Amino acid dipepetide frequency for Alistipes sp. CAG:831

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.028AlaAla: 9.028 ± 0.162	0.97AlaCys: 0.97 ± 0.039	4.975AlaAsp: 4.975 ± 0.075	5.403AlaGlu: 5.403 ± 0.093	3.192AlaPhe: 3.192 ± 0.074	6.747AlaGly: 6.747 ± 0.108	1.291AlaHis: 1.291 ± 0.04	4.475AlaIle: 4.475 ± 0.094	3.286AlaLys: 3.286 ± 0.076	7.844AlaLeu: 7.844 ± 0.135	2.338AlaMet: 2.338 ± 0.056	2.341AlaAsn: 2.341 ± 0.064	2.69AlaPro: 2.69 ± 0.065	2.542AlaGln: 2.542 ± 0.063	4.289AlaArg: 4.289 ± 0.084	5.453AlaSer: 5.453 ± 0.091	3.569AlaThr: 3.569 ± 0.08	7.373AlaVal: 7.373 ± 0.137	0.874AlaTrp: 0.874 ± 0.036	2.738AlaTyr: 2.738 ± 0.066	0.001AlaXaa: 0.001 ± 0.001
Cys	0.991CysAla: 0.991 ± 0.04	0.209CysCys: 0.209 ± 0.018	0.709CysAsp: 0.709 ± 0.029	0.643CysGlu: 0.643 ± 0.033	0.508CysPhe: 0.508 ± 0.024	1.359CysGly: 1.359 ± 0.042	0.261CysHis: 0.261 ± 0.022	0.83CysIle: 0.83 ± 0.032	0.453CysLys: 0.453 ± 0.025	1.04CysLeu: 1.04 ± 0.037	0.283CysMet: 0.283 ± 0.018	0.472CysAsn: 0.472 ± 0.029	0.64CysPro: 0.64 ± 0.033	0.279CysGln: 0.279 ± 0.021	0.936CysArg: 0.936 ± 0.041	0.976CysSer: 0.976 ± 0.038	0.678CysThr: 0.678 ± 0.025	0.797CysVal: 0.797 ± 0.036	0.141CysTrp: 0.141 ± 0.015	0.488CysTyr: 0.488 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.456AspAla: 4.456 ± 0.082	0.707AspCys: 0.707 ± 0.035	2.702AspAsp: 2.702 ± 0.071	3.691AspGlu: 3.691 ± 0.074	3.032AspPhe: 3.032 ± 0.064	5.158AspGly: 5.158 ± 0.104	0.874AspHis: 0.874 ± 0.038	4.824AspIle: 4.824 ± 0.085	2.838AspLys: 2.838 ± 0.07	4.862AspLeu: 4.862 ± 0.083	1.782AspMet: 1.782 ± 0.052	2.648AspAsn: 2.648 ± 0.063	2.492AspPro: 2.492 ± 0.062	1.142AspGln: 1.142 ± 0.039	3.707AspArg: 3.707 ± 0.085	3.863AspSer: 3.863 ± 0.093	3.134AspThr: 3.134 ± 0.07	3.787AspVal: 3.787 ± 0.071	0.791AspTrp: 0.791 ± 0.033	2.771AspTyr: 2.771 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	5.622GluAla: 5.622 ± 0.108	0.683GluCys: 0.683 ± 0.029	3.923GluAsp: 3.923 ± 0.066	5.018GluGlu: 5.018 ± 0.098	2.433GluPhe: 2.433 ± 0.069	4.552GluGly: 4.552 ± 0.076	1.276GluHis: 1.276 ± 0.044	4.432GluIle: 4.432 ± 0.102	4.154GluLys: 4.154 ± 0.087	5.719GluLeu: 5.719 ± 0.09	2.015GluMet: 2.015 ± 0.062	2.89GluAsn: 2.89 ± 0.073	2.067GluPro: 2.067 ± 0.062	2.162GluGln: 2.162 ± 0.056	3.688GluArg: 3.688 ± 0.088	3.409GluSer: 3.409 ± 0.075	3.215GluThr: 3.215 ± 0.082	4.395GluVal: 4.395 ± 0.079	0.796GluTrp: 0.796 ± 0.032	2.894GluTyr: 2.894 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.027PheAla: 3.027 ± 0.066	0.578PheCys: 0.578 ± 0.024	2.74PheAsp: 2.74 ± 0.058	2.361PheGlu: 2.361 ± 0.049	1.886PhePhe: 1.886 ± 0.055	3.3PheGly: 3.3 ± 0.079	0.779PheHis: 0.779 ± 0.035	2.817PheIle: 2.817 ± 0.068	1.859PheLys: 1.859 ± 0.046	3.816PheLeu: 3.816 ± 0.074	1.179PheMet: 1.179 ± 0.038	1.894PheAsn: 1.894 ± 0.056	1.751PhePro: 1.751 ± 0.05	1.021PheGln: 1.021 ± 0.036	2.555PheArg: 2.555 ± 0.062	3.327PheSer: 3.327 ± 0.074	2.596PheThr: 2.596 ± 0.053	2.616PheVal: 2.616 ± 0.059	0.491PheTrp: 0.491 ± 0.024	1.745PheTyr: 1.745 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.348GlyAla: 5.348 ± 0.107	1.15GlyCys: 1.15 ± 0.043	4.191GlyAsp: 4.191 ± 0.071	4.735GlyGlu: 4.735 ± 0.087	3.12GlyPhe: 3.12 ± 0.069	5.795GlyGly: 5.795 ± 0.113	1.453GlyHis: 1.453 ± 0.049	5.458GlyIle: 5.458 ± 0.093	4.389GlyLys: 4.389 ± 0.093	6.34GlyLeu: 6.34 ± 0.103	2.419GlyMet: 2.419 ± 0.059	3.171GlyAsn: 3.171 ± 0.067	1.869GlyPro: 1.869 ± 0.051	2.344GlyGln: 2.344 ± 0.058	4.62GlyArg: 4.62 ± 0.083	4.89GlySer: 4.89 ± 0.099	4.67GlyThr: 4.67 ± 0.087	5.245GlyVal: 5.245 ± 0.097	0.957GlyTrp: 0.957 ± 0.037	3.381GlyTyr: 3.381 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	1.095HisAla: 1.095 ± 0.04	0.286HisCys: 0.286 ± 0.018	0.934HisAsp: 0.934 ± 0.036	1.0HisGlu: 1.0 ± 0.041	0.969HisPhe: 0.969 ± 0.042	1.353HisGly: 1.353 ± 0.051	0.428HisHis: 0.428 ± 0.03	1.413HisIle: 1.413 ± 0.042	0.793HisLys: 0.793 ± 0.032	1.611HisLeu: 1.611 ± 0.04	0.28HisMet: 0.28 ± 0.017	0.801HisAsn: 0.801 ± 0.038	1.053HisPro: 1.053 ± 0.038	0.488HisGln: 0.488 ± 0.027	1.029HisArg: 1.029 ± 0.041	1.172HisSer: 1.172 ± 0.041	0.961HisThr: 0.961 ± 0.04	0.974HisVal: 0.974 ± 0.033	0.217HisTrp: 0.217 ± 0.017	0.865HisTyr: 0.865 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.565IleAla: 5.565 ± 0.092	0.941IleCys: 0.941 ± 0.04	4.292IleAsp: 4.292 ± 0.083	4.283IleGlu: 4.283 ± 0.086	2.828IlePhe: 2.828 ± 0.068	4.656IleGly: 4.656 ± 0.09	1.162IleHis: 1.162 ± 0.039	4.327IleIle: 4.327 ± 0.096	2.971IleLys: 2.971 ± 0.081	6.047IleLeu: 6.047 ± 0.099	1.521IleMet: 1.521 ± 0.048	2.587IleAsn: 2.587 ± 0.061	3.34IlePro: 3.34 ± 0.076	1.78IleGln: 1.78 ± 0.06	3.811IleArg: 3.811 ± 0.076	5.02IleSer: 5.02 ± 0.089	3.791IleThr: 3.791 ± 0.077	4.614IleVal: 4.614 ± 0.085	0.62IleTrp: 0.62 ± 0.028	2.444IleTyr: 2.444 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.296LysAla: 4.296 ± 0.093	0.476LysCys: 0.476 ± 0.027	3.209LysAsp: 3.209 ± 0.072	3.953LysGlu: 3.953 ± 0.097	1.653LysPhe: 1.653 ± 0.05	3.624LysGly: 3.624 ± 0.075	0.742LysHis: 0.742 ± 0.03	3.348LysIle: 3.348 ± 0.085	3.078LysLys: 3.078 ± 0.079	3.6LysLeu: 3.6 ± 0.075	1.582LysMet: 1.582 ± 0.048	2.073LysAsn: 2.073 ± 0.053	1.686LysPro: 1.686 ± 0.05	1.47LysGln: 1.47 ± 0.049	2.305LysArg: 2.305 ± 0.064	2.819LysSer: 2.819 ± 0.064	2.504LysThr: 2.504 ± 0.058	3.646LysVal: 3.646 ± 0.074	0.603LysTrp: 0.603 ± 0.028	2.288LysTyr: 2.288 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	7.098LeuAla: 7.098 ± 0.107	1.379LeuCys: 1.379 ± 0.04	5.048LeuAsp: 5.048 ± 0.106	5.578LeuGlu: 5.578 ± 0.096	3.738LeuPhe: 3.738 ± 0.078	6.033LeuGly: 6.033 ± 0.115	1.763LeuHis: 1.763 ± 0.046	5.524LeuIle: 5.524 ± 0.107	4.645LeuLys: 4.645 ± 0.09	8.67LeuLeu: 8.67 ± 0.16	2.486LeuMet: 2.486 ± 0.063	3.74LeuAsn: 3.74 ± 0.076	4.127LeuPro: 4.127 ± 0.071	2.752LeuGln: 2.752 ± 0.064	5.558LeuArg: 5.558 ± 0.1	7.127LeuSer: 7.127 ± 0.132	5.591LeuThr: 5.591 ± 0.1	5.218LeuVal: 5.218 ± 0.085	0.854LeuTrp: 0.854 ± 0.034	3.541LeuTyr: 3.541 ± 0.078	0.001LeuXaa: 0.001 ± 0.001
Met	2.395MetAla: 2.395 ± 0.056	0.258MetCys: 0.258 ± 0.022	1.74MetAsp: 1.74 ± 0.048	1.949MetGlu: 1.949 ± 0.058	0.983MetPhe: 0.983 ± 0.037	1.87MetGly: 1.87 ± 0.055	0.436MetHis: 0.436 ± 0.022	1.673MetIle: 1.673 ± 0.051	1.796MetLys: 1.796 ± 0.05	2.684MetLeu: 2.684 ± 0.056	0.78MetMet: 0.78 ± 0.034	1.315MetAsn: 1.315 ± 0.044	1.262MetPro: 1.262 ± 0.044	0.963MetGln: 0.963 ± 0.035	1.617MetArg: 1.617 ± 0.048	1.908MetSer: 1.908 ± 0.048	1.7MetThr: 1.7 ± 0.045	1.716MetVal: 1.716 ± 0.053	0.226MetTrp: 0.226 ± 0.019	0.883MetTyr: 0.883 ± 0.032	0.001MetXaa: 0.001 ± 0.001
Asn	3.119AsnAla: 3.119 ± 0.078	0.45AsnCys: 0.45 ± 0.026	2.02AsnAsp: 2.02 ± 0.056	2.1AsnGlu: 2.1 ± 0.049	1.805AsnPhe: 1.805 ± 0.056	3.183AsnGly: 3.183 ± 0.076	0.687AsnHis: 0.687 ± 0.028	3.332AsnIle: 3.332 ± 0.075	1.805AsnLys: 1.805 ± 0.052	3.477AsnLeu: 3.477 ± 0.077	1.132AsnMet: 1.132 ± 0.044	1.763AsnAsn: 1.763 ± 0.058	2.249AsnPro: 2.249 ± 0.057	1.017AsnGln: 1.017 ± 0.041	2.19AsnArg: 2.19 ± 0.062	2.45AsnSer: 2.45 ± 0.062	2.404AsnThr: 2.404 ± 0.068	2.745AsnVal: 2.745 ± 0.058	0.513AsnTrp: 0.513 ± 0.028	1.745AsnTyr: 1.745 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	3.766ProAla: 3.766 ± 0.088	0.411ProCys: 0.411 ± 0.025	3.196ProAsp: 3.196 ± 0.072	3.915ProGlu: 3.915 ± 0.081	1.776ProPhe: 1.776 ± 0.048	3.241ProGly: 3.241 ± 0.07	0.69ProHis: 0.69 ± 0.032	1.978ProIle: 1.978 ± 0.053	1.582ProLys: 1.582 ± 0.043	3.45ProLeu: 3.45 ± 0.072	1.036ProMet: 1.036 ± 0.037	1.165ProAsn: 1.165 ± 0.038	0.997ProPro: 0.997 ± 0.042	1.379ProGln: 1.379 ± 0.037	1.649ProArg: 1.649 ± 0.049	2.563ProSer: 2.563 ± 0.058	1.64ProThr: 1.64 ± 0.05	3.756ProVal: 3.756 ± 0.082	0.451ProTrp: 0.451 ± 0.029	1.665ProTyr: 1.665 ± 0.049	0.003ProXaa: 0.003 ± 0.002
Gln	2.298GlnAla: 2.298 ± 0.057	0.318GlnCys: 0.318 ± 0.021	1.663GlnAsp: 1.663 ± 0.051	2.158GlnGlu: 2.158 ± 0.057	1.128GlnPhe: 1.128 ± 0.036	1.92GlnGly: 1.92 ± 0.051	0.493GlnHis: 0.493 ± 0.028	1.995GlnIle: 1.995 ± 0.054	1.663GlnLys: 1.663 ± 0.049	2.471GlnLeu: 2.471 ± 0.065	0.983GlnMet: 0.983 ± 0.042	1.382GlnAsn: 1.382 ± 0.049	1.047GlnPro: 1.047 ± 0.04	1.151GlnGln: 1.151 ± 0.061	1.517GlnArg: 1.517 ± 0.049	1.648GlnSer: 1.648 ± 0.052	1.634GlnThr: 1.634 ± 0.046	1.826GlnVal: 1.826 ± 0.054	0.407GlnTrp: 0.407 ± 0.022	1.382GlnTyr: 1.382 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.585ArgAla: 3.585 ± 0.083	0.641ArgCys: 0.641 ± 0.03	3.159ArgAsp: 3.159 ± 0.068	3.937ArgGlu: 3.937 ± 0.073	2.395ArgPhe: 2.395 ± 0.055	3.377ArgGly: 3.377 ± 0.068	1.244ArgHis: 1.244 ± 0.044	4.349ArgIle: 4.349 ± 0.086	3.4ArgLys: 3.4 ± 0.071	5.471ArgLeu: 5.471 ± 0.107	1.92ArgMet: 1.92 ± 0.058	2.609ArgAsn: 2.609 ± 0.069	2.183ArgPro: 2.183 ± 0.058	2.051ArgGln: 2.051 ± 0.058	3.774ArgArg: 3.774 ± 0.09	3.234ArgSer: 3.234 ± 0.075	3.29ArgThr: 3.29 ± 0.069	3.131ArgVal: 3.131 ± 0.065	0.766ArgTrp: 0.766 ± 0.034	2.563ArgTyr: 2.563 ± 0.061	0.003ArgXaa: 0.003 ± 0.002
Ser	5.358SerAla: 5.358 ± 0.082	0.945SerCys: 0.945 ± 0.034	3.866SerAsp: 3.866 ± 0.073	3.982SerGlu: 3.982 ± 0.073	2.956SerPhe: 2.956 ± 0.065	6.152SerGly: 6.152 ± 0.11	1.137SerHis: 1.137 ± 0.041	4.325SerIle: 4.325 ± 0.081	2.613SerLys: 2.613 ± 0.065	6.615SerLeu: 6.615 ± 0.109	1.817SerMet: 1.817 ± 0.044	2.217SerAsn: 2.217 ± 0.067	2.775SerPro: 2.775 ± 0.062	1.757SerGln: 1.757 ± 0.042	3.744SerArg: 3.744 ± 0.075	4.679SerSer: 4.679 ± 0.108	3.569SerThr: 3.569 ± 0.074	4.956SerVal: 4.956 ± 0.093	0.817SerTrp: 0.817 ± 0.038	2.699SerTyr: 2.699 ± 0.068	0.001SerXaa: 0.001 ± 0.001
Thr	5.375ThrAla: 5.375 ± 0.103	0.551ThrCys: 0.551 ± 0.024	3.552ThrAsp: 3.552 ± 0.076	3.29ThrGlu: 3.29 ± 0.057	2.552ThrPhe: 2.552 ± 0.061	4.975ThrGly: 4.975 ± 0.091	0.883ThrHis: 0.883 ± 0.035	3.342ThrIle: 3.342 ± 0.083	1.987ThrLys: 1.987 ± 0.055	5.218ThrLeu: 5.218 ± 0.105	1.246ThrMet: 1.246 ± 0.039	1.654ThrAsn: 1.654 ± 0.052	2.786ThrPro: 2.786 ± 0.061	1.317ThrGln: 1.317 ± 0.045	2.346ThrArg: 2.346 ± 0.057	3.287ThrSer: 3.287 ± 0.075	2.765ThrThr: 2.765 ± 0.07	5.253ThrVal: 5.253 ± 0.098	0.628ThrTrp: 0.628 ± 0.029	2.115ThrTyr: 2.115 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.17ValAla: 5.17 ± 0.088	0.984ValCys: 0.984 ± 0.037	4.127ValAsp: 4.127 ± 0.081	4.502ValGlu: 4.502 ± 0.092	2.899ValPhe: 2.899 ± 0.055	4.225ValGly: 4.225 ± 0.085	1.145ValHis: 1.145 ± 0.044	4.674ValIle: 4.674 ± 0.082	3.231ValLys: 3.231 ± 0.064	6.905ValLeu: 6.905 ± 0.103	1.866ValMet: 1.866 ± 0.046	2.865ValAsn: 2.865 ± 0.063	3.12ValPro: 3.12 ± 0.071	1.951ValGln: 1.951 ± 0.051	4.381ValArg: 4.381 ± 0.08	5.471ValSer: 5.471 ± 0.094	4.327ValThr: 4.327 ± 0.1	4.52ValVal: 4.52 ± 0.092	0.74ValTrp: 0.74 ± 0.029	2.666ValTyr: 2.666 ± 0.068	0.0ValXaa: 0.0 ± 0.0
Trp	0.766TrpAla: 0.766 ± 0.032	0.196TrpCys: 0.196 ± 0.016	0.658TrpAsp: 0.658 ± 0.027	0.693TrpGlu: 0.693 ± 0.033	0.493TrpPhe: 0.493 ± 0.028	0.8TrpGly: 0.8 ± 0.038	0.212TrpHis: 0.212 ± 0.017	0.72TrpIle: 0.72 ± 0.035	0.729TrpLys: 0.729 ± 0.03	1.184TrpLeu: 1.184 ± 0.046	0.412TrpMet: 0.412 ± 0.026	0.658TrpAsn: 0.658 ± 0.032	0.376TrpPro: 0.376 ± 0.023	0.378TrpGln: 0.378 ± 0.022	0.584TrpArg: 0.584 ± 0.032	0.743TrpSer: 0.743 ± 0.035	0.622TrpThr: 0.622 ± 0.034	0.676TrpVal: 0.676 ± 0.025	0.176TrpTrp: 0.176 ± 0.016	0.504TrpTyr: 0.504 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.061TyrAla: 3.061 ± 0.072	0.561TyrCys: 0.561 ± 0.029	2.558TyrAsp: 2.558 ± 0.066	2.151TyrGlu: 2.151 ± 0.05	1.992TyrPhe: 1.992 ± 0.053	3.22TyrGly: 3.22 ± 0.073	0.767TyrHis: 0.767 ± 0.033	2.762TyrIle: 2.762 ± 0.061	1.682TyrLys: 1.682 ± 0.047	3.448TyrLeu: 3.448 ± 0.065	1.078TyrMet: 1.078 ± 0.043	1.942TyrAsn: 1.942 ± 0.061	1.796TyrPro: 1.796 ± 0.055	1.138TyrGln: 1.138 ± 0.043	2.78TyrArg: 2.78 ± 0.078	2.938TyrSer: 2.938 ± 0.074	2.462TyrThr: 2.462 ± 0.062	2.523TyrVal: 2.523 ± 0.055	0.516TyrTrp: 0.516 ± 0.028	1.988TyrTyr: 1.988 ± 0.059	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.011XaaXaa: 0.011 ± 0.004

Statistics based on 2179 proteins (759939 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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