Amino acid dipepetide frequency for Fictibacillus enclensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.883AlaAla: 6.883 ± 0.102
0.609AlaCys: 0.609 ± 0.02
3.556AlaAsp: 3.556 ± 0.055
5.02AlaGlu: 5.02 ± 0.066
3.472AlaPhe: 3.472 ± 0.064
6.358AlaGly: 6.358 ± 0.085
1.393AlaHis: 1.393 ± 0.034
5.492AlaIle: 5.492 ± 0.076
4.672AlaLys: 4.672 ± 0.062
7.541AlaLeu: 7.541 ± 0.082
2.153AlaMet: 2.153 ± 0.046
2.553AlaAsn: 2.553 ± 0.053
2.345AlaPro: 2.345 ± 0.046
2.349AlaGln: 2.349 ± 0.044
2.886AlaArg: 2.886 ± 0.055
4.467AlaSer: 4.467 ± 0.074
3.275AlaThr: 3.275 ± 0.062
6.154AlaVal: 6.154 ± 0.075
0.669AlaTrp: 0.669 ± 0.025
2.299AlaTyr: 2.299 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.482CysAla: 0.482 ± 0.019
0.108CysCys: 0.108 ± 0.01
0.407CysAsp: 0.407 ± 0.019
0.468CysGlu: 0.468 ± 0.019
0.325CysPhe: 0.325 ± 0.017
0.692CysGly: 0.692 ± 0.023
0.225CysHis: 0.225 ± 0.014
0.501CysIle: 0.501 ± 0.019
0.352CysLys: 0.352 ± 0.017
0.76CysLeu: 0.76 ± 0.027
0.191CysMet: 0.191 ± 0.012
0.29CysAsn: 0.29 ± 0.015
0.373CysPro: 0.373 ± 0.016
0.235CysGln: 0.235 ± 0.014
0.335CysArg: 0.335 ± 0.015
0.558CysSer: 0.558 ± 0.02
0.43CysThr: 0.43 ± 0.02
0.439CysVal: 0.439 ± 0.021
0.084CysTrp: 0.084 ± 0.008
0.268CysTyr: 0.268 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.421AspAla: 3.421 ± 0.05
0.406AspCys: 0.406 ± 0.017
2.247AspAsp: 2.247 ± 0.051
3.929AspGlu: 3.929 ± 0.065
2.302AspPhe: 2.302 ± 0.041
3.419AspGly: 3.419 ± 0.062
1.347AspHis: 1.347 ± 0.032
3.626AspIle: 3.626 ± 0.057
2.838AspLys: 2.838 ± 0.051
5.069AspLeu: 5.069 ± 0.059
1.329AspMet: 1.329 ± 0.03
1.642AspAsn: 1.642 ± 0.042
2.185AspPro: 2.185 ± 0.041
2.12AspGln: 2.12 ± 0.045
2.378AspArg: 2.378 ± 0.043
2.5AspSer: 2.5 ± 0.046
2.378AspThr: 2.378 ± 0.041
3.691AspVal: 3.691 ± 0.056
0.646AspTrp: 0.646 ± 0.025
2.097AspTyr: 2.097 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
5.584GluAla: 5.584 ± 0.068
0.416GluCys: 0.416 ± 0.018
3.573GluAsp: 3.573 ± 0.053
6.751GluGlu: 6.751 ± 0.093
2.417GluPhe: 2.417 ± 0.044
4.499GluGly: 4.499 ± 0.057
1.591GluHis: 1.591 ± 0.039
5.017GluIle: 5.017 ± 0.069
6.43GluLys: 6.43 ± 0.082
6.935GluLeu: 6.935 ± 0.092
2.208GluMet: 2.208 ± 0.042
3.511GluAsn: 3.511 ± 0.055
2.004GluPro: 2.004 ± 0.045
3.162GluGln: 3.162 ± 0.056
3.6GluArg: 3.6 ± 0.065
3.385GluSer: 3.385 ± 0.056
3.744GluThr: 3.744 ± 0.055
4.849GluVal: 4.849 ± 0.075
0.837GluTrp: 0.837 ± 0.025
2.051GluTyr: 2.051 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
3.072PheAla: 3.072 ± 0.063
0.394PheCys: 0.394 ± 0.016
2.196PheAsp: 2.196 ± 0.043
2.622PheGlu: 2.622 ± 0.055
2.302PhePhe: 2.302 ± 0.057
3.464PheGly: 3.464 ± 0.055
1.047PheHis: 1.047 ± 0.028
3.355PheIle: 3.355 ± 0.066
2.294PheLys: 2.294 ± 0.041
4.488PheLeu: 4.488 ± 0.076
1.24PheMet: 1.24 ± 0.036
1.766PheAsn: 1.766 ± 0.038
1.758PhePro: 1.758 ± 0.042
1.526PheGln: 1.526 ± 0.032
1.594PheArg: 1.594 ± 0.037
3.239PheSer: 3.239 ± 0.052
2.568PheThr: 2.568 ± 0.042
3.056PheVal: 3.056 ± 0.053
0.487PheTrp: 0.487 ± 0.021
1.715PheTyr: 1.715 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
5.2GlyAla: 5.2 ± 0.075
0.68GlyCys: 0.68 ± 0.021
3.26GlyAsp: 3.26 ± 0.055
4.601GlyGlu: 4.601 ± 0.064
3.487GlyPhe: 3.487 ± 0.058
5.308GlyGly: 5.308 ± 0.083
1.522GlyHis: 1.522 ± 0.039
6.087GlyIle: 6.087 ± 0.073
5.429GlyLys: 5.429 ± 0.07
7.196GlyLeu: 7.196 ± 0.089
2.374GlyMet: 2.374 ± 0.044
2.81GlyAsn: 2.81 ± 0.043
2.018GlyPro: 2.018 ± 0.043
2.371GlyGln: 2.371 ± 0.055
2.963GlyArg: 2.963 ± 0.048
4.477GlySer: 4.477 ± 0.059
4.315GlyThr: 4.315 ± 0.06
5.287GlyVal: 5.287 ± 0.072
0.898GlyTrp: 0.898 ± 0.031
2.853GlyTyr: 2.853 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.449HisAla: 1.449 ± 0.036
0.187HisCys: 0.187 ± 0.013
1.034HisAsp: 1.034 ± 0.028
1.523HisGlu: 1.523 ± 0.036
1.149HisPhe: 1.149 ± 0.032
1.518HisGly: 1.518 ± 0.036
0.728HisHis: 0.728 ± 0.028
1.409HisIle: 1.409 ± 0.033
1.091HisLys: 1.091 ± 0.029
2.322HisLeu: 2.322 ± 0.046
0.566HisMet: 0.566 ± 0.022
0.779HisAsn: 0.779 ± 0.025
1.285HisPro: 1.285 ± 0.03
0.935HisGln: 0.935 ± 0.026
0.928HisArg: 0.928 ± 0.024
1.34HisSer: 1.34 ± 0.037
1.109HisThr: 1.109 ± 0.026
1.508HisVal: 1.508 ± 0.033
0.254HisTrp: 0.254 ± 0.014
0.934HisTyr: 0.934 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.78IleAla: 5.78 ± 0.087
0.6IleCys: 0.6 ± 0.021
3.659IleAsp: 3.659 ± 0.054
4.914IleGlu: 4.914 ± 0.07
2.848IlePhe: 2.848 ± 0.057
5.793IleGly: 5.793 ± 0.081
1.734IleHis: 1.734 ± 0.034
4.831IleIle: 4.831 ± 0.091
4.359IleLys: 4.359 ± 0.064
6.695IleLeu: 6.695 ± 0.083
1.726IleMet: 1.726 ± 0.036
2.864IleAsn: 2.864 ± 0.052
3.278IlePro: 3.278 ± 0.049
2.709IleGln: 2.709 ± 0.046
3.033IleArg: 3.033 ± 0.05
4.846IleSer: 4.846 ± 0.067
4.051IleThr: 4.051 ± 0.057
4.856IleVal: 4.856 ± 0.071
0.661IleTrp: 0.661 ± 0.024
2.117IleTyr: 2.117 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
5.06LysAla: 5.06 ± 0.078
0.278LysCys: 0.278 ± 0.013
3.834LysAsp: 3.834 ± 0.066
6.883LysGlu: 6.883 ± 0.078
1.763LysPhe: 1.763 ± 0.037
4.925LysGly: 4.925 ± 0.063
1.262LysHis: 1.262 ± 0.031
4.167LysIle: 4.167 ± 0.062
6.228LysLys: 6.228 ± 0.084
5.542LysLeu: 5.542 ± 0.056
2.178LysMet: 2.178 ± 0.044
3.267LysAsn: 3.267 ± 0.053
2.393LysPro: 2.393 ± 0.045
3.01LysGln: 3.01 ± 0.052
3.322LysArg: 3.322 ± 0.052
3.487LysSer: 3.487 ± 0.06
3.737LysThr: 3.737 ± 0.055
4.662LysVal: 4.662 ± 0.066
0.824LysTrp: 0.824 ± 0.029
1.917LysTyr: 1.917 ± 0.037
0.0LysXaa: 0.0 ± 0.0
Leu
7.532LeuAla: 7.532 ± 0.088
0.736LeuCys: 0.736 ± 0.023
4.754LeuAsp: 4.754 ± 0.061
6.361LeuGlu: 6.361 ± 0.083
4.844LeuPhe: 4.844 ± 0.076
6.872LeuGly: 6.872 ± 0.083
2.048LeuHis: 2.048 ± 0.042
6.884LeuIle: 6.884 ± 0.084
6.786LeuLys: 6.786 ± 0.078
10.287LeuLeu: 10.287 ± 0.141
2.586LeuMet: 2.586 ± 0.049
4.249LeuAsn: 4.249 ± 0.055
4.267LeuPro: 4.267 ± 0.059
3.718LeuGln: 3.718 ± 0.057
3.733LeuArg: 3.733 ± 0.059
7.053LeuSer: 7.053 ± 0.088
5.472LeuThr: 5.472 ± 0.066
6.391LeuVal: 6.391 ± 0.078
0.88LeuTrp: 0.88 ± 0.031
3.005LeuTyr: 3.005 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.366MetAla: 2.366 ± 0.048
0.138MetCys: 0.138 ± 0.01
1.621MetAsp: 1.621 ± 0.039
2.107MetGlu: 2.107 ± 0.044
0.986MetPhe: 0.986 ± 0.032
1.989MetGly: 1.989 ± 0.043
0.453MetHis: 0.453 ± 0.019
2.045MetIle: 2.045 ± 0.045
2.542MetLys: 2.542 ± 0.045
2.548MetLeu: 2.548 ± 0.046
0.891MetMet: 0.891 ± 0.027
1.551MetAsn: 1.551 ± 0.035
1.097MetPro: 1.097 ± 0.034
0.935MetGln: 0.935 ± 0.027
1.076MetArg: 1.076 ± 0.029
1.667MetSer: 1.667 ± 0.033
1.536MetThr: 1.536 ± 0.034
1.932MetVal: 1.932 ± 0.038
0.184MetTrp: 0.184 ± 0.013
0.753MetTyr: 0.753 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.794AsnAla: 2.794 ± 0.045
0.301AsnCys: 0.301 ± 0.017
2.049AsnAsp: 2.049 ± 0.04
3.147AsnGlu: 3.147 ± 0.051
1.498AsnPhe: 1.498 ± 0.032
3.341AsnGly: 3.341 ± 0.054
1.055AsnHis: 1.055 ± 0.028
2.878AsnIle: 2.878 ± 0.055
2.625AsnLys: 2.625 ± 0.047
3.627AsnLeu: 3.627 ± 0.058
1.142AsnMet: 1.142 ± 0.031
1.74AsnAsn: 1.74 ± 0.046
2.115AsnPro: 2.115 ± 0.038
1.722AsnGln: 1.722 ± 0.039
2.011AsnArg: 2.011 ± 0.036
2.134AsnSer: 2.134 ± 0.042
2.096AsnThr: 2.096 ± 0.043
3.008AsnVal: 3.008 ± 0.05
0.54AsnTrp: 0.54 ± 0.021
1.467AsnTyr: 1.467 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.794ProAla: 2.794 ± 0.049
0.241ProCys: 0.241 ± 0.014
2.28ProAsp: 2.28 ± 0.044
3.321ProGlu: 3.321 ± 0.053
2.123ProPhe: 2.123 ± 0.045
2.871ProGly: 2.871 ± 0.056
0.875ProHis: 0.875 ± 0.025
2.415ProIle: 2.415 ± 0.05
2.233ProLys: 2.233 ± 0.046
3.793ProLeu: 3.793 ± 0.061
0.892ProMet: 0.892 ± 0.029
1.434ProAsn: 1.434 ± 0.038
1.146ProPro: 1.146 ± 0.032
1.265ProGln: 1.265 ± 0.03
1.212ProArg: 1.212 ± 0.032
2.52ProSer: 2.52 ± 0.042
1.748ProThr: 1.748 ± 0.038
3.544ProVal: 3.544 ± 0.061
0.442ProTrp: 0.442 ± 0.02
1.514ProTyr: 1.514 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.756GlnAla: 2.756 ± 0.05
0.228GlnCys: 0.228 ± 0.014
1.664GlnAsp: 1.664 ± 0.043
2.9GlnGlu: 2.9 ± 0.044
1.505GlnPhe: 1.505 ± 0.037
2.338GlnGly: 2.338 ± 0.048
0.853GlnHis: 0.853 ± 0.025
2.275GlnIle: 2.275 ± 0.043
2.969GlnLys: 2.969 ± 0.054
3.845GlnLeu: 3.845 ± 0.06
1.19GlnMet: 1.19 ± 0.034
1.643GlnAsn: 1.643 ± 0.037
1.332GlnPro: 1.332 ± 0.032
1.886GlnGln: 1.886 ± 0.066
1.62GlnArg: 1.62 ± 0.04
2.156GlnSer: 2.156 ± 0.042
1.975GlnThr: 1.975 ± 0.04
2.359GlnVal: 2.359 ± 0.049
0.487GlnTrp: 0.487 ± 0.02
1.324GlnTyr: 1.324 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.581ArgAla: 2.581 ± 0.045
0.271ArgCys: 0.271 ± 0.015
2.131ArgAsp: 2.131 ± 0.051
3.323ArgGlu: 3.323 ± 0.055
2.003ArgPhe: 2.003 ± 0.043
2.522ArgGly: 2.522 ± 0.049
0.88ArgHis: 0.88 ± 0.028
3.1ArgIle: 3.1 ± 0.047
3.274ArgLys: 3.274 ± 0.052
4.16ArgLeu: 4.16 ± 0.063
1.401ArgMet: 1.401 ± 0.036
1.918ArgAsn: 1.918 ± 0.038
1.427ArgPro: 1.427 ± 0.035
1.611ArgGln: 1.611 ± 0.041
2.001ArgArg: 2.001 ± 0.043
2.463ArgSer: 2.463 ± 0.047
2.202ArgThr: 2.202 ± 0.043
2.729ArgVal: 2.729 ± 0.045
0.462ArgTrp: 0.462 ± 0.02
1.594ArgTyr: 1.594 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
4.189SerAla: 4.189 ± 0.06
0.457SerCys: 0.457 ± 0.018
2.855SerAsp: 2.855 ± 0.048
3.83SerGlu: 3.83 ± 0.059
3.271SerPhe: 3.271 ± 0.054
4.71SerGly: 4.71 ± 0.062
1.337SerHis: 1.337 ± 0.034
4.619SerIle: 4.619 ± 0.062
3.796SerLys: 3.796 ± 0.058
6.477SerLeu: 6.477 ± 0.071
1.861SerMet: 1.861 ± 0.043
2.154SerAsn: 2.154 ± 0.044
2.401SerPro: 2.401 ± 0.047
2.058SerGln: 2.058 ± 0.038
2.619SerArg: 2.619 ± 0.049
4.346SerSer: 4.346 ± 0.077
3.097SerThr: 3.097 ± 0.049
4.416SerVal: 4.416 ± 0.062
0.727SerTrp: 0.727 ± 0.027
2.28SerTyr: 2.28 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.272ThrAla: 4.272 ± 0.058
0.388ThrCys: 0.388 ± 0.015
2.579ThrAsp: 2.579 ± 0.046
3.455ThrGlu: 3.455 ± 0.053
2.441ThrPhe: 2.441 ± 0.046
4.644ThrGly: 4.644 ± 0.08
1.084ThrHis: 1.084 ± 0.028
3.985ThrIle: 3.985 ± 0.066
3.145ThrLys: 3.145 ± 0.055
5.139ThrLeu: 5.139 ± 0.058
1.315ThrMet: 1.315 ± 0.031
2.088ThrAsn: 2.088 ± 0.041
2.416ThrPro: 2.416 ± 0.038
1.431ThrGln: 1.431 ± 0.033
1.959ThrArg: 1.959 ± 0.039
3.207ThrSer: 3.207 ± 0.048
2.683ThrThr: 2.683 ± 0.046
4.329ThrVal: 4.329 ± 0.057
0.552ThrTrp: 0.552 ± 0.022
1.799ThrTyr: 1.799 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
5.09ValAla: 5.09 ± 0.073
0.669ValCys: 0.669 ± 0.024
3.481ValAsp: 3.481 ± 0.057
4.357ValGlu: 4.357 ± 0.066
3.239ValPhe: 3.239 ± 0.052
4.51ValGly: 4.51 ± 0.068
1.508ValHis: 1.508 ± 0.036
5.651ValIle: 5.651 ± 0.073
4.802ValLys: 4.802 ± 0.071
7.334ValLeu: 7.334 ± 0.072
1.928ValMet: 1.928 ± 0.04
3.057ValAsn: 3.057 ± 0.047
3.072ValPro: 3.072 ± 0.054
2.49ValGln: 2.49 ± 0.041
2.707ValArg: 2.707 ± 0.05
4.836ValSer: 4.836 ± 0.064
4.233ValThr: 4.233 ± 0.058
5.112ValVal: 5.112 ± 0.076
0.675ValTrp: 0.675 ± 0.025
2.414ValTyr: 2.414 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.692TrpAla: 0.692 ± 0.025
0.085TrpCys: 0.085 ± 0.008
0.541TrpAsp: 0.541 ± 0.02
0.673TrpGlu: 0.673 ± 0.028
0.495TrpPhe: 0.495 ± 0.022
0.793TrpGly: 0.793 ± 0.028
0.222TrpHis: 0.222 ± 0.013
0.816TrpIle: 0.816 ± 0.024
0.825TrpLys: 0.825 ± 0.027
1.226TrpLeu: 1.226 ± 0.039
0.399TrpMet: 0.399 ± 0.018
0.6TrpAsn: 0.6 ± 0.023
0.303TrpPro: 0.303 ± 0.017
0.391TrpGln: 0.391 ± 0.016
0.433TrpArg: 0.433 ± 0.019
0.658TrpSer: 0.658 ± 0.024
0.51TrpThr: 0.51 ± 0.021
0.716TrpVal: 0.716 ± 0.02
0.159TrpTrp: 0.159 ± 0.012
0.348TrpTyr: 0.348 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.152TyrAla: 2.152 ± 0.043
0.332TyrCys: 0.332 ± 0.015
1.846TyrAsp: 1.846 ± 0.042
2.38TyrGlu: 2.38 ± 0.044
1.712TyrPhe: 1.712 ± 0.044
2.569TyrGly: 2.569 ± 0.046
0.883TyrHis: 0.883 ± 0.026
2.202TyrIle: 2.202 ± 0.042
2.048TyrLys: 2.048 ± 0.041
3.475TyrLeu: 3.475 ± 0.051
0.843TyrMet: 0.843 ± 0.026
1.371TyrAsn: 1.371 ± 0.034
1.448TyrPro: 1.448 ± 0.035
1.381TyrGln: 1.381 ± 0.031
1.646TyrArg: 1.646 ± 0.039
2.163TyrSer: 2.163 ± 0.043
1.753TyrThr: 1.753 ± 0.036
2.127TyrVal: 2.127 ± 0.04
0.419TyrTrp: 0.419 ± 0.019
1.339TyrTyr: 1.339 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4409 proteins (1274383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski