Amino acid dipepetide frequency for Chryseobacterium sp. Leaf201

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.859AlaAla: 4.859 ± 0.093	0.554AlaCys: 0.554 ± 0.024	3.766AlaAsp: 3.766 ± 0.058	4.508AlaGlu: 4.508 ± 0.076	3.22AlaPhe: 3.22 ± 0.055	5.015AlaGly: 5.015 ± 0.077	1.036AlaHis: 1.036 ± 0.035	4.26AlaIle: 4.26 ± 0.073	4.495AlaLys: 4.495 ± 0.065	5.766AlaLeu: 5.766 ± 0.085	1.517AlaMet: 1.517 ± 0.041	3.268AlaAsn: 3.268 ± 0.055	1.946AlaPro: 1.946 ± 0.045	2.517AlaGln: 2.517 ± 0.042	2.146AlaArg: 2.146 ± 0.045	4.08AlaSer: 4.08 ± 0.062	3.461AlaThr: 3.461 ± 0.073	4.836AlaVal: 4.836 ± 0.07	0.624AlaTrp: 0.624 ± 0.026	2.42AlaTyr: 2.42 ± 0.049	0.001AlaXaa: 0.001 ± 0.001
Cys	0.437CysAla: 0.437 ± 0.017	0.111CysCys: 0.111 ± 0.011	0.384CysAsp: 0.384 ± 0.02	0.42CysGlu: 0.42 ± 0.017	0.443CysPhe: 0.443 ± 0.02	0.636CysGly: 0.636 ± 0.025	0.188CysHis: 0.188 ± 0.014	0.614CysIle: 0.614 ± 0.021	0.432CysLys: 0.432 ± 0.018	0.629CysLeu: 0.629 ± 0.022	0.169CysMet: 0.169 ± 0.011	0.395CysAsn: 0.395 ± 0.019	0.335CysPro: 0.335 ± 0.02	0.205CysGln: 0.205 ± 0.012	0.261CysArg: 0.261 ± 0.016	0.583CysSer: 0.583 ± 0.024	0.415CysThr: 0.415 ± 0.019	0.414CysVal: 0.414 ± 0.019	0.07CysTrp: 0.07 ± 0.008	0.31CysTyr: 0.31 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.572AspAla: 3.572 ± 0.056	0.386AspCys: 0.386 ± 0.021	2.724AspAsp: 2.724 ± 0.051	3.932AspGlu: 3.932 ± 0.07	3.883AspPhe: 3.883 ± 0.054	3.503AspGly: 3.503 ± 0.063	1.125AspHis: 1.125 ± 0.029	4.225AspIle: 4.225 ± 0.059	4.133AspLys: 4.133 ± 0.058	5.061AspLeu: 5.061 ± 0.075	1.17AspMet: 1.17 ± 0.029	2.795AspAsn: 2.795 ± 0.053	1.949AspPro: 1.949 ± 0.04	1.839AspGln: 1.839 ± 0.038	2.188AspArg: 2.188 ± 0.046	2.943AspSer: 2.943 ± 0.054	2.491AspThr: 2.491 ± 0.053	3.223AspVal: 3.223 ± 0.053	0.744AspTrp: 0.744 ± 0.025	2.836AspTyr: 2.836 ± 0.058	0.002AspXaa: 0.002 ± 0.001
Glu	4.002GluAla: 4.002 ± 0.063	0.37GluCys: 0.37 ± 0.018	3.487GluAsp: 3.487 ± 0.062	4.837GluGlu: 4.837 ± 0.092	3.047GluPhe: 3.047 ± 0.05	3.513GluGly: 3.513 ± 0.058	1.241GluHis: 1.241 ± 0.03	5.765GluIle: 5.765 ± 0.081	6.688GluLys: 6.688 ± 0.093	5.618GluLeu: 5.618 ± 0.076	1.717GluMet: 1.717 ± 0.033	5.013GluAsn: 5.013 ± 0.066	1.512GluPro: 1.512 ± 0.038	2.282GluGln: 2.282 ± 0.052	2.472GluArg: 2.472 ± 0.052	3.428GluSer: 3.428 ± 0.059	3.559GluThr: 3.559 ± 0.057	3.884GluVal: 3.884 ± 0.068	0.642GluTrp: 0.642 ± 0.022	2.593GluTyr: 2.593 ± 0.048	0.002GluXaa: 0.002 ± 0.001
Phe	3.193PheAla: 3.193 ± 0.053	0.467PheCys: 0.467 ± 0.019	3.109PheAsp: 3.109 ± 0.053	3.169PheGlu: 3.169 ± 0.056	2.824PhePhe: 2.824 ± 0.056	3.642PheGly: 3.642 ± 0.053	0.935PheHis: 0.935 ± 0.03	4.087PheIle: 4.087 ± 0.075	3.526PheLys: 3.526 ± 0.059	4.917PheLeu: 4.917 ± 0.072	1.188PheMet: 1.188 ± 0.03	3.192PheAsn: 3.192 ± 0.063	1.884PhePro: 1.884 ± 0.041	1.585PheGln: 1.585 ± 0.042	2.065PheArg: 2.065 ± 0.038	4.364PheSer: 4.364 ± 0.057	3.334PheThr: 3.334 ± 0.052	2.868PheVal: 2.868 ± 0.051	0.617PheTrp: 0.617 ± 0.026	2.395PheTyr: 2.395 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.011GlyAla: 4.011 ± 0.064	0.572GlyCys: 0.572 ± 0.023	3.062GlyAsp: 3.062 ± 0.048	3.594GlyGlu: 3.594 ± 0.059	3.765GlyPhe: 3.765 ± 0.057	4.597GlyGly: 4.597 ± 0.099	1.041GlyHis: 1.041 ± 0.029	5.483GlyIle: 5.483 ± 0.078	5.571GlyLys: 5.571 ± 0.072	5.431GlyLeu: 5.431 ± 0.065	1.686GlyMet: 1.686 ± 0.039	4.229GlyAsn: 4.229 ± 0.078	1.326GlyPro: 1.326 ± 0.035	2.156GlyGln: 2.156 ± 0.043	2.342GlyArg: 2.342 ± 0.05	4.289GlySer: 4.289 ± 0.081	4.414GlyThr: 4.414 ± 0.09	3.846GlyVal: 3.846 ± 0.069	0.79GlyTrp: 0.79 ± 0.023	2.885GlyTyr: 2.885 ± 0.058	0.002GlyXaa: 0.002 ± 0.001
His	0.956HisAla: 0.956 ± 0.028	0.176HisCys: 0.176 ± 0.011	0.834HisAsp: 0.834 ± 0.025	1.09HisGlu: 1.09 ± 0.03	1.196HisPhe: 1.196 ± 0.036	1.0HisGly: 1.0 ± 0.029	0.542HisHis: 0.542 ± 0.026	1.377HisIle: 1.377 ± 0.036	1.16HisLys: 1.16 ± 0.032	1.783HisLeu: 1.783 ± 0.043	0.344HisMet: 0.344 ± 0.018	0.906HisAsn: 0.906 ± 0.025	0.911HisPro: 0.911 ± 0.028	0.787HisGln: 0.787 ± 0.028	0.662HisArg: 0.662 ± 0.025	1.078HisSer: 1.078 ± 0.031	0.921HisThr: 0.921 ± 0.025	0.804HisVal: 0.804 ± 0.026	0.231HisTrp: 0.231 ± 0.014	0.889HisTyr: 0.889 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.007IleAla: 5.007 ± 0.065	0.663IleCys: 0.663 ± 0.023	4.346IleAsp: 4.346 ± 0.057	4.8IleGlu: 4.8 ± 0.069	3.893IlePhe: 3.893 ± 0.062	4.657IleGly: 4.657 ± 0.075	1.379IleHis: 1.379 ± 0.038	5.916IleIle: 5.916 ± 0.091	5.578IleLys: 5.578 ± 0.084	6.876IleLeu: 6.876 ± 0.088	1.448IleMet: 1.448 ± 0.034	4.621IleAsn: 4.621 ± 0.063	3.331IlePro: 3.331 ± 0.058	2.655IleGln: 2.655 ± 0.045	2.869IleArg: 2.869 ± 0.046	6.053IleSer: 6.053 ± 0.077	4.57IleThr: 4.57 ± 0.069	4.116IleVal: 4.116 ± 0.059	0.669IleTrp: 0.669 ± 0.024	2.787IleTyr: 2.787 ± 0.047	0.001IleXaa: 0.001 ± 0.001
Lys	4.841LysAla: 4.841 ± 0.077	0.352LysCys: 0.352 ± 0.016	4.787LysAsp: 4.787 ± 0.067	5.895LysGlu: 5.895 ± 0.083	3.291LysPhe: 3.291 ± 0.055	4.45LysGly: 4.45 ± 0.063	1.251LysHis: 1.251 ± 0.034	6.892LysIle: 6.892 ± 0.094	7.089LysLys: 7.089 ± 0.093	6.121LysLeu: 6.121 ± 0.076	2.277LysMet: 2.277 ± 0.044	6.099LysAsn: 6.099 ± 0.099	2.503LysPro: 2.503 ± 0.047	2.525LysGln: 2.525 ± 0.05	2.513LysArg: 2.513 ± 0.05	4.659LysSer: 4.659 ± 0.064	4.725LysThr: 4.725 ± 0.064	4.611LysVal: 4.611 ± 0.069	0.726LysTrp: 0.726 ± 0.025	3.103LysTyr: 3.103 ± 0.052	0.002LysXaa: 0.002 ± 0.001
Leu	5.458LeuAla: 5.458 ± 0.077	0.682LeuCys: 0.682 ± 0.027	4.712LeuAsp: 4.712 ± 0.06	5.661LeuGlu: 5.661 ± 0.087	4.582LeuPhe: 4.582 ± 0.076	5.59LeuGly: 5.59 ± 0.077	1.56LeuHis: 1.56 ± 0.037	6.478LeuIle: 6.478 ± 0.08	7.669LeuLys: 7.669 ± 0.093	7.936LeuLeu: 7.936 ± 0.109	2.302LeuMet: 2.302 ± 0.044	5.472LeuAsn: 5.472 ± 0.081	3.651LeuPro: 3.651 ± 0.058	3.267LeuGln: 3.267 ± 0.056	3.069LeuArg: 3.069 ± 0.051	6.562LeuSer: 6.562 ± 0.077	4.916LeuThr: 4.916 ± 0.07	4.774LeuVal: 4.774 ± 0.07	0.806LeuTrp: 0.806 ± 0.028	3.298LeuTyr: 3.298 ± 0.062	0.002LeuXaa: 0.002 ± 0.001
Met	1.648MetAla: 1.648 ± 0.038	0.139MetCys: 0.139 ± 0.01	1.25MetAsp: 1.25 ± 0.031	1.593MetGlu: 1.593 ± 0.036	0.906MetPhe: 0.906 ± 0.03	1.445MetGly: 1.445 ± 0.037	0.378MetHis: 0.378 ± 0.018	1.741MetIle: 1.741 ± 0.036	2.614MetLys: 2.614 ± 0.044	2.024MetLeu: 2.024 ± 0.046	0.803MetMet: 0.803 ± 0.027	1.563MetAsn: 1.563 ± 0.033	0.921MetPro: 0.921 ± 0.028	0.817MetGln: 0.817 ± 0.025	0.846MetArg: 0.846 ± 0.027	1.427MetSer: 1.427 ± 0.035	1.268MetThr: 1.268 ± 0.03	1.513MetVal: 1.513 ± 0.039	0.17MetTrp: 0.17 ± 0.012	0.804MetTyr: 0.804 ± 0.027	0.001MetXaa: 0.001 ± 0.001
Asn	3.97AsnAla: 3.97 ± 0.059	0.424AsnCys: 0.424 ± 0.019	3.051AsnAsp: 3.051 ± 0.051	3.631AsnGlu: 3.631 ± 0.056	3.354AsnPhe: 3.354 ± 0.06	4.343AsnGly: 4.343 ± 0.08	1.108AsnHis: 1.108 ± 0.03	5.158AsnIle: 5.158 ± 0.071	4.0AsnLys: 4.0 ± 0.071	5.371AsnLeu: 5.371 ± 0.075	1.365AsnMet: 1.365 ± 0.035	3.891AsnAsn: 3.891 ± 0.082	3.041AsnPro: 3.041 ± 0.053	2.182AsnGln: 2.182 ± 0.047	2.289AsnArg: 2.289 ± 0.048	3.994AsnSer: 3.994 ± 0.068	3.6AsnThr: 3.6 ± 0.055	3.471AsnVal: 3.471 ± 0.053	0.733AsnTrp: 0.733 ± 0.026	2.945AsnTyr: 2.945 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	2.598ProAla: 2.598 ± 0.059	0.22ProCys: 0.22 ± 0.014	2.37ProAsp: 2.37 ± 0.051	3.154ProGlu: 3.154 ± 0.058	1.874ProPhe: 1.874 ± 0.044	2.241ProGly: 2.241 ± 0.049	0.568ProHis: 0.568 ± 0.023	2.04ProIle: 2.04 ± 0.044	2.502ProLys: 2.502 ± 0.054	2.905ProLeu: 2.905 ± 0.054	0.796ProMet: 0.796 ± 0.03	2.048ProAsn: 2.048 ± 0.044	0.859ProPro: 0.859 ± 0.032	1.32ProGln: 1.32 ± 0.034	0.947ProArg: 0.947 ± 0.028	2.202ProSer: 2.202 ± 0.042	1.863ProThr: 1.863 ± 0.047	3.092ProVal: 3.092 ± 0.051	0.332ProTrp: 0.332 ± 0.018	1.496ProTyr: 1.496 ± 0.036	0.002ProXaa: 0.002 ± 0.001
Gln	2.15GlnAla: 2.15 ± 0.047	0.186GlnCys: 0.186 ± 0.012	1.79GlnAsp: 1.79 ± 0.037	2.345GlnGlu: 2.345 ± 0.05	1.734GlnPhe: 1.734 ± 0.035	1.796GlnGly: 1.796 ± 0.041	0.646GlnHis: 0.646 ± 0.023	2.688GlnIle: 2.688 ± 0.047	3.197GlnLys: 3.197 ± 0.059	3.229GlnLeu: 3.229 ± 0.056	0.956GlnMet: 0.956 ± 0.03	2.628GlnAsn: 2.628 ± 0.052	1.255GlnPro: 1.255 ± 0.036	1.557GlnGln: 1.557 ± 0.04	1.268GlnArg: 1.268 ± 0.036	2.105GlnSer: 2.105 ± 0.048	1.954GlnThr: 1.954 ± 0.044	1.949GlnVal: 1.949 ± 0.041	0.378GlnTrp: 0.378 ± 0.018	1.614GlnTyr: 1.614 ± 0.04	0.002GlnXaa: 0.002 ± 0.001
Arg	1.89ArgAla: 1.89 ± 0.043	0.212ArgCys: 0.212 ± 0.013	1.787ArgAsp: 1.787 ± 0.036	2.383ArgGlu: 2.383 ± 0.046	1.983ArgPhe: 1.983 ± 0.035	1.816ArgGly: 1.816 ± 0.039	0.612ArgHis: 0.612 ± 0.025	3.062ArgIle: 3.062 ± 0.049	3.364ArgLys: 3.364 ± 0.06	3.294ArgLeu: 3.294 ± 0.055	1.031ArgMet: 1.031 ± 0.033	2.483ArgAsn: 2.483 ± 0.049	1.131ArgPro: 1.131 ± 0.037	1.344ArgGln: 1.344 ± 0.032	1.386ArgArg: 1.386 ± 0.04	1.985ArgSer: 1.985 ± 0.04	1.964ArgThr: 1.964 ± 0.041	1.972ArgVal: 1.972 ± 0.036	0.398ArgTrp: 0.398 ± 0.019	1.569ArgTyr: 1.569 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.358SerAla: 4.358 ± 0.065	0.629SerCys: 0.629 ± 0.026	3.666SerAsp: 3.666 ± 0.058	4.329SerGlu: 4.329 ± 0.065	3.798SerPhe: 3.798 ± 0.063	5.305SerGly: 5.305 ± 0.086	1.11SerHis: 1.11 ± 0.03	4.424SerIle: 4.424 ± 0.061	4.562SerLys: 4.562 ± 0.062	6.086SerLeu: 6.086 ± 0.074	1.438SerMet: 1.438 ± 0.032	3.398SerAsn: 3.398 ± 0.059	2.304SerPro: 2.304 ± 0.047	2.315SerGln: 2.315 ± 0.044	2.356SerArg: 2.356 ± 0.049	4.504SerSer: 4.504 ± 0.079	3.475SerThr: 3.475 ± 0.076	4.504SerVal: 4.504 ± 0.067	0.728SerTrp: 0.728 ± 0.026	2.798SerTyr: 2.798 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.401ThrAla: 4.401 ± 0.082	0.35ThrCys: 0.35 ± 0.018	3.445ThrAsp: 3.445 ± 0.05	3.676ThrGlu: 3.676 ± 0.054	2.903ThrPhe: 2.903 ± 0.05	4.638ThrGly: 4.638 ± 0.086	0.902ThrHis: 0.902 ± 0.028	3.818ThrIle: 3.818 ± 0.056	3.551ThrLys: 3.551 ± 0.06	5.07ThrLeu: 5.07 ± 0.064	1.023ThrMet: 1.023 ± 0.034	2.874ThrAsn: 2.874 ± 0.059	2.36ThrPro: 2.36 ± 0.052	1.918ThrGln: 1.918 ± 0.043	1.757ThrArg: 1.757 ± 0.042	3.652ThrSer: 3.652 ± 0.066	3.238ThrThr: 3.238 ± 0.089	4.289ThrVal: 4.289 ± 0.067	0.574ThrTrp: 0.574 ± 0.027	2.339ThrTyr: 2.339 ± 0.049	0.002ThrXaa: 0.002 ± 0.001
Val	3.838ValAla: 3.838 ± 0.064	0.486ValCys: 0.486 ± 0.019	3.118ValAsp: 3.118 ± 0.061	3.564ValGlu: 3.564 ± 0.061	3.39ValPhe: 3.39 ± 0.054	3.513ValGly: 3.513 ± 0.063	0.951ValHis: 0.951 ± 0.029	4.559ValIle: 4.559 ± 0.068	4.88ValLys: 4.88 ± 0.078	5.6ValLeu: 5.6 ± 0.066	1.502ValMet: 1.502 ± 0.039	3.652ValAsn: 3.652 ± 0.061	2.361ValPro: 2.361 ± 0.047	1.998ValGln: 1.998 ± 0.041	2.044ValArg: 2.044 ± 0.037	4.586ValSer: 4.586 ± 0.063	3.61ValThr: 3.61 ± 0.068	3.726ValVal: 3.726 ± 0.065	0.615ValTrp: 0.615 ± 0.026	2.554ValTyr: 2.554 ± 0.043	0.002ValXaa: 0.002 ± 0.001
Trp	0.626TrpAla: 0.626 ± 0.025	0.095TrpCys: 0.095 ± 0.009	0.593TrpAsp: 0.593 ± 0.025	0.699TrpGlu: 0.699 ± 0.025	0.569TrpPhe: 0.569 ± 0.021	0.711TrpGly: 0.711 ± 0.03	0.196TrpHis: 0.196 ± 0.012	0.727TrpIle: 0.727 ± 0.026	0.918TrpLys: 0.918 ± 0.029	0.888TrpLeu: 0.888 ± 0.027	0.33TrpMet: 0.33 ± 0.019	0.804TrpAsn: 0.804 ± 0.024	0.222TrpPro: 0.222 ± 0.016	0.436TrpGln: 0.436 ± 0.02	0.348TrpArg: 0.348 ± 0.016	0.616TrpSer: 0.616 ± 0.024	0.558TrpThr: 0.558 ± 0.024	0.586TrpVal: 0.586 ± 0.022	0.139TrpTrp: 0.139 ± 0.011	0.416TrpTyr: 0.416 ± 0.022	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.474TyrAla: 2.474 ± 0.047	0.375TyrCys: 0.375 ± 0.017	2.438TyrAsp: 2.438 ± 0.056	2.391TyrGlu: 2.391 ± 0.046	2.705TyrPhe: 2.705 ± 0.05	2.678TyrGly: 2.678 ± 0.053	0.878TyrHis: 0.878 ± 0.028	2.922TyrIle: 2.922 ± 0.05	2.785TyrLys: 2.785 ± 0.054	3.842TyrLeu: 3.842 ± 0.066	0.806TyrMet: 0.806 ± 0.026	2.589TyrAsn: 2.589 ± 0.055	1.627TyrPro: 1.627 ± 0.04	1.722TyrGln: 1.722 ± 0.037	1.838TyrArg: 1.838 ± 0.033	2.977TyrSer: 2.977 ± 0.045	2.445TyrThr: 2.445 ± 0.054	2.069TyrVal: 2.069 ± 0.048	0.489TyrTrp: 0.489 ± 0.021	2.095TyrTyr: 2.095 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3820 proteins (1236993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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