277 ± 0.071	0.829GlyCys: 0.829 ± 0.03	3.518GlyAsp: 3.518 ± 0.057	3.935GlyGlu: 3.935 ± 0.062	3.194GlyPhe: 3.194 ± 0.052	4.787GlyGly: 4.787 ± 0.086	1.238GlyHis: 1.238 ± 0.035	5.558GlyIle: 5.558 ± 0.063	5.367GlyLys: 5.367 ± 0.076	5.917GlyLeu: 5.917 ± 0.08	2.077GlyMet: 2.077 ± 0.049	3.804GlyAsn: 3.804 ± 0.069	1.244GlyPro: 1.244 ± 0.032	2.021GlyGln: 2.021 ± 0.047	2.809GlyArg: 2.809 ± 0.058	4.289GlySer: 4.289 ± 0.073	4.128GlyThr: 4.128 ± 0.077	4.828GlyVal: 4.828 ± 0.064	1.053GlyTrp: 1.053 ± 0.033	3.588GlyTyr: 3.588 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.156HisAla: 1.156 ± 0.036	0.264HisCys: 0.264 ± 0.018	0.941HisAsp: 0.941 ± 0.027	0.988HisGlu: 0.988 ± 0.028	1.073HisPhe: 1.073 ± 0.031	1.174HisGly: 1.174 ± 0.032	0.459HisHis: 0.459 ± 0.023	1.467HisIle: 1.467 ± 0.038	1.031HisLys: 1.031 ± 0.028	1.856HisLeu: 1.856 ± 0.046	0.337HisMet: 0.337 ± 0.017	0.938HisAsn: 0.938 ± 0.028	1.061HisPro: 1.061 ± 0.034	0.619HisGln: 0.619 ± 0.022	0.815HisArg: 0.815 ± 0.029	1.265HisSer: 1.265 ± 0.033	0.982HisThr: 0.982 ± 0.024	0.953HisVal: 0.953 ± 0.027	0.258HisTrp: 0.258 ± 0.015	0.942HisTyr: 0.942 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.42IleAla: 5.42 ± 0.074	0.939IleCys: 0.939 ± 0.03	4.347IleAsp: 4.347 ± 0.063	4.514IleGlu: 4.514 ± 0.07	2.949IlePhe: 2.949 ± 0.062	4.99IleGly: 4.99 ± 0.08	1.482IleHis: 1.482 ± 0.037	5.146IleIle: 5.146 ± 0.081	4.722IleLys: 4.722 ± 0.065	6.509IleLeu: 6.509 ± 0.081	1.541IleMet: 1.541 ± 0.038	3.977IleAsn: 3.977 ± 0.063	3.362IlePro: 3.362 ± 0.057	2.273IleGln: 2.273 ± 0.053	3.422IleArg: 3.422 ± 0.061	5.319IleSer: 5.319 ± 0.073	4.235IleThr: 4.235 ± 0.067	4.372IleVal: 4.372 ± 0.074	0.817IleTrp: 0.817 ± 0.029	3.058IleTyr: 3.058 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.908LysAla: 4.908 ± 0.081	0.528LysCys: 0.528 ± 0.021	4.317LysAsp: 4.317 ± 0.058	5.567LysGlu: 5.567 ± 0.085	2.182LysPhe: 2.182 ± 0.046	4.877LysGly: 4.877 ± 0.075	1.28LysHis: 1.28 ± 0.036	4.681LysIle: 4.681 ± 0.068	5.404LysLys: 5.404 ± 0.084	5.641LysLeu: 5.641 ± 0.071	2.157LysMet: 2.157 ± 0.047	3.864LysAsn: 3.864 ± 0.064	2.087LysPro: 2.087 ± 0.048	2.644LysGln: 2.644 ± 0.055	3.172LysArg: 3.172 ± 0.055	3.931LysSer: 3.931 ± 0.058	3.702LysThr: 3.702 ± 0.064	4.41LysVal: 4.41 ± 0.062	0.805LysTrp: 0.805 ± 0.027	3.175LysTyr: 3.175 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	5.991LeuAla: 5.991 ± 0.085	1.203LeuCys: 1.203 ± 0.036	4.672LeuAsp: 4.672 ± 0.065	4.882LeuGlu: 4.882 ± 0.08	4.706LeuPhe: 4.706 ± 0.071	5.594LeuGly: 5.594 ± 0.088	1.743LeuHis: 1.743 ± 0.036	6.131LeuIle: 6.131 ± 0.083	6.837LeuLys: 6.837 ± 0.078	9.117LeuLeu: 9.117 ± 0.143	2.365LeuMet: 2.365 ± 0.047	5.177LeuAsn: 5.177 ± 0.07	3.975LeuPro: 3.975 ± 0.062	3.266LeuGln: 3.266 ± 0.056	4.039LeuArg: 4.039 ± 0.063	7.162LeuSer: 7.162 ± 0.088	5.079LeuThr: 5.079 ± 0.082	4.965LeuVal: 4.965 ± 0.072	1.052LeuTrp: 1.052 ± 0.035	3.846LeuTyr: 3.846 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.805MetAla: 1.805 ± 0.041	0.196MetCys: 0.196 ± 0.014	1.483MetAsp: 1.483 ± 0.038	1.647MetGlu: 1.647 ± 0.039	0.962MetPhe: 0.962 ± 0.034	1.802MetGly: 1.802 ± 0.04	0.455MetHis: 0.455 ± 0.017	1.666MetIle: 1.666 ± 0.044	2.462MetLys: 2.462 ± 0.042	2.358MetLeu: 2.358 ± 0.05	0.7MetMet: 0.7 ± 0.026	1.587MetAsn: 1.587 ± 0.037	1.161MetPro: 1.161 ± 0.031	1.0MetGln: 1.0 ± 0.027	1.22MetArg: 1.22 ± 0.03	1.535MetSer: 1.535 ± 0.037	1.381MetThr: 1.381 ± 0.037	1.485MetVal: 1.485 ± 0.036	0.236MetTrp: 0.236 ± 0.013	0.832MetTyr: 0.832 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.683AsnAla: 3.683 ± 0.063	0.503AsnCys: 0.503 ± 0.024	2.844AsnAsp: 2.844 ± 0.053	3.275AsnGlu: 3.275 ± 0.057	2.373AsnPhe: 2.373 ± 0.043	4.234AsnGly: 4.234 ± 0.07	0.99AsnHis: 0.99 ± 0.031	4.478AsnIle: 4.478 ± 0.072	3.709AsnLys: 3.709 ± 0.06	4.661AsnLeu: 4.661 ± 0.069	1.351AsnMet: 1.351 ± 0.038	3.083AsnAsn: 3.083 ± 0.063	2.634AsnPro: 2.634 ± 0.047	1.742AsnGln: 1.742 ± 0.042	2.424AsnArg: 2.424 ± 0.041	3.392AsnSer: 3.392 ± 0.068	3.073AsnThr: 3.073 ± 0.059	3.26AsnVal: 3.26 ± 0.062	0.732AsnTrp: 0.732 ± 0.026	2.67AsnTyr: 2.67 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.518ProAla: 2.518 ± 0.048	0.338ProCys: 0.338 ± 0.015	2.509ProAsp: 2.509 ± 0.051	2.921ProGlu: 2.921 ± 0.051	1.8ProPhe: 1.8 ± 0.038	2.363ProGly: 2.363 ± 0.047	0.705ProHis: 0.705 ± 0.025	2.443ProIle: 2.443 ± 0.05	2.037ProLys: 2.037 ± 0.038	3.299ProLeu: 3.299 ± 0.059	0.873ProMet: 0.873 ± 0.027	1.874ProAsn: 1.874 ± 0.044	0.775ProPro: 0.775 ± 0.024	1.378ProGln: 1.378 ± 0.035	1.232ProArg: 1.232 ± 0.037	2.347ProSer: 2.347 ± 0.05	1.982ProThr: 1.982 ± 0.045	2.803ProVal: 2.803 ± 0.056	0.469ProTrp: 0.469 ± 0.02	1.781ProTyr: 1.781 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.292GlnAla: 2.292 ± 0.039	0.275GlnCys: 0.275 ± 0.016	1.611GlnAsp: 1.611 ± 0.037	2.052GlnGlu: 2.052 ± 0.045	1.306GlnPhe: 1.306 ± 0.032	1.947GlnGly: 1.947 ± 0.037	0.629GlnHis: 0.629 ± 0.028	2.438GlnIle: 2.438 ± 0.047	2.487GlnLys: 2.487 ± 0.046	3.37GlnLeu: 3.37 ± 0.062	0.963GlnMet: 0.963 ± 0.03	1.924GlnAsn: 1.924 ± 0.045	1.141GlnPro: 1.141 ± 0.027	1.493GlnGln: 1.493 ± 0.041	1.598GlnArg: 1.598 ± 0.043	2.098GlnSer: 2.098 ± 0.045	1.976GlnThr: 1.976 ± 0.046	2.051GlnVal: 2.051 ± 0.042	0.489GlnTrp: 0.489 ± 0.021	1.511GlnTyr: 1.511 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.541ArgAla: 2.541 ± 0.057	0.418ArgCys: 0.418 ± 0.02	2.153ArgAsp: 2.153 ± 0.044	2.728ArgGlu: 2.728 ± 0.055	2.14ArgPhe: 2.14 ± 0.046	2.368ArgGly: 2.368 ± 0.049	0.833ArgHis: 0.833 ± 0.026	3.614ArgIle: 3.614 ± 0.056	3.325ArgLys: 3.325 ± 0.061	4.324ArgLeu: 4.324 ± 0.067	1.374ArgMet: 1.374 ± 0.036	2.49ArgAsn: 2.49 ± 0.047	1.466ArgPro: 1.466 ± 0.043	1.632ArgGln: 1.632 ± 0.041	1.99ArgArg: 1.99 ± 0.05	2.56ArgSer: 2.56 ± 0.05	2.282ArgThr: 2.282 ± 0.043	2.563ArgVal: 2.563 ± 0.05	0.669ArgTrp: 0.669 ± 0.024	2.128ArgTyr: 2.128 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.339SerAla: 4.339 ± 0.07	0.825SerCys: 0.825 ± 0.026	3.608SerAsp: 3.608 ± 0.056	3.658SerGlu: 3.658 ± 0.055	3.662SerPhe: 3.662 ± 0.057	4.974SerGly: 4.974 ± 0.069	1.148SerHis: 1.148 ± 0.034	5.07SerIle: 5.07 ± 0.073	3.864SerLys: 3.864 ± 0.055	6.441SerLeu: 6.441 ± 0.083	1.523SerMet: 1.523 ± 0.038	3.269SerAsn: 3.269 ± 0.06	2.489SerPro: 2.489 ± 0.048	2.01SerGln: 2.01 ± 0.047	2.704SerArg: 2.704 ± 0.049	4.702SerSer: 4.702 ± 0.083	3.64SerThr: 3.64 ± 0.056	4.322SerVal: 4.322 ± 0.061	0.912SerTrp: 0.912 ± 0.036	3.121SerTyr: 3.121 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.793ThrAla: 3.793 ± 0.068	0.519ThrCys: 0.519 ± 0.022	3.396ThrAsp: 3.396 ± 0.054	3.087ThrGlu: 3.087 ± 0.054	2.682ThrPhe: 2.682 ± 0.054	4.38ThrGly: 4.38 ± 0.071	1.031ThrHis: 1.031 ± 0.031	3.955ThrIle: 3.955 ± 0.062	3.094ThrLys: 3.094 ± 0.051	5.325ThrLeu: 5.325 ± 0.072	1.116ThrMet: 1.116 ± 0.031	2.805ThrAsn: 2.805 ± 0.05	2.686ThrPro: 2.686 ± 0.045	1.833ThrGln: 1.833 ± 0.044	2.06ThrArg: 2.06 ± 0.043	3.583ThrSer: 3.583 ± 0.066	3.117ThrThr: 3.117 ± 0.07	3.622ThrVal: 3.622 ± 0.061	0.657ThrTrp: 0.657 ± 0.024	2.537ThrTyr: 2.537 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.336ValAla: 4.336 ± 0.069	0.874ValCys: 0.874 ± 0.029	3.641ValAsp: 3.641 ± 0.064	3.759ValGlu: 3.759 ± 0.064	2.809ValPhe: 2.809 ± 0.053	4.004ValGly: 4.004 ± 0.062	1.026ValHis: 1.026 ± 0.029	4.5ValIle: 4.5 ± 0.073	4.237ValLys: 4.237 ± 0.06	5.514ValLeu: 5.514 ± 0.077	1.577ValMet: 1.577 ± 0.035	3.475ValAsn: 3.475 ± 0.063	2.336ValPro: 2.336 ± 0.054	1.822ValGln: 1.822 ± 0.038	2.72ValArg: 2.72 ± 0.053	4.537ValSer: 4.537 ± 0.063	3.512ValThr: 3.512 ± 0.066	4.087ValVal: 4.087 ± 0.074	0.687ValTrp: 0.687 ± 0.024	2.697ValTyr: 2.697 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.764TrpAla: 0.764 ± 0.025	0.167TrpCys: 0.167 ± 0.013	0.739TrpAsp: 0.739 ± 0.027	0.751TrpGlu: 0.751 ± 0.03	0.563TrpPhe: 0.563 ± 0.02	1.015TrpGly: 1.015 ± 0.034	0.262TrpHis: 0.262 ± 0.015	0.865TrpIle: 0.865 ± 0.028	0.93TrpLys: 0.93 ± 0.031	1.137TrpLeu: 1.137 ± 0.037	0.425TrpMet: 0.425 ± 0.018	0.93TrpAsn: 0.93 ± 0.029	0.299TrpPro: 0.299 ± 0.018	0.488TrpGln: 0.488 ± 0.025	0.565TrpArg: 0.565 ± 0.022	0.767TrpSer: 0.767 ± 0.03	0.701TrpThr: 0.701 ± 0.028	0.78TrpVal: 0.78 ± 0.026	0.189TrpTrp: 0.189 ± 0.012	0.528TrpTyr: 0.528 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.011TyrAla: 3.011 ± 0.052	0.532TyrCys: 0.532 ± 0.02	2.639TyrAsp: 2.639 ± 0.055	2.33TyrGlu: 2.33 ± 0.05	2.209TyrPhe: 2.209 ± 0.039	3.065TyrGly: 3.065 ± 0.062	0.879TyrHis: 0.879 ± 0.029	3.094TyrIle: 3.094 ± 0.061	2.95TyrLys: 2.95 ± 0.049	4.148TyrLeu: 4.148 ± 0.064	1.079TyrMet: 1.079 ± 0.029	2.807TyrAsn: 2.807 ± 0.059	1.957TyrPro: 1.957 ± 0.047	1.618TyrGln: 1.618 ± 0.042	2.151TyrArg: 2.151 ± 0.048	3.167TyrSer: 3.167 ± 0.056	2.732TyrThr: 2.732 ± 0.048	2.513TyrVal: 2.513 ± 0.049	0.622TyrTrp: 0.622 ± 0.022	2.251TyrTyr: 2.251 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2881 proteins (1119731 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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