Amino acid dipepetide frequency for Escherichia phage P1 (Bacteriophage P1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.209AlaAla: 9.209 ± 0.85
0.711AlaCys: 0.711 ± 0.181
5.867AlaAsp: 5.867 ± 0.53
6.436AlaGlu: 6.436 ± 0.555
3.698AlaPhe: 3.698 ± 0.44
6.044AlaGly: 6.044 ± 0.521
1.244AlaHis: 1.244 ± 0.288
6.08AlaIle: 6.08 ± 0.478
5.227AlaLys: 5.227 ± 0.506
8.853AlaLeu: 8.853 ± 0.687
2.24AlaMet: 2.24 ± 0.228
3.947AlaAsn: 3.947 ± 0.392
2.987AlaPro: 2.987 ± 0.349
4.16AlaGln: 4.16 ± 0.374
6.08AlaArg: 6.08 ± 0.592
5.404AlaSer: 5.404 ± 0.509
5.44AlaThr: 5.44 ± 0.418
5.476AlaVal: 5.476 ± 0.467
1.102AlaTrp: 1.102 ± 0.229
2.489AlaTyr: 2.489 ± 0.299
0.0AlaXaa: 0.0 ± 0.0
Cys
0.747CysAla: 0.747 ± 0.158
0.32CysCys: 0.32 ± 0.116
0.604CysAsp: 0.604 ± 0.177
0.533CysGlu: 0.533 ± 0.142
0.462CysPhe: 0.462 ± 0.129
0.889CysGly: 0.889 ± 0.181
0.356CysHis: 0.356 ± 0.124
0.569CysIle: 0.569 ± 0.16
0.533CysLys: 0.533 ± 0.14
0.604CysLeu: 0.604 ± 0.173
0.142CysMet: 0.142 ± 0.074
0.284CysAsn: 0.284 ± 0.108
0.391CysPro: 0.391 ± 0.122
0.462CysGln: 0.462 ± 0.169
1.173CysArg: 1.173 ± 0.221
0.96CysSer: 0.96 ± 0.25
0.533CysThr: 0.533 ± 0.131
0.676CysVal: 0.676 ± 0.151
0.249CysTrp: 0.249 ± 0.102
0.533CysTyr: 0.533 ± 0.151
0.0CysXaa: 0.0 ± 0.0
Asp
5.689AspAla: 5.689 ± 0.512
0.569AspCys: 0.569 ± 0.158
4.124AspAsp: 4.124 ± 0.531
4.16AspGlu: 4.16 ± 0.511
2.347AspPhe: 2.347 ± 0.276
4.978AspGly: 4.978 ± 0.361
1.031AspHis: 1.031 ± 0.274
3.52AspIle: 3.52 ± 0.366
2.951AspLys: 2.951 ± 0.315
4.516AspLeu: 4.516 ± 0.476
2.347AspMet: 2.347 ± 0.319
2.702AspAsn: 2.702 ± 0.432
2.204AspPro: 2.204 ± 0.293
1.849AspGln: 1.849 ± 0.285
2.844AspArg: 2.844 ± 0.354
4.764AspSer: 4.764 ± 0.427
3.378AspThr: 3.378 ± 0.471
4.089AspVal: 4.089 ± 0.407
0.924AspTrp: 0.924 ± 0.188
1.956AspTyr: 1.956 ± 0.252
0.0AspXaa: 0.0 ± 0.0
Glu
5.653GluAla: 5.653 ± 0.563
0.498GluCys: 0.498 ± 0.118
3.52GluAsp: 3.52 ± 0.345
4.444GluGlu: 4.444 ± 0.424
3.022GluPhe: 3.022 ± 0.367
3.662GluGly: 3.662 ± 0.393
1.493GluHis: 1.493 ± 0.223
4.302GluIle: 4.302 ± 0.38
4.267GluLys: 4.267 ± 0.515
7.111GluLeu: 7.111 ± 0.477
2.382GluMet: 2.382 ± 0.302
2.773GluAsn: 2.773 ± 0.333
1.92GluPro: 1.92 ± 0.345
3.342GluGln: 3.342 ± 0.411
4.267GluArg: 4.267 ± 0.458
3.627GluSer: 3.627 ± 0.439
2.916GluThr: 2.916 ± 0.287
4.267GluVal: 4.267 ± 0.351
0.853GluTrp: 0.853 ± 0.167
2.062GluTyr: 2.062 ± 0.281
0.0GluXaa: 0.0 ± 0.0
Phe
2.524PheAla: 2.524 ± 0.301
0.462PheCys: 0.462 ± 0.133
2.667PheAsp: 2.667 ± 0.257
2.204PheGlu: 2.204 ± 0.228
1.6PhePhe: 1.6 ± 0.227
2.098PheGly: 2.098 ± 0.299
0.569PheHis: 0.569 ± 0.173
2.88PheIle: 2.88 ± 0.379
2.062PheLys: 2.062 ± 0.305
2.524PheLeu: 2.524 ± 0.285
0.996PheMet: 0.996 ± 0.177
2.382PheAsn: 2.382 ± 0.291
1.458PhePro: 1.458 ± 0.267
1.316PheGln: 1.316 ± 0.224
1.884PheArg: 1.884 ± 0.231
3.022PheSer: 3.022 ± 0.393
2.133PheThr: 2.133 ± 0.344
2.418PheVal: 2.418 ± 0.247
0.427PheTrp: 0.427 ± 0.128
1.102PheTyr: 1.102 ± 0.233
0.0PheXaa: 0.0 ± 0.0
Gly
5.049GlyAla: 5.049 ± 0.531
0.818GlyCys: 0.818 ± 0.232
4.444GlyAsp: 4.444 ± 0.486
4.231GlyGlu: 4.231 ± 0.331
2.56GlyPhe: 2.56 ± 0.245
4.729GlyGly: 4.729 ± 0.538
1.031GlyHis: 1.031 ± 0.188
4.16GlyIle: 4.16 ± 0.373
5.049GlyLys: 5.049 ± 0.45
4.8GlyLeu: 4.8 ± 0.4
1.991GlyMet: 1.991 ± 0.263
3.2GlyAsn: 3.2 ± 0.441
1.102GlyPro: 1.102 ± 0.215
2.133GlyGln: 2.133 ± 0.286
4.124GlyArg: 4.124 ± 0.489
3.484GlySer: 3.484 ± 0.386
4.018GlyThr: 4.018 ± 0.51
4.871GlyVal: 4.871 ± 0.43
1.031GlyTrp: 1.031 ± 0.183
2.133GlyTyr: 2.133 ± 0.316
0.0GlyXaa: 0.0 ± 0.0
His
1.458HisAla: 1.458 ± 0.255
0.249HisCys: 0.249 ± 0.098
0.889HisAsp: 0.889 ± 0.216
0.96HisGlu: 0.96 ± 0.168
0.711HisPhe: 0.711 ± 0.172
1.316HisGly: 1.316 ± 0.204
0.498HisHis: 0.498 ± 0.137
0.853HisIle: 0.853 ± 0.206
0.853HisLys: 0.853 ± 0.192
1.636HisLeu: 1.636 ± 0.229
0.249HisMet: 0.249 ± 0.104
0.996HisAsn: 0.996 ± 0.239
0.818HisPro: 0.818 ± 0.157
0.996HisGln: 0.996 ± 0.141
1.387HisArg: 1.387 ± 0.224
1.244HisSer: 1.244 ± 0.222
0.818HisThr: 0.818 ± 0.137
1.138HisVal: 1.138 ± 0.214
0.178HisTrp: 0.178 ± 0.069
0.676HisTyr: 0.676 ± 0.175
0.0HisXaa: 0.0 ± 0.0
Ile
6.08IleAla: 6.08 ± 0.506
0.818IleCys: 0.818 ± 0.167
3.947IleAsp: 3.947 ± 0.405
4.587IleGlu: 4.587 ± 0.46
1.813IlePhe: 1.813 ± 0.198
3.698IleGly: 3.698 ± 0.392
0.996IleHis: 0.996 ± 0.276
3.236IleIle: 3.236 ± 0.378
3.342IleLys: 3.342 ± 0.496
4.409IleLeu: 4.409 ± 0.435
1.102IleMet: 1.102 ± 0.171
3.662IleAsn: 3.662 ± 0.484
2.738IlePro: 2.738 ± 0.249
2.204IleGln: 2.204 ± 0.289
3.449IleArg: 3.449 ± 0.336
4.942IleSer: 4.942 ± 0.396
4.231IleThr: 4.231 ± 0.328
2.88IleVal: 2.88 ± 0.291
0.427IleTrp: 0.427 ± 0.129
1.778IleTyr: 1.778 ± 0.227
0.0IleXaa: 0.0 ± 0.0
Lys
6.471LysAla: 6.471 ± 0.6
0.356LysCys: 0.356 ± 0.125
3.129LysAsp: 3.129 ± 0.383
4.658LysGlu: 4.658 ± 0.406
2.027LysPhe: 2.027 ± 0.372
3.449LysGly: 3.449 ± 0.362
1.102LysHis: 1.102 ± 0.186
3.413LysIle: 3.413 ± 0.451
4.196LysLys: 4.196 ± 0.526
5.013LysLeu: 5.013 ± 0.469
1.529LysMet: 1.529 ± 0.239
3.022LysAsn: 3.022 ± 0.399
2.24LysPro: 2.24 ± 0.275
2.56LysGln: 2.56 ± 0.306
2.56LysArg: 2.56 ± 0.312
4.48LysSer: 4.48 ± 0.516
3.911LysThr: 3.911 ± 0.392
3.2LysVal: 3.2 ± 0.381
0.924LysTrp: 0.924 ± 0.176
2.098LysTyr: 2.098 ± 0.293
0.0LysXaa: 0.0 ± 0.0
Leu
8.356LeuAla: 8.356 ± 0.58
1.316LeuCys: 1.316 ± 0.293
5.262LeuAsp: 5.262 ± 0.398
6.044LeuGlu: 6.044 ± 0.544
2.809LeuPhe: 2.809 ± 0.244
4.516LeuGly: 4.516 ± 0.453
1.636LeuHis: 1.636 ± 0.231
3.911LeuIle: 3.911 ± 0.42
6.222LeuLys: 6.222 ± 0.488
6.969LeuLeu: 6.969 ± 0.581
2.56LeuMet: 2.56 ± 0.318
4.302LeuAsn: 4.302 ± 0.356
4.196LeuPro: 4.196 ± 0.44
3.271LeuGln: 3.271 ± 0.32
5.476LeuArg: 5.476 ± 0.45
6.72LeuSer: 6.72 ± 0.43
5.262LeuThr: 5.262 ± 0.468
5.333LeuVal: 5.333 ± 0.424
0.782LeuTrp: 0.782 ± 0.156
2.204LeuTyr: 2.204 ± 0.221
0.0LeuXaa: 0.0 ± 0.0
Met
2.951MetAla: 2.951 ± 0.329
0.427MetCys: 0.427 ± 0.123
1.387MetAsp: 1.387 ± 0.267
1.173MetGlu: 1.173 ± 0.194
0.924MetPhe: 0.924 ± 0.158
1.671MetGly: 1.671 ± 0.201
0.356MetHis: 0.356 ± 0.133
1.671MetIle: 1.671 ± 0.263
1.422MetLys: 1.422 ± 0.217
2.596MetLeu: 2.596 ± 0.271
0.64MetMet: 0.64 ± 0.139
1.493MetAsn: 1.493 ± 0.226
1.173MetPro: 1.173 ± 0.177
1.209MetGln: 1.209 ± 0.228
2.062MetArg: 2.062 ± 0.25
1.813MetSer: 1.813 ± 0.254
1.564MetThr: 1.564 ± 0.269
1.173MetVal: 1.173 ± 0.223
0.178MetTrp: 0.178 ± 0.095
0.391MetTyr: 0.391 ± 0.125
0.0MetXaa: 0.0 ± 0.0
Asn
4.587AsnAla: 4.587 ± 0.474
0.284AsnCys: 0.284 ± 0.092
2.276AsnAsp: 2.276 ± 0.37
3.342AsnGlu: 3.342 ± 0.381
1.138AsnPhe: 1.138 ± 0.23
4.124AsnGly: 4.124 ± 0.476
0.818AsnHis: 0.818 ± 0.152
3.307AsnIle: 3.307 ± 0.356
3.164AsnLys: 3.164 ± 0.28
3.733AsnLeu: 3.733 ± 0.386
0.64AsnMet: 0.64 ± 0.13
2.276AsnAsn: 2.276 ± 0.308
2.133AsnPro: 2.133 ± 0.333
1.813AsnGln: 1.813 ± 0.239
2.311AsnArg: 2.311 ± 0.342
3.342AsnSer: 3.342 ± 0.343
2.596AsnThr: 2.596 ± 0.349
2.951AsnVal: 2.951 ± 0.337
0.64AsnTrp: 0.64 ± 0.159
1.6AsnTyr: 1.6 ± 0.263
0.0AsnXaa: 0.0 ± 0.0
Pro
3.484ProAla: 3.484 ± 0.357
0.391ProCys: 0.391 ± 0.157
2.844ProAsp: 2.844 ± 0.366
3.769ProGlu: 3.769 ± 0.357
1.6ProPhe: 1.6 ± 0.255
2.631ProGly: 2.631 ± 0.327
0.64ProHis: 0.64 ± 0.167
1.742ProIle: 1.742 ± 0.23
1.884ProLys: 1.884 ± 0.259
3.022ProLeu: 3.022 ± 0.332
0.427ProMet: 0.427 ± 0.117
1.6ProAsn: 1.6 ± 0.256
1.636ProPro: 1.636 ± 0.246
1.209ProGln: 1.209 ± 0.196
1.707ProArg: 1.707 ± 0.293
2.667ProSer: 2.667 ± 0.289
2.382ProThr: 2.382 ± 0.224
3.342ProVal: 3.342 ± 0.314
0.391ProTrp: 0.391 ± 0.096
1.458ProTyr: 1.458 ± 0.267
0.0ProXaa: 0.0 ± 0.0
Gln
3.484GlnAla: 3.484 ± 0.341
0.391GlnCys: 0.391 ± 0.132
1.849GlnAsp: 1.849 ± 0.218
2.667GlnGlu: 2.667 ± 0.286
1.28GlnPhe: 1.28 ± 0.258
1.458GlnGly: 1.458 ± 0.203
1.138GlnHis: 1.138 ± 0.203
2.276GlnIle: 2.276 ± 0.272
2.702GlnLys: 2.702 ± 0.323
4.089GlnLeu: 4.089 ± 0.413
1.422GlnMet: 1.422 ± 0.224
1.884GlnAsn: 1.884 ± 0.249
1.422GlnPro: 1.422 ± 0.221
2.631GlnGln: 2.631 ± 0.358
2.773GlnArg: 2.773 ± 0.307
2.276GlnSer: 2.276 ± 0.253
1.884GlnThr: 1.884 ± 0.237
2.204GlnVal: 2.204 ± 0.302
0.604GlnTrp: 0.604 ± 0.142
1.813GlnTyr: 1.813 ± 0.225
0.0GlnXaa: 0.0 ± 0.0
Arg
5.511ArgAla: 5.511 ± 0.431
0.569ArgCys: 0.569 ± 0.152
3.271ArgAsp: 3.271 ± 0.312
3.733ArgGlu: 3.733 ± 0.318
2.204ArgPhe: 2.204 ± 0.236
3.058ArgGly: 3.058 ± 0.343
1.067ArgHis: 1.067 ± 0.217
4.018ArgIle: 4.018 ± 0.374
4.409ArgLys: 4.409 ± 0.469
6.08ArgLeu: 6.08 ± 0.481
1.778ArgMet: 1.778 ± 0.258
2.524ArgAsn: 2.524 ± 0.265
2.24ArgPro: 2.24 ± 0.235
2.062ArgGln: 2.062 ± 0.283
4.8ArgArg: 4.8 ± 0.581
2.987ArgSer: 2.987 ± 0.32
3.058ArgThr: 3.058 ± 0.359
3.307ArgVal: 3.307 ± 0.302
0.996ArgTrp: 0.996 ± 0.211
2.098ArgTyr: 2.098 ± 0.179
0.0ArgXaa: 0.0 ± 0.0
Ser
6.044SerAla: 6.044 ± 0.434
0.96SerCys: 0.96 ± 0.21
4.516SerAsp: 4.516 ± 0.429
3.52SerGlu: 3.52 ± 0.35
2.382SerPhe: 2.382 ± 0.377
6.116SerGly: 6.116 ± 0.523
0.996SerHis: 0.996 ± 0.148
4.373SerIle: 4.373 ± 0.302
3.698SerLys: 3.698 ± 0.603
6.258SerLeu: 6.258 ± 0.499
1.813SerMet: 1.813 ± 0.271
2.809SerAsn: 2.809 ± 0.297
2.347SerPro: 2.347 ± 0.267
2.667SerGln: 2.667 ± 0.3
3.52SerArg: 3.52 ± 0.327
3.947SerSer: 3.947 ± 0.439
3.556SerThr: 3.556 ± 0.344
4.587SerVal: 4.587 ± 0.378
0.711SerTrp: 0.711 ± 0.17
1.778SerTyr: 1.778 ± 0.294
0.0SerXaa: 0.0 ± 0.0
Thr
6.329ThrAla: 6.329 ± 0.705
0.356ThrCys: 0.356 ± 0.114
3.556ThrAsp: 3.556 ± 0.355
3.2ThrGlu: 3.2 ± 0.292
2.027ThrPhe: 2.027 ± 0.309
4.338ThrGly: 4.338 ± 0.457
1.031ThrHis: 1.031 ± 0.173
3.591ThrIle: 3.591 ± 0.357
2.88ThrLys: 2.88 ± 0.349
5.44ThrLeu: 5.44 ± 0.423
1.316ThrMet: 1.316 ± 0.252
1.778ThrAsn: 1.778 ± 0.294
3.556ThrPro: 3.556 ± 0.377
2.204ThrGln: 2.204 ± 0.28
2.844ThrArg: 2.844 ± 0.335
3.591ThrSer: 3.591 ± 0.46
3.058ThrThr: 3.058 ± 0.396
3.484ThrVal: 3.484 ± 0.361
0.604ThrTrp: 0.604 ± 0.126
1.991ThrTyr: 1.991 ± 0.366
0.0ThrXaa: 0.0 ± 0.0
Val
5.333ValAla: 5.333 ± 0.48
0.782ValCys: 0.782 ± 0.198
4.124ValAsp: 4.124 ± 0.38
3.876ValGlu: 3.876 ± 0.353
2.133ValPhe: 2.133 ± 0.319
3.307ValGly: 3.307 ± 0.302
0.924ValHis: 0.924 ± 0.205
3.733ValIle: 3.733 ± 0.383
3.662ValLys: 3.662 ± 0.429
5.333ValLeu: 5.333 ± 0.472
1.493ValMet: 1.493 ± 0.218
3.591ValAsn: 3.591 ± 0.307
2.631ValPro: 2.631 ± 0.246
2.24ValGln: 2.24 ± 0.283
3.556ValArg: 3.556 ± 0.432
4.836ValSer: 4.836 ± 0.368
4.196ValThr: 4.196 ± 0.382
3.982ValVal: 3.982 ± 0.372
0.853ValTrp: 0.853 ± 0.16
1.6ValTyr: 1.6 ± 0.242
0.0ValXaa: 0.0 ± 0.0
Trp
1.244TrpAla: 1.244 ± 0.231
0.32TrpCys: 0.32 ± 0.107
0.711TrpAsp: 0.711 ± 0.133
0.747TrpGlu: 0.747 ± 0.17
0.64TrpPhe: 0.64 ± 0.134
0.604TrpGly: 0.604 ± 0.151
0.427TrpHis: 0.427 ± 0.13
1.031TrpIle: 1.031 ± 0.207
0.498TrpLys: 0.498 ± 0.11
1.493TrpLeu: 1.493 ± 0.276
0.178TrpMet: 0.178 ± 0.093
0.427TrpAsn: 0.427 ± 0.135
0.462TrpPro: 0.462 ± 0.148
0.604TrpGln: 0.604 ± 0.162
0.747TrpArg: 0.747 ± 0.155
0.64TrpSer: 0.64 ± 0.177
0.569TrpThr: 0.569 ± 0.139
0.604TrpVal: 0.604 ± 0.143
0.356TrpTrp: 0.356 ± 0.106
0.32TrpTyr: 0.32 ± 0.098
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.489TyrAla: 2.489 ± 0.257
0.427TyrCys: 0.427 ± 0.108
1.956TyrAsp: 1.956 ± 0.302
2.098TyrGlu: 2.098 ± 0.259
1.351TyrPhe: 1.351 ± 0.216
2.276TyrGly: 2.276 ± 0.34
0.569TyrHis: 0.569 ± 0.131
1.671TyrIle: 1.671 ± 0.256
1.316TyrLys: 1.316 ± 0.228
2.667TyrLeu: 2.667 ± 0.281
0.996TyrMet: 0.996 ± 0.188
1.422TyrAsn: 1.422 ± 0.231
1.173TyrPro: 1.173 ± 0.214
1.351TyrGln: 1.351 ± 0.232
2.204TyrArg: 2.204 ± 0.351
1.849TyrSer: 1.849 ± 0.269
1.671TyrThr: 1.671 ± 0.235
2.204TyrVal: 2.204 ± 0.303
0.391TyrTrp: 0.391 ± 0.139
0.676TyrTyr: 0.676 ± 0.19
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 110 proteins (28126 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski