Amino acid dipepetide frequency for Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.782AlaAla: 3.782 ± 0.809
1.621AlaCys: 1.621 ± 0.706
0.54AlaAsp: 0.54 ± 0.361
3.241AlaGlu: 3.241 ± 1.215
2.701AlaPhe: 2.701 ± 0.988
5.943AlaGly: 5.943 ± 2.431
1.08AlaHis: 1.08 ± 0.795
3.782AlaIle: 3.782 ± 1.389
5.943AlaLys: 5.943 ± 1.211
4.862AlaLeu: 4.862 ± 1.477
1.08AlaMet: 1.08 ± 0.723
2.701AlaAsn: 2.701 ± 1.368
5.402AlaPro: 5.402 ± 1.625
2.161AlaGln: 2.161 ± 1.155
4.322AlaArg: 4.322 ± 0.901
3.241AlaSer: 3.241 ± 1.071
5.943AlaThr: 5.943 ± 0.937
3.241AlaVal: 3.241 ± 0.499
1.621AlaTrp: 1.621 ± 0.683
1.621AlaTyr: 1.621 ± 0.607
0.0AlaXaa: 0.0 ± 0.0
Cys
1.621CysAla: 1.621 ± 0.732
0.0CysCys: 0.0 ± 0.0
0.54CysAsp: 0.54 ± 0.361
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.54CysGly: 0.54 ± 0.361
1.08CysHis: 1.08 ± 0.723
1.08CysIle: 1.08 ± 0.723
0.54CysLys: 0.54 ± 0.361
2.161CysLeu: 2.161 ± 1.019
0.0CysMet: 0.0 ± 0.0
0.54CysAsn: 0.54 ± 0.361
2.701CysPro: 2.701 ± 1.602
0.54CysGln: 0.54 ± 0.554
0.0CysArg: 0.0 ± 0.0
1.08CysSer: 1.08 ± 0.723
1.08CysThr: 1.08 ± 0.521
0.0CysVal: 0.0 ± 0.0
0.54CysTrp: 0.54 ± 0.361
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.322AspAla: 4.322 ± 1.962
0.54AspCys: 0.54 ± 0.361
3.241AspAsp: 3.241 ± 1.297
0.0AspGlu: 0.0 ± 0.0
3.241AspPhe: 3.241 ± 1.215
1.621AspGly: 1.621 ± 1.084
1.08AspHis: 1.08 ± 1.062
2.701AspIle: 2.701 ± 0.791
1.621AspLys: 1.621 ± 1.084
5.943AspLeu: 5.943 ± 2.562
0.0AspMet: 0.0 ± 0.0
1.621AspAsn: 1.621 ± 0.732
0.54AspPro: 0.54 ± 0.531
3.241AspGln: 3.241 ± 1.026
1.08AspArg: 1.08 ± 0.795
4.862AspSer: 4.862 ± 1.678
1.621AspThr: 1.621 ± 0.732
1.08AspVal: 1.08 ± 0.493
2.161AspTrp: 2.161 ± 0.721
1.08AspTyr: 1.08 ± 0.795
0.0AspXaa: 0.0 ± 0.0
Glu
6.483GluAla: 6.483 ± 1.423
0.54GluCys: 0.54 ± 0.361
2.161GluAsp: 2.161 ± 0.574
8.644GluGlu: 8.644 ± 1.919
0.0GluPhe: 0.0 ± 0.0
0.54GluGly: 0.54 ± 0.531
0.0GluHis: 0.0 ± 0.0
3.782GluIle: 3.782 ± 1.433
3.241GluLys: 3.241 ± 0.502
3.241GluLeu: 3.241 ± 1.644
0.54GluMet: 0.54 ± 0.361
2.161GluAsn: 2.161 ± 0.975
3.241GluPro: 3.241 ± 1.297
0.0GluGln: 0.0 ± 0.0
3.241GluArg: 3.241 ± 1.297
4.322GluSer: 4.322 ± 1.117
1.621GluThr: 1.621 ± 1.592
0.54GluVal: 0.54 ± 0.531
0.54GluTrp: 0.54 ± 0.361
