Amino acid dipepetide frequency for Bacteroides sp. CAG:443

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.692AlaAla: 5.692 ± 0.102
1.161AlaCys: 1.161 ± 0.036
4.39AlaAsp: 4.39 ± 0.061
4.833AlaGlu: 4.833 ± 0.081
3.071AlaPhe: 3.071 ± 0.052
5.296AlaGly: 5.296 ± 0.088
1.275AlaHis: 1.275 ± 0.039
4.68AlaIle: 4.68 ± 0.068
4.001AlaLys: 4.001 ± 0.075
6.524AlaLeu: 6.524 ± 0.081
1.982AlaMet: 1.982 ± 0.049
3.148AlaAsn: 3.148 ± 0.065
2.308AlaPro: 2.308 ± 0.047
2.748AlaGln: 2.748 ± 0.058
3.109AlaArg: 3.109 ± 0.07
4.466AlaSer: 4.466 ± 0.07
3.93AlaThr: 3.93 ± 0.067
4.694AlaVal: 4.694 ± 0.081
0.788AlaTrp: 0.788 ± 0.032
3.116AlaTyr: 3.116 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.817CysAla: 0.817 ± 0.03
0.225CysCys: 0.225 ± 0.015
0.634CysAsp: 0.634 ± 0.027
0.678CysGlu: 0.678 ± 0.027
0.683CysPhe: 0.683 ± 0.024
1.073CysGly: 1.073 ± 0.038
0.34CysHis: 0.34 ± 0.02
0.988CysIle: 0.988 ± 0.034
0.747CysLys: 0.747 ± 0.028
1.219CysLeu: 1.219 ± 0.037
0.405CysMet: 0.405 ± 0.018
0.614CysAsn: 0.614 ± 0.025
0.612CysPro: 0.612 ± 0.025
0.387CysGln: 0.387 ± 0.02
0.639CysArg: 0.639 ± 0.025
0.863CysSer: 0.863 ± 0.034
0.775CysThr: 0.775 ± 0.027
0.782CysVal: 0.782 ± 0.028
0.171CysTrp: 0.171 ± 0.014
0.556CysTyr: 0.556 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.875AspAla: 3.875 ± 0.07
0.621AspCys: 0.621 ± 0.027
2.568AspAsp: 2.568 ± 0.055
4.058AspGlu: 4.058 ± 0.069
2.982AspPhe: 2.982 ± 0.056
4.071AspGly: 4.071 ± 0.077
0.817AspHis: 0.817 ± 0.032
4.065AspIle: 4.065 ± 0.069
3.884AspLys: 3.884 ± 0.075
4.724AspLeu: 4.724 ± 0.07
1.727AspMet: 1.727 ± 0.046
2.805AspAsn: 2.805 ± 0.061
1.908AspPro: 1.908 ± 0.048
1.304AspGln: 1.304 ± 0.041
2.389AspArg: 2.389 ± 0.047
3.019AspSer: 3.019 ± 0.064
2.791AspThr: 2.791 ± 0.056
3.552AspVal: 3.552 ± 0.071
0.851AspTrp: 0.851 ± 0.033
2.98AspTyr: 2.98 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.035GluAla: 5.035 ± 0.078
0.658GluCys: 0.658 ± 0.027
3.14GluAsp: 3.14 ± 0.064
5.004GluGlu: 5.004 ± 0.086
2.414GluPhe: 2.414 ± 0.046
4.446GluGly: 4.446 ± 0.069
1.347GluHis: 1.347 ± 0.038
4.446GluIle: 4.446 ± 0.089
5.3GluLys: 5.3 ± 0.092
6.111GluLeu: 6.111 ± 0.092
2.018GluMet: 2.018 ± 0.042
3.549GluAsn: 3.549 ± 0.07
1.677GluPro: 1.677 ± 0.039
2.749GluGln: 2.749 ± 0.062
3.163GluArg: 3.163 ± 0.069
3.013GluSer: 3.013 ± 0.054
3.394GluThr: 3.394 ± 0.06
4.384GluVal: 4.384 ± 0.069
0.814GluTrp: 0.814 ± 0.028
2.695GluTyr: 2.695 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.969PheAla: 2.969 ± 0.055
0.684PheCys: 0.684 ± 0.027
2.748PheAsp: 2.748 ± 0.055
2.346PheGlu: 2.346 ± 0.048
2.12PhePhe: 2.12 ± 0.056
3.214PheGly: 3.214 ± 0.067
0.973PheHis: 0.973 ± 0.031
3.097PheIle: 3.097 ± 0.06
2.232PheLys: 2.232 ± 0.041
4.014PheLeu: 4.014 ± 0.08
1.233PheMet: 1.233 ± 0.032
2.215PheAsn: 2.215 ± 0.05
1.795PhePro: 1.795 ± 0.04
1.373PheGln: 1.373 ± 0.034
2.167PheArg: 2.167 ± 0.046
3.382PheSer: 3.382 ± 0.055
2.86PheThr: 2.86 ± 0.061
2.838PheVal: 2.838 ± 0.058
0.573PheTrp: 0.573 ± 0.023
2.044PheTyr: 2.044 ± 0.054
0.001PheXaa: 0.001 ± 0.001
Gly
4.409GlyAla: 4.409 ± 0.077
0.981GlyCys: 0.981 ± 0.033
3.416GlyAsp: 3.416 ± 0.061
4.22GlyGlu: 4.22 ± 0.075
3.164GlyPhe: 3.164 ± 0.061
4.809GlyGly: 4.809 ± 0.091
1.314GlyHis: 1.314 ± 0.035
5.473GlyIle: 5.473 ± 0.087
5.271GlyLys: 5.271 ± 0.071
5.938GlyLeu: 5.938 ± 0.084
2.191GlyMet: 2.191 ± 0.047
3.763GlyAsn: 3.763 ± 0.072
1.271GlyPro: 1.271 ± 0.038
2.104GlyGln: 2.104 ± 0.046
2.748GlyArg: 2.748 ± 0.051
4.081GlySer: 4.081 ± 0.084
4.25GlyThr: 4.25 ± 0.073
4.868GlyVal: 4.868 ± 0.078
1.025GlyTrp: 1.025 ± 0.04
3.465GlyTyr: 3.465 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.328HisAla: 1.328 ± 0.04
0.321HisCys: 0.321 ± 0.019
0.988HisAsp: 0.988 ± 0.031
1.11HisGlu: 1.11 ± 0.033
1.098HisPhe: 1.098 ± 0.032
1.154HisGly: 1.154 ± 0.035
0.54HisHis: 0.54 ± 0.024
1.54HisIle: 1.54 ± 0.043
1.013HisLys: 1.013 ± 0.032
1.822HisLeu: 1.822 ± 0.045
0.401HisMet: 0.401 ± 0.021
0.921HisAsn: 0.921 ± 0.031
1.121HisPro: 1.121 ± 0.034
0.676HisGln: 0.676 ± 0.026
0.933HisArg: 0.933 ± 0.033
1.105HisSer: 1.105 ± 0.036
1.224HisThr: 1.224 ± 0.036
1.139HisVal: 1.139 ± 0.035
0.255HisTrp: 0.255 ± 0.017
0.916HisTyr: 0.916 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.154IleAla: 5.154 ± 0.085
1.074IleCys: 1.074 ± 0.035
4.239IleAsp: 4.239 ± 0.063
4.167IleGlu: 4.167 ± 0.072
2.784IlePhe: 2.784 ± 0.068
4.684IleGly: 4.684 ± 0.072
1.411IleHis: 1.411 ± 0.041
4.428IleIle: 4.428 ± 0.084
3.892IleLys: 3.892 ± 0.076
5.924IleLeu: 5.924 ± 0.1
1.554IleMet: 1.554 ± 0.045
3.314IleAsn: 3.314 ± 0.061
3.13IlePro: 3.13 ± 0.066
2.312IleGln: 2.312 ± 0.058
3.42IleArg: 3.42 ± 0.067
4.581IleSer: 4.581 ± 0.073
3.951IleThr: 3.951 ± 0.065
4.433IleVal: 4.433 ± 0.076
0.74IleTrp: 0.74 ± 0.03
2.792IleTyr: 2.792 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.82LysAla: 4.82 ± 0.079
0.576LysCys: 0.576 ± 0.027
3.919LysAsp: 3.919 ± 0.069
5.681LysGlu: 5.681 ± 0.085
2.128LysPhe: 2.128 ± 0.048
4.483LysGly: 4.483 ± 0.07
1.255LysHis: 1.255 ± 0.035
3.935LysIle: 3.935 ± 0.069
4.808LysLys: 4.808 ± 0.087
5.453LysLeu: 5.453 ± 0.072
2.042LysMet: 2.042 ± 0.043
3.465LysAsn: 3.465 ± 0.066
2.028LysPro: 2.028 ± 0.046
2.667LysGln: 2.667 ± 0.053
2.958LysArg: 2.958 ± 0.055
3.067LysSer: 3.067 ± 0.063
3.37LysThr: 3.37 ± 0.064
4.334LysVal: 4.334 ± 0.073
0.786LysTrp: 0.786 ± 0.031
2.904LysTyr: 2.904 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
6.425LeuAla: 6.425 ± 0.083
1.426LeuCys: 1.426 ± 0.038
4.687LeuAsp: 4.687 ± 0.063
5.134LeuGlu: 5.134 ± 0.077
4.358LeuPhe: 4.358 ± 0.068
5.69LeuGly: 5.69 ± 0.087
1.904LeuHis: 1.904 ± 0.053
5.532LeuIle: 5.532 ± 0.088
6.429LeuLys: 6.429 ± 0.079
8.758LeuLeu: 8.758 ± 0.125
2.528LeuMet: 2.528 ± 0.052
4.741LeuAsn: 4.741 ± 0.074
4.017LeuPro: 4.017 ± 0.076
3.56LeuGln: 3.56 ± 0.054
4.104LeuArg: 4.104 ± 0.064
6.647LeuSer: 6.647 ± 0.094
5.447LeuThr: 5.447 ± 0.067
5.173LeuVal: 5.173 ± 0.081
1.002LeuTrp: 1.002 ± 0.036
3.784LeuTyr: 3.784 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.075MetAla: 2.075 ± 0.052
0.271MetCys: 0.271 ± 0.017
1.521MetAsp: 1.521 ± 0.041
1.882MetGlu: 1.882 ± 0.045
1.076MetPhe: 1.076 ± 0.035
1.911MetGly: 1.911 ± 0.047
0.528MetHis: 0.528 ± 0.023
1.712MetIle: 1.712 ± 0.049
2.618MetLys: 2.618 ± 0.05
2.536MetLeu: 2.536 ± 0.053
0.804MetMet: 0.804 ± 0.029
1.683MetAsn: 1.683 ± 0.044
1.218MetPro: 1.218 ± 0.035
1.122MetGln: 1.122 ± 0.032
1.296MetArg: 1.296 ± 0.035
1.524MetSer: 1.524 ± 0.035
1.544MetThr: 1.544 ± 0.042
1.541MetVal: 1.541 ± 0.037
0.257MetTrp: 0.257 ± 0.017
0.934MetTyr: 0.934 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.419AsnAla: 3.419 ± 0.065
0.56AsnCys: 0.56 ± 0.025
2.526AsnAsp: 2.526 ± 0.052
3.142AsnGlu: 3.142 ± 0.071
2.213AsnPhe: 2.213 ± 0.053
3.919AsnGly: 3.919 ± 0.078
0.983AsnHis: 0.983 ± 0.032
3.794AsnIle: 3.794 ± 0.065
3.069AsnLys: 3.069 ± 0.06
4.538AsnLeu: 4.538 ± 0.08
1.437AsnMet: 1.437 ± 0.038
2.6AsnAsn: 2.6 ± 0.067
2.476AsnPro: 2.476 ± 0.05
1.65AsnGln: 1.65 ± 0.039
2.399AsnArg: 2.399 ± 0.056
2.693AsnSer: 2.693 ± 0.06
2.827AsnThr: 2.827 ± 0.063
3.2AsnVal: 3.2 ± 0.067
0.694AsnTrp: 0.694 ± 0.029
2.442AsnTyr: 2.442 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.853ProAla: 2.853 ± 0.062
0.385ProCys: 0.385 ± 0.023
2.594ProAsp: 2.594 ± 0.053
3.457ProGlu: 3.457 ± 0.06
1.803ProPhe: 1.803 ± 0.047
2.433ProGly: 2.433 ± 0.059
0.712ProHis: 0.712 ± 0.026
2.158ProIle: 2.158 ± 0.052
1.921ProLys: 1.921 ± 0.05
3.254ProLeu: 3.254 ± 0.064
0.991ProMet: 0.991 ± 0.033
1.636ProAsn: 1.636 ± 0.034
0.788ProPro: 0.788 ± 0.03
1.531ProGln: 1.531 ± 0.042
1.222ProArg: 1.222 ± 0.04
2.273ProSer: 2.273 ± 0.055
1.894ProThr: 1.894 ± 0.044
3.129ProVal: 3.129 ± 0.06
0.438ProTrp: 0.438 ± 0.022
1.89ProTyr: 1.89 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
2.747GlnAla: 2.747 ± 0.065
0.356GlnCys: 0.356 ± 0.021
1.572GlnAsp: 1.572 ± 0.039
2.464GlnGlu: 2.464 ± 0.058
1.378GlnPhe: 1.378 ± 0.041
2.086GlnGly: 2.086 ± 0.047
0.741GlnHis: 0.741 ± 0.03
2.477GlnIle: 2.477 ± 0.056
2.508GlnLys: 2.508 ± 0.061
3.419GlnLeu: 3.419 ± 0.062
1.078GlnMet: 1.078 ± 0.029
1.854GlnAsn: 1.854 ± 0.043
1.363GlnPro: 1.363 ± 0.038
1.829GlnGln: 1.829 ± 0.059
1.637GlnArg: 1.637 ± 0.039
2.013GlnSer: 2.013 ± 0.05
2.168GlnThr: 2.168 ± 0.051
2.336GlnVal: 2.336 ± 0.057
0.478GlnTrp: 0.478 ± 0.02
1.603GlnTyr: 1.603 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.748ArgAla: 2.748 ± 0.06
0.514ArgCys: 0.514 ± 0.025
2.056ArgAsp: 2.056 ± 0.053
2.909ArgGlu: 2.909 ± 0.058
2.216ArgPhe: 2.216 ± 0.048
2.42ArgGly: 2.42 ± 0.054
0.888ArgHis: 0.888 ± 0.027
3.585ArgIle: 3.585 ± 0.064
3.32ArgLys: 3.32 ± 0.059
4.444ArgLeu: 4.444 ± 0.067
1.541ArgMet: 1.541 ± 0.038
2.464ArgAsn: 2.464 ± 0.062
1.664ArgPro: 1.664 ± 0.043
1.885ArgGln: 1.885 ± 0.046
2.249ArgArg: 2.249 ± 0.054
2.396ArgSer: 2.396 ± 0.049
2.499ArgThr: 2.499 ± 0.045
2.583ArgVal: 2.583 ± 0.053
0.622ArgTrp: 0.622 ± 0.029
2.25ArgTyr: 2.25 ± 0.054
0.001ArgXaa: 0.001 ± 0.001
Ser
4.081SerAla: 4.081 ± 0.077
0.881SerCys: 0.881 ± 0.03
3.365SerAsp: 3.365 ± 0.068
3.526SerGlu: 3.526 ± 0.058
3.274SerPhe: 3.274 ± 0.065
4.563SerGly: 4.563 ± 0.076
1.187SerHis: 1.187 ± 0.036
4.091SerIle: 4.091 ± 0.057
3.222SerLys: 3.222 ± 0.061
6.011SerLeu: 6.011 ± 0.096
1.543SerMet: 1.543 ± 0.035
2.611SerAsn: 2.611 ± 0.061
2.261SerPro: 2.261 ± 0.054
2.066SerGln: 2.066 ± 0.046
2.673SerArg: 2.673 ± 0.05
4.033SerSer: 4.033 ± 0.092
3.292SerThr: 3.292 ± 0.068
4.266SerVal: 4.266 ± 0.067
0.856SerTrp: 0.856 ± 0.031
2.893SerTyr: 2.893 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.031ThrAla: 4.031 ± 0.068
0.695ThrCys: 0.695 ± 0.03
3.593ThrAsp: 3.593 ± 0.063
3.52ThrGlu: 3.52 ± 0.069
2.742ThrPhe: 2.742 ± 0.055
4.42ThrGly: 4.42 ± 0.074
1.064ThrHis: 1.064 ± 0.03
3.857ThrIle: 3.857 ± 0.07
2.633ThrLys: 2.633 ± 0.057
5.574ThrLeu: 5.574 ± 0.075
1.247ThrMet: 1.247 ± 0.038
2.524ThrAsn: 2.524 ± 0.062
2.876ThrPro: 2.876 ± 0.049
1.868ThrGln: 1.868 ± 0.047
2.248ThrArg: 2.248 ± 0.051
3.508ThrSer: 3.508 ± 0.067
3.112ThrThr: 3.112 ± 0.072
3.993ThrVal: 3.993 ± 0.071
0.657ThrTrp: 0.657 ± 0.027
2.649ThrTyr: 2.649 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.745ValAla: 4.745 ± 0.085
1.075ValCys: 1.075 ± 0.032
3.711ValAsp: 3.711 ± 0.066
4.023ValGlu: 4.023 ± 0.073
2.745ValPhe: 2.745 ± 0.049
3.98ValGly: 3.98 ± 0.078
1.141ValHis: 1.141 ± 0.031
4.344ValIle: 4.344 ± 0.072
4.195ValLys: 4.195 ± 0.072
5.828ValLeu: 5.828 ± 0.077
1.713ValMet: 1.713 ± 0.04
3.296ValAsn: 3.296 ± 0.053
2.624ValPro: 2.624 ± 0.056
2.047ValGln: 2.047 ± 0.042
3.063ValArg: 3.063 ± 0.052
4.627ValSer: 4.627 ± 0.073
3.92ValThr: 3.92 ± 0.065
4.52ValVal: 4.52 ± 0.073
0.742ValTrp: 0.742 ± 0.029
2.793ValTyr: 2.793 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.769TrpAla: 0.769 ± 0.029
0.176TrpCys: 0.176 ± 0.014
0.691TrpAsp: 0.691 ± 0.031
0.737TrpGlu: 0.737 ± 0.031
0.55TrpPhe: 0.55 ± 0.025
0.979TrpGly: 0.979 ± 0.036
0.268TrpHis: 0.268 ± 0.018
0.852TrpIle: 0.852 ± 0.034
0.928TrpLys: 0.928 ± 0.034
1.215TrpLeu: 1.215 ± 0.036
0.455TrpMet: 0.455 ± 0.02
0.823TrpAsn: 0.823 ± 0.03
0.233TrpPro: 0.233 ± 0.019
0.479TrpGln: 0.479 ± 0.022
0.543TrpArg: 0.543 ± 0.023
0.707TrpSer: 0.707 ± 0.029
0.686TrpThr: 0.686 ± 0.032
0.709TrpVal: 0.709 ± 0.028
0.212TrpTrp: 0.212 ± 0.016
0.542TrpTyr: 0.542 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.221TyrAla: 3.221 ± 0.05
0.567TyrCys: 0.567 ± 0.025
2.633TyrAsp: 2.633 ± 0.055
2.466TyrGlu: 2.466 ± 0.05
2.08TyrPhe: 2.08 ± 0.05
3.129TyrGly: 3.129 ± 0.076
0.917TyrHis: 0.917 ± 0.03
2.931TyrIle: 2.931 ± 0.062
2.688TyrLys: 2.688 ± 0.054
4.039TyrLeu: 4.039 ± 0.073
1.165TyrMet: 1.165 ± 0.038
2.554TyrAsn: 2.554 ± 0.057
1.992TyrPro: 1.992 ± 0.046
1.751TyrGln: 1.751 ± 0.049
2.294TyrArg: 2.294 ± 0.052
2.698TyrSer: 2.698 ± 0.053
2.875TyrThr: 2.875 ± 0.067
2.656TyrVal: 2.656 ± 0.053
0.59TyrTrp: 0.59 ± 0.026
2.178TyrTyr: 2.178 ± 0.053
0.001TyrXaa: 0.001 ± 0.001
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.002XaaVal: 0.002 ± 0.001
0.001XaaTrp: 0.001 ± 0.001
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 2710 proteins (996151 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski