Amino acid dipepetide frequency for Cohnella candidum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.489AlaAla: 11.489 ± 0.131	0.797AlaCys: 0.797 ± 0.022	5.285AlaAsp: 5.285 ± 0.073	6.649AlaGlu: 6.649 ± 0.085	3.819AlaPhe: 3.819 ± 0.059	8.333AlaGly: 8.333 ± 0.092	1.385AlaHis: 1.385 ± 0.031	5.221AlaIle: 5.221 ± 0.065	4.544AlaLys: 4.544 ± 0.064	9.13AlaLeu: 9.13 ± 0.079	2.573AlaMet: 2.573 ± 0.038	2.701AlaAsn: 2.701 ± 0.036	3.173AlaPro: 3.173 ± 0.048	2.726AlaGln: 2.726 ± 0.046	4.419AlaArg: 4.419 ± 0.06	5.964AlaSer: 5.964 ± 0.079	3.678AlaThr: 3.678 ± 0.051	7.757AlaVal: 7.757 ± 0.087	1.242AlaTrp: 1.242 ± 0.031	2.897AlaTyr: 2.897 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.593CysAla: 0.593 ± 0.021	0.093CysCys: 0.093 ± 0.008	0.36CysAsp: 0.36 ± 0.016	0.405CysGlu: 0.405 ± 0.017	0.299CysPhe: 0.299 ± 0.014	0.792CysGly: 0.792 ± 0.024	0.168CysHis: 0.168 ± 0.011	0.347CysIle: 0.347 ± 0.014	0.234CysLys: 0.234 ± 0.013	0.73CysLeu: 0.73 ± 0.024	0.181CysMet: 0.181 ± 0.011	0.204CysAsn: 0.204 ± 0.012	0.344CysPro: 0.344 ± 0.016	0.159CysGln: 0.159 ± 0.01	0.536CysArg: 0.536 ± 0.02	0.467CysSer: 0.467 ± 0.019	0.367CysThr: 0.367 ± 0.017	0.465CysVal: 0.465 ± 0.017	0.087CysTrp: 0.087 ± 0.008	0.227CysTyr: 0.227 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	4.734AspAla: 4.734 ± 0.069	0.324AspCys: 0.324 ± 0.016	2.578AspAsp: 2.578 ± 0.047	3.682AspGlu: 3.682 ± 0.051	2.223AspPhe: 2.223 ± 0.038	4.698AspGly: 4.698 ± 0.075	1.028AspHis: 1.028 ± 0.027	3.079AspIle: 3.079 ± 0.048	2.55AspLys: 2.55 ± 0.046	5.083AspLeu: 5.083 ± 0.06	1.338AspMet: 1.338 ± 0.027	1.667AspAsn: 1.667 ± 0.036	2.848AspPro: 2.848 ± 0.05	1.626AspGln: 1.626 ± 0.036	3.627AspArg: 3.627 ± 0.055	2.744AspSer: 2.744 ± 0.044	2.461AspThr: 2.461 ± 0.041	3.744AspVal: 3.744 ± 0.048	0.998AspTrp: 0.998 ± 0.027	1.927AspTyr: 1.927 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.622GluAla: 6.622 ± 0.076	0.369GluCys: 0.369 ± 0.017	3.1GluAsp: 3.1 ± 0.044	5.218GluGlu: 5.218 ± 0.086	2.152GluPhe: 2.152 ± 0.041	4.642GluGly: 4.642 ± 0.056	1.313GluHis: 1.313 ± 0.032	4.087GluIle: 4.087 ± 0.06	3.513GluLys: 3.513 ± 0.059	6.622GluLeu: 6.622 ± 0.076	1.852GluMet: 1.852 ± 0.039	2.228GluAsn: 2.228 ± 0.034	2.5GluPro: 2.5 ± 0.044	2.782GluGln: 2.782 ± 0.049	4.77GluArg: 4.77 ± 0.069	3.619GluSer: 3.619 ± 0.049	3.727GluThr: 3.727 ± 0.054	4.07GluVal: 4.07 ± 0.06	1.058GluTrp: 1.058 ± 0.027	1.783GluTyr: 1.783 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.876PheAla: 3.876 ± 0.05	0.342PheCys: 0.342 ± 0.017	2.382PheAsp: 2.382 ± 0.034	2.392PheGlu: 2.392 ± 0.042	1.739PhePhe: 1.739 ± 0.043	3.696PheGly: 3.696 ± 0.053	0.936PheHis: 0.936 ± 0.024	2.285PheIle: 2.285 ± 0.049	1.68PheLys: 1.68 ± 0.034	4.023PheLeu: 4.023 ± 0.062	1.02PheMet: 1.02 ± 0.029	1.349PheAsn: 1.349 ± 0.033	1.808PhePro: 1.808 ± 0.042	1.257PheGln: 1.257 ± 0.031	2.687PheArg: 2.687 ± 0.048	2.561PheSer: 2.561 ± 0.042	2.256PheThr: 2.256 ± 0.037	3.156PheVal: 3.156 ± 0.051	0.55PheTrp: 0.55 ± 0.02	1.355PheTyr: 1.355 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.459GlyAla: 6.459 ± 0.085	0.692GlyCys: 0.692 ± 0.021	3.874GlyAsp: 3.874 ± 0.056	4.816GlyGlu: 4.816 ± 0.066	3.604GlyPhe: 3.604 ± 0.059	6.553GlyGly: 6.553 ± 0.096	1.542GlyHis: 1.542 ± 0.03	5.573GlyIle: 5.573 ± 0.067	4.699GlyLys: 4.699 ± 0.063	7.787GlyLeu: 7.787 ± 0.084	2.619GlyMet: 2.619 ± 0.038	2.738GlyAsn: 2.738 ± 0.054	2.28GlyPro: 2.28 ± 0.038	2.696GlyGln: 2.696 ± 0.047	4.474GlyArg: 4.474 ± 0.055	5.065GlySer: 5.065 ± 0.073	4.839GlyThr: 4.839 ± 0.07	5.71GlyVal: 5.71 ± 0.063	1.387GlyTrp: 1.387 ± 0.033	2.953GlyTyr: 2.953 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.674HisAla: 1.674 ± 0.039	0.164HisCys: 0.164 ± 0.01	1.012HisAsp: 1.012 ± 0.027	1.21HisGlu: 1.21 ± 0.03	0.911HisPhe: 0.911 ± 0.026	1.658HisGly: 1.658 ± 0.032	0.542HisHis: 0.542 ± 0.02	0.945HisIle: 0.945 ± 0.024	0.674HisLys: 0.674 ± 0.019	1.928HisLeu: 1.928 ± 0.046	0.461HisMet: 0.461 ± 0.015	0.505HisAsn: 0.505 ± 0.018	1.313HisPro: 1.313 ± 0.035	0.596HisGln: 0.596 ± 0.019	1.252HisArg: 1.252 ± 0.028	1.029HisSer: 1.029 ± 0.025	0.866HisThr: 0.866 ± 0.024	1.434HisVal: 1.434 ± 0.033	0.339HisTrp: 0.339 ± 0.014	0.812HisTyr: 0.812 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.774IleAla: 5.774 ± 0.064	0.467IleCys: 0.467 ± 0.018	3.331IleAsp: 3.331 ± 0.045	3.57IleGlu: 3.57 ± 0.05	2.011IlePhe: 2.011 ± 0.044	5.371IleGly: 5.371 ± 0.068	1.243IleHis: 1.243 ± 0.025	2.809IleIle: 2.809 ± 0.048	2.188IleLys: 2.188 ± 0.043	5.282IleLeu: 5.282 ± 0.077	1.298IleMet: 1.298 ± 0.028	1.734IleAsn: 1.734 ± 0.035	3.021IlePro: 3.021 ± 0.038	2.001IleGln: 2.001 ± 0.033	4.443IleArg: 4.443 ± 0.056	3.504IleSer: 3.504 ± 0.047	2.963IleThr: 2.963 ± 0.041	4.981IleVal: 4.981 ± 0.072	0.689IleTrp: 0.689 ± 0.022	1.642IleTyr: 1.642 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.373LysAla: 4.373 ± 0.055	0.193LysCys: 0.193 ± 0.013	2.725LysAsp: 2.725 ± 0.05	3.661LysGlu: 3.661 ± 0.055	1.515LysPhe: 1.515 ± 0.034	3.308LysGly: 3.308 ± 0.06	0.868LysHis: 0.868 ± 0.023	2.844LysIle: 2.844 ± 0.048	2.713LysLys: 2.713 ± 0.048	5.086LysLeu: 5.086 ± 0.06	1.444LysMet: 1.444 ± 0.035	1.675LysAsn: 1.675 ± 0.039	2.456LysPro: 2.456 ± 0.046	1.924LysGln: 1.924 ± 0.038	2.852LysArg: 2.852 ± 0.047	2.729LysSer: 2.729 ± 0.042	2.681LysThr: 2.681 ± 0.047	3.328LysVal: 3.328 ± 0.053	0.708LysTrp: 0.708 ± 0.019	1.46LysTyr: 1.46 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	9.669LeuAla: 9.669 ± 0.093	0.789LeuCys: 0.789 ± 0.022	5.158LeuAsp: 5.158 ± 0.067	6.096LeuGlu: 6.096 ± 0.081	4.585LeuPhe: 4.585 ± 0.07	7.116LeuGly: 7.116 ± 0.078	2.003LeuHis: 2.003 ± 0.039	5.851LeuIle: 5.851 ± 0.07	5.084LeuLys: 5.084 ± 0.061	11.07LeuLeu: 11.07 ± 0.116	2.495LeuMet: 2.495 ± 0.048	3.541LeuAsn: 3.541 ± 0.053	4.837LeuPro: 4.837 ± 0.062	3.701LeuGln: 3.701 ± 0.052	5.842LeuArg: 5.842 ± 0.073	6.756LeuSer: 6.756 ± 0.075	5.68LeuThr: 5.68 ± 0.066	6.474LeuVal: 6.474 ± 0.071	1.113LeuTrp: 1.113 ± 0.029	3.012LeuTyr: 3.012 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.62MetAla: 2.62 ± 0.049	0.143MetCys: 0.143 ± 0.009	1.441MetAsp: 1.441 ± 0.032	1.769MetGlu: 1.769 ± 0.035	0.99MetPhe: 0.99 ± 0.025	1.777MetGly: 1.777 ± 0.034	0.438MetHis: 0.438 ± 0.019	1.583MetIle: 1.583 ± 0.031	1.78MetLys: 1.78 ± 0.037	2.773MetLeu: 2.773 ± 0.043	0.786MetMet: 0.786 ± 0.027	1.299MetAsn: 1.299 ± 0.031	1.297MetPro: 1.297 ± 0.031	0.931MetGln: 0.931 ± 0.027	1.368MetArg: 1.368 ± 0.026	1.699MetSer: 1.699 ± 0.036	1.663MetThr: 1.663 ± 0.036	1.662MetVal: 1.662 ± 0.034	0.224MetTrp: 0.224 ± 0.012	0.653MetTyr: 0.653 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.081AsnAla: 3.081 ± 0.047	0.175AsnCys: 0.175 ± 0.01	1.774AsnAsp: 1.774 ± 0.039	2.04AsnGlu: 2.04 ± 0.037	1.19AsnPhe: 1.19 ± 0.026	3.414AsnGly: 3.414 ± 0.062	0.616AsnHis: 0.616 ± 0.019	1.861AsnIle: 1.861 ± 0.036	1.554AsnLys: 1.554 ± 0.042	3.093AsnLeu: 3.093 ± 0.048	0.815AsnMet: 0.815 ± 0.024	1.172AsnAsn: 1.172 ± 0.032	1.999AsnPro: 1.999 ± 0.039	1.087AsnGln: 1.087 ± 0.029	2.283AsnArg: 2.283 ± 0.045	1.628AsnSer: 1.628 ± 0.037	1.6AsnThr: 1.6 ± 0.035	2.74AsnVal: 2.74 ± 0.049	0.486AsnTrp: 0.486 ± 0.018	1.083AsnTyr: 1.083 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.364ProAla: 4.364 ± 0.064	0.262ProCys: 0.262 ± 0.013	3.067ProAsp: 3.067 ± 0.047	3.693ProGlu: 3.693 ± 0.052	1.981ProPhe: 1.981 ± 0.037	3.553ProGly: 3.553 ± 0.051	0.907ProHis: 0.907 ± 0.024	2.36ProIle: 2.36 ± 0.038	1.841ProLys: 1.841 ± 0.036	4.252ProLeu: 4.252 ± 0.055	1.056ProMet: 1.056 ± 0.03	1.53ProAsn: 1.53 ± 0.035	1.556ProPro: 1.556 ± 0.036	1.376ProGln: 1.376 ± 0.033	1.794ProArg: 1.794 ± 0.038	2.895ProSer: 2.895 ± 0.053	1.894ProThr: 1.894 ± 0.04	3.519ProVal: 3.519 ± 0.049	0.62ProTrp: 0.62 ± 0.023	1.588ProTyr: 1.588 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.539GlnAla: 3.539 ± 0.057	0.156GlnCys: 0.156 ± 0.01	1.609GlnAsp: 1.609 ± 0.029	2.228GlnGlu: 2.228 ± 0.041	1.297GlnPhe: 1.297 ± 0.029	2.567GlnGly: 2.567 ± 0.049	0.614GlnHis: 0.614 ± 0.02	2.001GlnIle: 2.001 ± 0.034	1.584GlnLys: 1.584 ± 0.034	3.447GlnLeu: 3.447 ± 0.045	0.964GlnMet: 0.964 ± 0.028	1.14GlnAsn: 1.14 ± 0.033	1.538GlnPro: 1.538 ± 0.026	1.361GlnGln: 1.361 ± 0.031	1.757GlnArg: 1.757 ± 0.038	2.004GlnSer: 2.004 ± 0.037	1.969GlnThr: 1.969 ± 0.039	2.261GlnVal: 2.261 ± 0.037	0.555GlnTrp: 0.555 ± 0.02	1.137GlnTyr: 1.137 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	4.135ArgAla: 4.135 ± 0.064	0.356ArgCys: 0.356 ± 0.017	2.941ArgAsp: 2.941 ± 0.045	4.598ArgGlu: 4.598 ± 0.071	2.686ArgPhe: 2.686 ± 0.043	3.593ArgGly: 3.593 ± 0.048	1.336ArgHis: 1.336 ± 0.034	3.967ArgIle: 3.967 ± 0.061	3.51ArgLys: 3.51 ± 0.051	6.483ArgLeu: 6.483 ± 0.075	1.958ArgMet: 1.958 ± 0.037	2.192ArgAsn: 2.192 ± 0.04	2.235ArgPro: 2.235 ± 0.042	2.315ArgGln: 2.315 ± 0.044	3.886ArgArg: 3.886 ± 0.071	3.514ArgSer: 3.514 ± 0.054	3.121ArgThr: 3.121 ± 0.047	3.784ArgVal: 3.784 ± 0.054	0.854ArgTrp: 0.854 ± 0.023	2.107ArgTyr: 2.107 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.782SerAla: 5.782 ± 0.074	0.395SerCys: 0.395 ± 0.017	3.184SerAsp: 3.184 ± 0.053	3.643SerGlu: 3.643 ± 0.059	2.839SerPhe: 2.839 ± 0.044	5.679SerGly: 5.679 ± 0.07	1.099SerHis: 1.099 ± 0.026	3.437SerIle: 3.437 ± 0.048	2.661SerLys: 2.661 ± 0.051	6.215SerLeu: 6.215 ± 0.065	1.68SerMet: 1.68 ± 0.03	1.854SerAsn: 1.854 ± 0.036	2.807SerPro: 2.807 ± 0.046	1.791SerGln: 1.791 ± 0.032	3.527SerArg: 3.527 ± 0.048	3.846SerSer: 3.846 ± 0.062	2.79SerThr: 2.79 ± 0.052	4.907SerVal: 4.907 ± 0.066	0.829SerTrp: 0.829 ± 0.025	1.97SerTyr: 1.97 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.215ThrAla: 5.215 ± 0.072	0.317ThrCys: 0.317 ± 0.017	2.979ThrAsp: 2.979 ± 0.05	3.192ThrGlu: 3.192 ± 0.049	2.298ThrPhe: 2.298 ± 0.041	4.72ThrGly: 4.72 ± 0.065	0.91ThrHis: 0.91 ± 0.024	3.171ThrIle: 3.171 ± 0.049	2.059ThrLys: 2.059 ± 0.041	5.309ThrLeu: 5.309 ± 0.063	1.289ThrMet: 1.289 ± 0.029	1.672ThrAsn: 1.672 ± 0.034	2.573ThrPro: 2.573 ± 0.046	1.423ThrGln: 1.423 ± 0.03	2.441ThrArg: 2.441 ± 0.041	2.974ThrSer: 2.974 ± 0.048	2.54ThrThr: 2.54 ± 0.05	4.853ThrVal: 4.853 ± 0.071	0.664ThrTrp: 0.664 ± 0.023	1.719ThrTyr: 1.719 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.878ValAla: 5.878 ± 0.069	0.667ValCys: 0.667 ± 0.023	3.646ValAsp: 3.646 ± 0.053	4.242ValGlu: 4.242 ± 0.054	3.088ValPhe: 3.088 ± 0.048	5.045ValGly: 5.045 ± 0.067	1.384ValHis: 1.384 ± 0.028	4.456ValIle: 4.456 ± 0.061	3.645ValLys: 3.645 ± 0.052	7.671ValLeu: 7.671 ± 0.071	1.878ValMet: 1.878 ± 0.03	2.693ValAsn: 2.693 ± 0.05	3.515ValPro: 3.515 ± 0.049	2.425ValGln: 2.425 ± 0.038	4.443ValArg: 4.443 ± 0.058	5.177ValSer: 5.177 ± 0.067	4.773ValThr: 4.773 ± 0.073	5.394ValVal: 5.394 ± 0.078	1.066ValTrp: 1.066 ± 0.028	2.448ValTyr: 2.448 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.029TrpAla: 1.029 ± 0.029	0.112TrpCys: 0.112 ± 0.008	0.74TrpAsp: 0.74 ± 0.024	0.809TrpGlu: 0.809 ± 0.023	0.596TrpPhe: 0.596 ± 0.019	0.988TrpGly: 0.988 ± 0.025	0.268TrpHis: 0.268 ± 0.013	0.925TrpIle: 0.925 ± 0.024	0.819TrpLys: 0.819 ± 0.025	1.65TrpLeu: 1.65 ± 0.033	0.471TrpMet: 0.471 ± 0.016	0.725TrpAsn: 0.725 ± 0.024	0.472TrpPro: 0.472 ± 0.018	0.505TrpGln: 0.505 ± 0.021	0.771TrpArg: 0.771 ± 0.025	0.91TrpSer: 0.91 ± 0.025	0.87TrpThr: 0.87 ± 0.026	0.876TrpVal: 0.876 ± 0.027	0.226TrpTrp: 0.226 ± 0.013	0.421TrpTyr: 0.421 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.877TyrAla: 2.877 ± 0.045	0.246TyrCys: 0.246 ± 0.014	1.773TyrAsp: 1.773 ± 0.04	2.112TyrGlu: 2.112 ± 0.041	1.528TyrPhe: 1.528 ± 0.032	2.856TyrGly: 2.856 ± 0.045	0.723TyrHis: 0.723 ± 0.024	1.518TyrIle: 1.518 ± 0.032	1.213TyrLys: 1.213 ± 0.028	3.237TyrLeu: 3.237 ± 0.049	0.717TyrMet: 0.717 ± 0.021	1.074TyrAsn: 1.074 ± 0.032	1.536TyrPro: 1.536 ± 0.039	1.048TyrGln: 1.048 ± 0.029	2.399TyrArg: 2.399 ± 0.043	1.852TyrSer: 1.852 ± 0.039	1.579TyrThr: 1.579 ± 0.034	2.423TyrVal: 2.423 ± 0.037	0.488TyrTrp: 0.488 ± 0.018	1.243TyrTyr: 1.243 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4698 proteins (1562592 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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