Amino acid dipepetide frequency for Aspergillus tanneri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.144AlaAla: 8.144 ± 0.053	1.062AlaCys: 1.062 ± 0.015	4.147AlaAsp: 4.147 ± 0.029	4.831AlaGlu: 4.831 ± 0.036	3.151AlaPhe: 3.151 ± 0.026	5.464AlaGly: 5.464 ± 0.038	1.775AlaHis: 1.775 ± 0.019	4.27AlaIle: 4.27 ± 0.035	3.676AlaLys: 3.676 ± 0.031	7.745AlaLeu: 7.745 ± 0.048	2.022AlaMet: 2.022 ± 0.019	2.933AlaAsn: 2.933 ± 0.026	4.296AlaPro: 4.296 ± 0.036	3.278AlaGln: 3.278 ± 0.026	4.712AlaArg: 4.712 ± 0.03	6.881AlaSer: 6.881 ± 0.044	4.986AlaThr: 4.986 ± 0.034	5.485AlaVal: 5.485 ± 0.035	1.125AlaTrp: 1.125 ± 0.017	2.175AlaTyr: 2.175 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.916CysAla: 0.916 ± 0.016	0.229CysCys: 0.229 ± 0.007	0.659CysAsp: 0.659 ± 0.011	0.618CysGlu: 0.618 ± 0.011	0.553CysPhe: 0.553 ± 0.01	0.914CysGly: 0.914 ± 0.015	0.354CysHis: 0.354 ± 0.008	0.739CysIle: 0.739 ± 0.012	0.51CysLys: 0.51 ± 0.01	1.325CysLeu: 1.325 ± 0.016	0.274CysMet: 0.274 ± 0.007	0.435CysAsn: 0.435 ± 0.01	0.652CysPro: 0.652 ± 0.012	0.471CysGln: 0.471 ± 0.011	0.763CysArg: 0.763 ± 0.013	0.958CysSer: 0.958 ± 0.015	0.679CysThr: 0.679 ± 0.013	0.811CysVal: 0.811 ± 0.013	0.2CysTrp: 0.2 ± 0.006	0.363CysTyr: 0.363 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.47AspAla: 4.47 ± 0.033	0.647AspCys: 0.647 ± 0.012	3.909AspAsp: 3.909 ± 0.037	4.242AspGlu: 4.242 ± 0.032	2.187AspPhe: 2.187 ± 0.023	3.994AspGly: 3.994 ± 0.04	1.304AspHis: 1.304 ± 0.019	3.27AspIle: 3.27 ± 0.025	2.298AspLys: 2.298 ± 0.022	5.231AspLeu: 5.231 ± 0.031	1.287AspMet: 1.287 ± 0.017	1.952AspAsn: 1.952 ± 0.021	3.427AspPro: 3.427 ± 0.029	1.961AspGln: 1.961 ± 0.024	3.205AspArg: 3.205 ± 0.029	4.249AspSer: 4.249 ± 0.035	2.976AspThr: 2.976 ± 0.024	3.718AspVal: 3.718 ± 0.026	0.887AspTrp: 0.887 ± 0.013	1.615AspTyr: 1.615 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.067GluAla: 5.067 ± 0.035	0.651GluCys: 0.651 ± 0.01	3.993GluAsp: 3.993 ± 0.035	5.175GluGlu: 5.175 ± 0.053	2.033GluPhe: 2.033 ± 0.021	3.593GluGly: 3.593 ± 0.029	1.37GluHis: 1.37 ± 0.018	3.224GluIle: 3.224 ± 0.031	3.607GluLys: 3.607 ± 0.035	5.326GluLeu: 5.326 ± 0.042	1.539GluMet: 1.539 ± 0.02	2.447GluAsn: 2.447 ± 0.023	2.683GluPro: 2.683 ± 0.027	2.523GluGln: 2.523 ± 0.023	3.824GluArg: 3.824 ± 0.034	4.465GluSer: 4.465 ± 0.038	3.531GluThr: 3.531 ± 0.028	3.585GluVal: 3.585 ± 0.029	0.879GluTrp: 0.879 ± 0.015	1.742GluTyr: 1.742 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.014PheAla: 3.014 ± 0.026	0.582PheCys: 0.582 ± 0.011	2.289PheAsp: 2.289 ± 0.021	2.062PheGlu: 2.062 ± 0.024	1.656PhePhe: 1.656 ± 0.019	2.85PheGly: 2.85 ± 0.036	0.996PheHis: 0.996 ± 0.016	1.875PheIle: 1.875 ± 0.023	1.437PheLys: 1.437 ± 0.018	3.726PheLeu: 3.726 ± 0.036	0.787PheMet: 0.787 ± 0.014	1.469PheAsn: 1.469 ± 0.018	2.03PhePro: 2.03 ± 0.02	1.499PheGln: 1.499 ± 0.018	2.01PheArg: 2.01 ± 0.023	3.062PheSer: 3.062 ± 0.028	2.159PheThr: 2.159 ± 0.02	2.459PheVal: 2.459 ± 0.024	0.647PheTrp: 0.647 ± 0.013	1.197PheTyr: 1.197 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.085GlyAla: 5.085 ± 0.039	0.913GlyCys: 0.913 ± 0.015	3.632GlyAsp: 3.632 ± 0.029	3.566GlyGlu: 3.566 ± 0.029	2.835GlyPhe: 2.835 ± 0.026	5.354GlyGly: 5.354 ± 0.056	1.734GlyHis: 1.734 ± 0.02	3.69GlyIle: 3.69 ± 0.029	3.327GlyLys: 3.327 ± 0.034	6.173GlyLeu: 6.173 ± 0.041	1.638GlyMet: 1.638 ± 0.019	2.459GlyAsn: 2.459 ± 0.026	3.301GlyPro: 3.301 ± 0.028	2.617GlyGln: 2.617 ± 0.026	4.045GlyArg: 4.045 ± 0.032	5.665GlySer: 5.665 ± 0.038	3.913GlyThr: 3.913 ± 0.031	4.416GlyVal: 4.416 ± 0.033	1.155GlyTrp: 1.155 ± 0.016	2.188GlyTyr: 2.188 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.866HisAla: 1.866 ± 0.021	0.346HisCys: 0.346 ± 0.008	1.325HisAsp: 1.325 ± 0.017	1.339HisGlu: 1.339 ± 0.017	0.955HisPhe: 0.955 ± 0.013	1.74HisGly: 1.74 ± 0.021	0.832HisHis: 0.832 ± 0.017	1.27HisIle: 1.27 ± 0.015	0.866HisLys: 0.866 ± 0.013	2.367HisLeu: 2.367 ± 0.021	0.527HisMet: 0.527 ± 0.01	0.861HisAsn: 0.861 ± 0.012	1.738HisPro: 1.738 ± 0.021	1.02HisGln: 1.02 ± 0.017	1.628HisArg: 1.628 ± 0.02	1.888HisSer: 1.888 ± 0.022	1.289HisThr: 1.289 ± 0.017	1.512HisVal: 1.512 ± 0.017	0.361HisTrp: 0.361 ± 0.008	0.723HisTyr: 0.723 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.208IleAla: 4.208 ± 0.035	0.779IleCys: 0.779 ± 0.012	2.898IleAsp: 2.898 ± 0.022	2.904IleGlu: 2.904 ± 0.027	2.107IlePhe: 2.107 ± 0.021	3.312IleGly: 3.312 ± 0.03	1.315IleHis: 1.315 ± 0.016	2.563IleIle: 2.563 ± 0.024	2.111IleLys: 2.111 ± 0.023	4.905IleLeu: 4.905 ± 0.033	1.035IleMet: 1.035 ± 0.014	1.865IleAsn: 1.865 ± 0.019	3.261IlePro: 3.261 ± 0.027	2.082IleGln: 2.082 ± 0.017	2.942IleArg: 2.942 ± 0.026	4.062IleSer: 4.062 ± 0.027	2.856IleThr: 2.856 ± 0.025	3.307IleVal: 3.307 ± 0.024	0.715IleTrp: 0.715 ± 0.012	1.503IleTyr: 1.503 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.844LysAla: 3.844 ± 0.035	0.494LysCys: 0.494 ± 0.01	2.713LysAsp: 2.713 ± 0.027	3.281LysGlu: 3.281 ± 0.033	1.419LysPhe: 1.419 ± 0.019	2.895LysGly: 2.895 ± 0.026	1.07LysHis: 1.07 ± 0.013	2.252LysIle: 2.252 ± 0.023	3.027LysLys: 3.027 ± 0.042	4.005LysLeu: 4.005 ± 0.033	0.996LysMet: 0.996 ± 0.014	1.731LysAsn: 1.731 ± 0.018	2.536LysPro: 2.536 ± 0.028	1.833LysGln: 1.833 ± 0.023	3.245LysArg: 3.245 ± 0.028	3.382LysSer: 3.382 ± 0.028	2.739LysThr: 2.739 ± 0.027	2.732LysVal: 2.732 ± 0.028	0.648LysTrp: 0.648 ± 0.012	1.389LysTyr: 1.389 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.797LeuAla: 7.797 ± 0.047	1.252LeuCys: 1.252 ± 0.016	5.369LeuAsp: 5.369 ± 0.035	5.718LeuGlu: 5.718 ± 0.04	3.46LeuPhe: 3.46 ± 0.03	6.068LeuGly: 6.068 ± 0.037	2.375LeuHis: 2.375 ± 0.026	4.068LeuIle: 4.068 ± 0.033	4.062LeuLys: 4.062 ± 0.035	8.696LeuLeu: 8.696 ± 0.062	1.912LeuMet: 1.912 ± 0.021	3.297LeuAsn: 3.297 ± 0.024	5.539LeuPro: 5.539 ± 0.036	4.148LeuGln: 4.148 ± 0.035	5.97LeuArg: 5.97 ± 0.034	7.714LeuSer: 7.714 ± 0.053	4.919LeuThr: 4.919 ± 0.034	5.824LeuVal: 5.824 ± 0.041	1.24LeuTrp: 1.24 ± 0.017	2.484LeuTyr: 2.484 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.29MetAla: 2.29 ± 0.025	0.252MetCys: 0.252 ± 0.007	1.347MetAsp: 1.347 ± 0.017	1.398MetGlu: 1.398 ± 0.02	0.767MetPhe: 0.767 ± 0.012	1.541MetGly: 1.541 ± 0.02	0.495MetHis: 0.495 ± 0.01	1.046MetIle: 1.046 ± 0.015	0.997MetLys: 0.997 ± 0.015	1.915MetLeu: 1.915 ± 0.02	0.561MetMet: 0.561 ± 0.012	0.837MetAsn: 0.837 ± 0.014	1.236MetPro: 1.236 ± 0.015	0.929MetGln: 0.929 ± 0.015	1.265MetArg: 1.265 ± 0.016	1.853MetSer: 1.853 ± 0.019	1.352MetThr: 1.352 ± 0.017	1.483MetVal: 1.483 ± 0.016	0.251MetTrp: 0.251 ± 0.008	0.561MetTyr: 0.561 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.04AsnAla: 3.04 ± 0.025	0.477AsnCys: 0.477 ± 0.011	1.958AsnAsp: 1.958 ± 0.02	2.083AsnGlu: 2.083 ± 0.018	1.367AsnPhe: 1.367 ± 0.017	2.915AsnGly: 2.915 ± 0.029	0.866AsnHis: 0.866 ± 0.012	2.181AsnIle: 2.181 ± 0.022	1.57AsnLys: 1.57 ± 0.02	3.359AsnLeu: 3.359 ± 0.024	0.86AsnMet: 0.86 ± 0.013	1.482AsnAsn: 1.482 ± 0.021	2.532AsnPro: 2.532 ± 0.023	1.388AsnGln: 1.388 ± 0.021	2.035AsnArg: 2.035 ± 0.02	2.773AsnSer: 2.773 ± 0.025	2.197AsnThr: 2.197 ± 0.02	2.418AsnVal: 2.418 ± 0.023	0.573AsnTrp: 0.573 ± 0.011	1.087AsnTyr: 1.087 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.662ProAla: 4.662 ± 0.038	0.531ProCys: 0.531 ± 0.011	3.337ProAsp: 3.337 ± 0.027	3.816ProGlu: 3.816 ± 0.036	2.101ProPhe: 2.101 ± 0.021	3.856ProGly: 3.856 ± 0.031	1.316ProHis: 1.316 ± 0.016	2.575ProIle: 2.575 ± 0.022	2.492ProLys: 2.492 ± 0.025	4.816ProLeu: 4.816 ± 0.038	1.105ProMet: 1.105 ± 0.015	2.196ProAsn: 2.196 ± 0.02	4.635ProPro: 4.635 ± 0.066	2.37ProGln: 2.37 ± 0.024	3.324ProArg: 3.324 ± 0.027	6.072ProSer: 6.072 ± 0.05	3.795ProThr: 3.795 ± 0.031	3.7ProVal: 3.7 ± 0.027	0.748ProTrp: 0.748 ± 0.011	1.537ProTyr: 1.537 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.328GlnAla: 3.328 ± 0.027	0.451GlnCys: 0.451 ± 0.01	2.092GlnAsp: 2.092 ± 0.025	2.563GlnGlu: 2.563 ± 0.027	1.352GlnPhe: 1.352 ± 0.018	2.503GlnGly: 2.503 ± 0.021	1.052GlnHis: 1.052 ± 0.017	1.994GlnIle: 1.994 ± 0.021	2.036GlnLys: 2.036 ± 0.023	3.664GlnLeu: 3.664 ± 0.033	0.935GlnMet: 0.935 ± 0.015	1.645GlnAsn: 1.645 ± 0.018	2.457GlnPro: 2.457 ± 0.025	2.281GlnGln: 2.281 ± 0.039	2.732GlnArg: 2.732 ± 0.028	3.242GlnSer: 3.242 ± 0.027	2.368GlnThr: 2.368 ± 0.024	2.335GlnVal: 2.335 ± 0.023	0.628GlnTrp: 0.628 ± 0.011	1.207GlnTyr: 1.207 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.536ArgAla: 4.536 ± 0.033	0.721ArgCys: 0.721 ± 0.011	3.384ArgAsp: 3.384 ± 0.03	3.883ArgGlu: 3.883 ± 0.034	2.245ArgPhe: 2.245 ± 0.021	3.663ArgGly: 3.663 ± 0.03	1.566ArgHis: 1.566 ± 0.018	3.028ArgIle: 3.028 ± 0.022	3.362ArgLys: 3.362 ± 0.036	5.693ArgLeu: 5.693 ± 0.038	1.371ArgMet: 1.371 ± 0.018	2.293ArgAsn: 2.293 ± 0.022	3.397ArgPro: 3.397 ± 0.026	2.663ArgGln: 2.663 ± 0.023	4.932ArgArg: 4.932 ± 0.043	4.795ArgSer: 4.795 ± 0.038	3.264ArgThr: 3.264 ± 0.028	3.553ArgVal: 3.553 ± 0.026	0.956ArgTrp: 0.956 ± 0.015	1.748ArgTyr: 1.748 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.368SerAla: 6.368 ± 0.037	0.882SerCys: 0.882 ± 0.015	4.281SerAsp: 4.281 ± 0.035	4.279SerGlu: 4.279 ± 0.032	3.082SerPhe: 3.082 ± 0.026	5.547SerGly: 5.547 ± 0.04	2.076SerHis: 2.076 ± 0.02	4.155SerIle: 4.155 ± 0.028	3.632SerLys: 3.632 ± 0.029	7.609SerLeu: 7.609 ± 0.042	1.807SerMet: 1.807 ± 0.02	3.037SerAsn: 3.037 ± 0.022	5.36SerPro: 5.36 ± 0.045	3.454SerGln: 3.454 ± 0.028	5.037SerArg: 5.037 ± 0.04	8.729SerSer: 8.729 ± 0.072	5.531SerThr: 5.531 ± 0.037	4.819SerVal: 4.819 ± 0.035	1.153SerTrp: 1.153 ± 0.015	2.171SerTyr: 2.171 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.026ThrAla: 5.026 ± 0.032	0.717ThrCys: 0.717 ± 0.012	2.915ThrAsp: 2.915 ± 0.027	3.181ThrGlu: 3.181 ± 0.028	2.186ThrPhe: 2.186 ± 0.022	4.273ThrGly: 4.273 ± 0.034	1.258ThrHis: 1.258 ± 0.016	3.096ThrIle: 3.096 ± 0.027	2.493ThrLys: 2.493 ± 0.024	5.36ThrLeu: 5.36 ± 0.037	1.251ThrMet: 1.251 ± 0.015	2.045ThrAsn: 2.045 ± 0.021	4.09ThrPro: 4.09 ± 0.034	2.077ThrGln: 2.077 ± 0.021	3.076ThrArg: 3.076 ± 0.028	5.144ThrSer: 5.144 ± 0.036	4.049ThrThr: 4.049 ± 0.036	4.005ThrVal: 4.005 ± 0.031	0.825ThrTrp: 0.825 ± 0.014	1.633ThrTyr: 1.633 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.247ValAla: 5.247 ± 0.036	0.85ValCys: 0.85 ± 0.013	3.992ValAsp: 3.992 ± 0.032	3.897ValGlu: 3.897 ± 0.029	2.572ValPhe: 2.572 ± 0.028	4.145ValGly: 4.145 ± 0.03	1.528ValHis: 1.528 ± 0.017	3.105ValIle: 3.105 ± 0.024	2.813ValLys: 2.813 ± 0.028	5.832ValLeu: 5.832 ± 0.044	1.403ValMet: 1.403 ± 0.016	2.363ValAsn: 2.363 ± 0.023	3.667ValPro: 3.667 ± 0.028	2.541ValGln: 2.541 ± 0.026	3.618ValArg: 3.618 ± 0.024	4.981ValSer: 4.981 ± 0.036	3.534ValThr: 3.534 ± 0.031	4.447ValVal: 4.447 ± 0.036	0.861ValTrp: 0.861 ± 0.014	1.819ValTyr: 1.819 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.108TrpAla: 1.108 ± 0.017	0.18TrpCys: 0.18 ± 0.007	0.925TrpAsp: 0.925 ± 0.018	0.861TrpGlu: 0.861 ± 0.013	0.539TrpPhe: 0.539 ± 0.012	0.909TrpGly: 0.909 ± 0.016	0.379TrpHis: 0.379 ± 0.008	0.804TrpIle: 0.804 ± 0.014	0.834TrpLys: 0.834 ± 0.012	1.343TrpLeu: 1.343 ± 0.016	0.394TrpMet: 0.394 ± 0.009	0.643TrpAsn: 0.643 ± 0.011	0.578TrpPro: 0.578 ± 0.012	0.573TrpGln: 0.573 ± 0.011	0.957TrpArg: 0.957 ± 0.016	1.014TrpSer: 1.014 ± 0.016	0.933TrpThr: 0.933 ± 0.015	0.892TrpVal: 0.892 ± 0.015	0.272TrpTrp: 0.272 ± 0.009	0.441TrpTyr: 0.441 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.145TyrAla: 2.145 ± 0.021	0.405TyrCys: 0.405 ± 0.009	1.661TyrAsp: 1.661 ± 0.019	1.559TyrGlu: 1.559 ± 0.019	1.239TyrPhe: 1.239 ± 0.017	2.168TyrGly: 2.168 ± 0.022	0.794TyrHis: 0.794 ± 0.014	1.525TyrIle: 1.525 ± 0.019	1.083TyrLys: 1.083 ± 0.015	2.82TyrLeu: 2.82 ± 0.025	0.671TyrMet: 0.671 ± 0.012	1.171TyrAsn: 1.171 ± 0.016	1.568TyrPro: 1.568 ± 0.02	1.158TyrGln: 1.158 ± 0.017	1.734TyrArg: 1.734 ± 0.018	2.083TyrSer: 2.083 ± 0.024	1.632TyrThr: 1.632 ± 0.018	1.715TyrVal: 1.715 ± 0.02	0.454TyrTrp: 0.454 ± 0.01	0.969TyrTyr: 0.969 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 13554 proteins (5103901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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