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.08PheAla: 1.08 ± 0.723
0.0PheCys: 0.0 ± 0.0
1.08PheAsp: 1.08 ± 0.723
0.0PheGlu: 0.0 ± 0.0
2.161PhePhe: 2.161 ± 1.155
2.701PheGly: 2.701 ± 1.831
0.0PheHis: 0.0 ± 0.0
1.08PheIle: 1.08 ± 0.901
1.621PheLys: 1.621 ± 0.607
5.943PheLeu: 5.943 ± 2.113
0.54PheMet: 0.54 ± 0.361
1.08PheAsn: 1.08 ± 0.723
2.701PhePro: 2.701 ± 0.398
2.161PheGln: 2.161 ± 1.155
1.08PheArg: 1.08 ± 0.493
4.322PheSer: 4.322 ± 1.752
2.701PheThr: 2.701 ± 1.317
3.241PheVal: 3.241 ± 1.071
1.621PheTrp: 1.621 ± 0.607
1.621PheTyr: 1.621 ± 0.732
0.0PheXaa: 0.0 ± 0.0
Gly
3.782GlyAla: 3.782 ± 1.287
1.621GlyCys: 1.621 ± 0.732
1.621GlyAsp: 1.621 ± 0.873
2.701GlyGlu: 2.701 ± 0.398
1.621GlyPhe: 1.621 ± 0.732
4.862GlyGly: 4.862 ± 0.429
0.54GlyHis: 0.54 ± 0.361
2.701GlyIle: 2.701 ± 0.627
6.483GlyLys: 6.483 ± 2.646
7.023GlyLeu: 7.023 ± 3.392
1.621GlyMet: 1.621 ± 0.607
2.161GlyAsn: 2.161 ± 1.446
0.54GlyPro: 0.54 ± 0.361
1.621GlyGln: 1.621 ± 0.683
6.483GlyArg: 6.483 ± 1.384
3.241GlySer: 3.241 ± 0.502
4.322GlyThr: 4.322 ± 0.49
1.621GlyVal: 1.621 ± 1.084
0.0GlyTrp: 0.0 ± 0.0
1.621GlyTyr: 1.621 ± 0.607
0.0GlyXaa: 0.0 ± 0.0
His
1.621HisAla: 1.621 ± 0.607
0.54HisCys: 0.54 ± 0.361
0.54HisAsp: 0.54 ± 0.361
3.241HisGlu: 3.241 ± 1.297
2.161HisPhe: 2.161 ± 0.605
0.54HisGly: 0.54 ± 0.361
2.701HisHis: 2.701 ± 0.791
1.08HisIle: 1.08 ± 0.723
0.54HisLys: 0.54 ± 0.361
5.402HisLeu: 5.402 ± 1.795
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.621HisPro: 1.621 ± 0.683
1.621HisGln: 1.621 ± 0.607
2.161HisArg: 2.161 ± 0.605
0.54HisSer: 0.54 ± 0.361
0.0HisThr: 0.0 ± 0.0
2.701HisVal: 2.701 ± 0.398
0.0HisTrp: 0.0 ± 0.0
2.161HisTyr: 2.161 ± 1.155
0.0HisXaa: 0.0 ± 0.0
Ile
3.241IleAla: 3.241 ± 1.297
0.0IleCys: 0.0 ± 0.0
2.701IleAsp: 2.701 ± 0.398
4.322IleGlu: 4.322 ± 0.901
1.621IlePhe: 1.621 ± 1.008
2.161IleGly: 2.161 ± 0.721
1.621IleHis: 1.621 ± 0.607
2.161IleIle: 2.161 ± 1.803
4.322IleLys: 4.322 ± 0.49
7.023IleLeu: 7.023 ± 3.921
0.54IleMet: 0.54 ± 0.361
3.241IleAsn: 3.241 ± 1.215
3.241IlePro: 3.241 ± 1.297
3.782IleGln: 3.782 ± 1.158
2.161IleArg: 2.161 ± 1.446
9.184IleSer: 9.184 ± 1.908
4.322IleThr: 4.322 ± 1.486
2.161IleVal: 2.161 ± 1.019
1.08IleTrp: 1.08 ± 0.901
0.54IleTyr: 0.54 ± 0.361
0.0IleXaa: 0.0 ± 0.0
Lys
3.782LysAla: 3.782 ± 0.774
0.54LysCys: 0.54 ± 0.361
1.621LysAsp: 1.621 ± 0.607
0.0LysGlu: 0.0 ± 0.0
1.621LysPhe: 1.621 ± 0.683
4.322LysGly: 4.322 ± 1.411
4.322LysHis: 4.322 ± 1.211
5.943LysIle: 5.943 ± 0.637
3.241LysLys: 3.241 ± 1.394
4.862LysLeu: 4.862 ± 1.688
2.701LysMet: 2.701 ± 1.388
2.161LysAsn: 2.161 ± 0.721
3.241LysPro: 3.241 ± 1.071
2.161LysGln: 2.161 ± 1.446
1.621LysArg: 1.621 ± 1.084
6.483LysSer: 6.483 ± 0.788
3.782LysThr: 3.782 ± 1.056
2.701LysVal: 2.701 ± 0.791
0.0LysTrp: 0.0 ± 0.0
3.241LysTyr: 3.241 ± 1.071
0.0LysXaa: 0.0 ± 0.0
Leu
6.483LeuAla: 6.483 ± 1.091
1.08LeuCys: 1.08 ± 0.723
3.782LeuAsp: 3.782 ± 0.747
6.483LeuGlu: 6.483 ± 2.133
5.402LeuPhe: 5.402 ± 2.213
4.322LeuGly: 4.322 ± 1.101
1.08LeuHis: 1.08 ± 0.723
7.563LeuIle: 7.563 ± 4.165
3.241LeuLys: 3.241 ± 0.499
17.288LeuLeu: 17.288 ± 7.523
1.621LeuMet: 1.621 ± 0.732
2.701LeuAsn: 2.701 ± 1.302
7.563LeuPro: 7.563 ± 1.383
3.782LeuGln: 3.782 ± 1.38
7.563LeuArg: 7.563 ± 0.956
9.184LeuSer: 9.184 ± 1.502
4.862LeuThr: 4.862 ± 1.51
8.644LeuVal: 8.644 ± 2.434
3.241LeuTrp: 3.241 ± 1.766
4.862LeuTyr: 4.862 ± 1.122
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
2.161MetAsp: 2.161 ± 0.574
0.54MetGlu: 0.54 ± 0.531
1.08MetPhe: 1.08 ± 0.901
2.161MetGly: 2.161 ± 0.975
1.08MetHis: 1.08 ± 0.795
1.08MetIle: 1.08 ± 0.493
1.08MetLys: 1.08 ± 0.723
1.08MetLeu: 1.08 ± 0.723
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.161MetPro: 2.161 ± 0.721
1.621MetGln: 1.621 ± 0.732
0.54MetArg: 0.54 ± 0.361
1.08MetSer: 1.08 ± 0.901
1.08MetThr: 1.08 ± 0.901
1.08MetVal: 1.08 ± 0.723
0.54MetTrp: 0.54 ± 0.554
0.54MetTyr: 0.54 ± 0.361
0.0MetXaa: 0.0 ± 0.0
Asn
2.701AsnAla: 2.701 ± 0.791
1.08AsnCys: 1.08 ± 0.795
0.54AsnAsp: 0.54 ± 0.361
1.621AsnGlu: 1.621 ± 0.607
1.621AsnPhe: 1.621 ± 1.084
1.08AsnGly: 1.08 ± 0.723
0.54AsnHis: 0.54 ± 0.361
0.54AsnIle: 0.54 ± 0.361
1.621AsnLys: 1.621 ± 0.683
2.161AsnLeu: 2.161 ± 0.993
2.161AsnMet: 2.161 ± 1.457
1.08AsnAsn: 1.08 ± 0.723
2.701AsnPro: 2.701 ± 1.135
0.54AsnGln: 0.54 ± 0.531
2.161AsnArg: 2.161 ± 1.446
1.621AsnSer: 1.621 ± 1.084
1.621AsnThr: 1.621 ± 0.683
3.782AsnVal: 3.782 ± 1.158
1.08AsnTrp: 1.08 ± 0.723
1.08AsnTyr: 1.08 ± 0.795
0.0AsnXaa: 0.0 ± 0.0
Pro
4.322ProAla: 4.322 ± 1.807
0.54ProCys: 0.54 ± 0.361
4.322ProAsp: 4.322 ± 1.211
3.782ProGlu: 3.782 ± 1.197
1.08ProPhe: 1.08 ± 0.723
3.782ProGly: 3.782 ± 1.764
1.621ProHis: 1.621 ± 0.683
2.701ProIle: 2.701 ± 1.368
3.782ProLys: 3.782 ± 0.747
8.104ProLeu: 8.104 ± 1.341
1.08ProMet: 1.08 ± 0.723
2.161ProAsn: 2.161 ± 1.446
2.701ProPro: 2.701 ± 0.925
3.782ProGln: 3.782 ± 0.659
7.023ProArg: 7.023 ± 2.345
5.402ProSer: 5.402 ± 0.652
5.943ProThr: 5.943 ± 2.58
3.241ProVal: 3.241 ± 0.499
2.161ProTrp: 2.161 ± 1.078
1.621ProTyr: 1.621 ± 0.607
0.0ProXaa: 0.0 ± 0.0
Gln
2.161GlnAla: 2.161 ± 0.605
1.08GlnCys: 1.08 ± 0.901
1.08GlnAsp: 1.08 ± 0.901
3.241GlnGlu: 3.241 ± 0.499
0.54GlnPhe: 0.54 ± 0.361
3.241GlnGly: 3.241 ± 1.941
3.782GlnHis: 3.782 ± 0.322
2.161GlnIle: 2.161 ± 0.721
2.161GlnLys: 2.161 ± 1.078
3.241GlnLeu: 3.241 ± 1.026
0.54GlnMet: 0.54 ± 0.361
0.54GlnAsn: 0.54 ± 0.531
3.241GlnPro: 3.241 ± 1.394
1.621GlnGln: 1.621 ± 1.592
1.621GlnArg: 1.621 ± 0.607
2.161GlnSer: 2.161 ± 1.446
3.241GlnThr: 3.241 ± 1.066
1.621GlnVal: 1.621 ± 1.084
1.621GlnTrp: 1.621 ± 1.268
0.54GlnTyr: 0.54 ± 0.361
0.0GlnXaa: 0.0 ± 0.0
Arg
8.644ArgAla: 8.644 ± 2.947
0.54ArgCys: 0.54 ± 0.361
4.322ArgAsp: 4.322 ± 1.211
2.701ArgGlu: 2.701 ± 0.398
2.161ArgPhe: 2.161 ± 1.446
4.322ArgGly: 4.322 ± 1.211
1.08ArgHis: 1.08 ± 0.723
5.943ArgIle: 5.943 ± 1.191
5.402ArgLys: 5.402 ± 2.736
8.644ArgLeu: 8.644 ± 0.576
0.54ArgMet: 0.54 ± 0.531
1.08ArgAsn: 1.08 ± 0.723
3.782ArgPro: 3.782 ± 0.774
0.0ArgGln: 0.0 ± 0.0
12.426ArgArg: 12.426 ± 3.046
4.862ArgSer: 4.862 ± 1.822
2.161ArgThr: 2.161 ± 0.605
0.54ArgVal: 0.54 ± 0.361
0.54ArgTrp: 0.54 ± 0.361
1.621ArgTyr: 1.621 ± 0.683
0.0ArgXaa: 0.0 ± 0.0
Ser
3.241SerAla: 3.241 ± 0.688
1.621SerCys: 1.621 ± 1.008
3.782SerAsp: 3.782 ± 0.322
1.08SerGlu: 1.08 ± 0.723
3.782SerPhe: 3.782 ± 0.809
2.161SerGly: 2.161 ± 0.574
2.701SerHis: 2.701 ± 0.791
5.943SerIle: 5.943 ± 0.937
5.402SerLys: 5.402 ± 2.417
7.563SerLeu: 7.563 ± 2.308
1.08SerMet: 1.08 ± 0.493
1.08SerAsn: 1.08 ± 0.723
9.184SerPro: 9.184 ± 1.567
2.161SerGln: 2.161 ± 0.721
9.724SerArg: 9.724 ± 3.212
16.207SerSer: 16.207 ± 1.906
3.782SerThr: 3.782 ± 1.149
4.862SerVal: 4.862 ± 2.195
0.54SerTrp: 0.54 ± 0.361
1.621SerTyr: 1.621 ± 1.084
0.0SerXaa: 0.0 ± 0.0
Thr
3.241ThrAla: 3.241 ± 1.215
0.0ThrCys: 0.0 ± 0.0
2.161ThrAsp: 2.161 ± 0.721
0.54ThrGlu: 0.54 ± 0.361
3.241ThrPhe: 3.241 ± 1.128
4.322ThrGly: 4.322 ± 0.465
2.701ThrHis: 2.701 ± 0.398
3.782ThrIle: 3.782 ± 0.897
0.54ThrLys: 0.54 ± 0.361
5.943ThrLeu: 5.943 ± 2.352
1.621ThrMet: 1.621 ± 0.649
2.701ThrAsn: 2.701 ± 0.398
7.023ThrPro: 7.023 ± 1.859
3.241ThrGln: 3.241 ± 1.913
3.241ThrArg: 3.241 ± 1.215
4.322ThrSer: 4.322 ± 0.924
8.104ThrThr: 8.104 ± 1.291
2.701ThrVal: 2.701 ± 0.945
1.621ThrTrp: 1.621 ± 0.873
2.161ThrTyr: 2.161 ± 0.721
0.0ThrXaa: 0.0 ± 0.0
Val
2.701ValAla: 2.701 ± 1.602
2.701ValCys: 2.701 ± 1.317
3.241ValAsp: 3.241 ± 1.071
0.54ValGlu: 0.54 ± 0.361
1.08ValPhe: 1.08 ± 0.723
3.782ValGly: 3.782 ± 1.429
0.0ValHis: 0.0 ± 0.0
2.161ValIle: 2.161 ± 0.574
2.161ValLys: 2.161 ± 0.605
3.782ValLeu: 3.782 ± 1.606
0.54ValMet: 0.54 ± 0.361
2.161ValAsn: 2.161 ± 0.975
4.322ValPro: 4.322 ± 0.816
1.621ValGln: 1.621 ± 0.683
3.241ValArg: 3.241 ± 0.499
3.782ValSer: 3.782 ± 1.606
3.782ValThr: 3.782 ± 0.747
2.701ValVal: 2.701 ± 0.791
0.54ValTrp: 0.54 ± 0.361
3.241ValTyr: 3.241 ± 1.752
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.621TrpGlu: 1.621 ± 0.732
0.0TrpPhe: 0.0 ± 0.0
2.701TrpGly: 2.701 ± 0.814
1.621TrpHis: 1.621 ± 0.607
1.621TrpIle: 1.621 ± 0.732
3.241TrpLys: 3.241 ± 0.499
1.08TrpLeu: 1.08 ± 0.795
1.08TrpMet: 1.08 ± 0.901
0.54TrpAsn: 0.54 ± 0.554
1.621TrpPro: 1.621 ± 0.683
1.08TrpGln: 1.08 ± 0.795
0.0TrpArg: 0.0 ± 0.0
1.08TrpSer: 1.08 ± 0.493
2.701TrpThr: 2.701 ± 0.988
0.0TrpVal: 0.0 ± 0.0
3.241TrpTrp: 3.241 ± 1.913
1.08TrpTyr: 1.08 ± 0.723
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.621TyrAla: 1.621 ± 0.607
0.0TyrCys: 0.0 ± 0.0
2.161TyrAsp: 2.161 ± 1.019
0.54TyrGlu: 0.54 ± 0.361
1.621TyrPhe: 1.621 ± 1.084
1.08TyrGly: 1.08 ± 0.795
0.54TyrHis: 0.54 ± 0.361
1.621TyrIle: 1.621 ± 0.607
2.161TyrLys: 2.161 ± 0.721
5.402TyrLeu: 5.402 ± 0.955
1.08TyrMet: 1.08 ± 0.521
2.161TyrAsn: 2.161 ± 0.605
1.621TyrPro: 1.621 ± 0.607
2.701TyrGln: 2.701 ± 1.135
1.621TyrArg: 1.621 ± 0.607
0.54TyrSer: 0.54 ± 0.361
0.54TyrThr: 0.54 ± 0.361
1.621TyrVal: 1.621 ± 0.732
1.621TyrTrp: 1.621 ± 0.607
0.54TyrTyr: 0.54 ± 0.361
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1852 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski