Amino acid dipepetide frequency for Odoribacter sp. CAG:788

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.565AlaAla: 5.565 ± 0.089	1.028AlaCys: 1.028 ± 0.026	4.235AlaAsp: 4.235 ± 0.062	4.755AlaGlu: 4.755 ± 0.071	3.199AlaPhe: 3.199 ± 0.052	6.032AlaGly: 6.032 ± 0.085	1.143AlaHis: 1.143 ± 0.034	4.655AlaIle: 4.655 ± 0.072	3.681AlaLys: 3.681 ± 0.064	6.781AlaLeu: 6.781 ± 0.089	1.691AlaMet: 1.691 ± 0.038	2.893AlaAsn: 2.893 ± 0.052	2.126AlaPro: 2.126 ± 0.041	2.393AlaGln: 2.393 ± 0.047	3.234AlaArg: 3.234 ± 0.065	3.75AlaSer: 3.75 ± 0.075	3.542AlaThr: 3.542 ± 0.076	5.166AlaVal: 5.166 ± 0.072	0.857AlaTrp: 0.857 ± 0.03	2.934AlaTyr: 2.934 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.698CysAla: 0.698 ± 0.033	0.227CysCys: 0.227 ± 0.016	0.658CysAsp: 0.658 ± 0.029	0.678CysGlu: 0.678 ± 0.026	0.645CysPhe: 0.645 ± 0.025	1.04CysGly: 1.04 ± 0.035	0.27CysHis: 0.27 ± 0.017	0.938CysIle: 0.938 ± 0.03	0.68CysLys: 0.68 ± 0.028	1.163CysLeu: 1.163 ± 0.037	0.313CysMet: 0.313 ± 0.015	0.583CysAsn: 0.583 ± 0.023	0.561CysPro: 0.561 ± 0.024	0.363CysGln: 0.363 ± 0.019	0.768CysArg: 0.768 ± 0.03	0.749CysSer: 0.749 ± 0.028	0.629CysThr: 0.629 ± 0.026	0.755CysVal: 0.755 ± 0.026	0.149CysTrp: 0.149 ± 0.012	0.524CysTyr: 0.524 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.434AspAla: 3.434 ± 0.058	0.607AspCys: 0.607 ± 0.024	2.332AspAsp: 2.332 ± 0.052	3.298AspGlu: 3.298 ± 0.063	3.089AspPhe: 3.089 ± 0.056	3.848AspGly: 3.848 ± 0.085	0.786AspHis: 0.786 ± 0.029	4.47AspIle: 4.47 ± 0.065	3.735AspLys: 3.735 ± 0.059	4.613AspLeu: 4.613 ± 0.064	1.557AspMet: 1.557 ± 0.041	2.679AspAsn: 2.679 ± 0.051	2.034AspPro: 2.034 ± 0.04	1.244AspGln: 1.244 ± 0.038	2.667AspArg: 2.667 ± 0.054	3.005AspSer: 3.005 ± 0.063	2.902AspThr: 2.902 ± 0.077	3.512AspVal: 3.512 ± 0.06	0.773AspTrp: 0.773 ± 0.027	2.868AspTyr: 2.868 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.831GluAla: 4.831 ± 0.084	0.59GluCys: 0.59 ± 0.022	3.27GluAsp: 3.27 ± 0.056	4.857GluGlu: 4.857 ± 0.091	2.557GluPhe: 2.557 ± 0.043	4.334GluGly: 4.334 ± 0.074	1.194GluHis: 1.194 ± 0.037	5.165GluIle: 5.165 ± 0.069	5.783GluLys: 5.783 ± 0.103	6.055GluLeu: 6.055 ± 0.089	1.871GluMet: 1.871 ± 0.046	3.845GluAsn: 3.845 ± 0.068	1.657GluPro: 1.657 ± 0.043	2.363GluGln: 2.363 ± 0.051	2.978GluArg: 2.978 ± 0.061	3.043GluSer: 3.043 ± 0.055	3.121GluThr: 3.121 ± 0.054	4.252GluVal: 4.252 ± 0.08	0.839GluTrp: 0.839 ± 0.028	2.824GluTyr: 2.824 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.941PheAla: 2.941 ± 0.058	0.666PheCys: 0.666 ± 0.023	2.614PheAsp: 2.614 ± 0.047	2.629PheGlu: 2.629 ± 0.045	2.441PhePhe: 2.441 ± 0.06	3.317PheGly: 3.317 ± 0.057	0.831PheHis: 0.831 ± 0.026	3.445PheIle: 3.445 ± 0.07	2.509PheLys: 2.509 ± 0.057	4.241PheLeu: 4.241 ± 0.083	1.285PheMet: 1.285 ± 0.036	2.364PheAsn: 2.364 ± 0.05	1.83PhePro: 1.83 ± 0.043	1.394PheGln: 1.394 ± 0.036	2.5PheArg: 2.5 ± 0.051	3.536PheSer: 3.536 ± 0.059	2.904PheThr: 2.904 ± 0.06	2.986PheVal: 2.986 ± 0.06	0.592PheTrp: 0.592 ± 0.023	2.102PheTyr: 2.102 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.312GlyAla: 4.312 ± 0.079	1.034GlyCys: 1.034 ± 0.041	3.617GlyAsp: 3.617 ± 0.07	4.492GlyGlu: 4.492 ± 0.069	3.368GlyPhe: 3.368 ± 0.058	5.177GlyGly: 5.177 ± 0.093	1.249GlyHis: 1.249 ± 0.036	6.092GlyIle: 6.092 ± 0.088	5.361GlyLys: 5.361 ± 0.069	6.159GlyLeu: 6.159 ± 0.088	2.103GlyMet: 2.103 ± 0.051	3.857GlyAsn: 3.857 ± 0.063	1.372GlyPro: 1.372 ± 0.038	2.244GlyGln: 2.244 ± 0.047	3.093GlyArg: 3.093 ± 0.055	3.93GlySer: 3.93 ± 0.064	4.062GlyThr: 4.062 ± 0.075	4.777GlyVal: 4.777 ± 0.079	0.923GlyTrp: 0.923 ± 0.029	3.392GlyTyr: 3.392 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.033HisAla: 1.033 ± 0.029	0.282HisCys: 0.282 ± 0.018	0.753HisAsp: 0.753 ± 0.027	0.89HisGlu: 0.89 ± 0.026	1.091HisPhe: 1.091 ± 0.037	1.044HisGly: 1.044 ± 0.036	0.387HisHis: 0.387 ± 0.02	1.481HisIle: 1.481 ± 0.038	0.954HisLys: 0.954 ± 0.03	1.776HisLeu: 1.776 ± 0.039	0.356HisMet: 0.356 ± 0.02	0.804HisAsn: 0.804 ± 0.027	1.063HisPro: 1.063 ± 0.035	0.501HisGln: 0.501 ± 0.025	0.905HisArg: 0.905 ± 0.028	1.042HisSer: 1.042 ± 0.033	1.014HisThr: 1.014 ± 0.029	0.924HisVal: 0.924 ± 0.029	0.227HisTrp: 0.227 ± 0.014	0.878HisTyr: 0.878 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.517IleAla: 5.517 ± 0.073	1.019IleCys: 1.019 ± 0.035	4.11IleAsp: 4.11 ± 0.058	4.552IleGlu: 4.552 ± 0.063	3.119IlePhe: 3.119 ± 0.067	5.101IleGly: 5.101 ± 0.075	1.349IleHis: 1.349 ± 0.036	4.784IleIle: 4.784 ± 0.072	4.101IleLys: 4.101 ± 0.07	6.814IleLeu: 6.814 ± 0.094	1.431IleMet: 1.431 ± 0.037	3.364IleAsn: 3.364 ± 0.061	3.384IlePro: 3.384 ± 0.055	2.365IleGln: 2.365 ± 0.049	4.25IleArg: 4.25 ± 0.064	4.704IleSer: 4.704 ± 0.069	4.205IleThr: 4.205 ± 0.074	4.891IleVal: 4.891 ± 0.073	0.785IleTrp: 0.785 ± 0.028	2.891IleTyr: 2.891 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.948LysAla: 4.948 ± 0.088	0.551LysCys: 0.551 ± 0.024	3.725LysAsp: 3.725 ± 0.063	5.253LysGlu: 5.253 ± 0.081	2.218LysPhe: 2.218 ± 0.049	4.314LysGly: 4.314 ± 0.065	1.072LysHis: 1.072 ± 0.033	4.935LysIle: 4.935 ± 0.074	5.028LysLys: 5.028 ± 0.087	5.396LysLeu: 5.396 ± 0.072	2.008LysMet: 2.008 ± 0.045	3.716LysAsn: 3.716 ± 0.065	2.137LysPro: 2.137 ± 0.047	2.356LysGln: 2.356 ± 0.058	2.893LysArg: 2.893 ± 0.053	3.309LysSer: 3.309 ± 0.057	3.588LysThr: 3.588 ± 0.055	4.178LysVal: 4.178 ± 0.059	0.782LysTrp: 0.782 ± 0.027	3.062LysTyr: 3.062 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.29LeuAla: 6.29 ± 0.09	1.325LeuCys: 1.325 ± 0.031	4.349LeuAsp: 4.349 ± 0.081	5.548LeuGlu: 5.548 ± 0.072	4.747LeuPhe: 4.747 ± 0.083	5.8LeuGly: 5.8 ± 0.081	1.648LeuHis: 1.648 ± 0.038	6.185LeuIle: 6.185 ± 0.089	6.883LeuLys: 6.883 ± 0.084	9.546LeuLeu: 9.546 ± 0.134	2.225LeuMet: 2.225 ± 0.05	4.832LeuAsn: 4.832 ± 0.078	4.245LeuPro: 4.245 ± 0.064	3.593LeuGln: 3.593 ± 0.061	4.241LeuArg: 4.241 ± 0.07	6.563LeuSer: 6.563 ± 0.094	5.561LeuThr: 5.561 ± 0.077	5.012LeuVal: 5.012 ± 0.079	1.047LeuTrp: 1.047 ± 0.035	3.807LeuTyr: 3.807 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.887MetAla: 1.887 ± 0.046	0.238MetCys: 0.238 ± 0.015	1.265MetAsp: 1.265 ± 0.031	1.759MetGlu: 1.759 ± 0.04	0.967MetPhe: 0.967 ± 0.034	1.744MetGly: 1.744 ± 0.044	0.408MetHis: 0.408 ± 0.017	1.662MetIle: 1.662 ± 0.039	2.209MetLys: 2.209 ± 0.048	2.335MetLeu: 2.335 ± 0.053	0.641MetMet: 0.641 ± 0.026	1.441MetAsn: 1.441 ± 0.035	1.151MetPro: 1.151 ± 0.028	1.032MetGln: 1.032 ± 0.03	1.173MetArg: 1.173 ± 0.035	1.473MetSer: 1.473 ± 0.04	1.462MetThr: 1.462 ± 0.034	1.503MetVal: 1.503 ± 0.036	0.238MetTrp: 0.238 ± 0.015	0.889MetTyr: 0.889 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.328AsnAla: 3.328 ± 0.052	0.547AsnCys: 0.547 ± 0.024	2.444AsnAsp: 2.444 ± 0.049	2.807AsnGlu: 2.807 ± 0.05	2.328AsnPhe: 2.328 ± 0.048	3.632AsnGly: 3.632 ± 0.063	0.867AsnHis: 0.867 ± 0.031	4.026AsnIle: 4.026 ± 0.063	3.058AsnLys: 3.058 ± 0.055	4.435AsnLeu: 4.435 ± 0.07	1.334AsnMet: 1.334 ± 0.034	2.539AsnAsn: 2.539 ± 0.059	2.554AsnPro: 2.554 ± 0.052	1.531AsnGln: 1.531 ± 0.036	2.732AsnArg: 2.732 ± 0.056	2.66AsnSer: 2.66 ± 0.051	2.974AsnThr: 2.974 ± 0.064	3.066AsnVal: 3.066 ± 0.057	0.706AsnTrp: 0.706 ± 0.026	2.526AsnTyr: 2.526 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.148ProAla: 3.148 ± 0.059	0.336ProCys: 0.336 ± 0.018	2.78ProAsp: 2.78 ± 0.051	3.782ProGlu: 3.782 ± 0.054	1.733ProPhe: 1.733 ± 0.04	2.985ProGly: 2.985 ± 0.059	0.666ProHis: 0.666 ± 0.025	1.91ProIle: 1.91 ± 0.038	1.744ProLys: 1.744 ± 0.04	3.423ProLeu: 3.423 ± 0.057	0.788ProMet: 0.788 ± 0.028	1.51ProAsn: 1.51 ± 0.041	0.891ProPro: 0.891 ± 0.027	1.356ProGln: 1.356 ± 0.041	1.359ProArg: 1.359 ± 0.033	1.911ProSer: 1.911 ± 0.043	1.704ProThr: 1.704 ± 0.04	3.591ProVal: 3.591 ± 0.06	0.447ProTrp: 0.447 ± 0.021	1.707ProTyr: 1.707 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.401GlnAla: 2.401 ± 0.045	0.299GlnCys: 0.299 ± 0.018	1.533GlnAsp: 1.533 ± 0.041	2.412GlnGlu: 2.412 ± 0.055	1.263GlnPhe: 1.263 ± 0.036	2.048GlnGly: 2.048 ± 0.047	0.581GlnHis: 0.581 ± 0.021	2.435GlnIle: 2.435 ± 0.052	2.545GlnLys: 2.545 ± 0.058	3.29GlnLeu: 3.29 ± 0.073	0.929GlnMet: 0.929 ± 0.031	1.742GlnAsn: 1.742 ± 0.044	1.253GlnPro: 1.253 ± 0.032	1.474GlnGln: 1.474 ± 0.045	1.525GlnArg: 1.525 ± 0.038	1.679GlnSer: 1.679 ± 0.044	1.917GlnThr: 1.917 ± 0.045	2.133GlnVal: 2.133 ± 0.051	0.429GlnTrp: 0.429 ± 0.021	1.397GlnTyr: 1.397 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.635ArgAla: 2.635 ± 0.056	0.495ArgCys: 0.495 ± 0.022	2.294ArgAsp: 2.294 ± 0.052	3.465ArgGlu: 3.465 ± 0.067	2.483ArgPhe: 2.483 ± 0.045	2.456ArgGly: 2.456 ± 0.045	0.934ArgHis: 0.934 ± 0.032	4.075ArgIle: 4.075 ± 0.064	3.735ArgLys: 3.735 ± 0.063	4.751ArgLeu: 4.751 ± 0.082	1.463ArgMet: 1.463 ± 0.035	2.586ArgAsn: 2.586 ± 0.052	1.709ArgPro: 1.709 ± 0.042	1.98ArgGln: 1.98 ± 0.043	2.193ArgArg: 2.193 ± 0.062	2.342ArgSer: 2.342 ± 0.054	2.419ArgThr: 2.419 ± 0.052	2.806ArgVal: 2.806 ± 0.051	0.641ArgTrp: 0.641 ± 0.025	2.444ArgTyr: 2.444 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.041SerAla: 4.041 ± 0.069	0.779SerCys: 0.779 ± 0.027	3.261SerAsp: 3.261 ± 0.055	3.419SerGlu: 3.419 ± 0.057	3.124SerPhe: 3.124 ± 0.052	4.974SerGly: 4.974 ± 0.074	0.994SerHis: 0.994 ± 0.029	3.81SerIle: 3.81 ± 0.06	2.827SerLys: 2.827 ± 0.055	5.756SerLeu: 5.756 ± 0.072	1.332SerMet: 1.332 ± 0.037	2.438SerAsn: 2.438 ± 0.054	2.278SerPro: 2.278 ± 0.044	1.706SerGln: 1.706 ± 0.036	2.857SerArg: 2.857 ± 0.057	3.513SerSer: 3.513 ± 0.066	2.742SerThr: 2.742 ± 0.055	4.615SerVal: 4.615 ± 0.068	0.84SerTrp: 0.84 ± 0.029	2.713SerTyr: 2.713 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.293ThrAla: 4.293 ± 0.068	0.528ThrCys: 0.528 ± 0.025	3.602ThrAsp: 3.602 ± 0.066	3.664ThrGlu: 3.664 ± 0.058	2.533ThrPhe: 2.533 ± 0.049	4.667ThrGly: 4.667 ± 0.071	0.954ThrHis: 0.954 ± 0.029	3.83ThrIle: 3.83 ± 0.064	2.539ThrLys: 2.539 ± 0.048	5.445ThrLeu: 5.445 ± 0.081	1.037ThrMet: 1.037 ± 0.03	2.258ThrAsn: 2.258 ± 0.056	2.758ThrPro: 2.758 ± 0.055	1.565ThrGln: 1.565 ± 0.046	2.139ThrArg: 2.139 ± 0.049	3.021ThrSer: 3.021 ± 0.056	3.16ThrThr: 3.16 ± 0.062	4.407ThrVal: 4.407 ± 0.091	0.648ThrTrp: 0.648 ± 0.028	2.368ThrTyr: 2.368 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.614ValAla: 4.614 ± 0.071	1.043ValCys: 1.043 ± 0.037	3.376ValAsp: 3.376 ± 0.059	3.861ValGlu: 3.861 ± 0.065	3.336ValPhe: 3.336 ± 0.061	4.098ValGly: 4.098 ± 0.069	1.011ValHis: 1.011 ± 0.032	4.945ValIle: 4.945 ± 0.072	4.495ValLys: 4.495 ± 0.075	6.23ValLeu: 6.23 ± 0.075	1.628ValMet: 1.628 ± 0.041	3.505ValAsn: 3.505 ± 0.064	2.512ValPro: 2.512 ± 0.044	1.87ValGln: 1.87 ± 0.041	3.201ValArg: 3.201 ± 0.06	4.518ValSer: 4.518 ± 0.069	3.865ValThr: 3.865 ± 0.092	4.847ValVal: 4.847 ± 0.089	0.819ValTrp: 0.819 ± 0.026	2.932ValTyr: 2.932 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.728TrpAla: 0.728 ± 0.025	0.181TrpCys: 0.181 ± 0.012	0.689TrpAsp: 0.689 ± 0.029	0.804TrpGlu: 0.804 ± 0.027	0.574TrpPhe: 0.574 ± 0.025	1.025TrpGly: 1.025 ± 0.034	0.219TrpHis: 0.219 ± 0.015	0.821TrpIle: 0.821 ± 0.031	0.822TrpLys: 0.822 ± 0.029	1.211TrpLeu: 1.211 ± 0.036	0.382TrpMet: 0.382 ± 0.017	0.728TrpAsn: 0.728 ± 0.027	0.322TrpPro: 0.322 ± 0.017	0.54TrpGln: 0.54 ± 0.023	0.567TrpArg: 0.567 ± 0.026	0.671TrpSer: 0.671 ± 0.027	0.694TrpThr: 0.694 ± 0.028	0.759TrpVal: 0.759 ± 0.024	0.181TrpTrp: 0.181 ± 0.014	0.566TrpTyr: 0.566 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.017TyrAla: 3.017 ± 0.045	0.613TyrCys: 0.613 ± 0.027	2.546TyrAsp: 2.546 ± 0.052	2.5TyrGlu: 2.5 ± 0.043	2.313TyrPhe: 2.313 ± 0.046	2.978TyrGly: 2.978 ± 0.056	0.842TyrHis: 0.842 ± 0.025	3.075TyrIle: 3.075 ± 0.054	2.781TyrLys: 2.781 ± 0.049	4.025TyrLeu: 4.025 ± 0.073	1.105TyrMet: 1.105 ± 0.029	2.409TyrAsn: 2.409 ± 0.056	1.936TyrPro: 1.936 ± 0.044	1.415TyrGln: 1.415 ± 0.037	2.631TyrArg: 2.631 ± 0.055	2.603TyrSer: 2.603 ± 0.054	2.951TyrThr: 2.951 ± 0.06	2.524TyrVal: 2.524 ± 0.048	0.558TyrTrp: 0.558 ± 0.025	2.292TyrTyr: 2.292 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3078 proteins (1124252 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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