Amino acid dipepetide frequency for Bifidobacterium bohemicum DSM 22767

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.521AlaAla: 11.521 ± 0.201	1.03AlaCys: 1.03 ± 0.046	6.863AlaAsp: 6.863 ± 0.131	5.419AlaGlu: 5.419 ± 0.108	3.374AlaPhe: 3.374 ± 0.09	8.782AlaGly: 8.782 ± 0.151	2.058AlaHis: 2.058 ± 0.067	4.974AlaIle: 4.974 ± 0.121	4.799AlaLys: 4.799 ± 0.105	9.747AlaLeu: 9.747 ± 0.169	2.936AlaMet: 2.936 ± 0.076	3.223AlaAsn: 3.223 ± 0.075	3.955AlaPro: 3.955 ± 0.096	4.358AlaGln: 4.358 ± 0.124	6.074AlaArg: 6.074 ± 0.111	6.819AlaSer: 6.819 ± 0.133	5.486AlaThr: 5.486 ± 0.102	8.469AlaVal: 8.469 ± 0.143	1.233AlaTrp: 1.233 ± 0.047	2.39AlaTyr: 2.39 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	1.047CysAla: 1.047 ± 0.045	0.141CysCys: 0.141 ± 0.017	0.603CysAsp: 0.603 ± 0.037	0.497CysGlu: 0.497 ± 0.03	0.337CysPhe: 0.337 ± 0.027	1.023CysGly: 1.023 ± 0.04	0.211CysHis: 0.211 ± 0.024	0.415CysIle: 0.415 ± 0.029	0.257CysLys: 0.257 ± 0.022	0.821CysLeu: 0.821 ± 0.042	0.255CysMet: 0.255 ± 0.02	0.253CysAsn: 0.253 ± 0.021	0.499CysPro: 0.499 ± 0.031	0.26CysGln: 0.26 ± 0.023	0.604CysArg: 0.604 ± 0.034	0.629CysSer: 0.629 ± 0.034	0.525CysThr: 0.525 ± 0.034	0.817CysVal: 0.817 ± 0.038	0.132CysTrp: 0.132 ± 0.013	0.22CysTyr: 0.22 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	6.869AspAla: 6.869 ± 0.155	0.611AspCys: 0.611 ± 0.03	5.099AspAsp: 5.099 ± 0.129	4.807AspGlu: 4.807 ± 0.097	2.506AspPhe: 2.506 ± 0.075	6.19AspGly: 6.19 ± 0.113	1.313AspHis: 1.313 ± 0.043	3.203AspIle: 3.203 ± 0.073	2.611AspLys: 2.611 ± 0.082	5.313AspLeu: 5.313 ± 0.103	1.71AspMet: 1.71 ± 0.055	1.845AspAsn: 1.845 ± 0.067	3.527AspPro: 3.527 ± 0.076	2.17AspGln: 2.17 ± 0.071	3.792AspArg: 3.792 ± 0.096	3.978AspSer: 3.978 ± 0.097	3.238AspThr: 3.238 ± 0.088	5.147AspVal: 5.147 ± 0.115	0.944AspTrp: 0.944 ± 0.045	1.768AspTyr: 1.768 ± 0.056	0.002AspXaa: 0.002 ± 0.002
Glu	5.779GluAla: 5.779 ± 0.109	0.416GluCys: 0.416 ± 0.03	3.008GluAsp: 3.008 ± 0.085	2.975GluGlu: 2.975 ± 0.082	1.741GluPhe: 1.741 ± 0.058	4.147GluGly: 4.147 ± 0.089	1.495GluHis: 1.495 ± 0.053	2.636GluIle: 2.636 ± 0.079	2.161GluLys: 2.161 ± 0.066	5.015GluLeu: 5.015 ± 0.101	1.348GluMet: 1.348 ± 0.044	2.008GluAsn: 2.008 ± 0.066	2.708GluPro: 2.708 ± 0.078	2.562GluGln: 2.562 ± 0.072	4.198GluArg: 4.198 ± 0.084	3.261GluSer: 3.261 ± 0.076	2.889GluThr: 2.889 ± 0.083	3.859GluVal: 3.859 ± 0.101	0.585GluTrp: 0.585 ± 0.03	1.49GluTyr: 1.49 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.7PheAla: 3.7 ± 0.089	0.369PheCys: 0.369 ± 0.026	2.706PheAsp: 2.706 ± 0.069	1.938PheGlu: 1.938 ± 0.065	1.181PhePhe: 1.181 ± 0.048	3.46PheGly: 3.46 ± 0.086	0.72PheHis: 0.72 ± 0.038	1.82PheIle: 1.82 ± 0.067	1.225PheLys: 1.225 ± 0.047	2.671PheLeu: 2.671 ± 0.084	0.812PheMet: 0.812 ± 0.043	1.288PheAsn: 1.288 ± 0.051	1.327PhePro: 1.327 ± 0.044	0.866PheGln: 0.866 ± 0.035	1.757PheArg: 1.757 ± 0.063	2.384PheSer: 2.384 ± 0.069	2.102PheThr: 2.102 ± 0.072	2.904PheVal: 2.904 ± 0.083	0.438PheTrp: 0.438 ± 0.03	0.84PheTyr: 0.84 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	7.759GlyAla: 7.759 ± 0.144	0.805GlyCys: 0.805 ± 0.042	4.869GlyAsp: 4.869 ± 0.09	4.226GlyGlu: 4.226 ± 0.095	3.316GlyPhe: 3.316 ± 0.074	6.679GlyGly: 6.679 ± 0.153	1.915GlyHis: 1.915 ± 0.058	4.521GlyIle: 4.521 ± 0.093	3.978GlyLys: 3.978 ± 0.081	7.549GlyLeu: 7.549 ± 0.131	2.302GlyMet: 2.302 ± 0.077	2.89GlyAsn: 2.89 ± 0.071	2.861GlyPro: 2.861 ± 0.075	3.071GlyGln: 3.071 ± 0.072	5.386GlyArg: 5.386 ± 0.125	6.013GlySer: 6.013 ± 0.133	4.93GlyThr: 4.93 ± 0.099	6.558GlyVal: 6.558 ± 0.111	1.214GlyTrp: 1.214 ± 0.049	2.534GlyTyr: 2.534 ± 0.067	0.002GlyXaa: 0.002 ± 0.002
His	1.947HisAla: 1.947 ± 0.062	0.237HisCys: 0.237 ± 0.021	1.745HisAsp: 1.745 ± 0.058	1.248HisGlu: 1.248 ± 0.046	0.703HisPhe: 0.703 ± 0.033	1.977HisGly: 1.977 ± 0.059	0.615HisHis: 0.615 ± 0.034	1.109HisIle: 1.109 ± 0.049	0.661HisLys: 0.661 ± 0.034	1.588HisLeu: 1.588 ± 0.055	0.566HisMet: 0.566 ± 0.037	0.727HisAsn: 0.727 ± 0.036	1.249HisPro: 1.249 ± 0.057	0.678HisGln: 0.678 ± 0.033	1.478HisArg: 1.478 ± 0.058	1.223HisSer: 1.223 ± 0.047	1.14HisThr: 1.14 ± 0.046	1.815HisVal: 1.815 ± 0.063	0.339HisTrp: 0.339 ± 0.027	0.661HisTyr: 0.661 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.839IleAla: 5.839 ± 0.11	0.587IleCys: 0.587 ± 0.035	4.027IleAsp: 4.027 ± 0.089	3.282IleGlu: 3.282 ± 0.075	1.511IlePhe: 1.511 ± 0.068	4.588IleGly: 4.588 ± 0.098	1.021IleHis: 1.021 ± 0.043	2.702IleIle: 2.702 ± 0.08	1.845IleLys: 1.845 ± 0.059	3.753IleLeu: 3.753 ± 0.112	1.045IleMet: 1.045 ± 0.05	1.806IleAsn: 1.806 ± 0.063	2.47IlePro: 2.47 ± 0.069	1.293IleGln: 1.293 ± 0.046	2.732IleArg: 2.732 ± 0.069	3.293IleSer: 3.293 ± 0.085	2.947IleThr: 2.947 ± 0.085	4.612IleVal: 4.612 ± 0.092	0.538IleTrp: 0.538 ± 0.028	1.251IleTyr: 1.251 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.927LysAla: 4.927 ± 0.108	0.177LysCys: 0.177 ± 0.019	2.736LysAsp: 2.736 ± 0.083	1.959LysGlu: 1.959 ± 0.07	1.021LysPhe: 1.021 ± 0.046	3.024LysGly: 3.024 ± 0.074	0.84LysHis: 0.84 ± 0.037	1.776LysIle: 1.776 ± 0.064	1.843LysLys: 1.843 ± 0.067	3.263LysLeu: 3.263 ± 0.082	0.986LysMet: 0.986 ± 0.038	1.467LysAsn: 1.467 ± 0.057	2.395LysPro: 2.395 ± 0.062	1.555LysGln: 1.555 ± 0.052	2.63LysArg: 2.63 ± 0.066	2.558LysSer: 2.558 ± 0.07	2.771LysThr: 2.771 ± 0.074	3.217LysVal: 3.217 ± 0.096	0.483LysTrp: 0.483 ± 0.035	1.088LysTyr: 1.088 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	9.397LeuAla: 9.397 ± 0.142	0.917LeuCys: 0.917 ± 0.04	5.934LeuAsp: 5.934 ± 0.115	4.518LeuGlu: 4.518 ± 0.101	2.978LeuPhe: 2.978 ± 0.086	7.027LeuGly: 7.027 ± 0.098	1.764LeuHis: 1.764 ± 0.059	4.665LeuIle: 4.665 ± 0.117	3.785LeuLys: 3.785 ± 0.09	7.619LeuLeu: 7.619 ± 0.148	2.203LeuMet: 2.203 ± 0.071	3.136LeuAsn: 3.136 ± 0.077	4.419LeuPro: 4.419 ± 0.085	2.507LeuGln: 2.507 ± 0.073	5.064LeuArg: 5.064 ± 0.105	5.916LeuSer: 5.916 ± 0.107	5.394LeuThr: 5.394 ± 0.097	6.563LeuVal: 6.563 ± 0.122	0.972LeuTrp: 0.972 ± 0.05	2.052LeuTyr: 2.052 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.81MetAla: 2.81 ± 0.07	0.257MetCys: 0.257 ± 0.024	1.585MetAsp: 1.585 ± 0.048	1.082MetGlu: 1.082 ± 0.045	0.886MetPhe: 0.886 ± 0.049	1.847MetGly: 1.847 ± 0.058	0.589MetHis: 0.589 ± 0.031	1.225MetIle: 1.225 ± 0.05	1.088MetLys: 1.088 ± 0.05	2.441MetLeu: 2.441 ± 0.075	0.701MetMet: 0.701 ± 0.037	1.028MetAsn: 1.028 ± 0.047	1.476MetPro: 1.476 ± 0.049	0.789MetGln: 0.789 ± 0.037	1.708MetArg: 1.708 ± 0.053	1.817MetSer: 1.817 ± 0.053	1.968MetThr: 1.968 ± 0.07	1.973MetVal: 1.973 ± 0.058	0.283MetTrp: 0.283 ± 0.025	0.494MetTyr: 0.494 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.715AsnAla: 3.715 ± 0.076	0.232AsnCys: 0.232 ± 0.025	2.467AsnAsp: 2.467 ± 0.076	1.826AsnGlu: 1.826 ± 0.058	0.984AsnPhe: 0.984 ± 0.047	3.495AsnGly: 3.495 ± 0.089	0.713AsnHis: 0.713 ± 0.04	1.657AsnIle: 1.657 ± 0.062	1.365AsnLys: 1.365 ± 0.054	2.694AsnLeu: 2.694 ± 0.063	0.879AsnMet: 0.879 ± 0.048	1.17AsnAsn: 1.17 ± 0.053	2.253AsnPro: 2.253 ± 0.06	1.228AsnGln: 1.228 ± 0.048	2.086AsnArg: 2.086 ± 0.058	1.899AsnSer: 1.899 ± 0.061	1.856AsnThr: 1.856 ± 0.061	2.632AsnVal: 2.632 ± 0.074	0.474AsnTrp: 0.474 ± 0.03	0.87AsnTyr: 0.87 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	4.503ProAla: 4.503 ± 0.095	0.397ProCys: 0.397 ± 0.025	3.365ProAsp: 3.365 ± 0.074	3.029ProGlu: 3.029 ± 0.082	1.627ProPhe: 1.627 ± 0.054	3.706ProGly: 3.706 ± 0.083	0.986ProHis: 0.986 ± 0.04	2.23ProIle: 2.23 ± 0.063	1.982ProLys: 1.982 ± 0.055	3.816ProLeu: 3.816 ± 0.093	1.179ProMet: 1.179 ± 0.048	1.715ProAsn: 1.715 ± 0.057	1.344ProPro: 1.344 ± 0.059	2.0ProGln: 2.0 ± 0.058	2.363ProArg: 2.363 ± 0.067	3.307ProSer: 3.307 ± 0.085	2.82ProThr: 2.82 ± 0.076	4.045ProVal: 4.045 ± 0.089	0.648ProTrp: 0.648 ± 0.035	1.407ProTyr: 1.407 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	4.119GlnAla: 4.119 ± 0.138	0.272GlnCys: 0.272 ± 0.022	1.755GlnAsp: 1.755 ± 0.063	1.708GlnGlu: 1.708 ± 0.052	1.074GlnPhe: 1.074 ± 0.041	2.659GlnGly: 2.659 ± 0.073	0.722GlnHis: 0.722 ± 0.035	1.956GlnIle: 1.956 ± 0.055	1.297GlnLys: 1.297 ± 0.052	3.089GlnLeu: 3.089 ± 0.076	1.088GlnMet: 1.088 ± 0.041	1.221GlnAsn: 1.221 ± 0.054	1.613GlnPro: 1.613 ± 0.061	1.52GlnGln: 1.52 ± 0.07	2.409GlnArg: 2.409 ± 0.066	2.405GlnSer: 2.405 ± 0.072	2.318GlnThr: 2.318 ± 0.064	2.609GlnVal: 2.609 ± 0.076	0.633GlnTrp: 0.633 ± 0.032	1.082GlnTyr: 1.082 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	5.159ArgAla: 5.159 ± 0.1	0.585ArgCys: 0.585 ± 0.036	3.606ArgAsp: 3.606 ± 0.081	3.435ArgGlu: 3.435 ± 0.083	2.578ArgPhe: 2.578 ± 0.069	3.929ArgGly: 3.929 ± 0.086	1.826ArgHis: 1.826 ± 0.06	3.467ArgIle: 3.467 ± 0.079	2.588ArgLys: 2.588 ± 0.078	5.821ArgLeu: 5.821 ± 0.098	1.838ArgMet: 1.838 ± 0.052	2.223ArgAsn: 2.223 ± 0.072	2.792ArgPro: 2.792 ± 0.075	2.727ArgGln: 2.727 ± 0.069	5.111ArgArg: 5.111 ± 0.13	3.862ArgSer: 3.862 ± 0.101	3.477ArgThr: 3.477 ± 0.08	4.398ArgVal: 4.398 ± 0.101	0.817ArgTrp: 0.817 ± 0.038	1.878ArgTyr: 1.878 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	6.563SerAla: 6.563 ± 0.131	0.596SerCys: 0.596 ± 0.031	4.514SerAsp: 4.514 ± 0.104	3.226SerGlu: 3.226 ± 0.077	2.126SerPhe: 2.126 ± 0.063	6.359SerGly: 6.359 ± 0.126	1.314SerHis: 1.314 ± 0.047	3.449SerIle: 3.449 ± 0.088	2.678SerLys: 2.678 ± 0.076	5.484SerLeu: 5.484 ± 0.099	1.789SerMet: 1.789 ± 0.064	2.256SerAsn: 2.256 ± 0.072	2.764SerPro: 2.764 ± 0.069	2.425SerGln: 2.425 ± 0.079	4.047SerArg: 4.047 ± 0.083	4.642SerSer: 4.642 ± 0.107	3.869SerThr: 3.869 ± 0.095	5.248SerVal: 5.248 ± 0.11	0.898SerTrp: 0.898 ± 0.043	1.65SerTyr: 1.65 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	5.878ThrAla: 5.878 ± 0.112	0.503ThrCys: 0.503 ± 0.033	3.767ThrAsp: 3.767 ± 0.084	2.65ThrGlu: 2.65 ± 0.065	2.038ThrPhe: 2.038 ± 0.074	5.329ThrGly: 5.329 ± 0.095	1.211ThrHis: 1.211 ± 0.043	3.182ThrIle: 3.182 ± 0.079	2.196ThrLys: 2.196 ± 0.072	5.352ThrLeu: 5.352 ± 0.105	1.467ThrMet: 1.467 ± 0.044	1.973ThrAsn: 1.973 ± 0.059	3.056ThrPro: 3.056 ± 0.082	1.961ThrGln: 1.961 ± 0.067	3.059ThrArg: 3.059 ± 0.073	3.642ThrSer: 3.642 ± 0.108	3.419ThrThr: 3.419 ± 0.084	5.124ThrVal: 5.124 ± 0.107	0.747ThrTrp: 0.747 ± 0.034	1.439ThrTyr: 1.439 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	8.366ValAla: 8.366 ± 0.145	0.958ValCys: 0.958 ± 0.046	5.387ValAsp: 5.387 ± 0.122	4.512ValGlu: 4.512 ± 0.111	2.964ValPhe: 2.964 ± 0.078	5.86ValGly: 5.86 ± 0.102	1.508ValHis: 1.508 ± 0.051	4.286ValIle: 4.286 ± 0.093	2.978ValLys: 2.978 ± 0.077	7.162ValLeu: 7.162 ± 0.129	1.971ValMet: 1.971 ± 0.062	2.774ValAsn: 2.774 ± 0.072	4.024ValPro: 4.024 ± 0.083	2.138ValGln: 2.138 ± 0.062	4.804ValArg: 4.804 ± 0.096	5.721ValSer: 5.721 ± 0.118	4.776ValThr: 4.776 ± 0.1	7.206ValVal: 7.206 ± 0.159	0.945ValTrp: 0.945 ± 0.041	1.766ValTyr: 1.766 ± 0.051	0.004ValXaa: 0.004 ± 0.003
Trp	1.049TrpAla: 1.049 ± 0.046	0.165TrpCys: 0.165 ± 0.018	0.749TrpAsp: 0.749 ± 0.037	0.415TrpGlu: 0.415 ± 0.026	0.529TrpPhe: 0.529 ± 0.031	0.886TrpGly: 0.886 ± 0.042	0.336TrpHis: 0.336 ± 0.024	0.669TrpIle: 0.669 ± 0.037	0.529TrpLys: 0.529 ± 0.03	1.379TrpLeu: 1.379 ± 0.064	0.381TrpMet: 0.381 ± 0.025	0.633TrpAsn: 0.633 ± 0.034	0.564TrpPro: 0.564 ± 0.033	0.546TrpGln: 0.546 ± 0.03	1.009TrpArg: 1.009 ± 0.046	0.861TrpSer: 0.861 ± 0.037	0.689TrpThr: 0.689 ± 0.04	0.857TrpVal: 0.857 ± 0.041	0.269TrpTrp: 0.269 ± 0.02	0.438TrpTyr: 0.438 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.565TyrAla: 2.565 ± 0.068	0.29TyrCys: 0.29 ± 0.028	1.857TyrAsp: 1.857 ± 0.07	1.529TyrGlu: 1.529 ± 0.05	1.035TyrPhe: 1.035 ± 0.046	2.413TyrGly: 2.413 ± 0.074	0.55TyrHis: 0.55 ± 0.033	1.202TyrIle: 1.202 ± 0.048	0.852TyrLys: 0.852 ± 0.041	2.254TyrLeu: 2.254 ± 0.065	0.587TyrMet: 0.587 ± 0.034	0.854TyrAsn: 0.854 ± 0.044	1.172TyrPro: 1.172 ± 0.045	0.893TyrGln: 0.893 ± 0.039	1.806TyrArg: 1.806 ± 0.066	1.662TyrSer: 1.662 ± 0.057	1.379TyrThr: 1.379 ± 0.05	2.056TyrVal: 2.056 ± 0.061	0.36TyrTrp: 0.36 ± 0.027	0.791TyrTyr: 0.791 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.002	0.004XaaPro: 0.004 ± 0.003	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 1631 proteins (569118 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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