Amino acid dipepetide frequency for Sphingomonas sp. K2R01-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.544AlaAla: 18.544 ± 0.199
1.011AlaCys: 1.011 ± 0.036
7.497AlaAsp: 7.497 ± 0.067
8.164AlaGlu: 8.164 ± 0.104
4.32AlaPhe: 4.32 ± 0.061
11.662AlaGly: 11.662 ± 0.155
2.384AlaHis: 2.384 ± 0.051
7.307AlaIle: 7.307 ± 0.093
4.133AlaLys: 4.133 ± 0.069
14.154AlaLeu: 14.154 ± 0.148
3.711AlaMet: 3.711 ± 0.059
3.377AlaAsn: 3.377 ± 0.07
6.224AlaPro: 6.224 ± 0.087
4.284AlaGln: 4.284 ± 0.069
9.893AlaArg: 9.893 ± 0.108
6.706AlaSer: 6.706 ± 0.096
6.726AlaThr: 6.726 ± 0.11
8.575AlaVal: 8.575 ± 0.083
1.524AlaTrp: 1.524 ± 0.038
2.579AlaTyr: 2.579 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.002CysAla: 1.002 ± 0.028
0.074CysCys: 0.074 ± 0.007
0.511CysAsp: 0.511 ± 0.021
0.4CysGlu: 0.4 ± 0.018
0.321CysPhe: 0.321 ± 0.018
0.875CysGly: 0.875 ± 0.031
0.225CysHis: 0.225 ± 0.022
0.313CysIle: 0.313 ± 0.015
0.185CysLys: 0.185 ± 0.013
0.654CysLeu: 0.654 ± 0.025
0.134CysMet: 0.134 ± 0.01
0.21CysAsn: 0.21 ± 0.014
0.439CysPro: 0.439 ± 0.021
0.202CysGln: 0.202 ± 0.014
0.549CysArg: 0.549 ± 0.028
0.457CysSer: 0.457 ± 0.018
0.438CysThr: 0.438 ± 0.017
0.545CysVal: 0.545 ± 0.023
0.123CysTrp: 0.123 ± 0.011
0.185CysTyr: 0.185 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.994AspAla: 7.994 ± 0.088
0.489AspCys: 0.489 ± 0.022
3.324AspAsp: 3.324 ± 0.053
3.353AspGlu: 3.353 ± 0.059
2.202AspPhe: 2.202 ± 0.041
5.636AspGly: 5.636 ± 0.107
1.21AspHis: 1.21 ± 0.035
3.149AspIle: 3.149 ± 0.053
1.769AspLys: 1.769 ± 0.042
5.446AspLeu: 5.446 ± 0.076
1.447AspMet: 1.447 ± 0.036
1.46AspAsn: 1.46 ± 0.038
3.727AspPro: 3.727 ± 0.052
1.782AspGln: 1.782 ± 0.038
4.756AspArg: 4.756 ± 0.059
2.448AspSer: 2.448 ± 0.052
2.71AspThr: 2.71 ± 0.051
4.175AspVal: 4.175 ± 0.056
1.073AspTrp: 1.073 ± 0.032
1.561AspTyr: 1.561 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.961GluAla: 7.961 ± 0.096
0.348GluCys: 0.348 ± 0.018
2.81GluAsp: 2.81 ± 0.059
2.986GluGlu: 2.986 ± 0.064
1.683GluPhe: 1.683 ± 0.037
4.663GluGly: 4.663 ± 0.073
1.201GluHis: 1.201 ± 0.033
3.268GluIle: 3.268 ± 0.054
2.123GluLys: 2.123 ± 0.047
5.062GluLeu: 5.062 ± 0.058
1.474GluMet: 1.474 ± 0.037
1.43GluAsn: 1.43 ± 0.034
2.583GluPro: 2.583 ± 0.055
1.991GluGln: 1.991 ± 0.044
5.018GluArg: 5.018 ± 0.076
2.421GluSer: 2.421 ± 0.048
3.348GluThr: 3.348 ± 0.05
3.56GluVal: 3.56 ± 0.061
0.737GluTrp: 0.737 ± 0.025
1.018GluTyr: 1.018 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.83PheAla: 4.83 ± 0.07
0.339PheCys: 0.339 ± 0.017
2.703PheAsp: 2.703 ± 0.057
2.174PheGlu: 2.174 ± 0.042
1.273PhePhe: 1.273 ± 0.039
3.822PheGly: 3.822 ± 0.055
0.697PheHis: 0.697 ± 0.026
1.488PheIle: 1.488 ± 0.037
0.933PheLys: 0.933 ± 0.03
2.949PheLeu: 2.949 ± 0.054
0.771PheMet: 0.771 ± 0.029
1.075PheAsn: 1.075 ± 0.033
1.498PhePro: 1.498 ± 0.042
0.914PheGln: 0.914 ± 0.027
2.224PheArg: 2.224 ± 0.042
2.049PheSer: 2.049 ± 0.044
2.092PheThr: 2.092 ± 0.041
2.616PheVal: 2.616 ± 0.045
0.5PheTrp: 0.5 ± 0.021
0.874PheTyr: 0.874 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
10.671GlyAla: 10.671 ± 0.138
0.855GlyCys: 0.855 ± 0.031
5.065GlyAsp: 5.065 ± 0.084
4.938GlyGlu: 4.938 ± 0.067
3.752GlyPhe: 3.752 ± 0.061
8.554GlyGly: 8.554 ± 0.147
1.735GlyHis: 1.735 ± 0.041
4.536GlyIle: 4.536 ± 0.068
3.454GlyLys: 3.454 ± 0.065
8.539GlyLeu: 8.539 ± 0.092
2.296GlyMet: 2.296 ± 0.045
2.568GlyAsn: 2.568 ± 0.076
3.607GlyPro: 3.607 ± 0.061
2.977GlyGln: 2.977 ± 0.051
6.425GlyArg: 6.425 ± 0.082
5.037GlySer: 5.037 ± 0.091
5.104GlyThr: 5.104 ± 0.142
6.571GlyVal: 6.571 ± 0.078
1.665GlyTrp: 1.665 ± 0.036
2.417GlyTyr: 2.417 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.423HisAla: 2.423 ± 0.048
0.214HisCys: 0.214 ± 0.014
1.138HisAsp: 1.138 ± 0.027
0.98HisGlu: 0.98 ± 0.03
0.839HisPhe: 0.839 ± 0.022
1.96HisGly: 1.96 ± 0.043
0.519HisHis: 0.519 ± 0.02
0.949HisIle: 0.949 ± 0.032
0.474HisLys: 0.474 ± 0.021
1.77HisLeu: 1.77 ± 0.04
0.482HisMet: 0.482 ± 0.022
0.49HisAsn: 0.49 ± 0.019
1.25HisPro: 1.25 ± 0.035
0.574HisGln: 0.574 ± 0.024
1.394HisArg: 1.394 ± 0.04
0.883HisSer: 0.883 ± 0.027
0.696HisThr: 0.696 ± 0.025
1.474HisVal: 1.474 ± 0.038
0.36HisTrp: 0.36 ± 0.015
0.558HisTyr: 0.558 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
8.352IleAla: 8.352 ± 0.088
0.464IleCys: 0.464 ± 0.021
3.959IleAsp: 3.959 ± 0.058
3.819IleGlu: 3.819 ± 0.06
1.643IlePhe: 1.643 ± 0.041
5.273IleGly: 5.273 ± 0.064
0.888IleHis: 0.888 ± 0.026
2.11IleIle: 2.11 ± 0.049
1.234IleLys: 1.234 ± 0.032
4.026IleLeu: 4.026 ± 0.064
0.875IleMet: 0.875 ± 0.026
1.486IleAsn: 1.486 ± 0.036
2.287IlePro: 2.287 ± 0.052
1.207IleGln: 1.207 ± 0.034
3.312IleArg: 3.312 ± 0.052
2.699IleSer: 2.699 ± 0.049
2.724IleThr: 2.724 ± 0.058
4.265IleVal: 4.265 ± 0.059
0.655IleTrp: 0.655 ± 0.022
1.013IleTyr: 1.013 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.306LysAla: 4.306 ± 0.063
0.151LysCys: 0.151 ± 0.011
1.598LysAsp: 1.598 ± 0.045
1.316LysGlu: 1.316 ± 0.038
0.841LysPhe: 0.841 ± 0.027
2.761LysGly: 2.761 ± 0.055
0.555LysHis: 0.555 ± 0.021
1.552LysIle: 1.552 ± 0.037
1.185LysLys: 1.185 ± 0.037
3.21LysLeu: 3.21 ± 0.064
0.76LysMet: 0.76 ± 0.029
0.745LysAsn: 0.745 ± 0.025
2.101LysPro: 2.101 ± 0.048
0.982LysGln: 0.982 ± 0.03
2.358LysArg: 2.358 ± 0.046
1.676LysSer: 1.676 ± 0.04
1.767LysThr: 1.767 ± 0.038
2.212LysVal: 2.212 ± 0.046
0.405LysTrp: 0.405 ± 0.019
0.622LysTyr: 0.622 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.497LeuAla: 13.497 ± 0.133
0.739LeuCys: 0.739 ± 0.022
6.449LeuAsp: 6.449 ± 0.084
4.826LeuGlu: 4.826 ± 0.073
3.568LeuPhe: 3.568 ± 0.064
8.438LeuGly: 8.438 ± 0.105
1.668LeuHis: 1.668 ± 0.04
5.019LeuIle: 5.019 ± 0.085
3.297LeuLys: 3.297 ± 0.059
8.813LeuLeu: 8.813 ± 0.126
2.029LeuMet: 2.029 ± 0.038
2.45LeuAsn: 2.45 ± 0.052
5.109LeuPro: 5.109 ± 0.075
2.403LeuGln: 2.403 ± 0.046
6.451LeuArg: 6.451 ± 0.071
6.045LeuSer: 6.045 ± 0.083
5.32LeuThr: 5.32 ± 0.079
7.06LeuVal: 7.06 ± 0.09
1.219LeuTrp: 1.219 ± 0.031
1.91LeuTyr: 1.91 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
3.159MetAla: 3.159 ± 0.054
0.163MetCys: 0.163 ± 0.012
1.052MetAsp: 1.052 ± 0.029
1.057MetGlu: 1.057 ± 0.029
0.679MetPhe: 0.679 ± 0.026
1.913MetGly: 1.913 ± 0.045
0.444MetHis: 0.444 ± 0.02
1.364MetIle: 1.364 ± 0.035
0.966MetLys: 0.966 ± 0.031
2.633MetLeu: 2.633 ± 0.044
0.645MetMet: 0.645 ± 0.025
0.667MetAsn: 0.667 ± 0.024
1.352MetPro: 1.352 ± 0.037
0.694MetGln: 0.694 ± 0.024
1.78MetArg: 1.78 ± 0.037
1.411MetSer: 1.411 ± 0.029
1.776MetThr: 1.776 ± 0.04
1.552MetVal: 1.552 ± 0.037
0.237MetTrp: 0.237 ± 0.013
0.277MetTyr: 0.277 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.514AsnAla: 3.514 ± 0.064
0.276AsnCys: 0.276 ± 0.016
1.504AsnAsp: 1.504 ± 0.042
1.21AsnGlu: 1.21 ± 0.03
1.033AsnPhe: 1.033 ± 0.031
2.566AsnGly: 2.566 ± 0.069
0.491AsnHis: 0.491 ± 0.022
1.44AsnIle: 1.44 ± 0.035
0.685AsnLys: 0.685 ± 0.027
2.508AsnLeu: 2.508 ± 0.051
0.548AsnMet: 0.548 ± 0.022
0.771AsnAsn: 0.771 ± 0.029
1.845AsnPro: 1.845 ± 0.046
0.779AsnGln: 0.779 ± 0.026
1.798AsnArg: 1.798 ± 0.036
1.345AsnSer: 1.345 ± 0.039
1.236AsnThr: 1.236 ± 0.039
2.011AsnVal: 2.011 ± 0.049
0.452AsnTrp: 0.452 ± 0.021
0.726AsnTyr: 0.726 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
6.65ProAla: 6.65 ± 0.088
0.345ProCys: 0.345 ± 0.016
3.61ProAsp: 3.61 ± 0.064
3.716ProGlu: 3.716 ± 0.058
1.834ProPhe: 1.834 ± 0.043
4.966ProGly: 4.966 ± 0.071
1.048ProHis: 1.048 ± 0.034
2.5ProIle: 2.5 ± 0.054
1.533ProLys: 1.533 ± 0.037
4.603ProLeu: 4.603 ± 0.065
1.191ProMet: 1.191 ± 0.033
1.284ProAsn: 1.284 ± 0.036
2.626ProPro: 2.626 ± 0.075
1.654ProGln: 1.654 ± 0.041
2.982ProArg: 2.982 ± 0.057
2.604ProSer: 2.604 ± 0.048
2.456ProThr: 2.456 ± 0.056
4.166ProVal: 4.166 ± 0.056
0.686ProTrp: 0.686 ± 0.026
1.056ProTyr: 1.056 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.99GlnAla: 3.99 ± 0.062
0.243GlnCys: 0.243 ± 0.014
1.31GlnAsp: 1.31 ± 0.029
1.262GlnGlu: 1.262 ± 0.034
1.135GlnPhe: 1.135 ± 0.032
2.536GlnGly: 2.536 ± 0.05
0.627GlnHis: 0.627 ± 0.025
1.81GlnIle: 1.81 ± 0.038
0.932GlnLys: 0.932 ± 0.029
2.973GlnLeu: 2.973 ± 0.054
0.826GlnMet: 0.826 ± 0.024
0.792GlnAsn: 0.792 ± 0.027
1.732GlnPro: 1.732 ± 0.034
1.105GlnGln: 1.105 ± 0.037
2.446GlnArg: 2.446 ± 0.052
1.755GlnSer: 1.755 ± 0.042
1.619GlnThr: 1.619 ± 0.044
2.003GlnVal: 2.003 ± 0.052
0.448GlnTrp: 0.448 ± 0.018
0.629GlnTyr: 0.629 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.036ArgAla: 9.036 ± 0.103
0.486ArgCys: 0.486 ± 0.02
4.215ArgAsp: 4.215 ± 0.067
3.948ArgGlu: 3.948 ± 0.058
3.107ArgPhe: 3.107 ± 0.063
5.145ArgGly: 5.145 ± 0.067
1.618ArgHis: 1.618 ± 0.041
4.153ArgIle: 4.153 ± 0.059
2.11ArgLys: 2.11 ± 0.044
7.873ArgLeu: 7.873 ± 0.097
1.924ArgMet: 1.924 ± 0.04
1.811ArgAsn: 1.811 ± 0.042
3.583ArgPro: 3.583 ± 0.058
2.364ArgGln: 2.364 ± 0.047
5.454ArgArg: 5.454 ± 0.085
3.544ArgSer: 3.544 ± 0.061
3.666ArgThr: 3.666 ± 0.056
4.946ArgVal: 4.946 ± 0.071
1.178ArgTrp: 1.178 ± 0.033
1.861ArgTyr: 1.861 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.722SerAla: 6.722 ± 0.091
0.431SerCys: 0.431 ± 0.021
3.114SerAsp: 3.114 ± 0.057
2.706SerGlu: 2.706 ± 0.046
2.221SerPhe: 2.221 ± 0.042
5.639SerGly: 5.639 ± 0.106
0.958SerHis: 0.958 ± 0.027
2.814SerIle: 2.814 ± 0.046
1.502SerLys: 1.502 ± 0.038
5.03SerLeu: 5.03 ± 0.07
1.189SerMet: 1.189 ± 0.031
1.459SerAsn: 1.459 ± 0.04
2.73SerPro: 2.73 ± 0.048
1.456SerGln: 1.456 ± 0.033
3.366SerArg: 3.366 ± 0.057
2.776SerSer: 2.776 ± 0.057
2.752SerThr: 2.752 ± 0.049
3.845SerVal: 3.845 ± 0.067
0.716SerTrp: 0.716 ± 0.021
1.416SerTyr: 1.416 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
6.495ThrAla: 6.495 ± 0.101
0.379ThrCys: 0.379 ± 0.018
2.946ThrAsp: 2.946 ± 0.055
2.497ThrGlu: 2.497 ± 0.044
1.734ThrPhe: 1.734 ± 0.043
5.831ThrGly: 5.831 ± 0.111
0.964ThrHis: 0.964 ± 0.028
3.113ThrIle: 3.113 ± 0.08
1.308ThrLys: 1.308 ± 0.038
6.013ThrLeu: 6.013 ± 0.097
1.161ThrMet: 1.161 ± 0.033
1.502ThrAsn: 1.502 ± 0.062
3.382ThrPro: 3.382 ± 0.054
1.526ThrGln: 1.526 ± 0.035
3.592ThrArg: 3.592 ± 0.054
2.693ThrSer: 2.693 ± 0.053
2.834ThrThr: 2.834 ± 0.064
4.114ThrVal: 4.114 ± 0.075
0.58ThrTrp: 0.58 ± 0.021
1.109ThrTyr: 1.109 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
9.533ValAla: 9.533 ± 0.114
0.513ValCys: 0.513 ± 0.022
4.589ValAsp: 4.589 ± 0.077
4.57ValGlu: 4.57 ± 0.064
2.221ValPhe: 2.221 ± 0.042
5.381ValGly: 5.381 ± 0.079
1.376ValHis: 1.376 ± 0.035
3.869ValIle: 3.869 ± 0.06
2.193ValLys: 2.193 ± 0.052
6.349ValLeu: 6.349 ± 0.078
1.635ValMet: 1.635 ± 0.038
2.093ValAsn: 2.093 ± 0.052
3.719ValPro: 3.719 ± 0.063
1.989ValGln: 1.989 ± 0.038
5.029ValArg: 5.029 ± 0.074
4.252ValSer: 4.252 ± 0.068
4.663ValThr: 4.663 ± 0.079
5.191ValVal: 5.191 ± 0.075
0.798ValTrp: 0.798 ± 0.026
1.385ValTyr: 1.385 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.335TrpAla: 1.335 ± 0.039
0.114TrpCys: 0.114 ± 0.011
0.761TrpAsp: 0.761 ± 0.027
0.589TrpGlu: 0.589 ± 0.02
0.534TrpPhe: 0.534 ± 0.023
0.948TrpGly: 0.948 ± 0.03
0.333TrpHis: 0.333 ± 0.017
0.734TrpIle: 0.734 ± 0.026
0.496TrpLys: 0.496 ± 0.019
1.647TrpLeu: 1.647 ± 0.037
0.328TrpMet: 0.328 ± 0.016
0.471TrpAsn: 0.471 ± 0.021
0.707TrpPro: 0.707 ± 0.025
0.593TrpGln: 0.593 ± 0.021
1.293TrpArg: 1.293 ± 0.032
0.848TrpSer: 0.848 ± 0.029
0.851TrpThr: 0.851 ± 0.026
0.838TrpVal: 0.838 ± 0.029
0.25TrpTrp: 0.25 ± 0.013
0.277TrpTyr: 0.277 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.765TyrAla: 2.765 ± 0.049
0.207TyrCys: 0.207 ± 0.013
1.557TyrAsp: 1.557 ± 0.042
1.173TyrGlu: 1.173 ± 0.032
0.879TyrPhe: 0.879 ± 0.026
2.197TyrGly: 2.197 ± 0.047
0.486TyrHis: 0.486 ± 0.018
0.806TyrIle: 0.806 ± 0.024
0.592TyrLys: 0.592 ± 0.024
2.058TyrLeu: 2.058 ± 0.042
0.393TyrMet: 0.393 ± 0.02
0.593TyrAsn: 0.593 ± 0.024
1.008TyrPro: 1.008 ± 0.028
0.698TyrGln: 0.698 ± 0.026
1.904TyrArg: 1.904 ± 0.042
1.192TyrSer: 1.192 ± 0.035
0.994TyrThr: 0.994 ± 0.034
1.628TyrVal: 1.628 ± 0.038
0.341TyrTrp: 0.341 ± 0.018
0.624TyrTyr: 0.624 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3865 proteins (1251040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski