Amino acid dipepetide frequency for Mycobacterium phage Vincenzo

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.007AlaAla: 20.007 ± 1.483
0.913AlaCys: 0.913 ± 0.238
10.438AlaAsp: 10.438 ± 0.747
7.002AlaGlu: 7.002 ± 0.537
2.566AlaPhe: 2.566 ± 0.314
10.873AlaGly: 10.873 ± 1.039
2.479AlaHis: 2.479 ± 0.33
4.436AlaIle: 4.436 ± 0.474
3.61AlaLys: 3.61 ± 0.427
11.482AlaLeu: 11.482 ± 0.9
2.914AlaMet: 2.914 ± 0.38
3.436AlaAsn: 3.436 ± 0.37
7.22AlaPro: 7.22 ± 0.54
5.132AlaGln: 5.132 ± 0.555
8.09AlaArg: 8.09 ± 0.547
5.915AlaSer: 5.915 ± 0.508
9.047AlaThr: 9.047 ± 0.613
11.221AlaVal: 11.221 ± 0.798
2.653AlaTrp: 2.653 ± 0.366
2.523AlaTyr: 2.523 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
1.131CysAla: 1.131 ± 0.264
0.174CysCys: 0.174 ± 0.105
0.739CysAsp: 0.739 ± 0.166
0.435CysGlu: 0.435 ± 0.122
0.304CysPhe: 0.304 ± 0.11
1.392CysGly: 1.392 ± 0.249
0.478CysHis: 0.478 ± 0.153
0.174CysIle: 0.174 ± 0.107
0.13CysLys: 0.13 ± 0.084
0.435CysLeu: 0.435 ± 0.155
0.261CysMet: 0.261 ± 0.097
0.304CysAsn: 0.304 ± 0.12
0.739CysPro: 0.739 ± 0.224
0.435CysGln: 0.435 ± 0.128
0.957CysArg: 0.957 ± 0.226
0.652CysSer: 0.652 ± 0.149
0.435CysThr: 0.435 ± 0.129
0.391CysVal: 0.391 ± 0.13
0.13CysTrp: 0.13 ± 0.067
0.348CysTyr: 0.348 ± 0.151
0.0CysXaa: 0.0 ± 0.0
Asp
8.568AspAla: 8.568 ± 0.793
0.696AspCys: 0.696 ± 0.218
5.785AspAsp: 5.785 ± 0.617
4.48AspGlu: 4.48 ± 0.669
1.74AspPhe: 1.74 ± 0.308
6.263AspGly: 6.263 ± 0.559
1.479AspHis: 1.479 ± 0.274
2.871AspIle: 2.871 ± 0.347
2.349AspLys: 2.349 ± 0.303
4.958AspLeu: 4.958 ± 0.424
1.914AspMet: 1.914 ± 0.314
1.957AspAsn: 1.957 ± 0.319
4.741AspPro: 4.741 ± 0.481
2.958AspGln: 2.958 ± 0.351
3.653AspArg: 3.653 ± 0.467
2.349AspSer: 2.349 ± 0.334
4.523AspThr: 4.523 ± 0.443
5.219AspVal: 5.219 ± 0.492
1.174AspTrp: 1.174 ± 0.216
1.827AspTyr: 1.827 ± 0.284
0.0AspXaa: 0.0 ± 0.0
Glu
6.133GluAla: 6.133 ± 0.502
0.522GluCys: 0.522 ± 0.125
2.784GluAsp: 2.784 ± 0.352
2.175GluGlu: 2.175 ± 0.356
1.87GluPhe: 1.87 ± 0.302
3.871GluGly: 3.871 ± 0.42
1.0GluHis: 1.0 ± 0.203
1.74GluIle: 1.74 ± 0.317
1.218GluLys: 1.218 ± 0.246
5.176GluLeu: 5.176 ± 0.582
0.739GluMet: 0.739 ± 0.172
0.87GluAsn: 0.87 ± 0.179
2.784GluPro: 2.784 ± 0.414
1.957GluGln: 1.957 ± 0.274
3.219GluArg: 3.219 ± 0.428
1.435GluSer: 1.435 ± 0.244
3.914GluThr: 3.914 ± 0.432
4.088GluVal: 4.088 ± 0.449
0.696GluTrp: 0.696 ± 0.171
1.261GluTyr: 1.261 ± 0.194
0.0GluXaa: 0.0 ± 0.0
Phe
2.61PheAla: 2.61 ± 0.303
0.043PheCys: 0.043 ± 0.046
2.784PheAsp: 2.784 ± 0.398
1.087PheGlu: 1.087 ± 0.262
0.478PhePhe: 0.478 ± 0.15
3.045PheGly: 3.045 ± 0.534
0.522PheHis: 0.522 ± 0.139
0.739PheIle: 0.739 ± 0.205
0.696PheLys: 0.696 ± 0.16
1.653PheLeu: 1.653 ± 0.276
0.13PheMet: 0.13 ± 0.072
0.565PheAsn: 0.565 ± 0.148
1.044PhePro: 1.044 ± 0.165
0.652PheGln: 0.652 ± 0.177
1.566PheArg: 1.566 ± 0.268
1.305PheSer: 1.305 ± 0.229
1.827PheThr: 1.827 ± 0.29
1.914PheVal: 1.914 ± 0.218
0.261PheTrp: 0.261 ± 0.101
0.565PheTyr: 0.565 ± 0.18
0.0PheXaa: 0.0 ± 0.0
Gly
10.482GlyAla: 10.482 ± 1.201
1.218GlyCys: 1.218 ± 0.279
5.35GlyAsp: 5.35 ± 0.532
4.001GlyGlu: 4.001 ± 0.381
2.218GlyPhe: 2.218 ± 0.401
12.657GlyGly: 12.657 ± 2.503
1.435GlyHis: 1.435 ± 0.26
3.827GlyIle: 3.827 ± 0.457
3.219GlyLys: 3.219 ± 0.336
8.264GlyLeu: 8.264 ± 0.63
1.783GlyMet: 1.783 ± 0.347
3.175GlyAsn: 3.175 ± 0.512
4.306GlyPro: 4.306 ± 0.428
4.088GlyGln: 4.088 ± 0.591
5.176GlyArg: 5.176 ± 0.479
5.872GlySer: 5.872 ± 0.693
7.263GlyThr: 7.263 ± 0.769
7.35GlyVal: 7.35 ± 0.683
2.479GlyTrp: 2.479 ± 0.394
2.74GlyTyr: 2.74 ± 0.345
0.0GlyXaa: 0.0 ± 0.0
His
2.175HisAla: 2.175 ± 0.358
0.261HisCys: 0.261 ± 0.131
1.305HisAsp: 1.305 ± 0.271
0.739HisGlu: 0.739 ± 0.169
0.391HisPhe: 0.391 ± 0.121
1.435HisGly: 1.435 ± 0.266
0.739HisHis: 0.739 ± 0.215
0.739HisIle: 0.739 ± 0.208
0.565HisLys: 0.565 ± 0.151
1.566HisLeu: 1.566 ± 0.253
0.217HisMet: 0.217 ± 0.094
0.609HisAsn: 0.609 ± 0.171
1.305HisPro: 1.305 ± 0.301
0.783HisGln: 0.783 ± 0.202
1.696HisArg: 1.696 ± 0.336
0.435HisSer: 0.435 ± 0.164
1.609HisThr: 1.609 ± 0.269
1.435HisVal: 1.435 ± 0.253
0.348HisTrp: 0.348 ± 0.123
0.739HisTyr: 0.739 ± 0.152
0.0HisXaa: 0.0 ± 0.0
Ile
5.263IleAla: 5.263 ± 0.478
0.304IleCys: 0.304 ± 0.126
3.61IleAsp: 3.61 ± 0.333
2.61IleGlu: 2.61 ± 0.386
1.044IlePhe: 1.044 ± 0.254
4.306IleGly: 4.306 ± 0.561
0.565IleHis: 0.565 ± 0.148
1.696IleIle: 1.696 ± 0.305
1.218IleLys: 1.218 ± 0.281
1.522IleLeu: 1.522 ± 0.248
0.478IleMet: 0.478 ± 0.127
1.131IleAsn: 1.131 ± 0.217
2.044IlePro: 2.044 ± 0.275
1.087IleGln: 1.087 ± 0.265
1.914IleArg: 1.914 ± 0.233
1.957IleSer: 1.957 ± 0.322
3.262IleThr: 3.262 ± 0.367
3.132IleVal: 3.132 ± 0.352
0.478IleTrp: 0.478 ± 0.122
0.739IleTyr: 0.739 ± 0.2
0.0IleXaa: 0.0 ± 0.0
Lys
3.958LysAla: 3.958 ± 0.56
0.087LysCys: 0.087 ± 0.06
1.218LysAsp: 1.218 ± 0.296
1.218LysGlu: 1.218 ± 0.247
0.609LysPhe: 0.609 ± 0.141
2.958LysGly: 2.958 ± 0.413
0.304LysHis: 0.304 ± 0.122
1.435LysIle: 1.435 ± 0.237
0.783LysLys: 0.783 ± 0.162
2.697LysLeu: 2.697 ± 0.365
0.609LysMet: 0.609 ± 0.17
0.87LysAsn: 0.87 ± 0.167
1.566LysPro: 1.566 ± 0.323
1.305LysGln: 1.305 ± 0.215
1.653LysArg: 1.653 ± 0.26
1.696LysSer: 1.696 ± 0.26
1.305LysThr: 1.305 ± 0.229
2.523LysVal: 2.523 ± 0.351
0.304LysTrp: 0.304 ± 0.109
0.826LysTyr: 0.826 ± 0.185
0.0LysXaa: 0.0 ± 0.0
Leu
11.395LeuAla: 11.395 ± 0.673
0.696LeuCys: 0.696 ± 0.172
5.176LeuAsp: 5.176 ± 0.578
4.088LeuGlu: 4.088 ± 0.372
1.783LeuPhe: 1.783 ± 0.281
7.524LeuGly: 7.524 ± 0.717
1.392LeuHis: 1.392 ± 0.288
3.088LeuIle: 3.088 ± 0.388
1.609LeuLys: 1.609 ± 0.389
7.089LeuLeu: 7.089 ± 0.576
1.696LeuMet: 1.696 ± 0.23
2.653LeuAsn: 2.653 ± 0.553
6.394LeuPro: 6.394 ± 0.605
2.175LeuGln: 2.175 ± 0.296
5.002LeuArg: 5.002 ± 0.546
3.697LeuSer: 3.697 ± 0.464
6.654LeuThr: 6.654 ± 0.453
6.263LeuVal: 6.263 ± 0.592
0.957LeuTrp: 0.957 ± 0.211
1.392LeuTyr: 1.392 ± 0.209
0.0LeuXaa: 0.0 ± 0.0
Met
3.045MetAla: 3.045 ± 0.329
0.348MetCys: 0.348 ± 0.106
1.435MetAsp: 1.435 ± 0.224
0.87MetGlu: 0.87 ± 0.209
0.565MetPhe: 0.565 ± 0.169
1.392MetGly: 1.392 ± 0.258
0.609MetHis: 0.609 ± 0.151
0.565MetIle: 0.565 ± 0.169
0.522MetLys: 0.522 ± 0.13
1.87MetLeu: 1.87 ± 0.276
0.261MetMet: 0.261 ± 0.085
0.609MetAsn: 0.609 ± 0.173
1.957MetPro: 1.957 ± 0.268
0.565MetGln: 0.565 ± 0.128
1.174MetArg: 1.174 ± 0.25
1.131MetSer: 1.131 ± 0.23
2.436MetThr: 2.436 ± 0.363
1.479MetVal: 1.479 ± 0.236
0.174MetTrp: 0.174 ± 0.105
0.391MetTyr: 0.391 ± 0.117
0.0MetXaa: 0.0 ± 0.0
Asn
4.219AsnAla: 4.219 ± 0.5
0.348AsnCys: 0.348 ± 0.105
1.914AsnAsp: 1.914 ± 0.293
1.479AsnGlu: 1.479 ± 0.248
0.478AsnPhe: 0.478 ± 0.15
3.566AsnGly: 3.566 ± 0.735
0.696AsnHis: 0.696 ± 0.201
1.305AsnIle: 1.305 ± 0.236
0.652AsnLys: 0.652 ± 0.17
1.522AsnLeu: 1.522 ± 0.371
0.609AsnMet: 0.609 ± 0.147
0.783AsnAsn: 0.783 ± 0.182
1.783AsnPro: 1.783 ± 0.29
0.826AsnGln: 0.826 ± 0.179
1.479AsnArg: 1.479 ± 0.261
1.348AsnSer: 1.348 ± 0.243
2.305AsnThr: 2.305 ± 0.399
2.218AsnVal: 2.218 ± 0.292
0.478AsnTrp: 0.478 ± 0.148
0.696AsnTyr: 0.696 ± 0.18
0.0AsnXaa: 0.0 ± 0.0
Pro
8.742ProAla: 8.742 ± 0.739
0.391ProCys: 0.391 ± 0.118
5.045ProAsp: 5.045 ± 0.755
3.132ProGlu: 3.132 ± 0.325
1.87ProPhe: 1.87 ± 0.268
7.394ProGly: 7.394 ± 0.545
0.739ProHis: 0.739 ± 0.185
1.827ProIle: 1.827 ± 0.289
1.261ProLys: 1.261 ± 0.241
3.914ProLeu: 3.914 ± 0.406
1.261ProMet: 1.261 ± 0.191
1.435ProAsn: 1.435 ± 0.221
5.393ProPro: 5.393 ± 0.533
1.783ProGln: 1.783 ± 0.263
2.697ProArg: 2.697 ± 0.255
2.784ProSer: 2.784 ± 0.413
4.741ProThr: 4.741 ± 0.497
5.741ProVal: 5.741 ± 0.557
1.305ProTrp: 1.305 ± 0.295
0.913ProTyr: 0.913 ± 0.216
0.0ProXaa: 0.0 ± 0.0
Gln
5.393GlnAla: 5.393 ± 0.622
0.348GlnCys: 0.348 ± 0.115
1.261GlnAsp: 1.261 ± 0.238
1.261GlnGlu: 1.261 ± 0.245
0.783GlnPhe: 0.783 ± 0.17
2.653GlnGly: 2.653 ± 0.312
0.696GlnHis: 0.696 ± 0.149
1.783GlnIle: 1.783 ± 0.316
1.0GlnLys: 1.0 ± 0.194
4.001GlnLeu: 4.001 ± 0.462
0.957GlnMet: 0.957 ± 0.246
0.826GlnAsn: 0.826 ± 0.219
1.957GlnPro: 1.957 ± 0.323
1.131GlnGln: 1.131 ± 0.243
3.392GlnArg: 3.392 ± 0.422
1.261GlnSer: 1.261 ± 0.221
2.131GlnThr: 2.131 ± 0.285
2.653GlnVal: 2.653 ± 0.31
0.957GlnTrp: 0.957 ± 0.231
0.826GlnTyr: 0.826 ± 0.161
0.0GlnXaa: 0.0 ± 0.0
Arg
7.307ArgAla: 7.307 ± 0.624
0.826ArgCys: 0.826 ± 0.216
3.871ArgAsp: 3.871 ± 0.437
3.045ArgGlu: 3.045 ± 0.368
1.261ArgPhe: 1.261 ± 0.203
4.219ArgGly: 4.219 ± 0.485
1.74ArgHis: 1.74 ± 0.275
2.566ArgIle: 2.566 ± 0.416
2.523ArgLys: 2.523 ± 0.279
5.785ArgLeu: 5.785 ± 0.515
1.914ArgMet: 1.914 ± 0.294
2.218ArgAsn: 2.218 ± 0.209
2.958ArgPro: 2.958 ± 0.472
2.479ArgGln: 2.479 ± 0.298
4.871ArgArg: 4.871 ± 0.609
3.305ArgSer: 3.305 ± 0.361
3.61ArgThr: 3.61 ± 0.401
4.48ArgVal: 4.48 ± 0.453
1.479ArgTrp: 1.479 ± 0.232
2.001ArgTyr: 2.001 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
6.133SerAla: 6.133 ± 0.588
0.652SerCys: 0.652 ± 0.173
3.045SerAsp: 3.045 ± 0.372
1.609SerGlu: 1.609 ± 0.242
0.957SerPhe: 0.957 ± 0.225
5.524SerGly: 5.524 ± 0.538
0.522SerHis: 0.522 ± 0.136
1.653SerIle: 1.653 ± 0.25
1.348SerLys: 1.348 ± 0.262
3.349SerLeu: 3.349 ± 0.409
1.131SerMet: 1.131 ± 0.237
1.696SerAsn: 1.696 ± 0.357
3.479SerPro: 3.479 ± 0.39
1.522SerGln: 1.522 ± 0.264
2.871SerArg: 2.871 ± 0.361
2.61SerSer: 2.61 ± 0.412
3.566SerThr: 3.566 ± 0.343
3.653SerVal: 3.653 ± 0.37
1.174SerTrp: 1.174 ± 0.259
1.087SerTyr: 1.087 ± 0.274
0.0SerXaa: 0.0 ± 0.0
Thr
9.916ThrAla: 9.916 ± 0.607
0.609ThrCys: 0.609 ± 0.159
4.828ThrAsp: 4.828 ± 0.358
3.175ThrGlu: 3.175 ± 0.34
1.392ThrPhe: 1.392 ± 0.246
7.524ThrGly: 7.524 ± 0.582
1.0ThrHis: 1.0 ± 0.204
3.305ThrIle: 3.305 ± 0.358
2.653ThrLys: 2.653 ± 0.387
5.437ThrLeu: 5.437 ± 0.514
1.827ThrMet: 1.827 ± 0.292
1.827ThrAsn: 1.827 ± 0.323
5.393ThrPro: 5.393 ± 0.606
1.957ThrGln: 1.957 ± 0.275
4.349ThrArg: 4.349 ± 0.487
3.653ThrSer: 3.653 ± 0.366
5.915ThrThr: 5.915 ± 0.703
6.568ThrVal: 6.568 ± 0.661
1.392ThrTrp: 1.392 ± 0.291
1.914ThrTyr: 1.914 ± 0.362
0.0ThrXaa: 0.0 ± 0.0
Val
9.873ValAla: 9.873 ± 0.681
0.783ValCys: 0.783 ± 0.168
5.698ValAsp: 5.698 ± 0.578
3.523ValGlu: 3.523 ± 0.356
2.044ValPhe: 2.044 ± 0.296
6.698ValGly: 6.698 ± 0.588
1.392ValHis: 1.392 ± 0.243
3.001ValIle: 3.001 ± 0.394
1.783ValLys: 1.783 ± 0.232
6.872ValLeu: 6.872 ± 0.563
1.914ValMet: 1.914 ± 0.354
2.697ValAsn: 2.697 ± 0.292
5.002ValPro: 5.002 ± 0.411
2.827ValGln: 2.827 ± 0.303
5.176ValArg: 5.176 ± 0.499
4.219ValSer: 4.219 ± 0.468
6.654ValThr: 6.654 ± 0.736
6.263ValVal: 6.263 ± 0.677
1.609ValTrp: 1.609 ± 0.304
1.696ValTyr: 1.696 ± 0.266
0.0ValXaa: 0.0 ± 0.0
Trp
2.653TrpAla: 2.653 ± 0.343
0.478TrpCys: 0.478 ± 0.142
1.218TrpAsp: 1.218 ± 0.237
0.565TrpGlu: 0.565 ± 0.182
0.696TrpPhe: 0.696 ± 0.26
1.087TrpGly: 1.087 ± 0.199
0.826TrpHis: 0.826 ± 0.224
0.826TrpIle: 0.826 ± 0.173
0.217TrpLys: 0.217 ± 0.097
1.435TrpLeu: 1.435 ± 0.279
0.391TrpMet: 0.391 ± 0.111
0.435TrpAsn: 0.435 ± 0.16
1.131TrpPro: 1.131 ± 0.247
0.478TrpGln: 0.478 ± 0.175
1.218TrpArg: 1.218 ± 0.227
1.131TrpSer: 1.131 ± 0.284
1.566TrpThr: 1.566 ± 0.325
1.392TrpVal: 1.392 ± 0.287
0.435TrpTrp: 0.435 ± 0.136
0.565TrpTyr: 0.565 ± 0.191
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.958TyrAla: 2.958 ± 0.324
0.348TyrCys: 0.348 ± 0.124
2.001TyrAsp: 2.001 ± 0.254
0.957TyrGlu: 0.957 ± 0.165
0.435TyrPhe: 0.435 ± 0.132
2.523TyrGly: 2.523 ± 0.344
0.478TyrHis: 0.478 ± 0.135
0.783TyrIle: 0.783 ± 0.212
0.565TyrLys: 0.565 ± 0.19
1.696TyrLeu: 1.696 ± 0.281
0.348TyrMet: 0.348 ± 0.136
0.609TyrAsn: 0.609 ± 0.149
1.174TyrPro: 1.174 ± 0.222
1.131TyrGln: 1.131 ± 0.205
2.305TyrArg: 2.305 ± 0.4
0.826TyrSer: 0.826 ± 0.197
1.914TyrThr: 1.914 ± 0.316
1.74TyrVal: 1.74 ± 0.281
0.261TyrTrp: 0.261 ± 0.106
0.609TyrTyr: 0.609 ± 0.18
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 98 proteins (22993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski