Amino acid dipepetide frequency for Fusobacterium sp. CAG:815

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.24AlaAla: 4.24 ± 0.122
0.896AlaCys: 0.896 ± 0.044
3.369AlaAsp: 3.369 ± 0.1
4.05AlaGlu: 4.05 ± 0.105
2.534AlaPhe: 2.534 ± 0.076
4.178AlaGly: 4.178 ± 0.11
0.967AlaHis: 0.967 ± 0.037
5.684AlaIle: 5.684 ± 0.121
6.486AlaLys: 6.486 ± 0.121
6.098AlaLeu: 6.098 ± 0.111
1.84AlaMet: 1.84 ± 0.059
3.58AlaAsn: 3.58 ± 0.092
1.962AlaPro: 1.962 ± 0.07
2.768AlaGln: 2.768 ± 0.085
2.341AlaArg: 2.341 ± 0.066
3.62AlaSer: 3.62 ± 0.087
3.409AlaThr: 3.409 ± 0.096
4.006AlaVal: 4.006 ± 0.088
0.364AlaTrp: 0.364 ± 0.029
2.186AlaTyr: 2.186 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.906CysAla: 0.906 ± 0.041
0.25CysCys: 0.25 ± 0.024
0.703CysAsp: 0.703 ± 0.038
0.873CysGlu: 0.873 ± 0.039
0.55CysPhe: 0.55 ± 0.029
1.168CysGly: 1.168 ± 0.056
0.202CysHis: 0.202 ± 0.017
0.876CysIle: 0.876 ± 0.044
0.958CysLys: 0.958 ± 0.049
0.953CysLeu: 0.953 ± 0.04
0.277CysMet: 0.277 ± 0.024
0.607CysAsn: 0.607 ± 0.038
0.623CysPro: 0.623 ± 0.043
0.339CysGln: 0.339 ± 0.029
0.39CysArg: 0.39 ± 0.033
0.858CysSer: 0.858 ± 0.04
0.61CysThr: 0.61 ± 0.034
0.769CysVal: 0.769 ± 0.036
0.095CysTrp: 0.095 ± 0.013
0.463CysTyr: 0.463 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.363AspAla: 3.363 ± 0.085
0.716AspCys: 0.716 ± 0.037
3.097AspAsp: 3.097 ± 0.096
4.333AspGlu: 4.333 ± 0.094
3.197AspPhe: 3.197 ± 0.078
3.493AspGly: 3.493 ± 0.097
0.547AspHis: 0.547 ± 0.032
5.561AspIle: 5.561 ± 0.117
5.901AspLys: 5.901 ± 0.115
5.415AspLeu: 5.415 ± 0.119
1.532AspMet: 1.532 ± 0.054
3.314AspAsn: 3.314 ± 0.092
1.334AspPro: 1.334 ± 0.07
0.849AspGln: 0.849 ± 0.04
1.838AspArg: 1.838 ± 0.058
3.32AspSer: 3.32 ± 0.079
2.676AspThr: 2.676 ± 0.068
3.788AspVal: 3.788 ± 0.091
0.476AspTrp: 0.476 ± 0.032
2.944AspTyr: 2.944 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
3.892GluAla: 3.892 ± 0.094
0.638GluCys: 0.638 ± 0.036
3.733GluAsp: 3.733 ± 0.1
5.085GluGlu: 5.085 ± 0.152
3.167GluPhe: 3.167 ± 0.087
2.514GluGly: 2.514 ± 0.078
1.08GluHis: 1.08 ± 0.043
6.257GluIle: 6.257 ± 0.14
7.12GluLys: 7.12 ± 0.129
6.267GluLeu: 6.267 ± 0.137
1.785GluMet: 1.785 ± 0.054
5.127GluAsn: 5.127 ± 0.103
1.571GluPro: 1.571 ± 0.065
2.487GluGln: 2.487 ± 0.084
2.318GluArg: 2.318 ± 0.071
3.114GluSer: 3.114 ± 0.074
3.449GluThr: 3.449 ± 0.092
4.116GluVal: 4.116 ± 0.094
0.383GluTrp: 0.383 ± 0.025
2.749GluTyr: 2.749 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
3.064PheAla: 3.064 ± 0.079
0.63PheCys: 0.63 ± 0.037
3.227PheAsp: 3.227 ± 0.075
3.004PheGlu: 3.004 ± 0.085
1.849PhePhe: 1.849 ± 0.063
2.944PheGly: 2.944 ± 0.09
0.632PheHis: 0.632 ± 0.034
3.465PheIle: 3.465 ± 0.111
3.706PheLys: 3.706 ± 0.079
3.939PheLeu: 3.939 ± 0.111
1.142PheMet: 1.142 ± 0.046
2.78PheAsn: 2.78 ± 0.081
1.323PhePro: 1.323 ± 0.055
1.197PheGln: 1.197 ± 0.043
1.401PheArg: 1.401 ± 0.056
3.176PheSer: 3.176 ± 0.083
2.321PheThr: 2.321 ± 0.068
3.09PheVal: 3.09 ± 0.08
0.319PheTrp: 0.319 ± 0.023
1.829PheTyr: 1.829 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
3.883GlyAla: 3.883 ± 0.096
0.885GlyCys: 0.885 ± 0.042
2.906GlyAsp: 2.906 ± 0.074
3.515GlyGlu: 3.515 ± 0.087
2.962GlyPhe: 2.962 ± 0.069
3.657GlyGly: 3.657 ± 0.107
1.06GlyHis: 1.06 ± 0.048
5.185GlyIle: 5.185 ± 0.11
5.276GlyLys: 5.276 ± 0.108
5.129GlyLeu: 5.129 ± 0.115
1.609GlyMet: 1.609 ± 0.06
2.948GlyAsn: 2.948 ± 0.082
1.104GlyPro: 1.104 ± 0.05
1.693GlyGln: 1.693 ± 0.055
2.059GlyArg: 2.059 ± 0.067
3.429GlySer: 3.429 ± 0.093
3.258GlyThr: 3.258 ± 0.09
4.161GlyVal: 4.161 ± 0.089
0.514GlyTrp: 0.514 ± 0.027
2.554GlyTyr: 2.554 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
0.895HisAla: 0.895 ± 0.037
0.239HisCys: 0.239 ± 0.022
0.807HisAsp: 0.807 ± 0.039
0.814HisGlu: 0.814 ± 0.036
0.689HisPhe: 0.689 ± 0.036
1.002HisGly: 1.002 ± 0.045
0.324HisHis: 0.324 ± 0.022
1.264HisIle: 1.264 ± 0.054
1.182HisLys: 1.182 ± 0.045
1.374HisLeu: 1.374 ± 0.051
0.29HisMet: 0.29 ± 0.026
0.94HisAsn: 0.94 ± 0.041
0.723HisPro: 0.723 ± 0.034
0.454HisGln: 0.454 ± 0.026
0.525HisArg: 0.525 ± 0.03
1.018HisSer: 1.018 ± 0.046
0.814HisThr: 0.814 ± 0.045
0.782HisVal: 0.782 ± 0.035
0.153HisTrp: 0.153 ± 0.017
0.63HisTyr: 0.63 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.766IleAla: 5.766 ± 0.122
1.175IleCys: 1.175 ± 0.046
5.495IleAsp: 5.495 ± 0.114
5.839IleGlu: 5.839 ± 0.127
3.591IlePhe: 3.591 ± 0.107
4.712IleGly: 4.712 ± 0.123
1.161IleHis: 1.161 ± 0.045
6.502IleIle: 6.502 ± 0.151
7.486IleLys: 7.486 ± 0.127
7.488IleLeu: 7.488 ± 0.151
1.846IleMet: 1.846 ± 0.053
5.132IleAsn: 5.132 ± 0.123
3.283IlePro: 3.283 ± 0.089
2.66IleGln: 2.66 ± 0.069
2.625IleArg: 2.625 ± 0.077
5.998IleSer: 5.998 ± 0.124
4.653IleThr: 4.653 ± 0.094
5.12IleVal: 5.12 ± 0.121
0.463IleTrp: 0.463 ± 0.027
2.839IleTyr: 2.839 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
5.699LysAla: 5.699 ± 0.132
0.977LysCys: 0.977 ± 0.046
5.602LysAsp: 5.602 ± 0.106
6.717LysGlu: 6.717 ± 0.127
3.928LysPhe: 3.928 ± 0.101
4.185LysGly: 4.185 ± 0.108
1.408LysHis: 1.408 ± 0.046
8.137LysIle: 8.137 ± 0.137
8.033LysLys: 8.033 ± 0.148
7.785LysLeu: 7.785 ± 0.131
2.695LysMet: 2.695 ± 0.077
6.874LysAsn: 6.874 ± 0.118
2.636LysPro: 2.636 ± 0.075
3.055LysGln: 3.055 ± 0.088
2.997LysArg: 2.997 ± 0.082
5.612LysSer: 5.612 ± 0.118
5.449LysThr: 5.449 ± 0.106
5.165LysVal: 5.165 ± 0.11
0.556LysTrp: 0.556 ± 0.033
4.161LysTyr: 4.161 ± 0.101
0.0LysXaa: 0.0 ± 0.0
Leu
6.218LeuAla: 6.218 ± 0.118
1.046LeuCys: 1.046 ± 0.049
5.078LeuAsp: 5.078 ± 0.101
5.954LeuGlu: 5.954 ± 0.127
3.686LeuPhe: 3.686 ± 0.094
5.697LeuGly: 5.697 ± 0.101
1.288LeuHis: 1.288 ± 0.051
6.339LeuIle: 6.339 ± 0.132
8.656LeuLys: 8.656 ± 0.16
7.321LeuLeu: 7.321 ± 0.154
2.104LeuMet: 2.104 ± 0.069
5.719LeuAsn: 5.719 ± 0.116
3.29LeuPro: 3.29 ± 0.074
2.707LeuGln: 2.707 ± 0.074
3.048LeuArg: 3.048 ± 0.088
6.282LeuSer: 6.282 ± 0.126
5.469LeuThr: 5.469 ± 0.093
5.183LeuVal: 5.183 ± 0.103
0.519LeuTrp: 0.519 ± 0.033
3.095LeuTyr: 3.095 ± 0.087
0.0LeuXaa: 0.0 ± 0.0
Met
1.893MetAla: 1.893 ± 0.061
0.277MetCys: 0.277 ± 0.022
1.372MetAsp: 1.372 ± 0.054
1.428MetGlu: 1.428 ± 0.05
1.059MetPhe: 1.059 ± 0.042
1.507MetGly: 1.507 ± 0.045
0.364MetHis: 0.364 ± 0.028
1.833MetIle: 1.833 ± 0.055
2.358MetLys: 2.358 ± 0.066
2.219MetLeu: 2.219 ± 0.068
0.691MetMet: 0.691 ± 0.044
1.676MetAsn: 1.676 ± 0.059
0.946MetPro: 0.946 ± 0.043
0.993MetGln: 0.993 ± 0.041
0.904MetArg: 0.904 ± 0.043
1.724MetSer: 1.724 ± 0.058
1.571MetThr: 1.571 ± 0.044
1.421MetVal: 1.421 ± 0.053
0.164MetTrp: 0.164 ± 0.02
0.831MetTyr: 0.831 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.835AsnAla: 3.835 ± 0.094
0.773AsnCys: 0.773 ± 0.041
3.094AsnAsp: 3.094 ± 0.081
3.542AsnGlu: 3.542 ± 0.093
2.992AsnPhe: 2.992 ± 0.087
3.642AsnGly: 3.642 ± 0.117
0.847AsnHis: 0.847 ± 0.042
5.845AsnIle: 5.845 ± 0.126
5.539AsnLys: 5.539 ± 0.114
5.912AsnLeu: 5.912 ± 0.132
1.423AsnMet: 1.423 ± 0.048
4.427AsnAsn: 4.427 ± 0.121
2.99AsnPro: 2.99 ± 0.076
1.918AsnGln: 1.918 ± 0.063
1.966AsnArg: 1.966 ± 0.068
4.573AsnSer: 4.573 ± 0.104
3.214AsnThr: 3.214 ± 0.089
3.784AsnVal: 3.784 ± 0.082
0.445AsnTrp: 0.445 ± 0.03
2.959AsnTyr: 2.959 ± 0.081
0.0AsnXaa: 0.0 ± 0.0
Pro
2.013ProAla: 2.013 ± 0.072
0.363ProCys: 0.363 ± 0.03
2.099ProAsp: 2.099 ± 0.077
2.715ProGlu: 2.715 ± 0.075
1.527ProPhe: 1.527 ± 0.053
1.157ProGly: 1.157 ± 0.043
0.55ProHis: 0.55 ± 0.029
2.653ProIle: 2.653 ± 0.08
2.88ProLys: 2.88 ± 0.08
2.556ProLeu: 2.556 ± 0.07
0.802ProMet: 0.802 ± 0.04
2.232ProAsn: 2.232 ± 0.068
0.86ProPro: 0.86 ± 0.044
1.631ProGln: 1.631 ± 0.052
0.938ProArg: 0.938 ± 0.041
1.835ProSer: 1.835 ± 0.058
2.092ProThr: 2.092 ± 0.074
2.547ProVal: 2.547 ± 0.067
0.217ProTrp: 0.217 ± 0.019
1.408ProTyr: 1.408 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.319GlnAla: 2.319 ± 0.071
0.275GlnCys: 0.275 ± 0.023
1.824GlnAsp: 1.824 ± 0.055
2.232GlnGlu: 2.232 ± 0.075
1.179GlnPhe: 1.179 ± 0.048
1.745GlnGly: 1.745 ± 0.063
0.439GlnHis: 0.439 ± 0.03
2.835GlnIle: 2.835 ± 0.078
3.341GlnLys: 3.341 ± 0.098
2.653GlnLeu: 2.653 ± 0.075
1.0GlnMet: 1.0 ± 0.042
2.518GlnAsn: 2.518 ± 0.078
0.975GlnPro: 0.975 ± 0.047
1.37GlnGln: 1.37 ± 0.063
1.239GlnArg: 1.239 ± 0.055
1.949GlnSer: 1.949 ± 0.066
1.964GlnThr: 1.964 ± 0.056
1.827GlnVal: 1.827 ± 0.062
0.177GlnTrp: 0.177 ± 0.018
1.224GlnTyr: 1.224 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
2.263ArgAla: 2.263 ± 0.066
0.401ArgCys: 0.401 ± 0.029
1.784ArgAsp: 1.784 ± 0.059
2.361ArgGlu: 2.361 ± 0.065
1.64ArgPhe: 1.64 ± 0.052
1.837ArgGly: 1.837 ± 0.072
0.528ArgHis: 0.528 ± 0.031
3.001ArgIle: 3.001 ± 0.082
3.041ArgLys: 3.041 ± 0.086
3.059ArgLeu: 3.059 ± 0.092
0.842ArgMet: 0.842 ± 0.039
2.002ArgAsn: 2.002 ± 0.059
1.097ArgPro: 1.097 ± 0.043
1.212ArgGln: 1.212 ± 0.045
1.343ArgArg: 1.343 ± 0.056
1.494ArgSer: 1.494 ± 0.046
1.762ArgThr: 1.762 ± 0.06
2.208ArgVal: 2.208 ± 0.057
0.275ArgTrp: 0.275 ± 0.023
1.401ArgTyr: 1.401 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
3.908SerAla: 3.908 ± 0.102
0.718SerCys: 0.718 ± 0.039
3.73SerAsp: 3.73 ± 0.086
4.021SerGlu: 4.021 ± 0.099
3.11SerPhe: 3.11 ± 0.083
4.05SerGly: 4.05 ± 0.101
0.955SerHis: 0.955 ± 0.039
5.253SerIle: 5.253 ± 0.091
5.622SerLys: 5.622 ± 0.118
5.528SerLeu: 5.528 ± 0.106
1.501SerMet: 1.501 ± 0.057
3.924SerAsn: 3.924 ± 0.091
1.955SerPro: 1.955 ± 0.064
2.261SerGln: 2.261 ± 0.068
2.093SerArg: 2.093 ± 0.07
4.296SerSer: 4.296 ± 0.111
3.651SerThr: 3.651 ± 0.092
3.977SerVal: 3.977 ± 0.107
0.443SerTrp: 0.443 ± 0.029
2.44SerTyr: 2.44 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
3.425ThrAla: 3.425 ± 0.094
0.632ThrCys: 0.632 ± 0.037
3.176ThrAsp: 3.176 ± 0.085
3.249ThrGlu: 3.249 ± 0.097
2.336ThrPhe: 2.336 ± 0.065
3.675ThrGly: 3.675 ± 0.084
0.898ThrHis: 0.898 ± 0.042
4.513ThrIle: 4.513 ± 0.103
4.626ThrLys: 4.626 ± 0.1
5.005ThrLeu: 5.005 ± 0.112
1.21ThrMet: 1.21 ± 0.051
3.199ThrAsn: 3.199 ± 0.096
2.645ThrPro: 2.645 ± 0.101
1.939ThrGln: 1.939 ± 0.061
1.847ThrArg: 1.847 ± 0.06
3.881ThrSer: 3.881 ± 0.098
3.396ThrThr: 3.396 ± 0.102
3.558ThrVal: 3.558 ± 0.088
0.328ThrTrp: 0.328 ± 0.021
1.975ThrTyr: 1.975 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
4.265ValAla: 4.265 ± 0.098
0.895ValCys: 0.895 ± 0.043
3.695ValAsp: 3.695 ± 0.081
4.402ValGlu: 4.402 ± 0.103
2.686ValPhe: 2.686 ± 0.076
3.939ValGly: 3.939 ± 0.094
0.853ValHis: 0.853 ± 0.041
5.111ValIle: 5.111 ± 0.108
5.422ValLys: 5.422 ± 0.104
5.621ValLeu: 5.621 ± 0.101
1.636ValMet: 1.636 ± 0.052
3.402ValAsn: 3.402 ± 0.094
2.192ValPro: 2.192 ± 0.063
2.0ValGln: 2.0 ± 0.067
2.113ValArg: 2.113 ± 0.067
4.037ValSer: 4.037 ± 0.094
3.245ValThr: 3.245 ± 0.088
4.216ValVal: 4.216 ± 0.09
0.403ValTrp: 0.403 ± 0.03
2.146ValTyr: 2.146 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.499TrpAla: 0.499 ± 0.035
0.102TrpCys: 0.102 ± 0.013
0.408TrpAsp: 0.408 ± 0.029
0.363TrpGlu: 0.363 ± 0.029
0.361TrpPhe: 0.361 ± 0.025
0.508TrpGly: 0.508 ± 0.035
0.151TrpHis: 0.151 ± 0.017
0.583TrpIle: 0.583 ± 0.038
0.461TrpLys: 0.461 ± 0.029
0.698TrpLeu: 0.698 ± 0.035
0.117TrpMet: 0.117 ± 0.016
0.441TrpAsn: 0.441 ± 0.028
0.118TrpPro: 0.118 ± 0.015
0.239TrpGln: 0.239 ± 0.017
0.22TrpArg: 0.22 ± 0.02
0.333TrpSer: 0.333 ± 0.025
0.332TrpThr: 0.332 ± 0.028
0.408TrpVal: 0.408 ± 0.031
0.08TrpTrp: 0.08 ± 0.012
0.268TrpTyr: 0.268 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.234TyrAla: 2.234 ± 0.061
0.583TyrCys: 0.583 ± 0.034
2.496TyrAsp: 2.496 ± 0.072
2.354TyrGlu: 2.354 ± 0.064
1.999TyrPhe: 1.999 ± 0.063
2.177TyrGly: 2.177 ± 0.065
0.663TyrHis: 0.663 ± 0.035
2.939TyrIle: 2.939 ± 0.096
3.576TyrLys: 3.576 ± 0.082
3.682TyrLeu: 3.682 ± 0.09
0.887TyrMet: 0.887 ± 0.037
2.875TyrAsn: 2.875 ± 0.097
1.447TyrPro: 1.447 ± 0.052
1.315TyrGln: 1.315 ± 0.055
1.343TyrArg: 1.343 ± 0.05
2.888TyrSer: 2.888 ± 0.08
2.177TyrThr: 2.177 ± 0.07
2.15TyrVal: 2.15 ± 0.069
0.319TyrTrp: 0.319 ± 0.025
1.776TyrTyr: 1.776 ± 0.076
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1820 proteins (548868 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski