Amino acid dipepetide frequency for Kroppenstedtia pulmonis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.788AlaAla: 5.788 ± 0.089	0.663AlaCys: 0.663 ± 0.027	3.539AlaAsp: 3.539 ± 0.071	4.728AlaGlu: 4.728 ± 0.086	3.03AlaPhe: 3.03 ± 0.071	6.091AlaGly: 6.091 ± 0.098	1.467AlaHis: 1.467 ± 0.036	4.538AlaIle: 4.538 ± 0.082	3.714AlaLys: 3.714 ± 0.064	7.625AlaLeu: 7.625 ± 0.102	1.956AlaMet: 1.956 ± 0.05	1.948AlaAsn: 1.948 ± 0.047	2.199AlaPro: 2.199 ± 0.056	2.565AlaGln: 2.565 ± 0.059	3.65AlaArg: 3.65 ± 0.061	3.94AlaSer: 3.94 ± 0.058	3.339AlaThr: 3.339 ± 0.059	6.163AlaVal: 6.163 ± 0.104	0.867AlaTrp: 0.867 ± 0.031	2.21AlaTyr: 2.21 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.447CysAla: 0.447 ± 0.026	0.119CysCys: 0.119 ± 0.013	0.438CysAsp: 0.438 ± 0.022	0.383CysGlu: 0.383 ± 0.021	0.398CysPhe: 0.398 ± 0.022	0.771CysGly: 0.771 ± 0.031	0.247CysHis: 0.247 ± 0.017	0.507CysIle: 0.507 ± 0.023	0.325CysLys: 0.325 ± 0.02	0.837CysLeu: 0.837 ± 0.029	0.214CysMet: 0.214 ± 0.015	0.26CysAsn: 0.26 ± 0.017	0.417CysPro: 0.417 ± 0.023	0.345CysGln: 0.345 ± 0.021	0.559CysArg: 0.559 ± 0.026	0.572CysSer: 0.572 ± 0.027	0.411CysThr: 0.411 ± 0.02	0.449CysVal: 0.449 ± 0.028	0.121CysTrp: 0.121 ± 0.011	0.292CysTyr: 0.292 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.156AspAla: 3.156 ± 0.065	0.423AspCys: 0.423 ± 0.021	2.227AspAsp: 2.227 ± 0.058	3.73AspGlu: 3.73 ± 0.075	1.93AspPhe: 1.93 ± 0.051	3.41AspGly: 3.41 ± 0.06	1.417AspHis: 1.417 ± 0.039	3.218AspIle: 3.218 ± 0.06	2.415AspLys: 2.415 ± 0.058	5.58AspLeu: 5.58 ± 0.083	1.378AspMet: 1.378 ± 0.035	1.328AspAsn: 1.328 ± 0.043	2.795AspPro: 2.795 ± 0.061	2.711AspGln: 2.711 ± 0.057	3.349AspArg: 3.349 ± 0.064	2.77AspSer: 2.77 ± 0.059	2.484AspThr: 2.484 ± 0.049	3.586AspVal: 3.586 ± 0.068	0.934AspTrp: 0.934 ± 0.036	1.709AspTyr: 1.709 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.464GluAla: 5.464 ± 0.086	0.432GluCys: 0.432 ± 0.021	3.443GluAsp: 3.443 ± 0.063	7.408GluGlu: 7.408 ± 0.134	1.795GluPhe: 1.795 ± 0.046	5.114GluGly: 5.114 ± 0.081	1.372GluHis: 1.372 ± 0.04	4.511GluIle: 4.511 ± 0.075	6.019GluLys: 6.019 ± 0.097	6.421GluLeu: 6.421 ± 0.098	2.215GluMet: 2.215 ± 0.05	2.417GluAsn: 2.417 ± 0.046	2.322GluPro: 2.322 ± 0.054	3.597GluGln: 3.597 ± 0.067	4.212GluArg: 4.212 ± 0.088	3.637GluSer: 3.637 ± 0.068	3.671GluThr: 3.671 ± 0.068	5.322GluVal: 5.322 ± 0.089	1.102GluTrp: 1.102 ± 0.037	1.886GluTyr: 1.886 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	2.665PheAla: 2.665 ± 0.061	0.38PheCys: 0.38 ± 0.02	2.014PheAsp: 2.014 ± 0.051	1.994PheGlu: 1.994 ± 0.045	2.069PhePhe: 2.069 ± 0.061	3.024PheGly: 3.024 ± 0.069	1.097PheHis: 1.097 ± 0.039	2.653PheIle: 2.653 ± 0.078	1.492PheLys: 1.492 ± 0.046	4.383PheLeu: 4.383 ± 0.088	0.969PheMet: 0.969 ± 0.038	1.197PheAsn: 1.197 ± 0.036	1.834PhePro: 1.834 ± 0.047	1.771PheGln: 1.771 ± 0.046	2.199PheArg: 2.199 ± 0.051	2.839PheSer: 2.839 ± 0.056	2.204PheThr: 2.204 ± 0.053	2.641PheVal: 2.641 ± 0.054	0.544PheTrp: 0.544 ± 0.026	1.375PheTyr: 1.375 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.114GlyAla: 5.114 ± 0.092	0.785GlyCys: 0.785 ± 0.028	3.597GlyAsp: 3.597 ± 0.069	5.359GlyGlu: 5.359 ± 0.086	3.188GlyPhe: 3.188 ± 0.071	5.715GlyGly: 5.715 ± 0.103	1.567GlyHis: 1.567 ± 0.045	5.93GlyIle: 5.93 ± 0.095	5.291GlyLys: 5.291 ± 0.088	7.638GlyLeu: 7.638 ± 0.107	2.559GlyMet: 2.559 ± 0.063	2.469GlyAsn: 2.469 ± 0.054	2.182GlyPro: 2.182 ± 0.051	2.476GlyGln: 2.476 ± 0.056	3.853GlyArg: 3.853 ± 0.081	4.433GlySer: 4.433 ± 0.074	4.152GlyThr: 4.152 ± 0.074	6.029GlyVal: 6.029 ± 0.086	1.277GlyTrp: 1.277 ± 0.04	2.794GlyTyr: 2.794 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.392HisAla: 1.392 ± 0.038	0.227HisCys: 0.227 ± 0.015	1.044HisAsp: 1.044 ± 0.035	1.224HisGlu: 1.224 ± 0.038	1.092HisPhe: 1.092 ± 0.036	1.557HisGly: 1.557 ± 0.047	0.871HisHis: 0.871 ± 0.035	1.445HisIle: 1.445 ± 0.038	0.883HisLys: 0.883 ± 0.028	2.686HisLeu: 2.686 ± 0.062	0.606HisMet: 0.606 ± 0.026	0.64HisAsn: 0.64 ± 0.027	1.629HisPro: 1.629 ± 0.047	1.239HisGln: 1.239 ± 0.04	1.555HisArg: 1.555 ± 0.043	1.248HisSer: 1.248 ± 0.037	1.192HisThr: 1.192 ± 0.039	1.598HisVal: 1.598 ± 0.045	0.333HisTrp: 0.333 ± 0.021	0.924HisTyr: 0.924 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.076IleAla: 5.076 ± 0.076	0.619IleCys: 0.619 ± 0.021	2.932IleAsp: 2.932 ± 0.059	3.416IleGlu: 3.416 ± 0.067	2.269IlePhe: 2.269 ± 0.06	5.221IleGly: 5.221 ± 0.084	1.89IleHis: 1.89 ± 0.049	3.664IleIle: 3.664 ± 0.072	2.787IleLys: 2.787 ± 0.059	6.986IleLeu: 6.986 ± 0.119	1.434IleMet: 1.434 ± 0.045	2.009IleAsn: 2.009 ± 0.054	3.516IlePro: 3.516 ± 0.06	3.44IleGln: 3.44 ± 0.064	4.716IleArg: 4.716 ± 0.065	4.172IleSer: 4.172 ± 0.071	3.554IleThr: 3.554 ± 0.06	4.256IleVal: 4.256 ± 0.086	0.764IleTrp: 0.764 ± 0.029	1.914IleTyr: 1.914 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.079LysAla: 4.079 ± 0.068	0.266LysCys: 0.266 ± 0.015	2.983LysAsp: 2.983 ± 0.062	5.945LysGlu: 5.945 ± 0.087	1.05LysPhe: 1.05 ± 0.038	4.848LysGly: 4.848 ± 0.076	1.043LysHis: 1.043 ± 0.038	3.042LysIle: 3.042 ± 0.058	4.834LysLys: 4.834 ± 0.097	4.498LysLeu: 4.498 ± 0.07	1.777LysMet: 1.777 ± 0.049	2.13LysAsn: 2.13 ± 0.051	2.358LysPro: 2.358 ± 0.053	2.782LysGln: 2.782 ± 0.06	3.541LysArg: 3.541 ± 0.062	2.889LysSer: 2.889 ± 0.052	2.941LysThr: 2.941 ± 0.054	4.424LysVal: 4.424 ± 0.084	0.932LysTrp: 0.932 ± 0.032	1.345LysTyr: 1.345 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	7.788LeuAla: 7.788 ± 0.092	0.873LeuCys: 0.873 ± 0.031	5.446LeuAsp: 5.446 ± 0.077	6.914LeuGlu: 6.914 ± 0.106	4.88LeuPhe: 4.88 ± 0.092	7.174LeuGly: 7.174 ± 0.109	2.245LeuHis: 2.245 ± 0.058	6.739LeuIle: 6.739 ± 0.103	6.056LeuLys: 6.056 ± 0.081	11.013LeuLeu: 11.013 ± 0.15	2.53LeuMet: 2.53 ± 0.058	3.474LeuAsn: 3.474 ± 0.055	4.801LeuPro: 4.801 ± 0.084	4.109LeuGln: 4.109 ± 0.075	5.161LeuArg: 5.161 ± 0.08	7.267LeuSer: 7.267 ± 0.1	5.711LeuThr: 5.711 ± 0.08	6.899LeuVal: 6.899 ± 0.097	1.246LeuTrp: 1.246 ± 0.039	3.069LeuTyr: 3.069 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.338MetAla: 2.338 ± 0.054	0.161MetCys: 0.161 ± 0.012	1.778MetAsp: 1.778 ± 0.047	2.399MetGlu: 2.399 ± 0.049	0.819MetPhe: 0.819 ± 0.029	2.326MetGly: 2.326 ± 0.053	0.407MetHis: 0.407 ± 0.022	1.959MetIle: 1.959 ± 0.052	2.239MetLys: 2.239 ± 0.052	2.398MetLeu: 2.398 ± 0.056	1.005MetMet: 1.005 ± 0.038	1.186MetAsn: 1.186 ± 0.035	1.073MetPro: 1.073 ± 0.033	0.796MetGln: 0.796 ± 0.028	1.293MetArg: 1.293 ± 0.039	1.508MetSer: 1.508 ± 0.044	1.63MetThr: 1.63 ± 0.042	2.172MetVal: 2.172 ± 0.056	0.243MetTrp: 0.243 ± 0.016	0.606MetTyr: 0.606 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	1.912AsnAla: 1.912 ± 0.048	0.231AsnCys: 0.231 ± 0.016	1.393AsnAsp: 1.393 ± 0.037	1.876AsnGlu: 1.876 ± 0.055	0.988AsnPhe: 0.988 ± 0.033	2.361AsnGly: 2.361 ± 0.058	0.944AsnHis: 0.944 ± 0.03	2.067AsnIle: 2.067 ± 0.04	1.71AsnLys: 1.71 ± 0.049	3.263AsnLeu: 3.263 ± 0.062	0.876AsnMet: 0.876 ± 0.03	1.023AsnAsn: 1.023 ± 0.034	2.147AsnPro: 2.147 ± 0.05	1.864AsnGln: 1.864 ± 0.046	2.748AsnArg: 2.748 ± 0.054	1.538AsnSer: 1.538 ± 0.041	1.503AsnThr: 1.503 ± 0.043	1.974AsnVal: 1.974 ± 0.05	0.489AsnTrp: 0.489 ± 0.024	0.879AsnTyr: 0.879 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	2.695ProAla: 2.695 ± 0.051	0.318ProCys: 0.318 ± 0.019	3.004ProAsp: 3.004 ± 0.064	3.723ProGlu: 3.723 ± 0.074	2.031ProPhe: 2.031 ± 0.055	3.401ProGly: 3.401 ± 0.056	1.075ProHis: 1.075 ± 0.04	2.521ProIle: 2.521 ± 0.055	2.095ProLys: 2.095 ± 0.047	4.433ProLeu: 4.433 ± 0.08	1.039ProMet: 1.039 ± 0.036	1.21ProAsn: 1.21 ± 0.038	1.577ProPro: 1.577 ± 0.044	1.591ProGln: 1.591 ± 0.039	1.928ProArg: 1.928 ± 0.05	2.677ProSer: 2.677 ± 0.055	2.001ProThr: 2.001 ± 0.048	3.868ProVal: 3.868 ± 0.066	0.608ProTrp: 0.608 ± 0.029	1.434ProTyr: 1.434 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.401GlnAla: 3.401 ± 0.063	0.266GlnCys: 0.266 ± 0.017	1.999GlnAsp: 1.999 ± 0.051	3.563GlnGlu: 3.563 ± 0.081	1.366GlnPhe: 1.366 ± 0.033	3.413GlnGly: 3.413 ± 0.063	0.887GlnHis: 0.887 ± 0.033	2.564GlnIle: 2.564 ± 0.058	2.581GlnLys: 2.581 ± 0.06	4.235GlnLeu: 4.235 ± 0.08	1.311GlnMet: 1.311 ± 0.038	1.276GlnAsn: 1.276 ± 0.04	1.782GlnPro: 1.782 ± 0.047	2.045GlnGln: 2.045 ± 0.056	2.389GlnArg: 2.389 ± 0.058	2.418GlnSer: 2.418 ± 0.049	2.18GlnThr: 2.18 ± 0.048	3.712GlnVal: 3.712 ± 0.065	0.642GlnTrp: 0.642 ± 0.025	1.218GlnTyr: 1.218 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.772ArgAla: 2.772 ± 0.056	0.433ArgCys: 0.433 ± 0.022	2.917ArgAsp: 2.917 ± 0.054	4.678ArgGlu: 4.678 ± 0.088	2.535ArgPhe: 2.535 ± 0.053	3.468ArgGly: 3.468 ± 0.057	1.391ArgHis: 1.391 ± 0.045	4.189ArgIle: 4.189 ± 0.07	3.836ArgLys: 3.836 ± 0.066	6.325ArgLeu: 6.325 ± 0.102	1.894ArgMet: 1.894 ± 0.043	2.109ArgAsn: 2.109 ± 0.052	2.018ArgPro: 2.018 ± 0.045	2.697ArgGln: 2.697 ± 0.062	3.562ArgArg: 3.562 ± 0.074	3.265ArgSer: 3.265 ± 0.059	2.497ArgThr: 2.497 ± 0.055	3.79ArgVal: 3.79 ± 0.073	0.882ArgTrp: 0.882 ± 0.034	2.243ArgTyr: 2.243 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.626SerAla: 3.626 ± 0.069	0.467SerCys: 0.467 ± 0.024	2.896SerAsp: 2.896 ± 0.071	3.485SerGlu: 3.485 ± 0.063	3.014SerPhe: 3.014 ± 0.062	4.9SerGly: 4.9 ± 0.069	1.45SerHis: 1.45 ± 0.044	3.762SerIle: 3.762 ± 0.071	2.784SerLys: 2.784 ± 0.057	6.899SerLeu: 6.899 ± 0.106	1.717SerMet: 1.717 ± 0.045	1.726SerAsn: 1.726 ± 0.044	2.721SerPro: 2.721 ± 0.057	2.411SerGln: 2.411 ± 0.052	3.438SerArg: 3.438 ± 0.066	3.75SerSer: 3.75 ± 0.075	2.852SerThr: 2.852 ± 0.057	4.401SerVal: 4.401 ± 0.064	0.865SerTrp: 0.865 ± 0.033	1.819SerTyr: 1.819 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.02ThrAla: 4.02 ± 0.072	0.432ThrCys: 0.432 ± 0.021	2.604ThrAsp: 2.604 ± 0.06	3.313ThrGlu: 3.313 ± 0.067	2.073ThrPhe: 2.073 ± 0.046	4.882ThrGly: 4.882 ± 0.067	1.183ThrHis: 1.183 ± 0.034	3.25ThrIle: 3.25 ± 0.063	2.24ThrLys: 2.24 ± 0.049	5.529ThrLeu: 5.529 ± 0.086	1.322ThrMet: 1.322 ± 0.042	1.509ThrAsn: 1.509 ± 0.041	2.677ThrPro: 2.677 ± 0.051	1.767ThrGln: 1.767 ± 0.045	2.612ThrArg: 2.612 ± 0.056	2.912ThrSer: 2.912 ± 0.059	2.554ThrThr: 2.554 ± 0.059	4.363ThrVal: 4.363 ± 0.079	0.656ThrTrp: 0.656 ± 0.028	1.638ThrTyr: 1.638 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.61ValAla: 5.61 ± 0.101	0.643ValCys: 0.643 ± 0.03	4.046ValAsp: 4.046 ± 0.07	5.396ValGlu: 5.396 ± 0.084	2.825ValPhe: 2.825 ± 0.064	5.295ValGly: 5.295 ± 0.081	1.649ValHis: 1.649 ± 0.045	5.15ValIle: 5.15 ± 0.094	4.094ValLys: 4.094 ± 0.075	7.525ValLeu: 7.525 ± 0.094	2.185ValMet: 2.185 ± 0.056	2.354ValAsn: 2.354 ± 0.052	3.158ValPro: 3.158 ± 0.065	2.883ValGln: 2.883 ± 0.057	3.785ValArg: 3.785 ± 0.074	4.666ValSer: 4.666 ± 0.074	4.335ValThr: 4.335 ± 0.078	5.488ValVal: 5.488 ± 0.091	0.927ValTrp: 0.927 ± 0.032	2.209ValTyr: 2.209 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.033	0.096TrpCys: 0.096 ± 0.012	0.644TrpAsp: 0.644 ± 0.026	0.975TrpGlu: 0.975 ± 0.034	0.624TrpPhe: 0.624 ± 0.029	0.989TrpGly: 0.989 ± 0.039	0.229TrpHis: 0.229 ± 0.017	1.153TrpIle: 1.153 ± 0.036	0.989TrpLys: 0.989 ± 0.034	1.634TrpLeu: 1.634 ± 0.047	0.588TrpMet: 0.588 ± 0.026	0.594TrpAsn: 0.594 ± 0.023	0.368TrpPro: 0.368 ± 0.02	0.481TrpGln: 0.481 ± 0.024	0.703TrpArg: 0.703 ± 0.03	0.855TrpSer: 0.855 ± 0.031	0.694TrpThr: 0.694 ± 0.03	1.108TrpVal: 1.108 ± 0.041	0.239TrpTrp: 0.239 ± 0.016	0.396TrpTyr: 0.396 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.911TyrAla: 1.911 ± 0.048	0.281TyrCys: 0.281 ± 0.021	1.603TyrAsp: 1.603 ± 0.043	1.853TyrGlu: 1.853 ± 0.045	1.37TyrPhe: 1.37 ± 0.041	2.447TyrGly: 2.447 ± 0.047	0.954TyrHis: 0.954 ± 0.032	1.775TyrIle: 1.775 ± 0.05	1.321TyrLys: 1.321 ± 0.04	3.491TyrLeu: 3.491 ± 0.063	0.759TyrMet: 0.759 ± 0.031	0.925TyrAsn: 0.925 ± 0.039	1.655TyrPro: 1.655 ± 0.043	1.678TyrGln: 1.678 ± 0.049	2.245TyrArg: 2.245 ± 0.051	1.625TyrSer: 1.625 ± 0.051	1.632TyrThr: 1.632 ± 0.04	1.98TyrVal: 1.98 ± 0.049	0.454TyrTrp: 0.454 ± 0.026	1.155TyrTyr: 1.155 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3096 proteins (918854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---