Amino acid dipepetide frequency for Thioalkalivibrio sp. (strain K90mix)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.653AlaAla: 13.653 ± 0.189	1.109AlaCys: 1.109 ± 0.034	6.405AlaAsp: 6.405 ± 0.088	8.381AlaGlu: 8.381 ± 0.13	3.811AlaPhe: 3.811 ± 0.075	9.638AlaGly: 9.638 ± 0.134	2.564AlaHis: 2.564 ± 0.062	5.361AlaIle: 5.361 ± 0.08	2.153AlaLys: 2.153 ± 0.055	13.467AlaLeu: 13.467 ± 0.169	3.078AlaMet: 3.078 ± 0.065	2.352AlaAsn: 2.352 ± 0.06	4.947AlaPro: 4.947 ± 0.082	4.115AlaGln: 4.115 ± 0.071	9.682AlaArg: 9.682 ± 0.137	5.152AlaSer: 5.152 ± 0.069	5.224AlaThr: 5.224 ± 0.08	8.04AlaVal: 8.04 ± 0.107	1.8AlaTrp: 1.8 ± 0.044	2.246AlaTyr: 2.246 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.836CysAla: 0.836 ± 0.03	0.109CysCys: 0.109 ± 0.011	0.481CysAsp: 0.481 ± 0.022	0.585CysGlu: 0.585 ± 0.026	0.229CysPhe: 0.229 ± 0.017	0.887CysGly: 0.887 ± 0.032	0.26CysHis: 0.26 ± 0.019	0.311CysIle: 0.311 ± 0.021	0.171CysLys: 0.171 ± 0.017	0.765CysLeu: 0.765 ± 0.029	0.163CysMet: 0.163 ± 0.013	0.205CysAsn: 0.205 ± 0.016	0.545CysPro: 0.545 ± 0.03	0.27CysGln: 0.27 ± 0.019	0.665CysArg: 0.665 ± 0.027	0.442CysSer: 0.442 ± 0.02	0.392CysThr: 0.392 ± 0.021	0.592CysVal: 0.592 ± 0.026	0.105CysTrp: 0.105 ± 0.011	0.212CysTyr: 0.212 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.186AspAla: 7.186 ± 0.104	0.521AspCys: 0.521 ± 0.024	4.082AspAsp: 4.082 ± 0.078	4.564AspGlu: 4.564 ± 0.094	2.148AspPhe: 2.148 ± 0.048	5.247AspGly: 5.247 ± 0.102	1.669AspHis: 1.669 ± 0.061	2.682AspIle: 2.682 ± 0.054	1.135AspLys: 1.135 ± 0.039	6.632AspLeu: 6.632 ± 0.093	1.32AspMet: 1.32 ± 0.039	1.337AspAsn: 1.337 ± 0.042	4.098AspPro: 4.098 ± 0.07	2.272AspGln: 2.272 ± 0.062	5.136AspArg: 5.136 ± 0.076	2.73AspSer: 2.73 ± 0.068	3.076AspThr: 3.076 ± 0.068	4.114AspVal: 4.114 ± 0.085	1.152AspTrp: 1.152 ± 0.039	1.657AspTyr: 1.657 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	9.021GluAla: 9.021 ± 0.151	0.47GluCys: 0.47 ± 0.023	4.087GluAsp: 4.087 ± 0.079	4.15GluGlu: 4.15 ± 0.087	2.012GluPhe: 2.012 ± 0.048	5.477GluGly: 5.477 ± 0.084	2.005GluHis: 2.005 ± 0.047	3.436GluIle: 3.436 ± 0.067	1.743GluLys: 1.743 ± 0.064	7.042GluLeu: 7.042 ± 0.108	1.636GluMet: 1.636 ± 0.047	1.7GluAsn: 1.7 ± 0.043	3.93GluPro: 3.93 ± 0.101	3.485GluGln: 3.485 ± 0.074	7.409GluArg: 7.409 ± 0.118	3.445GluSer: 3.445 ± 0.065	3.802GluThr: 3.802 ± 0.07	4.992GluVal: 4.992 ± 0.09	0.977GluTrp: 0.977 ± 0.034	1.506GluTyr: 1.506 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.574PheAla: 3.574 ± 0.078	0.327PheCys: 0.327 ± 0.022	2.529PheAsp: 2.529 ± 0.063	2.45PheGlu: 2.45 ± 0.052	1.222PhePhe: 1.222 ± 0.048	3.087PheGly: 3.087 ± 0.067	0.765PheHis: 0.765 ± 0.03	1.41PheIle: 1.41 ± 0.055	0.651PheLys: 0.651 ± 0.027	3.191PheLeu: 3.191 ± 0.08	0.767PheMet: 0.767 ± 0.034	0.931PheAsn: 0.931 ± 0.044	1.493PhePro: 1.493 ± 0.044	1.092PheGln: 1.092 ± 0.037	2.362PheArg: 2.362 ± 0.056	1.759PheSer: 1.759 ± 0.049	1.58PheThr: 1.58 ± 0.047	2.572PheVal: 2.572 ± 0.064	0.498PheTrp: 0.498 ± 0.024	0.833PheTyr: 0.833 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.912GlyAla: 7.912 ± 0.112	0.885GlyCys: 0.885 ± 0.037	5.078GlyAsp: 5.078 ± 0.094	5.811GlyGlu: 5.811 ± 0.093	3.207GlyPhe: 3.207 ± 0.063	6.841GlyGly: 6.841 ± 0.106	2.265GlyHis: 2.265 ± 0.063	4.202GlyIle: 4.202 ± 0.087	2.189GlyLys: 2.189 ± 0.058	9.254GlyLeu: 9.254 ± 0.13	2.406GlyMet: 2.406 ± 0.057	1.969GlyAsn: 1.969 ± 0.065	3.473GlyPro: 3.473 ± 0.067	3.302GlyGln: 3.302 ± 0.07	6.537GlyArg: 6.537 ± 0.105	4.082GlySer: 4.082 ± 0.08	4.149GlyThr: 4.149 ± 0.063	6.27GlyVal: 6.27 ± 0.098	1.408GlyTrp: 1.408 ± 0.047	2.235GlyTyr: 2.235 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.724HisAla: 2.724 ± 0.063	0.272HisCys: 0.272 ± 0.019	1.475HisAsp: 1.475 ± 0.05	1.555HisGlu: 1.555 ± 0.044	0.889HisPhe: 0.889 ± 0.036	2.316HisGly: 2.316 ± 0.067	0.785HisHis: 0.785 ± 0.038	0.945HisIle: 0.945 ± 0.035	0.472HisLys: 0.472 ± 0.025	2.662HisLeu: 2.662 ± 0.06	0.581HisMet: 0.581 ± 0.025	0.593HisAsn: 0.593 ± 0.027	1.823HisPro: 1.823 ± 0.044	0.853HisGln: 0.853 ± 0.032	1.956HisArg: 1.956 ± 0.046	1.141HisSer: 1.141 ± 0.043	1.154HisThr: 1.154 ± 0.037	1.565HisVal: 1.565 ± 0.043	0.434HisTrp: 0.434 ± 0.024	0.732HisTyr: 0.732 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.474IleAla: 5.474 ± 0.087	0.358IleCys: 0.358 ± 0.021	3.167IleAsp: 3.167 ± 0.073	3.956IleGlu: 3.956 ± 0.078	1.229IlePhe: 1.229 ± 0.039	4.178IleGly: 4.178 ± 0.082	1.106IleHis: 1.106 ± 0.035	1.746IleIle: 1.746 ± 0.058	1.027IleLys: 1.027 ± 0.04	4.465IleLeu: 4.465 ± 0.072	0.765IleMet: 0.765 ± 0.034	1.244IleAsn: 1.244 ± 0.043	2.45IlePro: 2.45 ± 0.059	1.589IleGln: 1.589 ± 0.043	3.569IleArg: 3.569 ± 0.064	2.181IleSer: 2.181 ± 0.054	2.441IleThr: 2.441 ± 0.051	3.208IleVal: 3.208 ± 0.064	0.515IleTrp: 0.515 ± 0.023	0.976IleTyr: 0.976 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.792LysAla: 2.792 ± 0.065	0.125LysCys: 0.125 ± 0.011	1.3LysAsp: 1.3 ± 0.044	1.25LysGlu: 1.25 ± 0.053	0.496LysPhe: 0.496 ± 0.027	1.888LysGly: 1.888 ± 0.05	0.527LysHis: 0.527 ± 0.024	1.021LysIle: 1.021 ± 0.041	1.005LysLys: 1.005 ± 0.045	2.052LysLeu: 2.052 ± 0.057	0.494LysMet: 0.494 ± 0.028	0.611LysAsn: 0.611 ± 0.028	1.345LysPro: 1.345 ± 0.042	0.799LysGln: 0.799 ± 0.034	1.916LysArg: 1.916 ± 0.055	1.135LysSer: 1.135 ± 0.038	1.334LysThr: 1.334 ± 0.04	1.648LysVal: 1.648 ± 0.048	0.207LysTrp: 0.207 ± 0.016	0.442LysTyr: 0.442 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.25LeuAla: 13.25 ± 0.161	0.784LeuCys: 0.784 ± 0.031	7.345LeuAsp: 7.345 ± 0.093	8.494LeuGlu: 8.494 ± 0.116	3.567LeuPhe: 3.567 ± 0.069	8.841LeuGly: 8.841 ± 0.123	2.509LeuHis: 2.509 ± 0.059	4.609LeuIle: 4.609 ± 0.09	2.711LeuLys: 2.711 ± 0.062	10.917LeuLeu: 10.917 ± 0.178	2.348LeuMet: 2.348 ± 0.058	2.691LeuAsn: 2.691 ± 0.058	5.665LeuPro: 5.665 ± 0.089	3.614LeuGln: 3.614 ± 0.075	8.438LeuArg: 8.438 ± 0.126	5.27LeuSer: 5.27 ± 0.083	5.132LeuThr: 5.132 ± 0.082	7.697LeuVal: 7.697 ± 0.111	1.338LeuTrp: 1.338 ± 0.05	2.167LeuTyr: 2.167 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.812MetAla: 2.812 ± 0.065	0.139MetCys: 0.139 ± 0.012	1.472MetAsp: 1.472 ± 0.043	1.486MetGlu: 1.486 ± 0.038	0.635MetPhe: 0.635 ± 0.032	1.876MetGly: 1.876 ± 0.051	0.551MetHis: 0.551 ± 0.026	1.094MetIle: 1.094 ± 0.038	0.751MetLys: 0.751 ± 0.031	2.386MetLeu: 2.386 ± 0.05	0.539MetMet: 0.539 ± 0.026	0.766MetAsn: 0.766 ± 0.026	1.347MetPro: 1.347 ± 0.038	1.054MetGln: 1.054 ± 0.034	1.776MetArg: 1.776 ± 0.043	1.535MetSer: 1.535 ± 0.044	1.442MetThr: 1.442 ± 0.037	1.602MetVal: 1.602 ± 0.043	0.172MetTrp: 0.172 ± 0.013	0.368MetTyr: 0.368 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.64AsnAla: 2.64 ± 0.047	0.197AsnCys: 0.197 ± 0.016	1.457AsnAsp: 1.457 ± 0.051	1.433AsnGlu: 1.433 ± 0.044	0.726AsnPhe: 0.726 ± 0.031	1.969AsnGly: 1.969 ± 0.055	0.56AsnHis: 0.56 ± 0.021	1.157AsnIle: 1.157 ± 0.035	0.523AsnLys: 0.523 ± 0.027	2.476AsnLeu: 2.476 ± 0.061	0.519AsnMet: 0.519 ± 0.025	0.588AsnAsn: 0.588 ± 0.026	1.852AsnPro: 1.852 ± 0.046	0.907AsnGln: 0.907 ± 0.034	2.125AsnArg: 2.125 ± 0.056	1.008AsnSer: 1.008 ± 0.042	1.326AsnThr: 1.326 ± 0.04	1.738AsnVal: 1.738 ± 0.049	0.334AsnTrp: 0.334 ± 0.019	0.505AsnTyr: 0.505 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.665ProAla: 5.665 ± 0.09	0.334ProCys: 0.334 ± 0.022	4.301ProAsp: 4.301 ± 0.069	5.598ProGlu: 5.598 ± 0.109	1.656ProPhe: 1.656 ± 0.045	5.008ProGly: 5.008 ± 0.085	1.179ProHis: 1.179 ± 0.045	2.026ProIle: 2.026 ± 0.047	1.066ProLys: 1.066 ± 0.034	5.0ProLeu: 5.0 ± 0.083	1.176ProMet: 1.176 ± 0.037	1.236ProAsn: 1.236 ± 0.038	2.706ProPro: 2.706 ± 0.057	1.727ProGln: 1.727 ± 0.043	3.511ProArg: 3.511 ± 0.063	2.438ProSer: 2.438 ± 0.052	2.222ProThr: 2.222 ± 0.051	4.311ProVal: 4.311 ± 0.072	0.787ProTrp: 0.787 ± 0.03	1.113ProTyr: 1.113 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.133GlnAla: 5.133 ± 0.082	0.29GlnCys: 0.29 ± 0.018	1.98GlnAsp: 1.98 ± 0.051	2.315GlnGlu: 2.315 ± 0.054	1.036GlnPhe: 1.036 ± 0.033	3.032GlnGly: 3.032 ± 0.059	0.962GlnHis: 0.962 ± 0.03	1.651GlnIle: 1.651 ± 0.051	0.879GlnLys: 0.879 ± 0.035	3.551GlnLeu: 3.551 ± 0.078	0.939GlnMet: 0.939 ± 0.033	0.793GlnAsn: 0.793 ± 0.029	1.997GlnPro: 1.997 ± 0.05	1.706GlnGln: 1.706 ± 0.052	3.36GlnArg: 3.36 ± 0.068	1.784GlnSer: 1.784 ± 0.051	1.817GlnThr: 1.817 ± 0.05	2.781GlnVal: 2.781 ± 0.062	0.575GlnTrp: 0.575 ± 0.027	0.806GlnTyr: 0.806 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	8.467ArgAla: 8.467 ± 0.124	0.562ArgCys: 0.562 ± 0.026	5.191ArgAsp: 5.191 ± 0.08	6.777ArgGlu: 6.777 ± 0.098	3.113ArgPhe: 3.113 ± 0.071	5.396ArgGly: 5.396 ± 0.098	2.316ArgHis: 2.316 ± 0.059	4.285ArgIle: 4.285 ± 0.078	1.957ArgLys: 1.957 ± 0.054	9.519ArgLeu: 9.519 ± 0.135	2.223ArgMet: 2.223 ± 0.055	1.909ArgAsn: 1.909 ± 0.047	3.987ArgPro: 3.987 ± 0.073	3.163ArgGln: 3.163 ± 0.06	6.662ArgArg: 6.662 ± 0.115	3.718ArgSer: 3.718 ± 0.07	3.309ArgThr: 3.309 ± 0.06	6.023ArgVal: 6.023 ± 0.084	1.178ArgTrp: 1.178 ± 0.038	2.199ArgTyr: 2.199 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.121SerAla: 5.121 ± 0.083	0.358SerCys: 0.358 ± 0.023	2.922SerAsp: 2.922 ± 0.064	3.311SerGlu: 3.311 ± 0.062	1.598SerPhe: 1.598 ± 0.043	4.958SerGly: 4.958 ± 0.085	1.053SerHis: 1.053 ± 0.033	2.156SerIle: 2.156 ± 0.051	0.955SerLys: 0.955 ± 0.034	5.101SerLeu: 5.101 ± 0.082	1.274SerMet: 1.274 ± 0.038	1.2SerAsn: 1.2 ± 0.04	2.602SerPro: 2.602 ± 0.056	1.676SerGln: 1.676 ± 0.043	3.852SerArg: 3.852 ± 0.071	2.428SerSer: 2.428 ± 0.054	2.39SerThr: 2.39 ± 0.054	3.445SerVal: 3.445 ± 0.065	0.616SerTrp: 0.616 ± 0.028	0.913SerTyr: 0.913 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.107ThrAla: 5.107 ± 0.078	0.384ThrCys: 0.384 ± 0.021	2.954ThrAsp: 2.954 ± 0.065	2.959ThrGlu: 2.959 ± 0.063	1.563ThrPhe: 1.563 ± 0.042	4.72ThrGly: 4.72 ± 0.076	1.141ThrHis: 1.141 ± 0.037	2.156ThrIle: 2.156 ± 0.048	0.8ThrLys: 0.8 ± 0.033	6.219ThrLeu: 6.219 ± 0.091	0.952ThrMet: 0.952 ± 0.029	0.997ThrAsn: 0.997 ± 0.032	3.265ThrPro: 3.265 ± 0.064	1.705ThrGln: 1.705 ± 0.048	3.879ThrArg: 3.879 ± 0.069	2.169ThrSer: 2.169 ± 0.054	2.526ThrThr: 2.526 ± 0.052	3.806ThrVal: 3.806 ± 0.065	0.612ThrTrp: 0.612 ± 0.029	0.985ThrTyr: 0.985 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.282ValAla: 8.282 ± 0.116	0.641ValCys: 0.641 ± 0.028	4.597ValAsp: 4.597 ± 0.073	5.19ValGlu: 5.19 ± 0.089	2.563ValPhe: 2.563 ± 0.06	5.358ValGly: 5.358 ± 0.079	1.718ValHis: 1.718 ± 0.051	3.815ValIle: 3.815 ± 0.071	1.44ValLys: 1.44 ± 0.048	8.009ValLeu: 8.009 ± 0.106	1.791ValMet: 1.791 ± 0.049	1.912ValAsn: 1.912 ± 0.046	3.579ValPro: 3.579 ± 0.065	2.459ValGln: 2.459 ± 0.054	5.667ValArg: 5.667 ± 0.089	3.644ValSer: 3.644 ± 0.068	3.92ValThr: 3.92 ± 0.067	5.918ValVal: 5.918 ± 0.091	0.847ValTrp: 0.847 ± 0.03	1.545ValTyr: 1.545 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.228TrpAla: 1.228 ± 0.038	0.131TrpCys: 0.131 ± 0.012	0.704TrpAsp: 0.704 ± 0.028	0.795TrpGlu: 0.795 ± 0.03	0.521TrpPhe: 0.521 ± 0.029	0.906TrpGly: 0.906 ± 0.032	0.349TrpHis: 0.349 ± 0.02	0.684TrpIle: 0.684 ± 0.03	0.298TrpLys: 0.298 ± 0.019	2.168TrpLeu: 2.168 ± 0.058	0.4TrpMet: 0.4 ± 0.022	0.405TrpAsn: 0.405 ± 0.021	0.75TrpPro: 0.75 ± 0.029	0.682TrpGln: 0.682 ± 0.027	1.211TrpArg: 1.211 ± 0.04	0.684TrpSer: 0.684 ± 0.03	0.575TrpThr: 0.575 ± 0.026	1.151TrpVal: 1.151 ± 0.034	0.293TrpTrp: 0.293 ± 0.019	0.323TrpTyr: 0.323 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.302TyrAla: 2.302 ± 0.048	0.228TyrCys: 0.228 ± 0.017	1.233TyrAsp: 1.233 ± 0.04	1.264TyrGlu: 1.264 ± 0.035	0.873TyrPhe: 0.873 ± 0.032	1.854TyrGly: 1.854 ± 0.048	0.645TyrHis: 0.645 ± 0.026	0.895TyrIle: 0.895 ± 0.034	0.462TyrLys: 0.462 ± 0.022	2.51TyrLeu: 2.51 ± 0.061	0.432TyrMet: 0.432 ± 0.023	0.601TyrAsn: 0.601 ± 0.028	1.201TyrPro: 1.201 ± 0.037	0.918TyrGln: 0.918 ± 0.032	2.243TyrArg: 2.243 ± 0.047	1.182TyrSer: 1.182 ± 0.04	1.091TyrThr: 1.091 ± 0.039	1.42TyrVal: 1.42 ± 0.038	0.408TyrTrp: 0.408 ± 0.019	0.611TyrTyr: 0.611 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2823 proteins (877254 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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