Amino acid dipepetide frequency for Advenella mimigardefordensis (strain DSM 17166 / LMG 22922 / DPN7)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.918AlaAla: 12.918 ± 0.13	1.151AlaCys: 1.151 ± 0.035	5.91AlaAsp: 5.91 ± 0.082	5.224AlaGlu: 5.224 ± 0.075	4.034AlaPhe: 4.034 ± 0.061	9.279AlaGly: 9.279 ± 0.101	2.212AlaHis: 2.212 ± 0.041	5.973AlaIle: 5.973 ± 0.072	3.473AlaLys: 3.473 ± 0.065	11.926AlaLeu: 11.926 ± 0.112	3.102AlaMet: 3.102 ± 0.057	3.128AlaAsn: 3.128 ± 0.052	4.507AlaPro: 4.507 ± 0.072	5.165AlaGln: 5.165 ± 0.069	6.888AlaArg: 6.888 ± 0.082	6.378AlaSer: 6.378 ± 0.078	5.73AlaThr: 5.73 ± 0.085	7.565AlaVal: 7.565 ± 0.077	1.43AlaTrp: 1.43 ± 0.036	2.488AlaTyr: 2.488 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.01CysAla: 1.01 ± 0.031	0.132CysCys: 0.132 ± 0.01	0.529CysAsp: 0.529 ± 0.02	0.489CysGlu: 0.489 ± 0.018	0.348CysPhe: 0.348 ± 0.016	0.902CysGly: 0.902 ± 0.029	0.284CysHis: 0.284 ± 0.017	0.515CysIle: 0.515 ± 0.018	0.263CysLys: 0.263 ± 0.014	0.888CysLeu: 0.888 ± 0.025	0.248CysMet: 0.248 ± 0.012	0.303CysAsn: 0.303 ± 0.013	0.501CysPro: 0.501 ± 0.02	0.32CysGln: 0.32 ± 0.016	0.514CysArg: 0.514 ± 0.02	0.55CysSer: 0.55 ± 0.02	0.52CysThr: 0.52 ± 0.021	0.783CysVal: 0.783 ± 0.023	0.115CysTrp: 0.115 ± 0.009	0.219CysTyr: 0.219 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.65AspAla: 5.65 ± 0.074	0.457AspCys: 0.457 ± 0.022	2.724AspAsp: 2.724 ± 0.054	3.174AspGlu: 3.174 ± 0.056	2.159AspPhe: 2.159 ± 0.042	4.046AspGly: 4.046 ± 0.063	1.151AspHis: 1.151 ± 0.034	3.459AspIle: 3.459 ± 0.057	2.157AspLys: 2.157 ± 0.059	5.213AspLeu: 5.213 ± 0.074	1.517AspMet: 1.517 ± 0.034	1.755AspAsn: 1.755 ± 0.039	2.701AspPro: 2.701 ± 0.049	2.036AspGln: 2.036 ± 0.035	2.993AspArg: 2.993 ± 0.055	2.885AspSer: 2.885 ± 0.058	2.94AspThr: 2.94 ± 0.049	3.889AspVal: 3.889 ± 0.053	0.872AspTrp: 0.872 ± 0.025	1.597AspTyr: 1.597 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.216GluAla: 5.216 ± 0.072	0.399GluCys: 0.399 ± 0.018	2.312GluAsp: 2.312 ± 0.041	2.493GluGlu: 2.493 ± 0.05	1.702GluPhe: 1.702 ± 0.036	3.337GluGly: 3.337 ± 0.051	1.448GluHis: 1.448 ± 0.028	2.871GluIle: 2.871 ± 0.044	2.675GluLys: 2.675 ± 0.051	5.115GluLeu: 5.115 ± 0.062	1.301GluMet: 1.301 ± 0.03	2.01GluAsn: 2.01 ± 0.04	2.372GluPro: 2.372 ± 0.043	3.29GluGln: 3.29 ± 0.057	3.694GluArg: 3.694 ± 0.052	2.968GluSer: 2.968 ± 0.047	2.787GluThr: 2.787 ± 0.045	3.52GluVal: 3.52 ± 0.061	0.702GluTrp: 0.702 ± 0.021	1.314GluTyr: 1.314 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.867PheAla: 3.867 ± 0.057	0.429PheCys: 0.429 ± 0.02	2.536PheAsp: 2.536 ± 0.052	2.107PheGlu: 2.107 ± 0.038	1.481PhePhe: 1.481 ± 0.043	3.307PheGly: 3.307 ± 0.054	0.724PheHis: 0.724 ± 0.025	2.107PheIle: 2.107 ± 0.04	1.264PheLys: 1.264 ± 0.035	3.354PheLeu: 3.354 ± 0.056	0.984PheMet: 0.984 ± 0.029	1.423PheAsn: 1.423 ± 0.032	1.658PhePro: 1.658 ± 0.035	1.137PheGln: 1.137 ± 0.029	1.908PheArg: 1.908 ± 0.036	2.642PheSer: 2.642 ± 0.046	2.135PheThr: 2.135 ± 0.039	2.792PheVal: 2.792 ± 0.053	0.53PheTrp: 0.53 ± 0.025	0.982PheTyr: 0.982 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.437GlyAla: 7.437 ± 0.1	0.839GlyCys: 0.839 ± 0.027	3.467GlyAsp: 3.467 ± 0.076	3.696GlyGlu: 3.696 ± 0.059	3.256GlyPhe: 3.256 ± 0.057	5.919GlyGly: 5.919 ± 0.085	1.746GlyHis: 1.746 ± 0.037	4.817GlyIle: 4.817 ± 0.066	3.761GlyLys: 3.761 ± 0.069	8.232GlyLeu: 8.232 ± 0.09	2.38GlyMet: 2.38 ± 0.045	2.639GlyAsn: 2.639 ± 0.07	2.727GlyPro: 2.727 ± 0.046	3.512GlyGln: 3.512 ± 0.064	4.437GlyArg: 4.437 ± 0.062	4.739GlySer: 4.739 ± 0.065	4.643GlyThr: 4.643 ± 0.079	6.098GlyVal: 6.098 ± 0.068	1.179GlyTrp: 1.179 ± 0.034	2.534GlyTyr: 2.534 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.428HisAla: 2.428 ± 0.043	0.27HisCys: 0.27 ± 0.016	1.182HisAsp: 1.182 ± 0.031	1.171HisGlu: 1.171 ± 0.03	0.936HisPhe: 0.936 ± 0.028	1.757HisGly: 1.757 ± 0.041	0.639HisHis: 0.639 ± 0.026	1.404HisIle: 1.404 ± 0.033	0.694HisLys: 0.694 ± 0.022	2.156HisLeu: 2.156 ± 0.042	0.586HisMet: 0.586 ± 0.022	0.655HisAsn: 0.655 ± 0.022	1.38HisPro: 1.38 ± 0.036	0.832HisGln: 0.832 ± 0.022	1.219HisArg: 1.219 ± 0.032	1.226HisSer: 1.226 ± 0.031	1.177HisThr: 1.177 ± 0.033	1.555HisVal: 1.555 ± 0.033	0.38HisTrp: 0.38 ± 0.016	0.745HisTyr: 0.745 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.873IleAla: 6.873 ± 0.081	0.597IleCys: 0.597 ± 0.022	3.425IleAsp: 3.425 ± 0.049	3.394IleGlu: 3.394 ± 0.05	1.871IlePhe: 1.871 ± 0.044	4.825IleGly: 4.825 ± 0.074	1.178IleHis: 1.178 ± 0.031	2.765IleIle: 2.765 ± 0.056	2.01IleLys: 2.01 ± 0.042	4.92IleLeu: 4.92 ± 0.08	1.236IleMet: 1.236 ± 0.032	2.13IleAsn: 2.13 ± 0.056	2.667IlePro: 2.667 ± 0.041	1.882IleGln: 1.882 ± 0.036	3.42IleArg: 3.42 ± 0.049	3.56IleSer: 3.56 ± 0.052	3.317IleThr: 3.317 ± 0.057	4.367IleVal: 4.367 ± 0.063	0.648IleTrp: 0.648 ± 0.022	1.349IleTyr: 1.349 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.887LysAla: 3.887 ± 0.066	0.212LysCys: 0.212 ± 0.013	2.048LysAsp: 2.048 ± 0.057	2.038LysGlu: 2.038 ± 0.038	1.007LysPhe: 1.007 ± 0.032	2.857LysGly: 2.857 ± 0.055	0.758LysHis: 0.758 ± 0.024	2.134LysIle: 2.134 ± 0.042	2.015LysLys: 2.015 ± 0.052	3.736LysLeu: 3.736 ± 0.057	1.04LysMet: 1.04 ± 0.026	1.484LysAsn: 1.484 ± 0.039	2.191LysPro: 2.191 ± 0.044	1.769LysGln: 1.769 ± 0.041	2.22LysArg: 2.22 ± 0.037	2.211LysSer: 2.211 ± 0.046	2.398LysThr: 2.398 ± 0.052	2.672LysVal: 2.672 ± 0.063	0.501LysTrp: 0.501 ± 0.022	0.964LysTyr: 0.964 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	12.108LeuAla: 12.108 ± 0.1	1.047LeuCys: 1.047 ± 0.033	5.584LeuAsp: 5.584 ± 0.074	4.892LeuGlu: 4.892 ± 0.059	3.841LeuPhe: 3.841 ± 0.065	7.897LeuGly: 7.897 ± 0.086	2.243LeuHis: 2.243 ± 0.048	5.619LeuIle: 5.619 ± 0.088	4.003LeuLys: 4.003 ± 0.066	10.54LeuLeu: 10.54 ± 0.127	2.554LeuMet: 2.554 ± 0.05	3.678LeuAsn: 3.678 ± 0.054	5.429LeuPro: 5.429 ± 0.069	4.409LeuGln: 4.409 ± 0.066	6.103LeuArg: 6.103 ± 0.081	6.982LeuSer: 6.982 ± 0.07	5.865LeuThr: 5.865 ± 0.093	7.008LeuVal: 7.008 ± 0.084	1.096LeuTrp: 1.096 ± 0.03	2.314LeuTyr: 2.314 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.855MetAla: 2.855 ± 0.049	0.202MetCys: 0.202 ± 0.013	1.226MetAsp: 1.226 ± 0.033	1.04MetGlu: 1.04 ± 0.025	0.81MetPhe: 0.81 ± 0.029	1.936MetGly: 1.936 ± 0.044	0.587MetHis: 0.587 ± 0.02	1.406MetIle: 1.406 ± 0.035	1.242MetLys: 1.242 ± 0.03	2.825MetLeu: 2.825 ± 0.06	0.698MetMet: 0.698 ± 0.025	1.123MetAsn: 1.123 ± 0.028	1.45MetPro: 1.45 ± 0.03	1.323MetGln: 1.323 ± 0.032	1.484MetArg: 1.484 ± 0.035	1.956MetSer: 1.956 ± 0.039	1.799MetThr: 1.799 ± 0.036	1.735MetVal: 1.735 ± 0.038	0.215MetTrp: 0.215 ± 0.012	0.544MetTyr: 0.544 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.637AsnAla: 3.637 ± 0.061	0.314AsnCys: 0.314 ± 0.014	1.721AsnAsp: 1.721 ± 0.047	1.73AsnGlu: 1.73 ± 0.037	1.095AsnPhe: 1.095 ± 0.032	2.814AsnGly: 2.814 ± 0.093	0.727AsnHis: 0.727 ± 0.022	1.968AsnIle: 1.968 ± 0.036	1.332AsnLys: 1.332 ± 0.032	3.187AsnLeu: 3.187 ± 0.06	0.911AsnMet: 0.911 ± 0.029	1.304AsnAsn: 1.304 ± 0.041	2.145AsnPro: 2.145 ± 0.038	1.34AsnGln: 1.34 ± 0.035	2.039AsnArg: 2.039 ± 0.04	1.747AsnSer: 1.747 ± 0.039	2.057AsnThr: 2.057 ± 0.037	2.475AsnVal: 2.475 ± 0.06	0.491AsnTrp: 0.491 ± 0.019	0.921AsnTyr: 0.921 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.805ProAla: 5.805 ± 0.085	0.34ProCys: 0.34 ± 0.016	3.467ProAsp: 3.467 ± 0.055	3.296ProGlu: 3.296 ± 0.05	1.86ProPhe: 1.86 ± 0.038	3.993ProGly: 3.993 ± 0.055	0.954ProHis: 0.954 ± 0.025	2.331ProIle: 2.331 ± 0.038	1.453ProLys: 1.453 ± 0.036	4.686ProLeu: 4.686 ± 0.064	1.13ProMet: 1.13 ± 0.034	1.425ProAsn: 1.425 ± 0.034	1.822ProPro: 1.822 ± 0.04	2.107ProGln: 2.107 ± 0.041	2.166ProArg: 2.166 ± 0.04	2.616ProSer: 2.616 ± 0.044	2.279ProThr: 2.279 ± 0.043	4.313ProVal: 4.313 ± 0.063	0.662ProTrp: 0.662 ± 0.023	1.387ProTyr: 1.387 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.584GlnAla: 5.584 ± 0.078	0.32GlnCys: 0.32 ± 0.016	2.1GlnAsp: 2.1 ± 0.045	2.217GlnGlu: 2.217 ± 0.042	1.524GlnPhe: 1.524 ± 0.036	2.985GlnGly: 2.985 ± 0.048	1.062GlnHis: 1.062 ± 0.032	2.509GlnIle: 2.509 ± 0.036	1.627GlnLys: 1.627 ± 0.037	4.586GlnLeu: 4.586 ± 0.063	1.228GlnMet: 1.228 ± 0.029	1.317GlnAsn: 1.317 ± 0.035	1.966GlnPro: 1.966 ± 0.04	2.475GlnGln: 2.475 ± 0.056	2.787GlnArg: 2.787 ± 0.047	2.475GlnSer: 2.475 ± 0.044	2.488GlnThr: 2.488 ± 0.043	3.126GlnVal: 3.126 ± 0.05	0.717GlnTrp: 0.717 ± 0.024	1.15GlnTyr: 1.15 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.509ArgAla: 5.509 ± 0.077	0.523ArgCys: 0.523 ± 0.018	3.104ArgAsp: 3.104 ± 0.054	3.545ArgGlu: 3.545 ± 0.053	2.532ArgPhe: 2.532 ± 0.037	3.462ArgGly: 3.462 ± 0.054	1.606ArgHis: 1.606 ± 0.038	3.775ArgIle: 3.775 ± 0.051	2.482ArgLys: 2.482 ± 0.041	6.501ArgLeu: 6.501 ± 0.073	1.648ArgMet: 1.648 ± 0.035	2.215ArgAsn: 2.215 ± 0.045	2.57ArgPro: 2.57 ± 0.048	3.157ArgGln: 3.157 ± 0.051	3.718ArgArg: 3.718 ± 0.06	3.398ArgSer: 3.398 ± 0.048	2.827ArgThr: 2.827 ± 0.046	4.032ArgVal: 4.032 ± 0.058	0.776ArgTrp: 0.776 ± 0.023	2.026ArgTyr: 2.026 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.387SerAla: 6.387 ± 0.074	0.492SerCys: 0.492 ± 0.02	3.205SerAsp: 3.205 ± 0.055	2.949SerGlu: 2.949 ± 0.048	2.29SerPhe: 2.29 ± 0.038	5.624SerGly: 5.624 ± 0.057	1.348SerHis: 1.348 ± 0.033	3.23SerIle: 3.23 ± 0.053	2.088SerLys: 2.088 ± 0.054	6.413SerLeu: 6.413 ± 0.078	1.686SerMet: 1.686 ± 0.034	1.853SerAsn: 1.853 ± 0.037	2.791SerPro: 2.791 ± 0.045	2.442SerGln: 2.442 ± 0.04	3.697SerArg: 3.697 ± 0.053	3.737SerSer: 3.737 ± 0.06	3.242SerThr: 3.242 ± 0.057	4.653SerVal: 4.653 ± 0.065	0.791SerTrp: 0.791 ± 0.025	1.64SerTyr: 1.64 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.737ThrAla: 5.737 ± 0.093	0.455ThrCys: 0.455 ± 0.019	2.988ThrAsp: 2.988 ± 0.052	2.672ThrGlu: 2.672 ± 0.046	2.09ThrPhe: 2.09 ± 0.04	4.947ThrGly: 4.947 ± 0.066	1.297ThrHis: 1.297 ± 0.033	3.129ThrIle: 3.129 ± 0.057	1.42ThrLys: 1.42 ± 0.037	6.555ThrLeu: 6.555 ± 0.065	1.214ThrMet: 1.214 ± 0.028	1.604ThrAsn: 1.604 ± 0.054	3.467ThrPro: 3.467 ± 0.051	2.337ThrGln: 2.337 ± 0.045	3.265ThrArg: 3.265 ± 0.055	3.223ThrSer: 3.223 ± 0.051	3.15ThrThr: 3.15 ± 0.057	4.347ThrVal: 4.347 ± 0.062	0.658ThrTrp: 0.658 ± 0.023	1.294ThrTyr: 1.294 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	7.91ValAla: 7.91 ± 0.09	0.811ValCys: 0.811 ± 0.025	3.661ValAsp: 3.661 ± 0.053	3.362ValGlu: 3.362 ± 0.055	2.901ValPhe: 2.901 ± 0.05	5.031ValGly: 5.031 ± 0.073	1.507ValHis: 1.507 ± 0.033	4.445ValIle: 4.445 ± 0.064	2.677ValLys: 2.677 ± 0.048	7.905ValLeu: 7.905 ± 0.085	2.03ValMet: 2.03 ± 0.039	2.644ValAsn: 2.644 ± 0.057	3.745ValPro: 3.745 ± 0.064	2.913ValGln: 2.913 ± 0.051	4.174ValArg: 4.174 ± 0.058	4.906ValSer: 4.906 ± 0.058	4.35ValThr: 4.35 ± 0.069	5.81ValVal: 5.81 ± 0.071	0.877ValTrp: 0.877 ± 0.026	1.77ValTyr: 1.77 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.032TrpAla: 1.032 ± 0.03	0.136TrpCys: 0.136 ± 0.009	0.629TrpAsp: 0.629 ± 0.024	0.586TrpGlu: 0.586 ± 0.02	0.58TrpPhe: 0.58 ± 0.026	0.882TrpGly: 0.882 ± 0.03	0.378TrpHis: 0.378 ± 0.016	0.716TrpIle: 0.716 ± 0.025	0.514TrpLys: 0.514 ± 0.021	1.813TrpLeu: 1.813 ± 0.038	0.389TrpMet: 0.389 ± 0.019	0.503TrpAsn: 0.503 ± 0.021	0.585TrpPro: 0.585 ± 0.02	0.748TrpGln: 0.748 ± 0.022	0.929TrpArg: 0.929 ± 0.03	0.785TrpSer: 0.785 ± 0.026	0.614TrpThr: 0.614 ± 0.022	0.894TrpVal: 0.894 ± 0.027	0.182TrpTrp: 0.182 ± 0.012	0.342TrpTyr: 0.342 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.632TyrAla: 2.632 ± 0.043	0.305TyrCys: 0.305 ± 0.014	1.561TyrAsp: 1.561 ± 0.037	1.452TyrGlu: 1.452 ± 0.034	1.05TyrPhe: 1.05 ± 0.028	2.258TyrGly: 2.258 ± 0.04	0.542TyrHis: 0.542 ± 0.02	1.259TyrIle: 1.259 ± 0.03	0.993TyrLys: 0.993 ± 0.03	2.659TyrLeu: 2.659 ± 0.045	0.575TyrMet: 0.575 ± 0.02	0.763TyrAsn: 0.763 ± 0.028	1.419TyrPro: 1.419 ± 0.033	1.047TyrGln: 1.047 ± 0.031	1.749TyrArg: 1.749 ± 0.04	1.574TyrSer: 1.574 ± 0.039	1.533TyrThr: 1.533 ± 0.041	1.794TyrVal: 1.794 ± 0.034	0.415TyrTrp: 0.415 ± 0.019	0.778TyrTyr: 0.778 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4072 proteins (1360965 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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