Amino acid dipepetide frequency for Tupaiid herpesvirus 1 (strain 1) (TuHV-1) (Herpesvirus tupaia (strain 1))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.966AlaAla: 19.966 ± 0.86
2.251AlaCys: 2.251 ± 0.221
5.275AlaAsp: 5.275 ± 0.357
5.997AlaGlu: 5.997 ± 0.422
2.973AlaPhe: 2.973 ± 0.251
8.78AlaGly: 8.78 ± 0.419
2.217AlaHis: 2.217 ± 0.222
2.423AlaIle: 2.423 ± 0.237
1.735AlaLys: 1.735 ± 0.206
9.055AlaLeu: 9.055 ± 0.529
1.083AlaMet: 1.083 ± 0.121
1.907AlaAsn: 1.907 ± 0.218
7.956AlaPro: 7.956 ± 0.471
2.337AlaGln: 2.337 ± 0.193
9.811AlaArg: 9.811 ± 0.498
7.096AlaSer: 7.096 ± 0.53
6.426AlaThr: 6.426 ± 0.389
7.406AlaVal: 7.406 ± 0.373
1.34AlaTrp: 1.34 ± 0.152
2.217AlaTyr: 2.217 ± 0.211
0.017AlaXaa: 0.017 ± 0.018
Cys
1.684CysAla: 1.684 ± 0.191
0.515CysCys: 0.515 ± 0.1
1.014CysAsp: 1.014 ± 0.153
1.186CysGlu: 1.186 ± 0.155
0.739CysPhe: 0.739 ± 0.127
1.289CysGly: 1.289 ± 0.18
0.412CysHis: 0.412 ± 0.084
0.498CysIle: 0.498 ± 0.1
0.344CysLys: 0.344 ± 0.081
2.388CysLeu: 2.388 ± 0.175
0.258CysMet: 0.258 ± 0.062
0.464CysAsn: 0.464 ± 0.083
1.048CysPro: 1.048 ± 0.136
0.739CysGln: 0.739 ± 0.11
2.199CysArg: 2.199 ± 0.236
1.375CysSer: 1.375 ± 0.172
1.083CysThr: 1.083 ± 0.176
1.735CysVal: 1.735 ± 0.181
0.275CysTrp: 0.275 ± 0.075
0.704CysTyr: 0.704 ± 0.104
0.0CysXaa: 0.0 ± 0.0
Asp
5.292AspAla: 5.292 ± 0.411
0.704AspCys: 0.704 ± 0.12
4.519AspAsp: 4.519 ± 0.443
4.055AspGlu: 4.055 ± 0.307
1.856AspPhe: 1.856 ± 0.176
5.172AspGly: 5.172 ± 0.37
1.083AspHis: 1.083 ± 0.12
1.083AspIle: 1.083 ± 0.153
0.533AspLys: 0.533 ± 0.109
5.756AspLeu: 5.756 ± 0.379
0.584AspMet: 0.584 ± 0.102
0.825AspAsn: 0.825 ± 0.094
3.402AspPro: 3.402 ± 0.298
0.979AspGln: 0.979 ± 0.138
5.739AspArg: 5.739 ± 0.414
2.646AspSer: 2.646 ± 0.213
2.028AspThr: 2.028 ± 0.193
3.557AspVal: 3.557 ± 0.264
0.687AspTrp: 0.687 ± 0.123
1.34AspTyr: 1.34 ± 0.144
0.0AspXaa: 0.0 ± 0.0
Glu
5.155GluAla: 5.155 ± 0.368
0.825GluCys: 0.825 ± 0.119
3.041GluAsp: 3.041 ± 0.242
3.832GluGlu: 3.832 ± 0.278
1.392GluPhe: 1.392 ± 0.16
2.251GluGly: 2.251 ± 0.189
1.581GluHis: 1.581 ± 0.2
1.924GluIle: 1.924 ± 0.203
1.254GluLys: 1.254 ± 0.16
5.361GluLeu: 5.361 ± 0.378
0.636GluMet: 0.636 ± 0.129
1.357GluAsn: 1.357 ± 0.14
4.21GluPro: 4.21 ± 0.427
2.148GluGln: 2.148 ± 0.226
6.839GluArg: 6.839 ± 0.467
3.385GluSer: 3.385 ± 0.27
4.141GluThr: 4.141 ± 0.296
2.423GluVal: 2.423 ± 0.207
0.722GluTrp: 0.722 ± 0.114
1.426GluTyr: 1.426 ± 0.158
0.0GluXaa: 0.0 ± 0.0
Phe
2.887PheAla: 2.887 ± 0.262
0.79PheCys: 0.79 ± 0.129
1.77PheAsp: 1.77 ± 0.163
1.856PheGlu: 1.856 ± 0.196
1.856PhePhe: 1.856 ± 0.184
2.44PheGly: 2.44 ± 0.237
1.048PheHis: 1.048 ± 0.149
0.962PheIle: 0.962 ± 0.147
0.687PheLys: 0.687 ± 0.125
3.746PheLeu: 3.746 ± 0.295
0.412PheMet: 0.412 ± 0.092
0.997PheAsn: 0.997 ± 0.125
1.564PhePro: 1.564 ± 0.165
1.065PheGln: 1.065 ± 0.128
3.179PheArg: 3.179 ± 0.255
2.062PheSer: 2.062 ± 0.198
1.839PheThr: 1.839 ± 0.171
2.835PheVal: 2.835 ± 0.239
0.619PheTrp: 0.619 ± 0.104
1.065PheTyr: 1.065 ± 0.154
0.0PheXaa: 0.0 ± 0.0
Gly
8.024GlyAla: 8.024 ± 0.432
0.859GlyCys: 0.859 ± 0.12
4.055GlyAsp: 4.055 ± 0.339
3.815GlyGlu: 3.815 ± 0.303
2.079GlyPhe: 2.079 ± 0.174
9.107GlyGly: 9.107 ± 1.08
1.632GlyHis: 1.632 ± 0.178
1.272GlyIle: 1.272 ± 0.133
1.1GlyLys: 1.1 ± 0.138
6.753GlyLeu: 6.753 ± 0.451
0.533GlyMet: 0.533 ± 0.097
1.151GlyAsn: 1.151 ± 0.144
5.705GlyPro: 5.705 ± 0.33
2.113GlyGln: 2.113 ± 0.178
8.11GlyArg: 8.11 ± 0.609
4.966GlySer: 4.966 ± 0.452
3.986GlyThr: 3.986 ± 0.256
4.33GlyVal: 4.33 ± 0.312
1.272GlyTrp: 1.272 ± 0.181
1.409GlyTyr: 1.409 ± 0.169
0.0GlyXaa: 0.0 ± 0.0
His
2.595HisAla: 2.595 ± 0.299
0.43HisCys: 0.43 ± 0.107
1.375HisAsp: 1.375 ± 0.178
1.1HisGlu: 1.1 ± 0.153
0.722HisPhe: 0.722 ± 0.127
2.423HisGly: 2.423 ± 0.268
1.117HisHis: 1.117 ± 0.154
0.567HisIle: 0.567 ± 0.095
0.292HisLys: 0.292 ± 0.084
2.99HisLeu: 2.99 ± 0.305
0.292HisMet: 0.292 ± 0.061
0.498HisAsn: 0.498 ± 0.094
2.045HisPro: 2.045 ± 0.456
0.773HisGln: 0.773 ± 0.152
2.732HisArg: 2.732 ± 0.249
1.306HisSer: 1.306 ± 0.127
1.237HisThr: 1.237 ± 0.161
1.684HisVal: 1.684 ± 0.135
0.241HisTrp: 0.241 ± 0.056
0.653HisTyr: 0.653 ± 0.095
0.0HisXaa: 0.0 ± 0.0
Ile
2.32IleAla: 2.32 ± 0.232
0.653IleCys: 0.653 ± 0.111
1.564IleAsp: 1.564 ± 0.186
1.254IleGlu: 1.254 ± 0.162
1.048IlePhe: 1.048 ± 0.154
1.839IleGly: 1.839 ± 0.206
0.704IleHis: 0.704 ± 0.134
0.79IleIle: 0.79 ± 0.122
0.687IleLys: 0.687 ± 0.112
2.612IleLeu: 2.612 ± 0.223
0.687IleMet: 0.687 ± 0.113
0.79IleAsn: 0.79 ± 0.135
1.461IlePro: 1.461 ± 0.177
0.722IleGln: 0.722 ± 0.106
2.801IleArg: 2.801 ± 0.267
2.199IleSer: 2.199 ± 0.201
1.529IleThr: 1.529 ± 0.228
2.526IleVal: 2.526 ± 0.257
0.481IleTrp: 0.481 ± 0.098
1.203IleTyr: 1.203 ± 0.145
0.0IleXaa: 0.0 ± 0.0
Lys
1.495LysAla: 1.495 ± 0.186
0.447LysCys: 0.447 ± 0.081
0.859LysAsp: 0.859 ± 0.158
1.048LysGlu: 1.048 ± 0.141
0.533LysPhe: 0.533 ± 0.101
0.67LysGly: 0.67 ± 0.118
0.567LysHis: 0.567 ± 0.106
0.997LysIle: 0.997 ± 0.138
0.876LysLys: 0.876 ± 0.146
2.096LysLeu: 2.096 ± 0.242
0.361LysMet: 0.361 ± 0.09
0.722LysAsn: 0.722 ± 0.138
1.357LysPro: 1.357 ± 0.166
0.619LysGln: 0.619 ± 0.125
2.165LysArg: 2.165 ± 0.222
1.323LysSer: 1.323 ± 0.184
1.512LysThr: 1.512 ± 0.16
1.014LysVal: 1.014 ± 0.149
0.292LysTrp: 0.292 ± 0.072
0.567LysTyr: 0.567 ± 0.105
0.0LysXaa: 0.0 ± 0.0
Leu
9.64LeuAla: 9.64 ± 0.527
2.766LeuCys: 2.766 ± 0.276
5.224LeuAsp: 5.224 ± 0.354
5.361LeuGlu: 5.361 ± 0.348
4.055LeuPhe: 4.055 ± 0.279
6.134LeuGly: 6.134 ± 0.36
2.99LeuHis: 2.99 ± 0.376
3.127LeuIle: 3.127 ± 0.259
2.491LeuLys: 2.491 ± 0.221
11.719LeuLeu: 11.719 ± 0.618
1.203LeuMet: 1.203 ± 0.133
2.887LeuAsn: 2.887 ± 0.247
6.151LeuPro: 6.151 ± 0.332
3.041LeuGln: 3.041 ± 0.377
10.55LeuArg: 10.55 ± 0.725
6.753LeuSer: 6.753 ± 0.4
5.584LeuThr: 5.584 ± 0.345
6.667LeuVal: 6.667 ± 0.347
1.272LeuTrp: 1.272 ± 0.177
3.815LeuTyr: 3.815 ± 0.306
0.0LeuXaa: 0.0 ± 0.0
Met
1.134MetAla: 1.134 ± 0.135
0.292MetCys: 0.292 ± 0.071
0.619MetAsp: 0.619 ± 0.116
0.739MetGlu: 0.739 ± 0.129
0.687MetPhe: 0.687 ± 0.12
0.567MetGly: 0.567 ± 0.101
0.206MetHis: 0.206 ± 0.074
0.567MetIle: 0.567 ± 0.107
0.395MetLys: 0.395 ± 0.088
1.735MetLeu: 1.735 ± 0.354
0.275MetMet: 0.275 ± 0.075
0.584MetAsn: 0.584 ± 0.091
0.601MetPro: 0.601 ± 0.133
0.43MetGln: 0.43 ± 0.075
0.911MetArg: 0.911 ± 0.111
1.117MetSer: 1.117 ± 0.131
0.876MetThr: 0.876 ± 0.13
0.533MetVal: 0.533 ± 0.118
0.378MetTrp: 0.378 ± 0.095
0.344MetTyr: 0.344 ± 0.071
0.0MetXaa: 0.0 ± 0.0
Asn
2.079AsnAla: 2.079 ± 0.198
0.43AsnCys: 0.43 ± 0.077
0.876AsnAsp: 0.876 ± 0.107
1.461AsnGlu: 1.461 ± 0.185
0.636AsnPhe: 0.636 ± 0.098
1.77AsnGly: 1.77 ± 0.192
0.533AsnHis: 0.533 ± 0.086
0.842AsnIle: 0.842 ± 0.134
0.567AsnLys: 0.567 ± 0.127
2.302AsnLeu: 2.302 ± 0.219
0.481AsnMet: 0.481 ± 0.095
0.55AsnAsn: 0.55 ± 0.098
1.34AsnPro: 1.34 ± 0.14
0.687AsnGln: 0.687 ± 0.126
2.062AsnArg: 2.062 ± 0.19
1.409AsnSer: 1.409 ± 0.202
1.306AsnThr: 1.306 ± 0.158
1.976AsnVal: 1.976 ± 0.21
0.275AsnTrp: 0.275 ± 0.067
0.412AsnTyr: 0.412 ± 0.086
0.0AsnXaa: 0.0 ± 0.0
Pro
8.746ProAla: 8.746 ± 0.554
1.22ProCys: 1.22 ± 0.165
3.522ProAsp: 3.522 ± 0.313
3.488ProGlu: 3.488 ± 0.281
2.199ProPhe: 2.199 ± 0.183
6.134ProGly: 6.134 ± 0.52
1.684ProHis: 1.684 ± 0.275
2.131ProIle: 2.131 ± 0.185
1.186ProLys: 1.186 ± 0.165
5.687ProLeu: 5.687 ± 0.352
0.911ProMet: 0.911 ± 0.15
1.048ProAsn: 1.048 ± 0.114
10.241ProPro: 10.241 ± 0.982
1.443ProGln: 1.443 ± 0.166
7.543ProArg: 7.543 ± 0.568
6.151ProSer: 6.151 ± 0.442
4.072ProThr: 4.072 ± 0.406
5.069ProVal: 5.069 ± 0.422
0.842ProTrp: 0.842 ± 0.127
1.426ProTyr: 1.426 ± 0.195
0.0ProXaa: 0.0 ± 0.0
Gln
2.028GlnAla: 2.028 ± 0.189
0.619GlnCys: 0.619 ± 0.092
1.134GlnAsp: 1.134 ± 0.115
1.168GlnGlu: 1.168 ± 0.159
0.704GlnPhe: 0.704 ± 0.116
1.014GlnGly: 1.014 ± 0.14
0.79GlnHis: 0.79 ± 0.134
1.083GlnIle: 1.083 ± 0.145
0.876GlnLys: 0.876 ± 0.12
3.952GlnLeu: 3.952 ± 0.347
0.567GlnMet: 0.567 ± 0.114
0.962GlnAsn: 0.962 ± 0.141
1.804GlnPro: 1.804 ± 0.197
1.873GlnGln: 1.873 ± 0.616
3.024GlnArg: 3.024 ± 0.292
1.65GlnSer: 1.65 ± 0.228
2.457GlnThr: 2.457 ± 0.197
2.234GlnVal: 2.234 ± 0.215
0.292GlnTrp: 0.292 ± 0.067
0.928GlnTyr: 0.928 ± 0.159
0.0GlnXaa: 0.0 ± 0.0
Arg
10.155ArgAla: 10.155 ± 0.665
1.959ArgCys: 1.959 ± 0.203
5.309ArgAsp: 5.309 ± 0.355
4.846ArgGlu: 4.846 ± 0.338
3.093ArgPhe: 3.093 ± 0.292
6.633ArgGly: 6.633 ± 0.393
3.385ArgHis: 3.385 ± 0.286
2.32ArgIle: 2.32 ± 0.186
1.873ArgLys: 1.873 ± 0.204
11.547ArgLeu: 11.547 ± 0.546
1.426ArgMet: 1.426 ± 0.41
1.787ArgAsn: 1.787 ± 0.187
8.093ArgPro: 8.093 ± 0.501
3.883ArgGln: 3.883 ± 0.314
14.176ArgArg: 14.176 ± 0.955
7.681ArgSer: 7.681 ± 0.493
5.773ArgThr: 5.773 ± 0.384
6.564ArgVal: 6.564 ± 0.432
1.546ArgTrp: 1.546 ± 0.215
2.938ArgTyr: 2.938 ± 0.227
0.0ArgXaa: 0.0 ± 0.0
Ser
7.526SerAla: 7.526 ± 0.429
1.22SerCys: 1.22 ± 0.163
3.746SerAsp: 3.746 ± 0.235
3.711SerGlu: 3.711 ± 0.291
1.839SerPhe: 1.839 ± 0.203
5.275SerGly: 5.275 ± 0.395
1.186SerHis: 1.186 ± 0.152
2.01SerIle: 2.01 ± 0.219
1.117SerLys: 1.117 ± 0.173
5.619SerLeu: 5.619 ± 0.391
0.825SerMet: 0.825 ± 0.137
1.375SerAsn: 1.375 ± 0.189
6.358SerPro: 6.358 ± 0.451
1.598SerGln: 1.598 ± 0.162
6.925SerArg: 6.925 ± 0.425
7.303SerSer: 7.303 ± 0.73
4.485SerThr: 4.485 ± 0.348
5.361SerVal: 5.361 ± 0.416
1.065SerTrp: 1.065 ± 0.125
1.564SerTyr: 1.564 ± 0.209
0.0SerXaa: 0.0 ± 0.0
Thr
6.907ThrAla: 6.907 ± 0.398
1.34ThrCys: 1.34 ± 0.148
2.612ThrAsp: 2.612 ± 0.232
3.677ThrGlu: 3.677 ± 0.32
2.234ThrPhe: 2.234 ± 0.234
3.832ThrGly: 3.832 ± 0.285
1.151ThrHis: 1.151 ± 0.166
1.735ThrIle: 1.735 ± 0.219
1.22ThrLys: 1.22 ± 0.143
5.43ThrLeu: 5.43 ± 0.366
0.894ThrMet: 0.894 ± 0.134
1.168ThrAsn: 1.168 ± 0.174
4.416ThrPro: 4.416 ± 0.345
1.478ThrGln: 1.478 ± 0.163
5.103ThrArg: 5.103 ± 0.335
3.677ThrSer: 3.677 ± 0.322
4.244ThrThr: 4.244 ± 0.381
6.306ThrVal: 6.306 ± 0.398
1.014ThrTrp: 1.014 ± 0.141
1.495ThrTyr: 1.495 ± 0.162
0.0ThrXaa: 0.0 ± 0.0
Val
7.492ValAla: 7.492 ± 0.359
1.684ValCys: 1.684 ± 0.168
3.368ValAsp: 3.368 ± 0.292
3.196ValGlu: 3.196 ± 0.216
3.316ValPhe: 3.316 ± 0.316
4.76ValGly: 4.76 ± 0.35
1.667ValHis: 1.667 ± 0.175
2.217ValIle: 2.217 ± 0.215
1.323ValLys: 1.323 ± 0.165
7.474ValLeu: 7.474 ± 0.375
0.911ValMet: 0.911 ± 0.148
1.718ValAsn: 1.718 ± 0.243
4.364ValPro: 4.364 ± 0.273
2.148ValGln: 2.148 ± 0.185
6.615ValArg: 6.615 ± 0.353
5.464ValSer: 5.464 ± 0.361
4.674ValThr: 4.674 ± 0.348
4.605ValVal: 4.605 ± 0.449
1.22ValTrp: 1.22 ± 0.164
2.217ValTyr: 2.217 ± 0.219
0.0ValXaa: 0.0 ± 0.0
Trp
0.979TrpAla: 0.979 ± 0.151
0.361TrpCys: 0.361 ± 0.073
0.601TrpAsp: 0.601 ± 0.11
0.67TrpGlu: 0.67 ± 0.113
0.722TrpPhe: 0.722 ± 0.119
0.601TrpGly: 0.601 ± 0.113
0.326TrpHis: 0.326 ± 0.096
0.498TrpIle: 0.498 ± 0.098
0.241TrpLys: 0.241 ± 0.068
1.581TrpLeu: 1.581 ± 0.195
0.206TrpMet: 0.206 ± 0.051
0.361TrpAsn: 0.361 ± 0.089
1.272TrpPro: 1.272 ± 0.172
0.515TrpGln: 0.515 ± 0.101
1.512TrpArg: 1.512 ± 0.211
0.997TrpSer: 0.997 ± 0.137
1.237TrpThr: 1.237 ± 0.159
0.979TrpVal: 0.979 ± 0.131
0.43TrpTrp: 0.43 ± 0.084
0.55TrpTyr: 0.55 ± 0.12
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.165TyrAla: 2.165 ± 0.177
0.584TyrCys: 0.584 ± 0.113
1.357TyrAsp: 1.357 ± 0.17
1.443TyrGlu: 1.443 ± 0.189
0.997TyrPhe: 0.997 ± 0.118
1.581TyrGly: 1.581 ± 0.168
0.79TyrHis: 0.79 ± 0.096
0.842TyrIle: 0.842 ± 0.149
0.722TyrLys: 0.722 ± 0.111
3.626TyrLeu: 3.626 ± 0.282
0.43TyrMet: 0.43 ± 0.106
0.842TyrAsn: 0.842 ± 0.17
1.357TyrPro: 1.357 ± 0.17
0.567TyrGln: 0.567 ± 0.108
2.99TyrArg: 2.99 ± 0.226
1.546TyrSer: 1.546 ± 0.192
1.426TyrThr: 1.426 ± 0.176
2.629TyrVal: 2.629 ± 0.217
0.378TyrTrp: 0.378 ± 0.08
0.928TyrTyr: 0.928 ± 0.129
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.017XaaThr: 0.017 ± 0.018
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 157 proteins (58199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski